Drug "Rozuvastatin" instructions for use characterizes as a lipid-lowering drug from the group of statins. The action of this selective agent is based on competitive inhibition of HMG-CoA reductase. As a result of the use of the drug "Rozuvastatin" (the instructions for use confirm this), the catabolism of LDL increases several times, the index of hepatic LDL receptors increases, and the amount of VLDL decreases. As for the pharmacokinetic properties of this lipid-lowering drug, a pronounced therapeutic effect from taking it is observed seven days after the start of the course of therapy, reaching its maximum result after four weeks.
The manufacturer recommends taking Rosuvastatin tablets to people suffering from a mixed form of hypercholesterolemia (type IIb) orhypercholesterolemia IIa (including heterozygous) as an addition to the diet.
At the same time, this lipid-lowering drug is most effective when other methods of treatment (physical activity, weight loss) do not lead to the achievement of the proper therapeutic result. In addition, the instructions for use advise using the selective Rosuvastatin remedy as an auxiliary drug during the treatment of homozygous familial hypercholesterolemia.
It is strictly forbidden to prescribe these pills if the patient has severe liver disease, myopathy, or severe disorders in the kidneys. During pregnancy, you should also not take the lipid-lowering agent Rosuvastatin. This medicine is also contraindicated during the lactation period. In addition, it is not recommended to take these tablets simultaneously with cyclosporine or in case of hypersensitivity to their components. Persons who have not reached the age of eighteen should also not be prescribed the selective agent Rosuvastatin. The instructions for use do not advise taking it in case of alcohol dependence, established renal failure or liver disease.
This lipid-lowering drug should be used with great caution in people suffering from electrolyte, endocrine or metabolic disorders, hypothyroidism or arterial hypotension. With sepsis,uncontrolled epilepsy, proteinuria, extensive injuries and surgical interventions, it is also worth refusing to take Rosuvastatin. In addition, hereditary muscle diseases and age over sixty-five are relative contraindications.
In conclusion, it should be said about the possible adverse reactions, the appearance of which can be triggered by taking Rosuvastatin. For example, many patients complain of abdominal pain, constipation, dizziness and nausea. In addition, there is a small risk of developing myopathy, proteinuria, asthenic syndrome and myalgia.
