Candles "Prednisolone" is a high-quality synthetic glucocorticoid hormone, which in its effectiveness is similar to the substance that is normally produced by the human adrenal glands. The drug has anti-inflammatory, anti-shock, anti-allergic, anti-proliferative, immunosuppressive, and antipruritic effect. To achieve a positive therapeutic result, you must first read the instructions, as well as choose the right dosage.
Medicine description
Candles "Prednisolone" are a more active dehydrated analogue of the multifunctional hydrocortisone, which can be used systemically or topically. The crystalline powder is odorless, white in color with a slight yellow tinge. The final molecular weight of the substance is 360 g/mol. In water, the drug is notdissolves.
The drug "Prednisolone" is a hormonal drug. It belongs to the group of glucocorticosteroids. These hormones are necessary for a person to maintain many important processes. First of all, this concerns the suppression of viral infections and dangerous pathologies. In addition, glucocorticosteroids have an immunosuppressive effect and eliminate swelling of the bronchi. Many experts prescribe "Prednisolone" as an anti-shock drug. Due to its high efficiency, the drug is also used for other complex ailments. Among them are bronchial asthma, systemic lupus erythematosus, rheumatoid arthritis, and psoriasis.
Prednisolone is used as an active ingredient. Excipients from different manufacturers may vary slightly, which is why you can study the composition on the package of the drug or in the attached instructions.
Pharmacological properties
Inflammation that occurs in the proliferative phase is effectively neutralized by high doses of Prednisolone. As a result, the activity of fibroblasts decreases in the patient, the production of reticuloendothelium and collagen is inhibited. The active substance promotes protein synthesis in the liver. The drug helps to stabilize the state of cell membranes, reduce the activity of metabolites and xenobiotics of increased toxicity. The completed therapy allows to achieve a powerful antitoxic effect.
Candles "Prednisolone" help to reduce the rate of development of lymphoid tissue. Maximuminvolution is achieved exclusively by long-term use of the drug. Due to this, the human bloodstream responds much better to vasoconstrictors, in addition, the receptors become more sensitive to catecholamines. During therapy, water and sodium may be retained in the body.
Operation principle
"Prednisolone" is a synthetic hormone that acts on human organs in a similar way to those compounds that are produced in the adrenal glands. The medication itself has the following principle of action:
- Eliminates the inflammatory process as quickly and efficiently as possible, regardless of its location and severity.
- Reduces shock and prevents death of the patient.
- Stops the uncontrolled reproduction of cells at the site of tissue damage, which prevents scarring.
- The development of an allergic reaction stops, and the symptoms characteristic of this condition are eliminated: itching, burning, swelling, rash.
- Suppresses the active release of fluid from inflammatory tissues.
- Normalizes the immune system.
All these effects from the use of "Prednisolone" develop extremely quickly, and the very positive effect of the drug is quite strong. Thanks to this, therapy can be prescribed even in case of a threat to life and in cases where other drugs have proven ineffective.
Indications for use
Skilled doctors prescribesuppositories "Prednisolone" as part of the complex therapy of hemorrhoids for the rapid relief of the symptoms of such a painful disease. High-quality suppositories allow you to qualitatively deal with the following pathologies:
- Polymyositis, dermatomyositis.
- Chronic connective tissue diseases.
- Acute adrenal insufficiency.
- Rheumatoid arthritis, rheumatic fever.
- Addison's disease.
- Myocarditis, systemic vasculitis.
- Hepatic coma.
- Asthma, status asthmaticus.
- Hepatitis.
- Leukemia, agranulocytosis, hemolytic anemia.
- Allergic rhinitis, urticaria, anaphylactic shock.
- Iritis, choroiditis.
- Iridocyclitis.
Before using the drug, be sure to read the instructions. Candles "Prednisolone" can be used to prevent the development of relapse or complications after surgery, which was aimed at removing hemorrhoids.
Contraindications
The instructions for the "Prednisolone" suppositories indicate that it is better not to use this medication for those patients who have been diagnosed with the following diseases:
- Digestive system damage: ulcers, abscesses, diverticulitis.
- Diseases of a parasitic or infectious nature. This applies to amoebiasis, tuberculosis, measles, and mycosis.
- Acute form of psychosis.
- Arterial hypertension, a chronic form of heart failure,recent myocardial infarction.
- Diabetes mellitus, hypothyroidism.
- Hypoalbuminemia.
- Glaucoma.
- Last stage obesity.
- Urolithiasis, severe liver or kidney failure.
- Polio.
- Eye diseases, open-angle glaucoma.
Rectal suppositories with prednisolone are strictly forbidden to use before vaccination and within 14 days after it. The drug can adversely affect the condition of pregnant women, as well as newborns who are breastfed.
How to use
In the instructions for use for Prednisolone suppositories, manufacturers indicated that before the procedure, the patient must cleanse the intestines with an enema. The suppository is inserted into the anus only in the supine position. At this time, it is desirable to press the knees to the chest. It is necessary to observe the elementary rules of personal hygiene, as well as to exclude any sudden movements during the introduction of candles. The patient must ensure that the base of the suppository is outside, for this it is held with a napkin. Most often, the procedure is performed twice a day. After the introduction of the suppository, you need to lie down for at least 40 minutes.
Side effects
Suppositories for hemorrhoids with prednisolone are actively used in modern medicine, but negative reactions of the body can occur if the patient has exceeded the dosage and terms of treatment. Most often, in such a situation,the following symptoms:
- Slow wound healing.
- Increased appetite.
- Slight increase in blood sugar.
- Decreased resistance to various infections.
- Increased anxiety, headache, nervousness.
In rare cases, the following manifestations are possible:
- Hypertension.
- Heat in the body, hiccups.
- Allergic reactions.
- Fasco, dizziness.
- Excessive sweating, lightening of skin color around the anus.
- Severe joint pain.
Numerous reviews of candles "Prednisolone" indicate that if you take the drug for 5 weeks without interruption or significantly exceed the allowable dosage, then there will inevitably be a risk of systemic disorders in the body. In such a situation, the function of the adrenal glands is inhibited, which increases the risk of developing Itsenko-Cushing's syndrome. The patient may experience bradycardia, arrhythmias, and cardiovascular disorders.
The use of a large dose of the hormone can provoke a violation of the water-s alt balance in the body, as well as cause the development of glycosuria and hyperglycemia. The medication can be the main cause of menstrual irregularities. Patients with diabetes may need an additional dose of insulin. Long-term use of glucocorticosteroid provokes a significant increase in blood pressure, and also increases the risk of developing heart failure, steroid myopathy, thrombosis, osteoporosis. Suppositories can be the main cause of a patient's loss of muscle mass.
The digestive system can react specifically to the action of a drug. Experts do not exclude the development of vomiting, nausea, steroid ulcers, and pancreatitis. A hormonal remedy can be the main cause of skin atrophy, hyperpigmentation, and increased sweating.
Special Instructions
Instructions for rectal suppositories with prednisolone contains information that discontinuation of therapy can provoke the development of a withdrawal syndrome, which is why it is necessary to carefully follow all the recommendations of the attending physician regarding dosage. For the duration of therapy, it is worth completely abandoning the use of alcoholic beverages. In addition, the drug can reduce the speed of psychomotor reactions, which is fraught with the development of hallucinations. That is why it is better to give up driving during therapy.
Principle of interaction with other medicines
Universal glucocorticosteroid interacts with various drugs:
- In combination with diuretics, electrolyte imbalance is aggravated.
- Combination therapy with salicylates increases the risk of bleeding.
- In gynecology, Prednisolone suppositories are forbidden to be combined with hormonal contraceptives, as this is fraught with an increased risk of developing undesirable effects of both drugs.
- Hypoglycemic drugs provoke a decrease in the levelglucose.
- Antipsychotic drugs increase the risk of developing cataracts.
Patients should always be aware that Prednisolone interacts with various medications, which is why there is always a risk of unwanted effects.
The consequences of an overdose
Even the most effective and safe remedy can cause great harm to the body if the allowable dosage is significantly exceeded. That is why only a specialist should make any adjustments to the treatment course. Otherwise, the development of disorders in the work of the cardiovascular system is not excluded.
Use during pregnancy
High-quality vaginal suppositories with prednisolone are strictly contraindicated in the first trimester of gestation. In all other cases, the drug is prescribed for he alth reasons. During breastfeeding, suppositories can be used only if the expected benefit significantly outweighs the potential risk. It is better to transfer the baby to artificial nutrition during therapy.
Treatment of little patients
Only the attending physician can prescribe Prednisolone suppositories for a child. The components of the drug can negatively affect the growth processes in childhood, which is why this hormonal agent is used only if there are serious indications and only under the supervision of a qualified doctor. Parents need to remember that such a medication is used only for acuteconditions, which is why the dosage should be minimal. It is forbidden to use suppositories longer than the prescribed time. For the treatment of children, experts recommend choosing more suitable medicines that will not harm the unformed body.
