What is the drug "Indapamide"? Analogues of this remedy, its instructions, side effects and indications for use will be presented below. In addition, from this article you will learn about whether this medication has contraindications, what to do in case of an overdose, how it should be taken, whether it can be combined with other drugs, and what experts think about it.
Composition of the medicinal product and its release form
In what form is this drug marketed? In the pharmacy, it can only be found in the form of biconvex tablets, covered with a white film shell.
What active substance does the drug "Indapamide" include? Analogues of this remedy (most of them) and the drug itself contain such an active ingredient as indapamide. As for excipients, the tablets include the following elements: lactose monohydrate, crospovidone, povidone K-30, magnesiumstearate, talc and sodium lauryl sulfate.
Pharmacological action of the drug
What are the properties of the drug "Indapamide", the price of which is presented at the very end of the article? This medicine belongs to the antihypertensive drug. In other words, it is a diuretic and a vasodilator.
In terms of its pharmacological properties, the drug is very close to thiazide diuretics and is taken in violation of the reabsorption of sodium s alts, which are located in the cortical segment of the loop of Henle. It is able to increase the excretion of chlorine, magnesium, sodium and potassium ions along with urine.
Why is the drug "Indapamide" prescribed? Analogues of this remedy and the mentioned medication itself have the ability to block "slowed down" calcium channels in a selective manner, increase the elasticity of the walls of blood vessels and lower the total vascular resistance (peripheral).
Taking this drug reduces the hypertrophy of the heart, or rather its left ventricle. It does not affect the amount of lipids in the blood, as well as carbohydrate metabolism, including in people with a disease such as diabetes.
The mentioned drug reduces the sensitivity of the vascular wall to angiotensin II and norepinephrine, reduces the production of stable and free oxygen radicals, stimulates the synthesis of prostaglandin E2.
After using the drug, the hypotensive effect develops by the end of the 1st week of therapy. At the same time, it lasts for 25 hours (after taking one tablet)
Pharmacokineticsmedicinal product
Where is the drug "Indapamide" absorbed? Instructions, reviews of experts say that after taking the drug inside, it is almost completely and instantly absorbed from the gastrointestinal tract. According to pharmacists, its bioavailability is 93%. Simultaneous intake of food slightly slows down the rate of absorption, although it does not affect the volume of the absorbed active element.
The maximum concentration of the active ingredient in the blood plasma is reached approximately 2 hours after taking one tablet. The half-life of the drug is 14-25 hours. Communication with blood proteins - about 79%.
This drug passes well through the histohematic barrier (including placental). It also passes into breast milk.
Metabolism of the medicinal substance is carried out in the liver. It is excreted by the kidneys (as metabolites) in the amount of 60-80% and 20% through the intestines.
Indications for use of the drug
In what cases is the drug "Indapamide" prescribed to patients? Indications for the use of this remedy include only one pathological condition of the patient. This is hypertension. In addition, the medication can be prescribed for sodium and water retention in the body. As a rule, this condition is very often observed in chronic heart failure.
Contraindications to the use of the drug
Now you know what the drug "Indapamide" is intended for (indications for useof this tool were presented a little higher). However, it should be noted that this medication has contraindications. These include the following factors:
- lactose intolerant patient;
- pregnancy period;
- galactosemia;
- hypokalemia;
- galactose or glucose malabsorption syndrome;
- lactation;
- simultaneous use of medications that can prolong the QT interval;
- severe renal failure (or stage of anuria);
- age of a person under 18 years of age (safety and efficacy of the drug in the treatment of children have not been established);
- pronounced hepatic, including with encephalopathy, insufficiency;
- hypersensitivity to the drug and other sulfonamide derivatives.
Careful use of medication
Many people are wondering: do I need a prescription to buy Indapamide? In fact, before using any drug, it is recommended to consult a doctor - only a specialist, after examination and based on the results of the tests, will be able to build a competent treatment regimen. As for our case, we note that the remedy in question is prescribed with extreme caution to people with diabetes mellitus, gout, as well as those patients who are allergic to sulfonamide derivatives.
Among other things, the medicine should be taken with caution in violations of the liver, kidneys and water-electrolyte imbalance.
During therapy, the doctor must constantly monitor the levelelectrolytes in the patient's blood (potassium, sodium, calcium).
The drug "Indapamide": instructions for use, expert reviews
According to the attached instructions, this medication must be taken orally, regardless of food intake. The tablet should be washed down with a sufficient amount of clean water.
How to take "Indapamide"? According to experts, this medication is better absorbed from the gastrointestinal tract only early in the morning. Therefore, it is recommended to take it exclusively at this time of day.
The dosage of the drug should be 2.5 mg (i.e. 1 tablet) per day. If after 4-8 weeks of therapy the desired effect has not been achieved, then the volume of the medication should not be increased (although doctors often do just that). This fact is due to the fact that with a large dosage, the risk of side effects increases. Instead, drug therapy should include another antihypertensive agent that is not a diuretic.
How to take "Indapamide" in this case? With the simultaneous appointment of two drugs, the dose of the drug we are considering remains the same, that is, 2.5 mg per day (early in the morning).
Overdose cases: symptoms, treatment
What happens if you take a large amount of the drug "Indapamide"? Reviews of doctors say that in such cases the patient experiences nausea, weakness and vomiting. In addition, the patient's water-electrolyte balance and the functioning of the digestive tract are disturbed. In some cases, the patient has a severe decreaseblood pressure and respiratory distress. Hepatic coma is possible in patients with cirrhosis of the liver.
How to treat? In case of an overdose, the patient should wash the stomach, correct the water and electrolyte balance, and apply symptomatic therapy.
Side effects after taking medication
Can there be negative reactions after taking the drug "Indapamide"? This drug has side effects. Let's list them right now.
- Digestive system: gastralgia, nausea, abdominal pain, vomiting, anorexia, constipation, dry mouth, pancreatitis, diarrhea, hepatic encephalopathy.
- Respiratory system: sinusitis, cough, rhinitis and pharyngitis.
- Nervous system: insomnia, asthenia, muscle spasms, nervousness, general weakness, anxiety, headaches, fatigue, vertigo, dizziness, depression, drowsiness, irritability, malaise and tension.
- Urinary system: nocturia, frequent infections and polyuria.
- Heart and blood vessels: arrhythmia, orthostatic hypotension, palpitations and ECG changes (i.e. hypokalemia).
- Allergies: hives, rash, hemorrhagic vasculitis and itching.
- Hematopoietic system: thrombocytopenia, hemolytic anemia, leukopenia, bone marrow aplasia and agranulocytosis.
- Laboratory indicators: glycosuria, hyperuricemia, increased plasma urea nitrogen, hyperglycemia, hypercreatininemia, hypokalemia, hypercalcemia, hyponatremia andhypochloremia.
- Other: exacerbation of systemic lupus erythematosus.
Interaction with other medicines
The drug "Indapamide", whose action is aimed at lowering pressure, is not recommended to be taken together with cardiac glycosides, as the likelihood of digitalis intoxication increases. If this remedy is used with calcium supplements and metformin, the patient may develop hypercalcemia and worsen lactic acidosis.
Simultaneous administration of the drug with corticosteroids, NSAIDs, sympathomimetics and tetracosactide lowers the hypotensive effect of the former. As for Baclofen, on the contrary, it intensifies with it.
Combining the drug with potassium-sparing diuretics is effective in a small number of patients. However, the possibility of developing hyper- or hypokalemia is not excluded, especially in patients with renal insufficiency and diabetes mellitus.
ACE inhibitors can increase the risk of hypotension and acute renal failure.
Kidney function may be impaired when high doses of iodine are used simultaneously.
Neuroleptics and imipramine antidepressants increase the hypotensive effect and increase the risk of orthostatic hypotension.
Special instructions for the use of the drug "Indapamide"
In what cases should the patient's blood picture be monitored after the appointment of the drug "Indapamide"? Reviews of doctors say thatthis medicine can change the amount of creatinine and potassium ions in patients who take laxatives, cardiac glycosides, and in people over 60 years of age.
When using this remedy, specialists are advised to systematically monitor the concentration of sodium, potassium and magnesium ions in the blood plasma, as patients may develop electrolyte disturbances. It is also necessary to monitor the pH, the concentration of uric acid, glucose and residual nitrogen.
Patients with cirrhosis of the liver (with severe edema or ascites), as well as heart failure and coronary heart disease, should be subjected to special control.
At increased risk are patients with an extended QT interval on the ECG (may be congenital or develop on the background of any pathology).
The first measurement of the concentration of potassium ions in the patient's blood is recommended during the first week of treatment.
Special attention is recommended for patients with diabetes. In particular, it is necessary to monitor the level of glucose in the blood, especially if a person is diagnosed with hypokalemia.
Patients taking this medication should compensate for water loss by drinking plenty of fluids per day. Moreover, at the very beginning of therapy, they need to control the functioning of the kidneys.
It is impossible not to say that the drug "Indapamide", analogues of which will be presented below, can give a positive result during doping control.
For patients withhyponatremia and arterial hypertension 3 days before the start of the use of angiotensin-converting enzyme inhibitors, diuretics should be discontinued. Treatment can be resumed a little later.
When prescribing Indapamide, specialists should take into account that sulfonamide derivatives can easily exacerbate a disease such as systemic lupus erythematosus.
To date, the safety and efficacy of the drug in the treatment of young children and adolescents has not been established.
In some cases, individual reactions are possible, which are associated with changes in blood pressure. As a rule, this occurs at the very beginning of therapy, as well as when using another antihypertensive drug. As a result, the ability to drive a machine and work with other mechanisms may decrease, which require increased attention.
Reviews of specialists and patients about the drug
Now you know what Indapamide is. Reviews, the price of this medicine will be presented right now.
Specialists claim that this medicine does its job well. It effectively lowers blood pressure and also acts as a diuretic.
Reviews about the drug "Indapamide" indicate that after its use, left ventricular hypertrophy decreases, and its hypotensive effect is manifested even in those patients who are on hemodialysis.
Regarding negative statements inthe address of the mentioned remedy, then most often they are associated with the manifestation of a large number of adverse reactions. However, it should be noted that such effects are observed only in those who exceeded the prescribed dosage of the drug or took it, despite the existing contraindications.
Price and analogues of the drug
How much does Indapamide cost? The price of this medication may be different (depending on the manufacturer and the markup of the pharmacy chain). However, on average, this remedy can be purchased for 95-100 Russian rubles (for 30 tablets).
But what to do if the patient could not find the drug "Indapamide"? Analogues, the price of which is also not very high, are sold in almost every pharmacy. Such medicines include the following: Indapamide retard, Akripamide, Indapamide-Teva, SR-Indamed, Acripamide retard, Ravel SR, Akuter-Sanovel, Retapres, Arindap”, “Lorvas”, “Arifon”, “Pamid”, “Arifon retard”, “Tenzar”, “Ipres Long”, “Vero-Indapamid”, “Indipam”, “Indap”, “Indiur”, “Indapamid-Verte”, “Ionic”, “Indapamide retard-Teva”, “Indapress”, “Indapamide Sandoz”, “Ionic retard”, “Indapamide-OBL”, “Indapamide Shtada” and so on.
It is strictly forbidden to take these funds at your own discretion and replace them with the Indapamide medication. Only a doctor should prescribe them, and only after a medical examination. Also, before taking these drugs, you must read the attached instructions.
Medicine storage conditions and expiry date
Storethe drug is necessary in a dry and dark place, which is inaccessible to small children. The storage temperature of the drug should not exceed 25 degrees. Its shelf life is 3 years. After the specified period, taking the medication is strictly prohibited.
