Various pathologies of the liver and biliary system develop not only because of bad habits, but also because of bad ecology, malnutrition and frequent use of medications. All these negative factors contribute to the formation of gallstones. The body develops multiple inflammatory processes. These diseases are treatable, which is based on the use of various medications. The most popular remedy is "Grinterol". Analogues, instructions for use and contraindications will be described in this article.
Pharmacological principle of action
The drug "Grinterol" belongs to the category of powerful hepatoprotectors. The active substance freely penetrates into the membranes of liver cells and protects them from the negative effects of bile components. The drug reduces the total concentration of biological acids, which have increased toxicity. Manufacturers of the drug "Grinterol" note that this tool has severalBuffs:
- Cholagogue. Stimulates the production and excretion of bile.
- Cholelitholytic. Helps dissolve small cholesterol stones that form in the gallbladder.
- Lipipidemic. Reduces the degree of intestinal absorption of lipophilic acids, contributing to their rapid removal from the body.
- Hypocholesterolemic. Significantly reduces the concentration of harmful cholesterol in the blood.
Patients rarely look for analogues of "Grinterol", as this drug has a slight immunomodulatory effect. The tool is involved in all important reactions that occur in the liver.
Composition and release form
The drug "Grinterol" is available in the form of small capsules. The product is sold in blister packs of 10 pieces. One carton pack may contain from 5 to 10 blisters.
One capsule contains the following ingredients:
- The active substance is ursodeoxycholic acid 250 mg.
- Auxiliary components: magnesium stearate, corn starch, silicon dioxide.
Purpose of ursodeoxycholic acid
Bile is essential for proper digestion of food. Many believe that if this substance is produced in the body of each person by special liver cells, then why take medicines based on it? And the thing is that the composition of bile includes many components. Thirdmake up universal acids that emulsify all fats. The classical pathogenesis of cholestatic liver diseases is based on an increased amount of hydrophobic substances that have a certain toxicity to he althy tissues of the organ.
Specialists came to the conclusion that the composition of bile must be changed so that it contains more useful substances. This can only be achieved if you take drugs that contain ursodeoxycholic acid.
Indications for use
Numerous positive reviews about "Grinterol" indicate that this medication is effective in the fight against many diseases. Qualified doctors often prescribe this medication to those patients who have been diagnosed with the following pathologies:
- Inflammation of the bile ducts.
- Cystic fibrosis.
- Cholelithiasis (but provided that the organ functions normally).
- Cirrhosis of the liver or biliary reflux gastritis (if the patient does not have symptoms of decompensation).
- Transforming once-he althy liver tissue into fatty tissue.
The instructions for use of "Grinterol" indicate that the drug can only dissolve cholesterol stones, the size of which does not exceed 2-3 centimeters in diameter.
Contraindications
Analogues of "Grinterol" are of interest to patients only if they are contraindicated in the use of this medication. The doctor may refuseprescribing the drug to those patients who have the following contraindications:
- The presence of acute inflammatory processes in the intestines, bile ducts, gallbladder.
- Increased sensitivity to the components that make up the medication.
- Presence of radio-positive gallstones (high calcium).
- Severe liver or kidney failure.
- Chronic pancreatitis.
- Children's age (up to 3 years do not prescribe capsules).
- Cirrhosis of the liver (stage of decompensation).
- Non-functioning gallbladder.
The patient must take into account all contraindications. Otherwise, you can only aggravate the state of he alth.
Instructions for the use of "Grinterol"
Analogues of this drug should be selected exclusively by a qualified doctor. If the patient has no contraindications, then he is prescribed a full-fledged therapy based on the studied medication. Patients whose body weight is less than 45 kg or have difficulty swallowing capsules should take a drug with ursodeoxycholic acid in a different dosage form. If it is necessary to achieve high-quality dissolution of cholesterol gallstones, then you need to adhere to a certain dosage. For 1 kg of body weight take 10 mg of the drug:
- Over 100 kg - 5 capsules.
- From 80 to 99 kg - 4pills.
- 60 to 79 - maximum 3 capsules.
- Up to 59 kg - 2 pills per day.
Capsules must be swallowed whole with plenty of non-carbonated water. The medicine is taken 1 time per day. It takes 6 to 24 months for gallstones to dissolve. If after a year the stones have not decreased in size, then treatment should be stopped. The effectiveness of therapy should be checked every six months. For these purposes, specialists use X-ray or ultrasound. Doctors also check to see if the stones have calcified. If this happens, then the treatment must be stopped.
For an effective fight against biliary reflux gastritis, use 250 mg of medication per day. The drug is taken only at bedtime. The therapy lasts two weeks. The extension of the course depends on the patient's condition. That is why each clinical picture is considered individually.
For high-quality symptomatic treatment of primary biliary cirrhosis, the optimal dosage is selected based on the patient's body weight. A maximum of 7 capsules per day can be taken. The first three months, the pills are consumed during the day, distributing the daily dose by 3 times. It is necessary to observe the regularity of reception. The first days the patient may experience increased clinical symptoms. In such a situation, treatment is not stopped, they simply take 250 mg of the drug per day. The dosage is increased gradually until the prescribed regimen is reached.
The use of "Grinterol" can significantly reduce proliferation in the bile ducts, stopprogression of histological changes and even eliminate unwanted hepatobiliary changes, provided that treatment is started in the early stages of cystic fibrosis.
Adverse reactions
The instructions for "Grinterol" indicate that exceeding the permissible dosage is fraught with a deterioration in the general condition of the patient. In such a situation, the digestive system, liver, biliary tract, soft tissues may suffer. Some patients complain of diarrhea and vomiting. In such a situation, it is necessary to reduce the daily dosage. If the negative manifestations do not stop, then the treatment is canceled.
Allergic rashes all over the body are not excluded. If a patient is being treated for primary biliary cirrhosis, the following adverse reactions may occur:
- Sharp pain in upper right abdomen.
- Transient decompensation of liver cirrhosis.
If the patient feels a deterioration in well-being, then he needs to urgently seek the advice of a therapist. In such a situation, a substitute for "Grinterol" may be needed.
Special Instructions
Clinical trials of "Grinterol" have shown that this drug has some nuances. They need to be considered before buying the drug. This way you can avoid the most common mistakes and reduce the risk of side effects.
Special Instructions:
- The drug "Grinterol" does not cause drowsiness and does not reduce the reaction. Because of this, patientscan drive and perform tasks that require increased concentration.
- During treatment, you need to periodically take tests to control the functioning of the body.
- The entire course of treatment should be under the strict supervision of doctors.
- An analogue of "Grinterol" is necessary if after 12 months of using the drug the patient does not have positive dynamics in the fight against the disease.
- During pregnancy, use the drug only if the risk of harm to the baby is minimal.
- The unique composition of "Grinterol" helps to cope only with small and medium calculi.
- After getting rid of cholesterol stones, therapy should be extended for another 3 months. Thanks to this, it is possible to dissolve the remains of calculi and prevent a possible recurrence of the pathology.
Medication does not mix well with alcoholic beverages. That is why during therapy you need to stop drinking alcohol.
Clinical studies of the effect of the drug on the fetus were carried out exclusively on animals. The experts did not reveal any carcinogenic or mutagenic effects. It is possible to use "Grinterol" during pregnancy only if the benefit to the mother is much higher than the risk to the developing fetus. There is no data on the release of the components of the drug along with breast milk, therefore, when using the drug, it is better to transfer the child to artificial mixtures.
Pediatricians often prescribe medication for children as young as three. Younger patients may have difficulty swallowing capsules, so the drug may be given as a suspension.
Interaction with other drugs
Most of all patients are interested in instructions for the use of "Grinterol" and analogues of this drug. But it is also important to think about the correct compatibility of medicines. For treatment to be truly effective, drug interactions must be considered:
- "Grinterol" several times enhances the effect of cyclosporine, which is why the dosage of drugs with this substance must be reduced.
- Useful antacids based on aluminum s alts and cholestyramine should be taken a maximum of 2 hours before "Grinterol". Otherwise, the action of the hepatoprotector will be reduced.
- Classic oral contraceptives significantly reduce the ability of ursodeoxycholic acid to dissolve existing cholesterol gallstones. That is why it is better to refuse such funds during treatment with "Grinterol".
- The drug reduces the effectiveness of ciprofloxacin. For the treatment to be effective, the doctor must choose the right dosage of medications.
If the doctor has prescribed "Grinterol" for the treatment of gallstones, then you need to be regularly examined in the hospital. For the period of drug therapy, the patient must periodically donate blood for analysis,undergo ultrasound of the gallbladder, as well as multifunctional cholecystography. Only in this case it is possible to control the effectiveness of the prescribed treatment.
Analogues of "Grinterol"
Cheap substitutes for this hepatoprotector are often of interest to those patients who have contraindications to the use of the drug. The following tools are most effective:
- Ursosan.
- Ursofalk.
- Ursodez.
- Urdoksa.
- Exhole.
- Livodex.
- Ursoliv.
- Choludexan.
- Odeston.
- Flamin.
- "Hofitol".
- Artichoke Extract.
Numerous reviews of analogues of "Grinterol" indicate that the modern pharmaceutical market is filled with a variety of drugs that do an excellent job with cholelithiasis. But the doctor should choose the right one!
Clinical efficacy of analogues of tablets "Grinterol"
Laboratory studies of the beneficial properties of ursodeoxycholic acid have been conducted around the world since the 90s of the last century. The experts were able to prove that medicines with this substance are effective for the treatment of primary biliary cirrhosis. The use of ursodeoxycholic acid at 14 mg per day reduces the baseline indicators of cholestasis in patients and suspendsdevelopment of a dangerous pathology.
In Russia, cheap analogues of "Grinterol" are indicated for the following cholestatic disorders:
- Cystic fibrosis.
- Intrarenal cholestasis of pregnancy.
- Primary sclerosing cholangitis.
- Cholestasis caused by parenteral nutrition.
Cheap analogues of "Grinterol" have the necessary efficiency even with cirrhosis of the liver. For example, in 2000, experts conducted many placebo-controlled studies of patients with alcoholic liver disease. As a result, liver function tests were significantly improved after taking 16mg/kg for a month.
Patient testimonials
The drug "Grinterol" is in demand, because with the help of this medication you can overcome gallstone disease. Patient reviews are positive. People note that the drug is highly effective, as it can be used to treat children who have reached the age of three. "Grinterol" does not affect the ability to drive vehicles, as well as potentially dangerous mechanisms. Taking the medication implies a mandatory consultation with a doctor. The dosage is calculated on an individual basis, as it all depends on the patient's condition.
