Cold diseases today are familiar to almost everyone. Probably, everyone has a “favorite” remedy in their home medicine cabinet to quickly lower the temperature, eliminate pain and fever. One of the popular and effective drugs in this case is Panadol Extra. It is often used to relieve pain in various localizations, reduce fever and eliminate fever after vaccination. This medicine belongs to NSAIDs, many people use it to eliminate fever and temperature during flu and SARS.
Characteristics and description of the drug
Panadol Extra is a combined drug, NSAIDs, analgesic and antipyretic. It is available in the form of tablets, one of which contains five hundred milligrams of paracetamol, as well as sixty-five milligrams of caffeine. As auxiliary components, Panadol Extra contains: sodium bicarbonate,sorbitol, citric acid, povidone and others.
These substances have an analgesic and antipyretic effect. Indications for use "Panadol Extra":
- Pain syndrome of varying intensity and localization.
- Pain after vaccination.
- Fever.
- High body temperature.
- SARS and influenza.
- Neuralgia, arthralgia.
- Algodysmenorrhea (painful menstruation).
One pack contains six strips, each containing two tablets.
Drug action
Panadol Extra tablets reduce body temperature, relieve pain. The drug is presented in the form of effervescent tablets, soluble in water. Its constituent paracetamol and caffeine reduce the concentration of prostaglandins in the central nervous system, as they block the synthesis of cyclooxygenase. Paracetamol acts on the centers of pain and thermoregulation. But it does not have an anti-inflammatory effect. Caffeine also helps to eliminate depression, which accompanies pain, excites the central nervous system. It eliminates fatigue and drowsiness, increases efficiency.
Paracetamol is absorbed in the gastrointestinal tract in a short time, distributed evenly through the liquids. It is excreted by the kidneys along with urine in the form of metabolites after about three hours. Its maximum concentration in the blood is observed after two hours. Caffeine is also rapidly absorbed, with most of it excreted in the urine after about three hours.
Panadol tablets: instructions for use
Children up totwelve years the drug can not be taken. The rest of the patients need to take one or two tablets four times a day. There should be at least four hours between doses. Tablets are dissolved in pure water in the amount of one hundred grams. The maximum allowable dosage is eight tablets per day. It is unacceptable to take other drugs that contain paracetamol or caffeine, and it is also not recommended to drink caffeinated drinks.
The duration of treatment should be determined by the doctor on a case-by-case basis. Usually the medicine is not used for more than three days, otherwise a doctor's consultation is required.
Use restrictions
There are some contraindications for the use of the drug. Painkillers are not recommended in these situations:
- Increased susceptibility to drug ingredients.
- Pathologies of the kidneys or liver in severe form.
- Hyperbilirubinemia.
- Blood diseases.
- Anemia and leukopenia.
- Alcohol addiction.
- Excitement of the National Assembly.
- Sleep disorder.
- Epilepsy.
- Hypertension, leukopenia.
- Pathologies of the heart and blood vessels.
- Severe atherosclerosis.
- Myocardial infarction.
- Tachycardia.
- Acute pancreatitis.
- Hyperthyroidism.
- Severe diabetes mellitus.
- Glaucoma.
- Thrombosis, atherosclerosis.
- Prostatic hypertrophy.
- Old age (more than sixtyyears).
- Children under the age of twelve.
- The period of treatment with antidepressants and beta-blockers.
- Congenital fructose intolerance.
- Spasms of vessels.
- The period of bearing and breastfeeding a child.
Interaction with other medicines
These pain pills should not be taken with alcoholic beverages. With the simultaneous use of "Cholestyramine", the effect of the drug will slow down. When using "Warfarin" increases the risk of bleeding. Barbiturates reduce the effectiveness of the drug. Anticonvulsant drugs increase the toxic effects of paracetamol on the liver. When using diuretics with paracetamol, their effectiveness decreases. The risk of developing a hypertensive crisis increases with the simultaneous use of drugs and MAO blockers.
Caffeine enhances the effect of psychostimulant drugs, and also reduces the effectiveness of hypnotics and sedatives, analgesics and anxiolytics. And also this substance, when taken simultaneously with thyroid-stimulating drugs, increases their effectiveness.
Features of using the medicine
If there are problems with the kidneys, as well as arthritis in a patient, an additional consultation with a specialist is required. The drug affects the results of laboratory blood tests for the concentration of glucose and uric acid.
When a person has severe infections, the likelihood of developing acidosis increases, which is accompanied by nausea and vomiting,loss of appetite, shortness of breath. If these symptoms appear, you should immediately contact a medical facility.
Concomitant use of caffeinated beverages increases the risk of sleep disorders, tremors, heart palpitations.
If negative symptoms persist for a long time, as well as a headache that does not go away, it is recommended to consult a doctor to prescribe a different medication.
Using Panadol Extra during pregnancy increases the risk of miscarriage.
If dizziness occurs after taking the pills, it is recommended to refrain from driving a car or other mechanisms for a while.
Complications and consequences
Usually the drug is well tolerated by all patients. But in some cases, side effects may occur. "Panadol Extra" causes such reactions:
- Nausea accompanied by vomiting.
- Pain in the abdomen or heart.
- Rashes on the skin and mucous membranes.
- Stevens-Johnson Disease.
- Swelling, erythema.
- Lyell's syndrome.
- Hypoglycemic coma.
- Anemia.
- Hematomas.
- Shortness of breath.
- Thrombocytopenia.
- Arrhythmia.
- Increased blood pressure.
- Sleep disorder.
- Dizziness.
- Bronchoconstriction.
- Hepatonecrosis.
- Disruption of the liver.
- Excitability, anxiety.
- Disorderfunctionality of the digestive tract.
If any negative symptoms appear, treatment should be stopped, and you should also seek advice from your doctor.
Exceeding allowable dosages
According to the instructions for the use of Panadol tablets, when using a large amount of the drug (more than ten grams), liver pathology develops. In people who have digestive disorders, HIV, epilepsy, alcoholism, an overdose occurs when taking five grams of the drug.
In case of an overdose, the following symptoms develop during the day:
- Nausea accompanied by vomiting.
- Pain syndrome in the abdomen.
- Pale skin.
On the second day, liver pathology, acidosis develops. In severe intoxication, liver failure, encephalopathy, hypoglycemia, and hemorrhages occur. Such phenomena can cause death.
Renal failure is manifested by severe pain in the lumbar region, hematuria. And also pancreatitis, arrhythmia may appear.
When using tablets in high doses, anemia, neutropenia, thrombocytopenia, pancytopenia, leukopenia, as well as disorientation in space, renal colic, capillary necrosis develop for a long period.
If symptoms of an overdose appear, the victim must be taken to a medical facility. And also the patient needs to be given a sorbent as soon as possible. Eight hours after poisoning, the effectivenessantidote is reduced. If necessary, the victim is administered "Acetylcysteine". At home, with mild poisoning, which is not accompanied by vomiting, you can give a Methionine tablet. And it is also allowed to take beta-blockers. Before taking the drugs, you need to rinse the stomach, in the presence of convulsions, give "Diazepam". Therapy of intoxication is symptomatic.
Additional information
"Panadol Extra" must be stored in a dry, dark place at an air temperature of up to twenty-five degrees Celsius. The shelf life is four years from the date of release of the medicine. Children should not have access to medicines.
Cost and purchase of the drug
This medication can be purchased at almost any pharmacy chain in the country. To buy it, you do not need a doctor's prescription, but you should not self-medicate. The cost of the medicine is about sixty-seven rubles per package.
Analogues
There are several analogues of this drug. The most common are:
- "Migrenol" - a drug that has a similar composition and pharmacological action. Well eliminates pain of varying intensity and localization, reduces the temperature during influenza and SARS, eliminates body aches. Its cost is one hundred and seventy rubles for a package of eight tablets.
- "Solpadein" - psychostimulant and analgesic. It has a similar pharmacological action and composition. Produced by an Irish company. The price of the medicine is one hundred and eightyrubles for a pack of twenty-four tablets.
- "Migrenium" - a similar drug. Its cost is one hundred and twenty-five rubles for a pack of twenty tablets.
Reviews
About the drug "Panadol Extra" reviews are mostly positive. Many consumers note that the drug has a quick effect, helps to reduce body temperature in a short time and eliminate pain and aches in the body. It is often used to treat colds. In addition, most patients note that they did not notice any side effects when using the medicine.
Many note the low cost of the drug. But there are also people who say that you need to wait a long time for the remedy to take effect.
Some patients, after reading the instructions, are afraid to use the medication, as it indicates a large number of contraindications and adverse reactions. But doctors say that with proper observance of all prescriptions and recommendations, there are no negative symptoms. Doctors often prescribe medication to their patients to relieve pain. The effect of the drug is observed for a long time, which is a plus.
Doctors emphasize that it is not necessary to increase the dosage of the drug, since in this case the risk of developing negative consequences increases several times. It is unacceptable to engage in self-medication, it is best to contact doctors in case of manifestation of diseases, they will help you choose the most suitable remedy.
