One of the representatives of the group of non-steroidal anti-inflammatory drugs is the drug "Indomethacin" (tablets). Due to its anti-inflammatory, analgesic and antipyretic effects, it is used to treat inflammatory diseases, eliminate pain, reduce swelling and restore joint mobility.
Medication description
The main active ingredient of the drug is indomethacin, which belongs to the derivatives of indoleacetic acid. The instruction describes the tablets inside the package of the drug "Indomethacin" as elements with a protective enteric coating, which allows the active substance to be released in the intestine, bypassing the stomach. The tablets are round, biconvex in shape, covered with a light brown shell on top.
Tablets come in several dosages: 25 mg, 50 mg and 100 mg of indomethacin. Available in packs of 10 or 40.
All dosage forms
Excepttablets, there are other forms of the drug "Indomethacin" for oral use, for example, capsules with prolonged action with a dosage of 75 mg. For rectal administration, suppositories with a dose of 50 mg are used. For external use, an ointment 5% and 10% and a gel 3% were created.
Mechanism of action
The drug is a systemic non-steroidal anti-inflammatory drug that has anti-inflammatory, decongestant, analgesic and antipyretic effects. The instruction attached to the drug "Indomethacin" (tablets) contains a description of the mechanism of operation of its active component, associated with a decrease in cyclooxygenase activity of types 1 and 2. In turn, this enzyme has less effect on arachidonic acid, which reduces its conversion to prostaglandins. It is these substances that cause inflammation and pain.
Indomethacin has an antiplatelet effect, reducing the aggregation of blood platelets. The substance relieves pain in joint pain in a calm and mobile state, reduces morning stiffness and swelling, increases range of motion.
The action of indomethacin is aimed at reducing inflammation. This effect is maximally manifested on the seventh day of treatment with the drug tablets.
What heals
Based on the mechanism of action, Indomethacin tablets instructions for use advise using for systemic treatment:
- articular syndrome;
- inflammatory diseases of the musculoskeletal system caused byrheumatic, psoriatic, rheumatoid, juvenile arthritis, humeroscapular periarthritis, ankylosing spondylitis, joint damage with osteitis deformans and urethrooculosynovial syndrome;
- degenerative diseases of the musculoskeletal system caused by osteochondrosis in radicular syndrome, deforming osteoarthritis of the joints, excluding hip and intervertebral arthrosis;
- diffuse disease involving connective tissue;
- rheumatism;
- purulent inflammatory lesions of the periarticular bursa and tendons;
- acute pain symptom in the lower back and other parts of the spine with neuralgia of the sciatic and other nerves, muscle inflammation;
- traumatic inflammation in soft tissues or joints.
It can be used to cope with headache, menstrual, toothache, algomenorrhea.
As an adjuvant for infectious and inflammatory diseases such as pharyngitis, tonsillitis, otitis media, the drug "Indomethacin" (tablets) is used. Indications for use include the treatment of cystitis, adnexitis, prostatitis.
The drug is effective for relieving febrile syndrome associated with lymphogranulomatosis, lymphoma, tumor metastases, when paracetamol and acetylsalicylic acid do not work.
How to take it right
The drug "Indomethacin" in tablets is prescribed to the patient in one dosage or another based on the degree of the disease. Usually adults start with a dose of 25 mg three times a day.once a day after meals.
If the effect of the treatment is not sufficiently pronounced, the dosage is doubled to 50 mg 3 times a day. The maximum allowable dose should not exceed 200 mg of indomethacin. After a noticeable improvement caused by drug therapy, treatment is stopped only after 4 weeks, using the same or reduced dose during this period. If patients take Indomethacin tablets for a long time, the instructions for use recommend using a dose of no more than 75 mg of the active substance per day.
Treatment of children
For a child, the daily dose is calculated by multiplying 2, 5 or 3 mg by his body weight, it is taken 3-4 times. For each age category, the use of the initial daily dose is provided:
- Children aged 3 to 7 are prescribed 50mg to 75mg, equivalent to 2 or 3 tablets;
- children from 7 to 12 years old are prescribed from 75 mg to 100 mg, which corresponds to 3 or 4 tablets;
- children from 12 years of age are prescribed from 100 mg to 125 mg, which corresponds to 4 or 5 tablets.
In the first few days, you should find out how the medicine works on the child's body, so use a small dose of medicine. The duration of therapy with the drug "Indomethacin" (tablets) is indicated by the instruction as a period of 6 to 7 days.
Reception Features
Due to the potential for adverse effects from taking Indomethacin tablets, it is best not to use it to treat acute rheumatic fever in childhood. Entering breast milk, the active substance penetrates intothe baby's blood, enhances the physiological jaundice of the baby and damage to liver cells. To prevent this, they cancel breastfeeding.
organism. It is necessary to control the function of problematic organs, once every 7 days to examine peripheral blood.
If allergic reactions to non-steroidal anti-inflammatory drugs have been observed in the past, then Indomethacin (tablets) is prescribed in extreme cases.
It is not recommended to perform hazardous types of work during treatment, as attention and psychomotor activity are impaired.
When not to take
There are diseases in which the drug "Indomethacin" (tablets) is contraindicated. Can't use it:
- with hypersensitivity to indomethacin;
- in the presence of erosive and ulcerative lesions of the digestive system in the acute phase;
- with the "aspirin triad", characterized by intolerance to acetylsalicylic acid, nasal polyps and bronchial asthma;
- with impaired hematopoiesis;
- with a pronounced change in the functioning of the liver and kidneys;
- with s alt and fluid retention with possible peripheral edema;
- in severe myocardial insufficiencychronic;
- high blood pressure;
- for bronchial asthma;
- with inflammation of the pancreas;
- in the third trimester of childbearing;
- when breastfeeding;
- in children under 3 years old.
Adverse reactions
Taking the drug "Indomethacin" (tablets) may be accompanied by side effects that adversely affect the state of the human body. Common adverse reactions include nausea, anorexia, abdominal pain, flatulence, constipation, indigestion.
In isolated cases, side effects may manifest as erosive and ulcerative lesions, bleeding and perforation of the walls of the stomach and intestines; aplastic or hemolytic anemia, leukopenia, thrombocytopenia, agranulocytosis, rash, hair loss, skin itching, convulsions, Quincke's edema, bronchospasm.
Very rare signs of Lyell's syndrome, anaphylactic shock, erythema nodosum.
During treatment, there may be a violation of the excretory work of the kidneys and liver, which increases the content of bilirubin, hepatic transaminase.
Prolonged use of the drug "Indomethacin" (tablets) does not exclude adverse reactions associated with sleep disturbance, dizziness, peripheral neuropathy, headache, agitation, irritability, fatigue. They are characterized by clouding of the cornea, conjunctivitis, hearing loss, tinnitus, high blood pressure,swelling.
Reviews
It is very important to follow all the rules for the use of the drug, to exclude all contraindications.
Reviews are ambiguous regarding the use of the drug "Indomethacin". Tablets have more side effects than dosage forms for external use. In addition, this medication belongs to type 1 and type 2 cyclooxygenase inhibitors, which are considered less effective and cause a number of adverse reactions from the gastrointestinal tract.
Rheumatologists and surgeons often prescribe more modern drugs from the oxicam group to their patients. They inhibit only type 2 cyclooxygenase without affecting the type 1 enzyme, which ensures the production of prostaglandins that protect the digestive system. That is why oxycams cause less harm to the stomach than the drug "Indomethacin" (tablets). The instruction includes negative reviews in the description of side effects, but this does not mean that they should all appear during treatment. It all depends on the characteristics of the body.
Many patients this remedy saves from back pain, myalgia, intercostal neuralgia, when other medicines do not help. And negative effects practically do not arise from treatment with the drug "Indomethacin". Reviews of the pill from recovered patients are positive. Although the risk is always present, and only the attending physician can prescribe such a serious drug.
Analogues
Pills with the active ingredient indomethacin are produced by manyforeign and domestic enterprises, such as Sopharma, Ludwig Meckle, Nycomed, Farmakhim, Berlin Hemi Menarini, Altfarm. Only each drug has its own trade name, its own composition of auxiliary components. All analogues have the same indications for use, side effects, contraindications.
The most popular drug is "Indomethacin Sopharma" (tablets). Produced in a dosage of 50 and 100 mg by Sopharma (Bulgaria). Refers to nonsteroidal anti-inflammatory drugs.
Another couple of equally well-known analogues are the medicines Indomethacin 50 mg Berlin-Chemie and Indomethacin 100 mg Berlin-Chemie. Produced in two dosages (50 and 100 mg each) by the Italian company Berlin-Chemie Menarini.
Indomethacin (tablets) has Russian analogues. They are produced in different dosage forms. The main analogues are:
- "Indomethacin-Acri" of the chemical and pharmaceutical plant JSC "Akrikhin";
- Indomethacin-Altpharm, LLC Altpharm;
- "Indomethacin-Biosintez", OJSC "Biosintez";
- Vero-Indomethacin, OJSC Veropharm.
