Non-steroidal anti-inflammatory drugs hold a strong leading position in the pharmaceutical markets around the world. These means of complex effects have antipyretic, anti-inflammatory and analgesic effects on the human body. One of these medicines is Ibuprom. The instruction regulates it as a very effective remedy for a variety of diseases.
Pharmacodynamics of the drug
"Ibuprom" is a derivative of phenylpropionic acid. The mechanism of influence is based on the suppression of the activity of COX (an enzyme, a precursor of prostaglandins, which in turn predominate in the processes of pathogenesis, the development of pain and feverish sensations). Moreover, the drug is characterized by non-selective inhibition of cyclooxygenase, i.e. "Ibuprom" equally inhibits the activity of both isoforms of this enzyme - COX-1 and COX-2.
Anesthetic effect of the drug "Ibuprom" instructions for usecauses two mechanisms - peripheral and central. The first one manifests itself indirectly through the inhibition of the production of prostaglandins. The influence of the second mechanism (central) is to suppress the production of the same prostaglandins in the central and peripheral regions of the NS. Due to the decrease in the lipid physiologically active substances present in the focus of inflammation, the sensitivity of the perception of chemical stimuli by receptors decreases. In the hypothalamus in the center of thermoregulation, suppression of prostaglandin synthesis leads to a decrease in body temperature during feverish conditions.
In addition, Ibuprom tablets (the instructions for the drug contain such information) suppress platelet aggregation (gluing) to some extent.
Composition and formulation of the medicinal product
Ibuprofen is the main active ingredient of Ibuprom. As auxiliary components, crospovidone, silicon dioxide, polyethylene glycol and a number of other substances (gelatin, starch, vegetable oil, sucrose, etc.) can be called.
There are several forms in which the drug is offered to consumers. The drug can be packaged in a sachet, in a polyvinyl bottle (50 tablets) or in blisters.
Depending on the volume of the main component in the drug, they talk about Ibuprom (200 mg of ibuprofen in one tablet) or the drug Ibuprom Max (400 mg of ibuprofen). However, that's not all. About such a variety as "Ibuprom Sprint Caps", the instruction reports that the drug is produced incapsules with a dose of 200 mg of the main active ingredient in each. "Ibuprom Extra" is also offered to patients in capsules, the volume of the main component in each is 400 mg. About Ibuprom Sinus, the instruction says that one tablet contains 200 mg of ibuprofen and 30 mg of pseudoephedrine hydrochloride.
Indications for use
A description of all the symptoms when a positive effect is obtained, contains instructions for such a remedy as Ibuprom tablets. The composition (analogues of the drug with the same active substance will have approximately the same effect) suggests that the drug will give a positive result in the treatment of diseases such as any inflammatory-degenerative problems in the spine and joints. Arthritis (rheumatoid, rheumatic, psoriatic), osteoarthritis, ankylosing spondylitis will not be an exception. "Ibuprom" is prescribed for inflammation of soft tissues and the musculoskeletal system caused by injuries, with radiculitis, bursitis, tendinitis. In addition, the drug is able to cope with headache and toothache, with neuralgia, myalgia, with pain syndrome in infectious and inflammatory diseases of the upper respiratory tract. Medical workers practice the appointment of "Ibuprom" in febrile conditions to reduce body temperature, with pain of mild or moderate moderation and of unclear origin.
"Ibuprom Max" instructions for use recommend taking in the presence of the same symptoms, when an increased dose of medication is required. "Ibuprom Extra"will also be effective for these symptoms.
"Ibuprom Sinus" (synonymous with "Ibuprom Sprint Caps") is usually prescribed to provide analgesic, anti-inflammatory and antipyretic effects, as well as to reduce swelling of the nasal mucosa and its paranasal sinuses. That is, the drug will be effective in the symptomatic treatment of colds, acute respiratory infections and flu, accompanied by headache, sore throat and muscles, high body temperature and inflammation of the mucous membranes of the nose and paranasal sinuses.
Possible applications
"Ibuprom" (tablets) instructions for use recommends prescribing individually for each patient, depending on the intensity of the clinical manifestations of the disease. The standard regimen for taking this drug is a single dose of 200 to 800 mg with a frequency of 3-4 times during the day. For small patients, the dosage is selected depending on body weight - 20-40 mg per kilogram of weight (this is the daily volume), divided into several doses throughout the day. The course of therapy usually lasts from 2 to 3 weeks. The maximum allowable dose per day for an adult patient is 2.4 g. It is taken during or after a meal and washed down with a small amount of liquid. It is undesirable to divide the tablet into parts.
"Ibuprom Max" is taken regardless of food, and it is required to drink it with a sufficient amount of water. It is undesirable to crush the tablet into parts.
As for Ibuprom Sprint Caps, for patients over 12 years of age, a single doseis 1-2 capsules every 4-6 hours. Take it during meals or after. For the elderly, there is no need to specifically select the dose, except in cases of pronounced insufficiency of the functioning of the kidneys and liver.
"Ibuprom Extra" instruction recommends taking 1 capsule every 4 hours (we are talking about patients over 12 years old), but not more than 3 capsules during the day. The medication is taken after meals, do not chew. For elderly patients, there is no need to specifically select the dose.
"Ibuprom Sinus" is taken 1-2 tablets before meals and washed down with water. Frequency - every 4-6 hours. The maximum daily allowance is 6 tablets.
Contraindications for taking Ibuprom medication
"Ibuprom" (tablets) instructions for use prohibits those who have hypersensitivity to ibuprofen or any auxiliary components of the drug. It is unacceptable to prescribe a medication to patients suffering from lesions of the digestive tract of an erosive-ulcerative nature (especially in the acute phase). Treatment with Ibuprom is also prohibited in the presence of the aspirin triad and in some diseases of the optic nerve. Deviations in the functioning of the hematopoietic system are also the basis for refusing to use any means from the NSAID group. It is not practiced to prescribe this drug to those patients who have severe disorders in the functioning of the kidneys and liver.
Invalid assignment andthe use of "Ibuprom" in parallel with other medicines from the group of nonsteroidal.
As for the medicine "Ibuprom Max", the instructions for use prohibit taking tablets for the same problems as "Ibuprom" itself.
"Ibuprom Extra", except for all the above contraindications, is not prescribed if patients have hemorrhagic diathesis, with cardiac insufficiency. Also, do not take this drug if you are dehydrated due to vomiting, diarrhea, or insufficient fluid intake.
The medication "Ibuprom Sinus" has all the above contraindications. In addition, it is not used for bronchial asthma, diabetes mellitus, with an increased level of thyroid hormones (hyperthyroidism). A contraindication is the presence in patients of pheochromocytoma (neoplasms in the tissues of the adrenal glands), hyperplasia (adenoma) of the prostate gland.
Negative manifestations
How is Ibuprom tolerated? The instruction contains information about the possibility of developing some side effects from different systems and organs while taking this remedy. The greatest number of reactions to the use of this NSAID is observed from the gastrointestinal tract. Patients report nausea, vomiting, discomfort in the epigastric region, the development of anorexia and ulcerative erosive lesions of the mucous membranes of the digestive tract.
From the side of the central nervous system, headaches, dizziness, agitation, deviations in the processes of sleep and visual perception are often observed. Probable reactions from the hematopoietic system when taking the medication for a long period - anemia, thrombocytopenia, agranulocytosis.
Various allergic reactions to Ibuprom are possible. Tablets (the instruction contains such information) can provoke the appearance of a rash, the development of Quincke's edema. In very rare cases, aseptic meningitis may occur (people with autoimmune diseases are most susceptible to such a reaction), bronchospastic syndrome. As local manifestations, patients report burning and tingling sensations on the skin, hyperemia.
"Ibuprom Sinus", in addition to all of the above, can cause shortness of breath, tachycardia, high blood pressure, hyperhidrosis.
Exceeding the permissible dose: consequences
In case of an overdose of drugs such as Ibuprom and Ibuprom Max, the instructions for use report the possible development of nausea and vomiting, pain in the epigastrium. Also in such a situation, drowsiness may occur, headache and dizziness may be felt, a decrease in blood pressure and the development of arrhythmias are possible. In severe situations, symptoms of metabolic acidosis appear, loss of consciousness with impaired respiratory function may occur.
In such conditions, urgent gastric lavage and symptomatic treatment are recommended. Oral intake of enterosorbents is practiced. The convulsive syndrome is removed with the help of Diazepam, Lorazepam.
In case of an overdose of Ibuprom Sprint Caps, in addition to all of the above,there is a possibility of disorientation, convulsions, coma. Possible liver dysfunction. In patients suffering from bronchial asthma, the course of the disease may worsen.
Prolonged use of Ibuprom Sinus may cause pathological changes in the blood, such as hemolytic anemia (increased breakdown of red blood cells), granulocytopenia (decrease in the number of granulocytes), thrombocytopenia (decrease in platelets).
What should I pay attention to?
"Ibuprom" instruction recommends taking with caution to those who have concomitant diseases of the liver, kidneys, chronic heart failure. If the patient has dyspeptic symptoms before starting therapy, or the patient has just undergone surgery, treatment with Ibuprom should also be started with great caution. The presence in the anamnesis of information about bleeding of any nature, about diseases of the digestive tract, allergic manifestations associated with the treatment of non-steroidal anti-inflammatory drugs, should also be a reason for careful attention to the patient's condition.
To avoid unpleasant surprises, it is necessary in the process of using Ibuprom to constantly monitor the functions of the kidneys and liver, peripheral blood patterns.
Both "Ibuprom" and "Ibuprom Max" instructions do not recommend the use in the 3rd trimester of pregnancy. In the 1st and 2nd trimesters, the use of this NSAID is justified only if the expected positive effect for the mother outweighs the possible negative consequences forbaby.
Ibuprofen, the main active component of Ibuprom, is excreted in breast milk in small doses, so it can be used during lactation to relieve pain and fever. However, if there is a question about long-term therapy with Ibuprom or the need to take large doses, you should discuss with your doctor the question of not breastfeeding.
The use of "Ibuprom Sinus" during pregnancy and breastfeeding is generally contraindicated.
Interaction with other drugs
Any form of "Ibuprom" ("Ibuprom Max", "Ibuprom Sprint Caps", "Ibuprom Extra") instructions for use prohibits taking in parallel with antihypertensive drugs and diuretics such as furosemide, hydrochlorothiazide, since their therapeutic effect may be substantially reduced.
The use of "Ibuprom" in tandem with antiplatelet and selective serotonin inhibitors increases the risk of developing GI bleeding. Further, this NSAID can increase the content of glycosides in the blood plasma and, thus, cause an exacerbation of heart failure. "Ibuprom" will enhance the effect of anticoagulants on the human body. For this reason, it is important to regularly monitor blood clotting, as ibuprofen significantly reduces platelet aggregation.
When used in parallel with lithium preparations and Methotrexate, the level of these substances inblood plasma. Tandem with cyclosporine will increase the nephrotoxicity of the latter.
The combination of "Ibuprom" with digitalis preparations (digitalis) can cause the development of cardiac arrhythmias. You should also not take this NSAID in tandem with acetylsalicylic acid (aspirin), as there is a possibility of increasing negative side effects.
The combination of quinolone antibacterial agents and any NSAIDs (including Ibuprom) increases the risk of developing a convulsive syndrome. And the combination with a drug such as Zinovudine increases the risk of developing hemarthrosis and hematomas in HIV-infected patients.
Patients' opinions about the drug
Nonsteroidal PVAs are serious drugs with generally a wide range of effects. Therefore, patient reviews of such funds are always both positive and negative. Ibuprom is no exception.
The majority of people who took the drug were satisfied with its effect. Pain is quickly stopped and for a long time they do not remind of themselves. The drug has proven itself well for painful menstruation, headaches and myositis, with myalgia and neuralgia.
At the same time, there are patients who were dissatisfied with the effect of the drug "Ibuprom". The instruction declares the rapid development of the effect of anesthesia, but many consumers did not feel the effects of this drug at all. In addition, many complained of adverse reactions in the form of nausea and headaches.
Sufficiently large group of peoplecomplained that "Ibuprom" did not completely remove the toothache. Although in this case it is not necessary to say that the drug is bad. The fact is that, for example, with acute pulpitis, no painkillers will help, except for an injection directly into the gum. In the case of toothache, Ibuprom is an opportunity to get to the dentist as soon as possible without experiencing severe pain.
In any case, NSAIDs are a new generation of analgesic and anti-inflammatory drugs that are effective in a very wide range of pathologies. This is the opinion of most consumers and he althcare professionals.
