Sodium acetate trihydrate is a regulator of water-electrolyte and acid-base balance. Plays an important role in the body. The substance is responsible for the replacement of sodium s alts and acetate ions. The component produces the following therapeutic effect:
- Detoxification.
- Rehydrating.
- Diuretic.
- Plasma replacement.
Sodium acetate trihydrate and sodium chloride are different substances. The first component is the sodium s alt of acetic acid, the crystals have a slight acetic aroma. And sodium chloride is the sodium s alt of hydrochloric acid.
Together they form a combined saline solution used for detoxification and rehydration.
Chemical properties
Sodium acetate is a white hygroscopic fine powder that dissolves in water. It decomposes at 324 degrees Celsius. Molecular weight is eighty-two grams per mole for the anhydrous form.
Sodium acetate trihydrate formula: CH3COONa3H2O.
Indications and contraindications
This substance is prescribed for the purpose of rehydration in the presence of the following ailments:
- Hyperkalemia (a pathological disease that provokes abnormally high levels of potassium in the blood).
- Cholera (an acute intestinal infection caused by the bacteria Vibrio Cholera).
- Acute dysentery (acute bacterial intestinal disease, which is characterized, as a rule, by a violation of the mucous membrane of the large intestine).
- Food poisoning (acute intestinal disorders caused by the intake of foods that contain harmful microorganisms and their toxins).
The following conditions are considered restrictions for use:
- Increased sensitivity.
- Kidney disease.
- Liver damage.
With extreme caution, sodium acetate trihydrate is used in the following cases:
- The patient's age is under eighteen.
- Retirement age.
- Pregnancy.
- Lactation.
Side effects
Like any other medicinal substance, sodium acetate trihydrate is capable of provoking certain negative reactions in the human body:
- Edema.
- Tachycardia (sudden increase in heart rate).
- High blood pressure.
If signs of poisoning occur, the patient is given hemodialysis and symptomatic therapy. Toxic dosage - 100 grams.
Abstract
According to the instructions forit is known that the drug is used intravenously under the control of laboratory parameters. The parameters of the fluid used and the amount of urine are checked every six hours. Within an hour, a solution is injected at a concentration that is from 7 to 10 percent of the patient's weight.
Further, the jet infusion is replaced by a drip, which lasts for forty-eight hours at a rate of 40 to 120 drops per minute. Before injection, sodium acetate is heated to 36-38 degrees. The solution is administered in a dosage that is necessary to restore the amount of fluid that was lost with feces, vomiting, as well as urine and sweat.
Treatment begins with a jet infusion of medication, followed by a transition to a drip in the following severe forms of the disease:
- Hypovolemic toxic shock (a life-threatening condition that is provoked by the poisoning of the body with components secreted by pathogenic microorganisms).
- Decompensated acidosis (a pathological process in which the alkaline balance of the blood gets off, namely, a low concentration of bicarbonate in such a biological fluid is noted).
- Anuria (a disease in which urine does not enter the bladder and, as a result, is not excreted from it).
Interaction with other drugs
When sodium acetate is combined with non-steroidal anti-inflammatory drugs, androgens, estrogens, as well as anabolic hormones, corticotropin, vasodilators or ganglionic blockers,enhanced sodium retention.
