The article will provide a list of non-steroidal anti-inflammatory drugs.
Exacerbation of diseases of the spine, as well as joints, is inevitably accompanied by pain, and, in addition, inflammatory processes. The primary task before prescribing further treatment is the relief of pain along with the removal of inflammatory reactions. Anti-inflammatory medications can help with this problem.
An extensive list of such new generation drugs makes it possible to choose the most effective medication in each specific situation. It makes no sense to talk about competitiveness due to the lack of analogues that can simultaneously have anti-inflammatory, analgesic and antipyretic effects. In our article we will talk about the latest anti-inflammatory drugs. In inflammation, they are indispensable.
How do these fundswork?
Inflammation in most situations is accompanied by pain, swelling, redness of tissues, fever and convulsions. Prostaglandins are directly involved in the enhancement of such processes. The process of producing prostaglandins directly depends on the cyclooxygenase enzymes, which are affected by anti-inflammatory drugs. Cyclooxygenase has two active isoforms with their own specific functions:
- In addition to being responsible for the appearance of prostaglandins, cyclooxygenase protects the gastric mucosa by influencing the viability of platelets. Drugs that have a non-selective effect and inhibit cyclooxygenases provoke a large number of different side effects.
- Cyclooxygenase is a specific enzyme that is actually absent in the norm, it is synthesized under the action of other mediators. The selective nature of the impact of the newest drugs is based on the blocking of this particular enzyme.
It is important to note that modern anti-inflammatory drugs produce the strongest analgesic effect, do not cause dependence and addiction.
New developments in anti-inflammatory drugs
Unlike glucocorticoids, these drugs do not contain any hormones and do not cause serious anomalies in the form of diabetes or hypertension. But the blocking of cyclooxygenase leads not only to a decrease in pain, and at the same time inflammatory processes, but also has a rather detrimental effect on the gastric mucosa, often causingappearance of ulcers. Coated drugs that prevent them from breaking down in the stomach have been unable to compete due to their harmful effects on the intestines.
Non-steroidal anti-inflammatory drugs of the new generation have a selective effect and this is what differs from previous medicines. They successfully influence the production of cyclooxygenase, inhibiting the production of prostaglandins. The drugs of the new category have not lost their effectiveness, and the negative impact on blood clotting, and, in addition, on the gastric mucosa and the vital activity of platelets is minimized. The latest anti-inflammatory drugs have the following properties:
- Anti-inflammatory effect is due to a decrease in the production of inflammatory mediators, and, in addition, a decrease in the permeability of the vascular walls.
- Blocking inflammatory factors significantly reduces irritation of nerve receptors, positively affecting the relief of pain.
- The action on the thermoregulatory centers makes it possible to cause an antipyretic effect.
Next, consider the cases in which the use of anti-inflammatory drugs is appropriate.
When should I take anti-inflammatory drugs?
The effectiveness of these drugs is observed in the treatment of diseases that are accompanied by inflammation, pain, fever or swelling. OftenAnti-inflammatory drugs are prescribed by doctors to treat a whole list of diseases. They can also be used by patients on their own. This group of medicines is used in the following cases:
- Against the background of exacerbation of diseases of the motor system with all kinds of arthritis, and with such diseases as arthrosis, osteochondrosis, spinal hernia, and so on.
- These medications are excellent in case of injuries, bruises, sprains and so on. Anti-inflammatory drugs for joints are popular.
- In the presence of severe pain during hepatic or renal colic.
- If headaches or gynecological pains are present.
- For the relief of pain in the postoperative period.
- To reduce temperature, regardless of its origin.
- Some drugs from this group are used to prevent heart attack, stroke, and, in addition, in the treatment of neurological disease.
It is important to keep in mind that absolutely every drug has a directed action. Self-administration of non-steroidal anti-inflammatory drugs for the treatment of various ailments can lead to unpredictable consequences.
Who should refrain from being treated with these drugs?
Even the latest developments do not completely protect drugs from unwanted effects on the body. In order to avoid certain negative consequences, it is best to refrain from using them in the following cases:
- A person has problems with blood vessels or with the heart.
- In the event that there are ailments of the stomach or intestines.
- In the presence of serious kidney pathologies.
- Against the background of high blood pressure, and, in addition, if there are problems with blood clotting.
It is important to emphasize that pregnant and lactating women are strictly prohibited from using these latest anti-inflammatory drugs.
Classification of anti-inflammatory drugs
Pharmacological research in the field of developing new drugs that have greater efficacy with high rates of competitiveness due to the reduction of side effects on the body is currently actively ongoing. There are about fifteen subgroups of drugs in this category on the market today. The classification of anti-inflammatory drugs divides them into the following two subgroups:
- The first generation of drugs is a list that consists of such medicines as Aspirin along with Naproxen, Ibuprofen, Voltaren, Nurofen, Diclofenac, Diklak, Movimed, "Metindol" and "Butadion".
- The new generation of anti-inflammatory drugs include Movalis, and, in addition, Nise with Nimesil and Celebrex.
There is another classification of non-steroidal anti-inflammatory drugs. The chemical composition of new generation medicines classifies them as acidic and non-acidic drugs:
- Salicylates include "Diflunisal" with"Aspirin".
- Phenylacetic acid drugs include Diclofenac along with Indomethacin, Tolmetin, Sulindac, Etodolac and Aceclofenac.
- Pyrazolidines include a list of drugs in the form of Phenylbutazone, Oxyphenbutazone and Azapropazone.
- Anthranilic acid is thought to be a drug called Mefenaminate.
- Propionic acid derivatives include a large list of anti-inflammatory drugs, including Ibuprofen along with Ketoprofen, Nabumeton, Pirprofen, Benoxaprofen, Flurbiprofen, Fenbufen, Fenoprofen, Naproxen and so on.
- The drugs of isonicotinic acid are mainly "Amizon". The list of anti-inflammatory drugs does not end here.
- The well-known "Analgin" is a derivative of pyrazolone.
- Oxycams are the most effective non-steroidal anti-inflammatory drugs. The list of such medicines includes Meloxicam, along with Piroxicam, Tenoxicam and Lornoxicam. The effect of these funds on the body is usually very long. And even despite their significant cost, thanks to their proven effectiveness, one can talk about their competitiveness.
- Non-acid drugs include Rofecoxib along with Nimesulide and Celecoxib.
What anti-inflammatory drugs for colds are best taken, only the attending physician can correctly determine. The effectiveness of therapy always depends on many individual factors.
Choice of drugs of different directions
Comparative characteristics of non-steroidal anti-inflammatory drugs makes it possible to identify the best of them in terms of the strength of their impact in various situations:
- A pronounced anti-inflammatory effect can be achieved during treatment with Diclofenac, Indomethacin, Flurbiprofen and Piroxicam.
- Ketorolac, Ketoprofen, Indomethacin and Diclofenac can boast of high competitiveness in pain relief.
- Efficiency against the background of a decrease in temperature is noted in such medicines as Aspirin, Nurofen and Nise.
It should be borne in mind that the trade name of medicines may differ significantly from the international name. In this regard, when purchasing medicines, you need to pay attention to the active ingredients in the composition.
New generation anti-inflammatory drugs
Medicines that belong to the latest generation are highly effective in terms of their impact. Due to the fact that against the background of their use, certain complications are minimized, these medicines, in addition, are highly competitive.
But it is important to consider that even the most harmless drug can be hazardous to he alth, so you should not start taking the remedy without reading the annotation, contraindications and without consulting your doctor. Next, let's take a look at the latest anti-inflammatory drugs.
Movalis
The leader among anti-inflammatory drugs can rightfully be called a drug called "Movalis", which has an extended period of exposure and is allowed for long-term use.
This remedy has a pronounced anti-inflammatory effect, which makes it possible to take it against the background of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis and so on. This medicine is not deprived of painkillers, and at the same time antipyretic properties. Movalis protects cartilage tissue well. This remedy is used for toothaches and headaches. The determination of dosage, along with the method of administration, directly depends on the severity, and, in addition, on the type of disease.
Use of "Nimesulide"
In terms of the analgesic effect of action, this drug surpasses many of its counterparts. Its effectiveness is achieved in twenty minutes. Its properties are used to relieve paroxysmal pain. This medicine relieves inflammation, providing an antioxidant effect on the body, positively affecting collagen fibers and cartilage in parallel.
This drug is prescribed against the background of traumatic, arthritic and toothache, as well as when a nerve is pinched. This medication is very well tolerated by patients. It rarely causes dizziness, headache, drowsiness, heartburn, nausea, or hives.
Treatment with Xekofam
"Xekofam" belongs to the group of oxycams. This remedy has an extended elimination time from the body. Influencemedication on the body lasts up to twelve hours. This remedy relieves pain so well that it is often compared to morphine. The drug does not cause any addiction and does not affect the nervous system. The decision on the frequency of use is made depending on the individual indicators of the patient.
Which anti-inflammatory non-steroidal joint drugs to choose?
Using Rofecoxib
The more common name for this medication is "Denebol". This drug will relieve pain, inflammation and swelling. It is prescribed for chronic polyarthritis, bursitis, rheumatoid arthritis, various injuries, and so on. The presented tool helps people to eliminate pain on the background of neuralgia, osteochondrosis, radicular syndrome and toothache. True, this medication is not recommended for use by those who have had a heart attack, and, in addition, to children under twelve years of age. It is not suitable for pregnant women and those patients who have heart or kidney problems.
Non-steroidal anti-inflammatory drugs for the treatment of joints can be purchased at any pharmacy.
Treatment with Celecoxib
This drug can significantly alleviate the patient's condition if he has osteochondrosis, arthrosis and other diseases. The presented medication relieves pain in humans well, and, in addition, effectively copes with inflammation. Side effects of Celecoxib on the digestive system are usually minimal ormissing at all.
Currently, anti-inflammatory drugs remain indispensable assistants in the treatment of many ailments. But you should not forget that they only remove symptoms that negatively affect your well-being, and the therapy of a particular disease should be carried out with other drugs and methods.
What is important to know when treating with modern anti-inflammatory drugs?
All new generation anti-inflammatory drugs for the treatment of joints are very widespread. With osteochondrosis, such drugs are prescribed in the form of injections, and as part of oral administration, tablets with capsules are used. Suppositories are produced directly for rectal use, and for external use there are many different gels and ointments.
But these medications may be contraindicated if patients have an increased individual intolerance to certain drug components. In particular, patients who are in old age should be extremely careful when taking such medicines. And against the background of treatment, these patients require the supervision of the attending physician, who will monitor the condition of their kidneys and liver.
The use of anti-inflammatory drugs is not recommended for the treatment of patients whose work requires increased attention, accuracy, quick reaction and coordination of movements, since exposure to such drugs can cause drowsiness along with weakness and headachespain.
It must be borne in mind that using only anti-inflammatory drugs in the treatment of osteochondrosis, and, in addition, arthritis and other similar diseases, it is simply impossible to achieve an absolute cure, since such drugs are intended only to get rid of pain and relieve inflammation. For the effective treatment of a particular disease, other drugs and different therapies are required.
It is important not to forget that long-term use of anti-inflammatory drugs for the treatment of various ailments can lead to unwanted side effects, therefore, without a prescription and regular monitoring of the attending physician, therapy with these drugs is unacceptable.
