Unfortunately, there are more and more people who suffer from peptic ulcers of the gastrointestinal tract today. And many of them were already convinced by their own experience of the effectiveness of the drug "De-Nol". But not everyone knows that today there is a domestic analogue of De-Nol, which is not inferior in pharmacological action to foreign drugs and costs several times cheaper. It is with such drugs that we will get acquainted further.
Drug "De-Nol"
Before we turn to the consideration of drug substitutes, it will be correct to recall what characteristics De-Nol has.
So, this medication has both an astringent and antiseptic effect, therefore it is effective in the treatment of gastrointestinal ulcers. The drug is produced in the Netherlands, which explains its relatively high cost.
The medicine is produced exclusively in tablet form and can be prescribed to patients from 4 years of age. Like De-Nol, analogues (domestic and foreign) in tablets for the treatment of younger childrenage is not used due to the impossibility of clear dosing.
Pharmacological properties of the drug
The main component of the drug is bismuth tripotassium dicitrate. This active substance, getting into the stomach, settles in an undissolved form and forms a protective film on the surface of ulcers and erosions. In addition, the drug promotes the production of prostaglandin E and activates the process of mucus formation. In patients, after 10 days of taking the medicine, increased epidermal growth in the defect zones is observed.
Medicine analogues
In case of peptic ulcers, gastritis and other gastrointestinal ailments, which are characterized by damage to the integrity of the gastric mucosa, the doctor may prescribe to the patient an analogue of "De-Nol" - domestic or foreign. The specialist, depending on the nature of the disease and its severity, will select the most appropriate and effective medicine. It can be either one of the structural substitutes, or a medication similar in pharmacological characteristics.
Like De-Nol itself, domestic analogues in Russia can be purchased at almost any pharmacy kiosk. This does not require a prescription from your doctor. However, it is worth noting that over-the-counter dispensing of medicines cannot serve as a motivation for self-treatment. After all, such carelessness can cause poor he alth and contribute to the emergence of complex concomitant diseases.
Novobismol drug
Thisthe antiulcer agent is produced in Russia and has a bactericidal effect on Helicobacter pylori. The active substance of the drug is bismuth tripotassium dicitrate. Due to the presence of this component, the medicine has both anti-inflammatory and astringent properties.
Getting into the acidic environment of the stomach, the drug binds a protein substrate that releases damaged areas of the mucosa. As a result of this process, a film forms on the surface of ulcers and erosions. In addition, this analogue of "De-Nol" (domestic drug "Novobismol") improves the secretion of bicarbonate and the synthesis of prostaglandin E.
The remedy is used for diseases such as functional dispersion, chronic gastroduodenitis and gastritis in the acute phase, duodenal and stomach ulcers. Quite often, the drug is prescribed to patients with irritable bowel syndrome.
Recommended medication for patients over 4 years old, but the daily dose should be calculated individually by a specialist. Take the remedy 30 minutes before meals 2-4 times a day for 6-8 weeks.
Drug reviews
Good in the treatment of peptic ulcers, not only the drug "De-Nol" has proven itself. Domestic analogues, Novobismol in particular, are also quite effective. This is evidenced by the positive feedback from patients and doctors.
As for isolated cases when patients speak negatively about the medicine, the reason for this is the side effects of Novobismol tablets. And this is quite understandable, becauseencephalopathy, various disorders of intestinal motility, nausea, vomiting, skin rashes (these are the possible reactions of the body to the remedy), cause a lot of discomfort.
In addition, this analogue of "De-Nol" (domestic drug "Novobismol") is contraindicated in case of violations of the liver and kidneys and during the period of bearing a baby and breastfeeding, which also causes resentment in some people.
Drug "Venter"
This domestically produced medication is an analogue of De-Nol in terms of the pharmacological group. It is prescribed to patients suffering from gastritis and peptic ulcers of the gastrointestinal tract. The drug can also be recommended for preventive purposes to prevent recurrence of erosive and ulcerative ailments. Often used to treat chronic gastritis and non-ulcerative dispersion. This analogue of "De-Nol" (domestic drug "Venter") is effective as part of complex therapy for hyperacid gastritis, peptic and medicinal ulcers, as well as gastroesophageal reflux disease.
As for the main active ingredient of the product, this function is performed by sucralfate, a disaccharide. The substance consists of sucrose sulfate and aluminum hydroxide. It interacts with the protein that is formed on the damaged areas of the mucosa, thus creating a protective film. Such a "shield" protects erosion and ulcers from exposure to hydrochloric acid and promotes effective tissue regeneration.
Application features and dosing system
Like any analogue of "De-Nol", the domestic medication "Venter" must be used 30 minutes before a meal. The daily dose of the drug is from 2 to 4 tablets and depends on the disease and the nature of its course. To achieve the maximum therapeutic effect and avoid possible adverse reactions, the dosage calculation should be entrusted to the attending doctor. The specialist will take into account all the individual characteristics of the patient and determine the duration of the course of therapy.
It is necessary to refuse the use of the drug in case of dysphagia, chronic renal dysfunction, bleeding or intestinal obstruction. Contraindications to taking the medication are also pregnancy and lactation.
Opinion of patients about the drug
Like the drug "De-Nol", analogues of domestic reviews are mostly positive. This is due to the high efficiency of drugs, which is achieved due to the pharmacological action of the main components. In particular, patients respond well to Venter. Judging by their words, people are very satisfied with the results of the treatment. They note the rapid improvement in the condition, the availability of the drug, and other advantageous characteristics that the drug has.
Despite the mass of grateful reviews, there are those patients whose memories of therapy cause only negative. Some have experienced side effects of the medication, such as myalgia, vertigo, bloating, skin rashes, nausea, vomiting, or headaches. Each of thesemanifestations causes significant discomfort.
Medication "Ventrisol"
As a rule, people choose domestic analogues in the process of searching for a substitute for De-Nol. "Ventrisol", meanwhile, is no worse. This is a Polish-made remedy, and it is quite often prescribed to patients who are diagnosed with ulcerative and erosive lesions of the gastrointestinal mucosa.
This medication in composition and pharmacological action is as close as possible to the drug "De-Nol". Its main active ingredient is also bismuth, which promotes the formation of a protective film on damaged areas of the mucous membrane. The drug is produced in tablet form and is indicated for use in gastritis, ulcerative lesions of the stomach and duodenum, as well as gastroduodenitis.
The active ingredient of the drug protects erosions and ulcers of the mucous membranes from the negative effects of hydrochloric acid, which contributes to their rapid scarring and healing. In addition, bismuth does not affect the acidity of gastric juice.
As for the features of the application and dosing system, then, like De-Nol, Ventrisol must be taken 30 minutes before meals. The course of treatment depends on the severity of the disease, so only the attending doctor is competent in this matter.
