In the article, we will consider instructions for use for Eufillin tablets.
It should be noted right away that such a drug quite effectively eliminates spasms with a barking dry cough, but does not directly treat cough, only temporarily alleviating the patient's condition. This time is necessary until the effect of other drugs begins. Thanks to Eufillin, the patient can breathe and does not feel pain. The features of the effect of the drug, its positive effect and possible side symptoms will be described in detail in this article.
Pharmacology
According to the instructions for Eufillin tablets, due to the pharmacological effect of the drug, bronchial muscles relax, mucociliary clearance increases, the function of diaphragm contraction is stimulated, and the functionality of not only the respiratory, but also the intercostal muscles is significantly reduced.
In addition, the action of the drug stimulates the respiratory center, increasing its sensitivity to carbon dioxide, as well as improving the ventilation of the alveoli.
Respiratory function returns to normal under the influence of medicinalmeans, increases the oxygen saturation of the blood and thereby reduces the content of carbon dioxide in it.
In addition, the stimulating effect of the drug is on the activity of the heart, increasing heart rate and increasing coronary blood flow and myocardial oxygen demand. The vascular tone of the skin, brain and kidneys is reduced.
In addition, the sphere of influence of Eufillin tablets includes:
- providing venodilating peripheral action;
- lower pressure in the pulmonary circulation;
- decrease in pulmonary vascular resistance;
- increased blood flow to the kidneys;
- Providing a moderate diuretic effect;
- inhibition of platelet aggregation;
- expansion of the biliary extrahepatic tract;
- strengthening resistance to erythrocyte deformation;
- decrease in blood clots and normalization of microcirculation;
- epileptogenic effect at high doses;
- increase in the acidity of gastric juice due to the tocolytic effect of the agent.
Drug pharmacokinetics
When the drug "Eufilin" penetrates into the patient's body, it is completely and quickly absorbed. The bioavailability index in percent is 90-100. The rate of absorption can be affected by food, but not by volume. The highest efficiency of taking the drug is achieved within two hours.
The drug can pass into a woman's breast milk for aboutten percent of the total dose and through the placental barrier, where its concentration is significantly higher than that in maternal plasma.
For the occurrence of bronchodilating signs of the active component of the drug, its content of 10-20 micrograms per milliliter is sufficient. Higher concentrations of it become toxic. Interestingly, the lower the level of the drug in the blood, the better the effect of excitation of the respiratory center is realized.
The drug is metabolized mainly in the liver, the half-life depends on the general condition of the patient. Its excretion occurs with the help of the kidneys.
When is this drug used?
The use of Eufillin tablets is justified for the treatment of patients suffering from a number of diseases requiring bronchodilator effects:
- bronchial obstructive syndrome;
- bronchial asthma;
- pulmonary emphysema;
- chronic obstructive pulmonary disease;
- obstructive chronic bronchitis;
- cor pulmonale syndrome;
- sleep apnea at night;
- pulmonary hypertension.
Regulations for taking pills
Pills "Eufillin" are taken orally. You can drink three times a day, 0.15 grams. The medicine must be taken after meals and washed down with clean water. In childhood, it is allowed to take the remedy four times, seven milligrams per kilogram of weight. The treatment course with the help of tablets is determined by a specialist. It can last from a few days to two months.
Contraindications for this drug
Eufillin tablets cannot be prescribed in situations where the patient has excessive sensitivity to the substances of the drug, especially to its active component.
In addition, the medication is contraindicated if the patient has a number of diagnostic indications:
- epilepsy;
- exacerbation of ulcer pathology of the duodenum and stomach;
- gastritis (if acidity is high);
- hypotension or severe hypertension;
- hemorrhagic type stroke;
- tachyarrhythmia;
- hemorrhage in the retina of the organs of vision;
- Children under three years of age.
Caution in the use of Eufillin tablets is required in the following cases:
- with severe coronary insufficiency (in the acute phase of angina pectoris, myocardial infarction);
- with widespread vascular atherosclerosis;
- for obstructive hypertrophic cardiomyopathy;
- in childhood;
- in advanced years;
- with frequent ventricular extrasystoles;
- during pregnancy;
- with excessive convulsive readiness;
- with gastroesophageal reflux;
- with kidney and liver failure;
- with prolonged hyperthermia;
- with ulcerative pathology of the duodenum and stomach;
- with uncontrolled thyrotoxicosis and hypothyroidism;
- for bleeding from the gastrointestinal tract.
Consequences of drug overdose
If the patient drank an excessive amount of Eufillin tablets, dangerous complications may occur. It is necessary to go to a medical facility in a timely manner and wash the stomach. The attending physician should immediately report all negative symptoms. Among them are the following:
- loss of appetite;
- vomiting;
- diarrhea;
- gastric bleeding;
- severe pain in the abdomen;
- fast heartbeat;
- overexcitement of the patient;
- insomnia;
- facial redness;
- appearance of feelings of fear and anxiety;
- onset of seizures and onset of epilepsy;
- loss of consciousness by a person;
- lower blood pressure;
- fear of light and dizziness.
Cough therapy with Eufillin
Often, when coughing, specialists prescribe treatment to patients with the help of "Euphyllin". Thanks to him, the bronchi quickly expand, and breathing improves in general. Attacks and pathological wheezing will pass. But it is not recommended to treat a small cough with such a strong drug. "Eufillin" is prescribed exclusively by the attending physician, if there are severe attacks.
If the patient has a painful cough and occasional choking, then it is allowed to drink the medicine three times a day. In this case, a six-hour interval should be maintained between each dose of the drug.
Interactions of this drug with other medicines
According to the instructions for use for Eufillin cough tablets, if you simultaneously take the drug with mineralocorticosteroids, glucocorticosteroids, beta-adrenergic stimulants, drugs for general anesthesia, Xanthine and drugs that stimulate the central nervous system, it can be increased the likelihood of adverse symptoms.
The use of antidiarrheals and enterosorbents will reduce the absorption of the main component of Eufillin.
Concomitant therapy with aminoglutethimide, isoniazid, rifampicin, sulfinpyrazone, phenobarbital, carbamazepine, phenytoin, moracizin and estrogen-containing oral contraceptives increases the clearance of the main active ingredient of the drug, and this may cause the need to increase the dosage.
Combination of macrolide drugs, allopurinol, verapamil, lincomycin, ticlopidine, cimetidine, thiabendazole, isoprenaline, propafenone, enoxacin, mexiletin, disulfiram, methotrexate, fluoroquinolonamine, recombinant interferon alfa, alcohol (even in small amounts) and vaccination the flu may require a reduction in the dose of "Euphyllin", as these drugs increase the intensity of its influence.
Eufillin cough tablets, when used simultaneously with diuretics and beta-adrenergic stimulants, increase the effectiveness of these funds. Decreased effectiveness from consumptionseen when combined with lithium preparations and beta-blockers.
Anti-antispasmodics work together perfectly, which cannot be said about other xanthine derivatives, which are not recommended to be used simultaneously with the drug.
This is confirmed by the instructions for the Eufillin cough tablets.
Analogues of "Euphyllin"
The remedy during therapy can be replaced with drugs that are similar in their active substance and composition. These include the following:
- "Eufillin Darnitsa";
- "Aminophylline Eskom";
- Eufillin solution for injections 2, 4%;
- "Aminophylline".
Reviews about tablets "Eufillin"
Reviews of the drug "Eufillin" are mostly positive. People who have used it are satisfied with the speed of action and the effectiveness of the drug in eliminating shortness of breath and facilitating breathing. Many patients use it to eliminate edema, and only an impressive list of side effects in some cases prevents the acquisition of this remedy. However, the affordable cost of this drug and the possibility of using it by different categories of patients is still of great importance in preferring it to other drugs of a similar group.
Thus, "Eufillin" is an ambulance, often saving the lives of those people who are suffocating from bronchial spasm. It plays the same role in violation of the blood circulation of the brain. The only thing that is not allowed in the treatment of "Eufillin" is amateur performance, thenthere is self-medication. Treatment should only be under the supervision of doctors.
