"Miropriston" is an antigestagen, which is produced in the form of tablets. They have a flat-cylindrical shape, a light yellow tint. The structure of the drug includes: mifepristone, sodium starch glycolate, calcium s alt and stearic acid, talc, cellulose.
According to the instructions for "Miropriston" (to stimulate labor), the pills block the action of progesterone at the level of receptors, which do not have gestagenic activity.
Useful properties
Improve the contractility of the muscular layer of the uterine wall, which consists of three layers of smooth muscle fibers. In addition, the drug increases the sensitivity of the myometrium to prostaglandins.
According to the instructions and reviews for "Miropriston" to stimulate labor, the drug helps to exfoliate the decidua and remove the fetal egg. The elimination half-life is approximately eighteen hours.
When the drug is prescribed
The drug is designed to terminate uterine pregnancy (up to 42 days without menstruation). Miropriston is used concomitantly with misoprostol and is also intended to prepare and induce labor.
Restrictions
Contraindications:
- Uterine fibroids - a benign tumor that occurs in the muscular layer of the uterus.
- Impaired hemostasis (the biological system that maintains the liquid state of the blood in the body is normal).
- Acute or chronic diseases of the liver and kidneys.
- Adrenal insufficiency.
- Porphyria is a hereditary disorder of pigment metabolism with an increased content of porphyrins in the blood and tissues and with their increased excretion with urine and feces.
- Providing long-term glucocorticosteroid treatment.
- Smoking at the age of 35.
- Increased sensitivity.
Restrictions on medical abortion:
- More than 42 days of amenorrhea (absence of menstruation for 6 months in a woman who used to have a normal menstrual cycle).
- "Interesting position" not supported by clinical studies.
- Ectopic pregnancy.
What other contraindications does the drug have
Prohibitions for preparation and induction of labor are:
- Vaginal bleeding of unknown origin during pregnancy.
- Eclampsia is a disease that occurs during pregnancy, as well as childbirth and in the postpartum period, in which blood pressure reaches such a level that there is a threat to the life of the mother.
- Difficult pregnancy that requires frequent monitoring and treatment in a hospital setting.
- Complication of a normal pregnancy, which may not manifest itself or manifest itself as edema, increased pressure, loss of protein in the urine, convulsions.
- Abnormal position of the fetus (a clinical situation in which the axis of the fetus forms a right or acute angle with the longitudinal axis of the uterus, the presenting part is missing).
- Severe forms of hemolytic damage to the fetus.
According to the annotation, Miropristone should be used with extreme caution in the following situations:
- Heart disease.
- Hypertension (a disease characterized by high blood pressure).
- Bronchial asthma (a lesion of the respiratory system, which is characterized by asthma attacks of varying duration and frequency).
- Obstructive lung disease (a condition characterized by partially irreversible airflow limitation in the respiratory system).
Instructions
Miropriston tablets are used only inmedical institutions that are equipped with special equipment, under the supervision of a doctor. In the presence of a specialist, a woman takes 3 tablets once (total 600 milligrams of mifepristone) with boiled water.
It is necessary to use the drug 1–1.5 hours after breakfast. After 36 to 48 hours, the patient must appear in the hospital for misoprostol 0.4 mg.
After 10-14 days, an examination is carried out. If necessary, hormone levels are taken to confirm that the pregnancy has ended.
According to the instructions and reviews for "Miropriston" to stimulate labor, it is known that if after two weeks the effect is not observed, mandatory vacuum aspiration and subsequent histological examination are prescribed.
Preparation for childbirth:
- In the presence of a doctor, the expectant mother takes one pill of "Miropriston". A day later, the procedure is repeated.
- After three days, the birth canal is assessed, if necessary, "Oxytocin" or prostaglandins are used.
Adverse reactions
"Miropriston" can provoke the following negative actions:
- Migraine.
- Hyperthermia is the accumulation of excess heat in the body with an increase in temperature, which is provoked by factors that cause poor heat transfer.
- Nausea.
- Gagging.
- Nettle rash.
Abortion may be accompanied bypain in the lower abdomen and bloody discharge from the vagina. In addition, an exacerbation of inflammation of the uterus and appendages is likely. Reviews of Miropristone tablets to stimulate labor are usually positive.
"Miropriston" is used not only to prevent unwanted pregnancy, but also to stimulate labor. Not always with a positive course, labor activity also occurs and goes according to plan - sometimes you have to resort to drugs.
How long does it take for Miropristone to induce labor? The medicine must be used strictly according to the doctor's prescription and only in medical institutions that specialize in female reproduction.
Labor activity is noted in the next 2-3 days after taking the drug. On average, labor begins 60 hours after taking the second pill.
According to reviews of "Miropriston" to stimulate labor, a pregnant woman after taking the drug should be under medical supervision and report any changes in her condition. Already in the first hours after taking the first pill, pain in the lower back is noted, one can note the discharge of the mucous plug.
All these unpleasant sensations, as a rule, gradually increase, clearly intensifying after the second pill. If 2 days after taking the second pill there is not even a hint of stimulation, another, stronger medication is prescribed.
Substitutes
Generics of "Miropristone" are:
- "Agesta".
- "Gynestril".
- "Zhenale".
- "Mifegin".
- "Mifepristone".
- "Pencrofton".
Shelf life - 60 months. They are used only in a hospital setting.
Opinions
Most of the doctors' reviews of "Miropriston" to stimulate labor are positive. Women report improved efficacy of the drug in both early pharmaceutical abortion and labor induction.
But there are also separate responses in which the representatives of the fair half share their negative experience of using this drug. As a rule, we are talking about interrupting an "interesting situation".
According to the reviews of Miropristone for labor induction, it is known that women indicate either pronounced negative effects of the drug, or a complete lack of action, which necessitated vacuum aspiration.
