"Ketoanalogues of amino acids" - a drug that helps restore protein-energy balance. Tablets are used in renal failure to reduce BUN and creatinine. The product ensures the intake of essential organic compounds into the body with a minimum intake of nitrogen.
What are "Keto analogs of amino acids"?
In pharmacology, there is a group that includes proteins and amino acids. The latter are structural elements of specific tissue proteins. And some organic acids, such as glutamic, aspartic, glycine are neurotransmitters.
A he althy person needs 70 g of protein per day. In a number of pathological conditions, the daily need for enzymes increases. To maintain normal life, synthesized proteins and amino acids are used. Parenteral administration of proteins can cause anaphylactic reactions. Mixtures of individual amino acids are used to avoid unwanted effects. They provide complete artificial nutrition without education.antibodies in the body.
“Ketoanalogues of amino acids” is a combined preparation, which includes substitutes for organic compounds whose metabolites can be included in the synthesis of higher fatty acids. The drugs are used as a nutritional treatment for kidney failure.
Composition
Dosage form of the drug "Ketoanalogues of amino acids" - film-coated tablets.
The composition of the substance is a complex of ten components necessary for the full functioning of the body. Active Ingredients:
- α-keto analogue of isoleucine (67 mg). It cannot be produced in the body, and therefore must come from food.
- Leucine alpha-keto analogue (101mg). A lack of leucine in the body is often due to an increase in estrogen levels.
- Keto-phenylalanine calcium monohydrate (68 mg).
- Ketalin calcium (86 mg). Together with isoleucine and leucine, valine serves as a source of energy for muscle cells.
- Methionine alpha hydroxy analogue (59 mg). Methionine helps lower blood cholesterol, improves liver function.
- Lysine monoacetate (105 mg).
- Threonine (53 mg). The amino acid is involved in the synthesis of collagen and elastin.
- Tryptophan (23 mg).
- Histidine (38 mg). Heterocyclic amino acid promotes tissue growth and regeneration.
- Tyrosine (30 mg). Amino acid promotes the production of melanin, improves the function of the adrenal glands.
Drug action and indications
Gradual decline in kidney function leads todisruption of the body. Treatment of the disease consists of symptomatic therapy and a special diet. The diet is a low-protein diet that includes amino acids.
Ketoanalogues of amino acids in tablets are prescribed for kidney failure to provide the body with nutrients. The drug completely replenishes the body with components that are a source of energy even with minimal nitrogen intake.
The drug significantly slows down the formation of urea and reduces the concentration of uremic toxins.
Ketoanalogues do not cause an increase in glomerular filtration in the remaining nephrons. Keto-containing supplements have a positive effect on renal hyperphosphatemia: they reduce the content of creatine in the blood, have a nephroprotective effect, and prevent the onset of the last dangerous stage of renal function extinction. Amino acids improve the course of fibrous generalized osteodystrophy.
The drug is prescribed for the prevention and treatment of protein metabolism disorders in adults and children from 3 years of age with severe renal dysfunction.
Method of application and dosage calculation
Tablets "Ketoanalogues of amino acids" are taken orally with meals. It is believed that with this method, the absorption and metabolism of the components of the product is significantly improved.
The drug is approved for use from the age of three. The dosage calculation depends on the patient's body weight. Assign 1 tablet (0.1 g) per 5 kg of body weight per day. Do not chew the tablet while taking it.
Remedydrink until the glomerular filtration rate does not exceed 25 ml / min. At the same time, patients should follow a low protein diet: no more than 40 g per day for adults and 1.4-0.8 g of protein per 1 kg of body weight for children.
During therapy, the calcium content in the blood is constantly monitored. With its increase, reduce the dosage.
"Ketoanalogues of amino acids": analogues
Pharmacological industry produces a wide variety of drugs containing proteins and amino acids for parenteral nutrition. Despite their general purpose, they are prescribed for certain diseases, depending on the composition. Among these drugs, there are not many those that are taken for kidney failure. They are produced in different countries and have different names.
"Keto analogs of amino acids" - trade names:
- "Ketosteril" is a drug used to treat kidney and protein-energy malnutrition. Manufacturer - German company Fresenius Kabi Deutschland GmbH;
- "Ketoaminol" - tablets prescribed to compensate for the lack of amino acids with metabolic properties. Manufacturer Chinese pharmaceutical company Nanjing Baijinyu Pharmaceutical;
- "Aminoven Infant" - solution for parenteral nutrition.
The above drugs are most widely used in the treatment of kidney failure. Other drugs are prescribed in complex therapy from an insufficient amount in the composition of essential amino acids:
- "Aminosteril" - a solution for intravenous and drip administration. The drug is designed to compensate for the lack of proteins;
- "Nefrotekt" - a solution for intravenous administration, prescribed to restore protein-energy balance in pathologies of the kidneys and ureter;
- "Nutriflex 70/180 lipid" - an emulsion designed to replenish nutrients when normal food intake is impossible or contraindicated.
Ketoaminol
The product is a generic drug "Ketoanalogues of amino acids". The drug is produced in tablets, which are taken to prevent and treat pathological changes in protein metabolism caused by a progressive decline in kidney functionality. "Ketoaminol" is prescribed in parallel with the diet, with low-protein foods.
Dosage is calculated based on patient weight 0.1g/kg per day. Unlike the remedy "Ketoanalogues of amino acids", the drug is approved for use only after the patient reaches 18 years of age. In addition to age, there are a number of contraindications:
- hypersensitivity to the substances that make up the tablets;
- disorders of amino acid metabolism;
- high serum calcium;
- prescribe with caution in patients with a hereditary predisposition to phenylketonuria.
Due to the lack of testing of the effect of the drug on the fetus, pregnant women should use the drug with extreme caution.
Ketosteril
Pharmacological actionthe drug "Ketosteril" is similar to the medicinal effect of the drug "Ketoanalogues of amino acids". The process of replenishing the body with the necessary enzymes and organic acids occurs due to transamination. Accelerates the processes of a diet with a properly selected content of carbohydrates (glucose), fats (lipids) and other things. If the keto analogue of aspartate is glutamate, then to speed up the transamination reaction, the glucose content in the diet is slightly increased.
The drug improves protein metabolism, reduces the toxic effects of metabolic decay products, without increasing the level of glomerular filtration. "Ketosteril" breaks down urea, accelerates the utilization of nitrogen-containing metabolic products.
During therapy, monitor the concentration of calcium in the blood. To prevent hypercalcemia, the use of drugs that improve calcium absorption is excluded: Ciprofloxacin, quinolone derivatives, iron preparations.
Aminoven Infant
Means for parenteral nutrition "Aminoven Infant" can be called a generic "Ketoanalogues of amino acids". The drug is used only for inpatient treatment, because it has a dosage form of a solution for injections of 6 and 10%.
Aminoven Infant contains the same amino acids as its Chinese counterpart. The drug is used for parenteral nutrition, administered intravenously or drip mainly into the central veins.
The dosage is selected individually, depending on the age, characteristics of the organism and the therapeutic effect. "Aminoven Infant" is administered until the patientwill be able to get enough nutrients from a normal diet.
Reviews
Diseases for which parenteral nutrition drugs are prescribed are very severe. Some patients are so emaciated that they hardly get out of bed. That is why there are few reviews about "Ketoanalogues of amino acids", they are left most often by relatives of patients.
Users say they do not understand tests, but they see that the he alth of their loved ones has improved significantly after using the drugs. Doctors confirm that there is an effect, and it is not short-lived. True, some mothers note that children drink the remedy in tablets with great reluctance, because the pills are hard and bitter. It takes a long time to persuade or trick the child to drink the medicine.
Those who have been discharged and are on outpatient treatment write that the pills are ideal for maintaining the required amount of amino acids at home. There is no need to go "on drips" or call a nurse at home.
