In the article, consider the indications for the use of Biseptol. It is a combination drug with a wide spectrum of action. Included in the group of sulfonamides. It is used for many diseases. Reviews about him are most often positive.
Composition of Biseptol, release form
"Biseptol" is produced by the manufacturer in several pharmacological forms:
- In the form of tablets with a dosage of 120 mg. In this case, each tablet of the medication contains sulfamethoxazole in an amount of 100 mg and trimethoprim in an amount of 20 mg. As auxiliary components, polyvinyl alcohol, talc, aseptin P, magnesium stearate, aseptin M, potato starch, propylene glycol are used. The tablets are packaged in a cell blister, 20 pieces in a blister. Each carton contains one of them.
- In the form of tablets with a dosage of 480 mg. In this case, each Biseptol tablet contains sulfamethoxazole in an amount of 400 mg, as well as trimethoprim in an amount of 80 mg. Additional components are similar to those in tablets with a dosage of 120 mg. Each carton of the drug also contains one contour blister containing 20 tablets. So it is said in the instructions for use for Biseptol. There are, however, other forms of release.
- In the form of a suspension intended for oral administration. Suspension "Biseptol" has a strawberry smell and light cream color. Each 5 ml contains sulfamethoxazole 200 mg and trimethoprim 40 mg. Strawberry flavor, purified water, propylene glycol, propylhydroxybenzoate, m altitol, citric acid, sodium saccharinate, methylhydroxybenzoate, sodium carboxymethylcellulose s alt, Cremophor RH 40, sodium hydrogen phosphate, magnesium aluminum silicate are used as auxiliary components in the manufacture of the suspension. The drug is packed in 80 ml bottles made of dark glass. Each carton contains one bottle of medicine. Indications and contraindications for the use of "Biseptol" in any form of release will be the same.
- In the form of a concentrate intended for the preparation of a solution for infusion. Packed in 5 ml glass ampoules. Each milliliter of the concentrate contains 80 mg of sulfamethaxazole and 16 mg of trimethoprim. Each carton contains 10 ampoules.
Indications for the use of "Biseptol"
The drug is intended for the treatment of diseases that have an infectious and inflammatory etymology and are sensitive to the main components of the drugfunds:
- Respiratory tract infections, including pleural empyema, lung abscesses, pneumonia, bronchitis.
- Sinusitis and otitis.
- Infections affecting the genitourinary system, including prostatitis, salpingitis, urethritis, pyelonephritis.
- Gonorrhea.
- Infections affecting the gastrointestinal tract, including diarrhea, cholera, dysentery of bacterial etymology, paratyphoid, typhoid fever.
- Infections affecting soft tissues and skin, including pyoderma and furunculosis.
Indications for the use of "Biseptol" must be strictly observed.
Contraindications for taking
"Biseptol" is contraindicated for admission if there are the following diseases or conditions:
- For diagnosed lesions of the hepatic parenchyma.
- With severe impairment of kidney function, when it is not possible to control the concentration of the drug in the blood.
- In severe renal failure.
- In severe blood diseases, including anemia due to lack of folic acid, megaloblastic anemia, leukopenia, agranulocytosis, B12-deficiency anemia, aplastic anemia.
- With hyperbilirubinemia in childhood.
- When diagnosed with a lack of glucose-6-phosphate dehydrogenase.
- During pregnancy, lactation.
- Age 0-3 months (for injection), age up to 36 months (for suspension).
- In case of hypersensitivity to any component included incomposition of the drug.
Care must be taken when prescribing Biseptol if the patient has thyroid pathologies, folic acid deficiency, signs of bronchial asthma.
Instructions for use for Biseptol tablets (120 mg) are very detailed.
Dosage
Pills, intramuscular or intravenous administration to patients from 12 years of age are prescribed for a double dose of 480 mg per day or a single dose of 960 mg. If the infection is severe, a triple dose of 480 mg is indicated. If the infection has a chronic course, a double dose of 480 mg per day is indicated. But no less.
Children up to 24 months of age are shown twice a dose of 120 mg, children 2-6 years old are shown twice a day up to 240 mg, children 6-12 years old are shown a double dose of up to 480 mg.
Suspension should be taken orally after meals with plenty of water. This is confirmed by the instructions for use. The price and indications of "Biseptol" are of interest to many.
Patients 12 years of age and older are prescribed 960 mg every 12 hours. If the infection is severe, up to 1440 mg every 12 hours. The course of treatment for infections affecting the urinary tract is 10-14 days, acute chronic bronchitis - two weeks, shigellosis, travelers' diarrhea - 5 days.
Children 3-6 months old are shown twice a day, 120 mg of suspension, children 7-36 months old are shown a double dose of up to 240 mg, children 4-6 years old are shown a double dose of up to 480 mg, children 7-12 years old are shown double dose up to 480 mg.
Minimum course of therapyis 4 days. Treatment should be continued for another two days after the symptoms of the disease have disappeared. The course of treatment may be longer if the disease is in a chronic form. Thus, therapy for brucellosis can reach 3-4 weeks, and typhoid fever - 4-12 weeks.
In order to prevent the recurrence of chronic infectious diseases of the urinary tract, patients from 12 years of age are prescribed a single dose at night of 4480 mg of the drug, for patients under 12 years of age - 12 mg / kg per day. Preventive therapy is carried out within 1-12 months. In the treatment of acute cystitis in patients 7-16 years old, a double dose of 480 mg of the drug is prescribed, the course is 3 days.
Treatment of gonorrhea involves taking the drug in an amount up to 2880 mg, which should be divided into three doses. This is indicated in the instructions for use for Biseptol. The price will be shown below.
Therapy of gonorrheal pharyngitis, if the patient has an increased sensitivity to penicillins, involves single doses of 4320 mg for 5 days. Therapy for pneumonia provoked by Pneumocystis carinii involves taking the drug for two weeks, every 6 hours at 120 mg / kg / day.
Intramuscularly, patients over 12 years of age are administered 480 mg every 12 hours, children 6-12 years old - 240 mg.
Intravenous drip in patients over 12 years old is administered every 12 hours at 960-1920 mg, patients 6-12 years old - 480 mg each, patients 6-30 months old - 240 mg, patients 1, 5-5 months old - 120 mg. It is imperative to adhere to the indications and instructions for the use of Biseptol.
Maximum efficiency from the use of the drug is achieved if its constant concentration in the blood is at the level of 5 mcg/ml.
In the treatment of malaria provoked by Plasmodium falciparum, intravenous infusions should be carried out twice a day, at 1920 mg. Treatment is carried out for two days. Reduced dosage required for children.
In order to achieve an increased concentration of the drug in the blood, it is administered by drip intravenously, previously dissolved in 200 ml of a special solvent. Infusions are carried out twice a day, for an hour.
Before administration, the drug is dissolved in the infusion solution in the following proportions: 5 ml of the drug in the form of a solution for 125 ml of the infusion solution, 10 ml for 125 ml, 15 ml for 500 ml.
If crystallization or turbidity is observed in the solution, its use is prohibited. The introduction is carried out for 1-1.5 hours, depending on the patient's need for fluid.
If it is necessary to limit the fluid entering the body, a solution is administered at a higher concentration - 5 ml of the drug is dissolved in 75 ml of solution for infusion. The dosage may be increased at the discretion of the physician by 50% if severe infectious pathologies are being treated.
Not everyone knows the indications for the use of Biseptol.
Side Effects
Typically, the drug is tolerated by patientsgood, but the appearance of negative reactions of the body, such as:
- Hyponatremia, hyperkalemia, metabolic hypoglycemia.
- Allergic reactions - scleral hyperemia, erythema multiforme exudative, fever, angioedema, allergic myocarditis, Stevens-Johnson syndrome, exfoliative dermatitis, rash, fever, urticaria, photosensitivity, pruritus, Lyell's syndrome.
- Myalgia and arthralgia from the musculoskeletal system.
- The urinary system may react with the appearance of toxic nephropathy accompanied by anuria and oliguria, hypocreatininemia, increased urea concentration, hematuria, crystalluria, impaired renal function, interstitial nephritis, polyuria.
- Hematopoietic system: methemoglobinemia, hypoprothrombinemia, eosinophilia, megaloblastic anemia, hemolytic anemia, aplastic anemia, agranulocytosis, neutropenia, thrombocytopenia, leukopenia.
- Gastrointestinal organs: pancreatitis, pseudomembranous enterocolitis, hepatitis, hepatonecrosis, cholestatic jaundice, increased activity of liver transaminases, cholestasis, stomatitis, glossitis, abdominal pain, gastritis, diarrhea, loss of appetite, vomiting, nausea.
- Respiratory organs: the appearance of pulmonary infiltrates, coughing, choking, bronchospasm.
- Nervous system: peripheral neuritis, tremor, apathy, aseptic meningitis in rare cases, depression, dizziness and headaches.
Indications for the use of the Biseptol medication are very extensive.
Overdose
Symptoms of an overdose of sulfonamides are as follows: the patient loses appetite, intestinal colic appears, crystalluria, hematuria, fever, loss of consciousness, drowsiness, headache, dizziness, vomiting, nausea.
In case of an overdose of trimethoprim, nausea and vomiting, dizziness, headaches, depression, and mental disorders are not excluded. There may be inhibition of the functionality of the bone marrow.
At the moment, medicine does not have data on how much co-trimoxazole can be life-threatening.
If co-trimoxazole is taken by a patient for a long period, a chronic overdose may occur. In this case, bone marrow functionality is inhibited, megaloblastic anemia, leukopenia, and thrombocytopenia develop.
If symptoms of an overdose are detected, you should immediately stop taking Biseptol and take measures to remove it from the gastrointestinal tract. Within a maximum of 2 hours after the last dose, it is important to do a gastric lavage, or provoke vomiting. If the patient's diuresis is insufficient, but kidney function is preserved, he is shown to drink plenty of fluids. It is also recommended to administer up to 10 mg/day of calcium folinate. Excretion of trimethoprim is facilitated by increased acidity of the urine, but there is a risk that the sulfonamide will crystallize in the kidneys.
It is necessary to observe the blood picture, the composition of electrolytes, and other biochemicalparameters. The effectiveness of peritoneal dialysis is absent, the effectiveness of hemodialysis is moderate. This tells us the instructions for use. Biseptol analogues should be selected by a doctor.
Interaction with other drugs
Simultaneous therapy with Biseptol and thiazide diuretics can provoke the development of thrombocytopenia and bleeding. These drug combinations are not recommended.
Co-trimoxazole is able to increase the activity of indirect anticoagulants, methotrexate, hypoglycemic drugs.
Under the influence of co-trimoxazole, the hepatic metabolism of phenytoin and warfarin is reduced, while their action is enhanced.
The half-life of trimethoprim decreases with concomitant administration of rifampicin.
Concomitant use of high doses of piracetam increases the risk of megaloblastic anemia.
The effectiveness of "Biseptol" is significantly reduced if procainamide, procaine, benzocaine are used in parallel.
Simultaneous therapy with phenytoins, barbiturates, PAS contributes to increased manifestation of folic acid deficiency.
According to the full instructions for "Biseptol", its action is enhanced when taking derivatives of salicylic acid.
Under the influence of the drug, the therapeutic effect of tricyclic antidepressants, oral contraceptives decreases.
Simultaneous use of medication with drugs that can inhibit bone marrow hematopoiesis mayincrease the risk of myelosuppression.
When taking cholestyramine, the absorption of other drugs is reduced, and therefore it is recommended to take them before taking co-trimoxazole 4-6 hours, or one hour after its use.
Indications for the use of the drug "Biseptol" we have considered.
Analogues
The main analogues of the Biseptol medication in terms of therapeutic action are sulfanilamide medicines such as Ingaflu, Ingalipt, Dermazin, Asakol.
Among the synomimes of the drug can be noted "Trimosul", "Sulotrim", "Sinersul", "Cotrimaxazole", "Cotrimaxol", "Oriprim", "Novotrimed", "Expazol", "Rancotrim", "Sulfatrim", "Primotren", "Eriprim", "Cotribene", "Bactreduct", "Vanadil", "Trimexazole", "Baktekod", "Aposulfatrin", "Vanadil", "Microcetim", "primazol", "Infectrim", "Methomid”, “Falprin”, “Gantrin”, “Bactramel”. "Abactrim", "Bactifer", "Andoprim", "Abacin", "Bactramine", "Bacterial", "Bactrim".
Instructions for use and prices of Biseptol analogues will not be considered. Below is the original.
Cost
The cost of a medicinal product varies depending on the region of sale and the pharmacy chain through which it is sold. The average price for a package of Biseptol at a dosage of 120 mg is 30 rubles, for a package at a dosage of 480 mg - 68 rubles. The cost of a package of "Biseptol" in ampoules fluctuates at the level of 350 rubles, and a bottle of suspension - at the level of 120 rubles.
With indications in the instructions for use for"Biseptol" can be found, but there is no information about the price.
Reviews about "Biseptol"
Patients and doctors very often leave positive feedback about "Biseptol" as a drug that is most effective against respiratory infections (bronchiectasis, furunculosis, otitis media, bronchial asthma).
In rare cases, the drug was not effective in the treatment of gonorrhea and acne.
Patients also report that quite often, while taking the drug, such negative reactions of the body as nausea and vomiting, a significant loss of appetite appear. Many consider Biseptol an outdated medication. However, the undoubted advantage is the democratic price of the drug and its availability to the general population. And besides, he has an extensive list of indications. According to reviews, the instructions for using "Biseptol" are simple and clear.
It is important to remember that the choice of a drug for the treatment of infectious diseases should be carried out by a specialist who can take into account the existing contraindications and the individual characteristics of each patient.
We looked at what Biseptol helps with. The list of diseases is very impressive.
