Fibrin is a protein that is the end result of blood clotting. It is formed as a result of the action of thrombin on the fibrogen.
Fibrin is an insoluble protein produced in the body in response to bleeding. This protein is a solid element consisting of fibrous filaments. The progenitor of fibrin is fibrinogen. It is a protein produced by the liver. It is in the blood. When tissues are damaged, bleeding occurs. To stop it, thrombin begins to work. It affects fibrinogen, thereby provoking its transformation into fibrin.
First, protein molecules combine into long strands that entangle the platelet, creating a rough mass. Gradually, it hardens and shrinks, forming a bloody clot. The sealing process is stabilized by the fibrin stabilizing factor.
The role of fibrin in inflammation
Fibrin production and inflammation are two closely related processes. Protein plays an important role in contact with decaying, damaged tissue. Thrombokinase released from the tissue comes into contact with fibrinogen.
When blood coagulates, all toxic substances are blocked in a clot. This featureThe effect of protein during the inflammatory process protects the body from the further spread of toxins and their negative effects. This reaction is called fixation. Thus, fibrin is also the body's protector from toxins.
Protection of the body
The formation of insoluble fibrin helps protect the body from blood loss, as well as from inflammatory processes. However, such a reaction causes pain and swelling, tissue damage, and a violation of their functionality. Subsequently, this is eliminated by reparative processes. At their early stage, special substances are produced that cause fibrin depolymerization. Such a reaction, even at the very beginning of the inflammatory process, can inhibit the effect of the protein on the pathological focus.
Fibrin function
When fibrinogen is converted into fibrin, special enzymes located in the focus of inflammation begin to act as inhibitors. This process is manifested by the polymerization of fibrinogen into fibrin. Based on this, the function of proteases is determined, which consists in liquefying materials by splitting fibrin and other protein molecules into peptides and amino acids. Also, the function of proteases is to inhibit the production of large molecules of the insoluble type.
Experiments carried out
Scientists conducted experiments on animals, during which it turned out that proteases introduced from the outside before the inflammatory process can completely prevent its development, and in some cases the pathology proceeded in a mild form. Experience has shown thatthe use of tryptic substances in most cases stops the development of inflammatory processes at the onset of the disease.
Prophylactic doses of enzymes reduced protein production.
Fibrin is not just a protein, but the creator of a protective barrier around the pathological focus, which protects against disease. Subsequently, this insoluble component serves to build connective tissue. He also participates in the processes of regeneration. The formation of scar tissue depends on the duration of preservation and the amount of fibrin production by the body.
So what is fibrin and what is it for? This substance is formed by the cells of the body in such an amount that is necessary to quickly stop bleeding and which will help to quickly restore damaged tissues. In some cases, fibrin is a pest. If it is produced and deposited in large quantities, then the protein can harm the body. As far as we know, fibrinolysis is a long process that cannot dissolve all excess protein. Moreover, certain conditions are necessary for this process.
To get rid of excess fibrin, a special enzyme treatment is prescribed.
Enzyme treatment
Recently, special attention has been paid to the properties of enzymes. This is especially true for proteases. For the treatment of fibrin, enzymes use substances of this particular type. They help dissolve excess protein, thereby preventing serious complications in the form of blood clots.
Propertiesproteolytic enzymes are different. They are able to have a fibrinolytic and immunomodulatory effect on the body, as well as improve blood circulation, work as decongestant, anti-inflammatory substances.
Since thrombus formation is based on the production of fibrin, a protease is needed, which causes a cleavage reaction of this substance. Without such an enzyme, it is impossible to break the protein into molecules, therefore, there will be no improvement in blood microcirculation.
With local exposure to protease, removal of necrotic plaque, resorption of fibrinous formation, thinning of a viscous secretion is possible.
