For only 50 rubles you can buy the drug "Milgamma" in pharmacies. The tool is used as an element of complex treatment of various nervous syndromes, diseases. In the instructions for use "Milgamma" the manufacturer recommends for neuritis, paresis, neuralgia, neuro-, polyneuro-, plexopathy and ganglionitis, osteochondrosis and convulsions at night. The latter is especially true for elderly patients. "Milgamma" is indicated for use at different ages: the drug is prescribed for both children and adults. There are several release forms. For the most pronounced effect, the drug is used strictly on the recommendation of a doctor and in accordance with the manufacturer's instructions.
General information
The instructions for use of "Milgamma" indicate that the product belongs to the category of multivitamins. On pharmacy shelves it is presented in the form of a solution that is injected into the musclecloth, as well as tablets (draggers), creams.
"Milgamma" cannot be used if installed:
- hypersensitivity to drug components;
- failure of functioning of the heart in a chronic decompensated form;
- pregnancy;
- breastfeeding.
In the form of injections, Milgamma is not suitable for children.
Features of use
The manufacturer recommends injecting deep into muscle tissue. If therapy is necessary against the background of a pronounced pain syndrome, it is necessary to use Milgamma in such a way as to achieve a high level of concentration of active compounds in the circulatory system as quickly as possible. For this, the course of treatment is subject to the following rules:
- dosage - 2 ml;
- frequency - twice a day;
- program duration - from five days to twice as long.
When relieving pain, the instructions for use of Milgamma recommend switching to a drug for oral use or injections with a reduced frequency - no more than three times a week. The duration of this course is up to three weeks. A similar approach requires mild forms of the disease. The doctor may recommend that you first reduce the frequency of injection of the drug, and then switch to tablets.
Instructions for the use of "Milgamma" draws the attention of patients to the belonging of the product to:
- analgesics;
- metabolic stimulants;
- drugs that protect the nervous system.
How does it work?
The effectiveness of the drug is due to the presence in its composition of B vitamins necessary for the nervous system, indispensable for preventing degeneration of the nervous tissue, stopping inflammatory processes. Vitamins have a positive effect on the condition of the musculoskeletal system.
Once in the body, thiamine, pyridoxine affect each other, mutually activating the action. Both substances have a positive effect on the state of the National Assembly, the neuromuscular system. Cyanocobalamin is essential for the production processes of the myelin sheath. Once in the human body, this component stops the pain syndrome caused by damage to the PNS. The substance activates the metabolic processes of nucleic acids, as it stimulates the action of folic acid.
Instructions for the use of "Milgamma Compositum" draws attention to the presence of lidocaine in the composition. This remedy has a local effect, relieves pain.
Side effects
The manufacturer mentions the possibility of an allergic reaction. It is expressed:
- activation of sweat production;
- increased heart rate;
- acne;
- itchy patches of skin;
- urticaria.
It is known that "Milgamma" can cause hypersensitivity reactions that manifest themselves:
- skin rash;
- angioneurotic edema;
- complicated breathing;
- anaphylactic shock.
Instructions forthe use of "Milgamma" in ampoules recommends administering the drug slowly enough. If this rule is violated, there is a possibility of systemic side effects:
- Irregular heartbeat;
- convulsiveness;
- dizziness.
Similarly, an overdose of Milgamma can manifest itself. An excess of the drug in the body manifests itself as an activation of side effects. When such a reaction is observed, the treatment is stopped and measures are taken to eliminate unpleasant symptoms.
Usage nuances
As indicated in the instructions for use, Milgamma injections are intended for intramuscular injection by a qualified specialist. The attending physician must supervise the procedure. If the symptoms are severe enough, hospitalization of the patient and injections strictly by the hospital staff are required.
Clinical observations showed no change in the ability to concentrate, control high-precision mechanisms under the influence of Milgamma injections. Instructions for use indicate that for the period of the course there is no need to limit labor activity, avoid driving.
Interaction chemistry
When in contact with substances containing sulfites, thiamine instantly decomposes. Once in contact with the decay products of this vitamin, other components of the drug also lose their activity. Levodopa stops the influence of B6. The use of "Milgamma" in the form of injections in combination with epinephrine, norepinephrine can cause additional stress on the cardiac system, as a result,activation of side effects. This is due to the presence of lidocaine in the composition of the drug. Epinephrine, norepinephrine are strictly prohibited if the permissible dose of local anesthetics is found to be exceeded.
Instructions for the use of injections "Milgamma" contains a mention of the impossibility of the simultaneous use of the drug and reducing, initiating oxidation reactions by substances. These include:
- mercuric chloride;
- tannic acid;
- sodium phenobarbital;
- metabisulphite;
- iodide;
- ammonium and iron citrate;
- benzylpenicillin;
- carbonate;
- riboflavin;
- acetate;
- dextrose.
Copper ions are capable of activating the processes of destruction of thiamine. Deactivation of thiamine is observed when the acidity of the medium increases above pH 3.
Cobalamin (B12) does not combine with heavy metal s alts. The combination in one solution of thiamine, cobalamin and other vitamins from the same group can lead to rapid deactivation of the composition under the influence of thiamine degradation products. To prevent such a reaction, it is necessary to introduce iron ions in low concentrations.
The instructions for using Milgamma injections mention the negative effect of riboflavin on other components of the composition if the substance is exposed to direct sunlight. Photolysis proceeds faster due to nicotinamide, and this process can be somewhat slowed down by introducing antioxidants into the substance.
Dynamics
In the instructions for the use of injections "Milgamma" intramuscularly recommendedresort to the composition if a person does not receive the required amount of trace elements, vitamin compounds with food. In various forms of release, "Milgamma" is suitable for people who need an increased amount of trace elements, vitamins due to diseases. To alleviate the patient's condition, but not harm the body, the use of the substance should be agreed with the attending physician. The doctor chooses the form of the drug, determines the dosage and duration of the course.
The instructions for use of Milgamma injections (reviews note that the drug in this form is prescribed quite often, although with a recommendation to switch to the oral form in the future) states that thiamine present in the medication is extremely important for metabolic carbohydrate processes. The vitamin takes part in the Krebs cycle, in the production of ATP, thiamine pyrophosphate.
Pyridoxine is no less important for the human body, since it is indispensable for the metabolic processes of protein structures, to some extent controls the metabolism of fats and carbohydrates. The analgesic lidocaine provides all types of pain relief available to modern medicine:
- terminal;
- conductor;
- infiltration.
Kinetics
In the instructions for the use of "Milgamma" intramuscularly, the manufacturer indicates that shortly after ingestion, thiamine is absorbed into the circulatory system. Studies have shown that on the first day of the therapeutic course, with the introduction of the drug in an amount of 50 mg, after a quarter of an hour inin the circulatory system, the concentration of thiamine reaches 484 ng / ml. In the tissues and organs of the body, thiamine is distributed unevenly. One tenth is observed in the blood plasma, 15% accumulate in leukocytes, and the predominant part (about 75%) in erythrocytes.
A distinctive feature of thiamine is the lack of reserves of this component in the human body. To maintain he alth, it is necessary to provide a daily supply of the compound. The substance is known to be able to cross the placenta, the blood-brain barrier, into breast milk.
Thiamine is excreted from the body with urine after 0.15 hours in the alpha phase, beta - in an hour. It takes two days for the withdrawal of the terminal phase. The instructions for use of Milgamma injections intramuscularly (reviews note that the manufacturer gives a clear and complete description of the product) indicate thiamine metabolites:
- pyramin;
- thiaminecarboxylic acid.
Manufacturer acknowledges that there are other metabolites. At present, their nature, chemical formula has not yet been established.
As studies have shown, thiamine is stored in minimal (compared to other vitamins) amounts in the body. Normally, in the body of an adult, no more than 30 mg of a substance in the form of pyrophosphate (it accounts for 80% of thiamine), about one tenth is assigned to triphosphate, and the rest to monophosphate.
Pyridoxine: kinetics
As follows from the instructions for use of "Milgamma" (2 ml - the dosage form of the drug), soon after the introduction of the composition, pyridoxine is injectively absorbed into the circulatory system,redistributed in the tissues and organs of the body. Pyridoxine plays the role of a coenzyme. The predominant part (about 80%) reacts with plasma proteins. Studies have shown that pyridoxine passes through the placenta and is excreted in breast milk. Transformation processes take place in the liver, with the formation of 4-pyridoxic acid, which leaves the body with urine. The duration of withdrawal is from two hours to five. Normally, the body contains pyridoxine in an amount of 40-150 mg. Elimination is estimated at 1.7-3.6 mg; replenishment is about 2.3%.
Milgamma cream
In the instructions for use of "Milgamma" (reviews confirm that the product works well), it is mentioned that in the form of a cream, the drug shows a moisturizing effect. The tool is intended for the treatment of legs. The main active component of the drug is urea, which can retain moisture in the skin. This is a completely natural compound that is found in he althy skin in a concentration of about one percent. Often, dry skin is due to a reduced amount of urea.
According to reviews, "Milgamma" (instructions for use when using must be followed exactly) is often prescribed by dermatologists. In medicine, urea has long been known as a reliable compound with a good reputation and a minimum of side effects. A cream containing urea helps retain moisture by binding it, which means it does not allow the skin to dry out. At the same time, itching disappears, the surfaces become softer. On the one hand, the skin becomesmore susceptible to moisture, while increasing the ability to accumulate liquid.
Milgamma ointment is made from urea and base. This minimizes the likelihood of allergies, skin irritations, makes the drug effective and safe, useful for the skin.
Application features
Ointment helps to soften the skin and increase their elasticity, relieve itching. In addition to the feet, "Milgamma" is suitable for treating knees and elbows. Under the influence of the cream, regeneration processes are activated, the skin structure is quickly restored.
The manufacturer does not use dyes, does not use aromatic additives, preservatives, making the drug as safe as possible and suitable for allergy sufferers.
"Milgamma": dragee
Instructions for the use of the drug in this form contains a mention of such active substances:
- pyridoxine hydrochloride;
- benfotiamine.
Both ingredients added at 100mg per dose.
Additionally, auxiliary components were used by the manufacturer:
- starch;
- cellulose;
- acacia powder;
- talc;
- wax;
- sucrose;
- povidone;
- polyethylene glycol;
- calcium carbonate;
- glycerides.
On sale are two formats: 30 and 60 capsules in one package. Be sure to come with instructions for use with the tablets "Milgamma", "Milgamma Compositum". Reviews of these formulations confirm: the drug is often prescribed for both adults andchildren. It rarely provokes allergic reactions, but it significantly improves the condition of people suffering from vitamin deficiencies in the body.
Terms of Use
Tablets "Milgamma" according to the instructions for use are used in a monthly course. A single dose is one capsule. On the day you can use "Milgamma" for food up to three times. Drink plenty of water with each dose. A fairly common practice is the beginning of a therapeutic course with injections, after which the transition to the oral form. The manufacturer recommends changing the application to the dragee as soon as possible.
According to reviews, Milgamma tablets (the instructions for use will have to be followed in order not to encounter side effects) are often prescribed if they are identified:
- paresis;
- neuritis;
- neuralgia;
- plexo-, polyneuro-, neuropathies;
- shingles and other ganglionitis.
Side effects
Using Milgamma can cause:
- vomit;
- nausea;
- allergic reactions;
- acne;
- convulsions;
- dizziness.
While taking the drug in extremely rare cases, there is a possibility of confusion, bradycardia, tachycardia, arrhythmia.
Is there an alternative?
If there is a need to replace the drug, you should first consult with your doctor. We examined in detail the instructions for the use of "Milgamma". analoguesdrug may act:
- "Undevit";
- "Hexavit";
- Vetoron.
The doctor may recommend Revit. The composition of "Gendevit" has a good reputation.
Regardless of whether you choose to use "Milgamma", analogues, instructions for the use of tablets, injections, solutions, it is important to follow it very precisely, otherwise the likelihood of side effects increases. If allergic reactions are known, it is necessary to warn the doctor about this at the stage of writing a prescription. The doctor will immediately advise which of the pharmaceutical products you can choose if Milgamma provokes a negative response of the body.
"Undevit": an analogue of injections "Milgamma"
Instructions for the use of this drug contains an indication of a fairly large complex of vitamins in the composition. In "Undevit" included:
- tocopherol;
- pyridoxine;
- riboflavin;
- vitamin C;
- retinol;
- nicotinamide;
- calcium;
- folic acid;
- thiamine;
- rutoside;
- cyanocobalamin.
The manufacturer used mint essential oil as an additional component.
On sale "Undevit" is presented in cardboard boxes containing instructions for use and a plastic container with 50 tablets.
Pharmacology
Undevita components work as follows:
- retinol activates the production of rhodopsin, cartilage, bone tissue, epithelium;
- thiaminestimulates carbohydrate metabolism, normalizes the work of the National Assembly;
- pyridoxine affects amino acid biochemical reactions, histamine;
- riboflavin normalizes tissue respiration;
- nicotinamide is indispensable for metabolic and respiratory processes;
- cyanocobolamine stimulates hematopoiesis, myelin production;
- vitamin C is involved in the production of hemoglobin, collagen, red blood cells, stimulates blood clotting, improves immunity;
- rutin reduces tissue permeability;
- folic acid is needed for metabolic processes involving cholines, nucleins, amino acids;
- tocopherol is involved in the production of proteins, is an antioxidant;
- calcium is essential for coenzyme synthesis.
Recommendations for use
The manufacturer advises the use of "Undevit" with a lack of vitamins in the body, as well as:
- need to support immunity while taking antimicrobials;
- recovering from a serious illness;
- need to stimulate metabolic processes during the growth and development of children, adolescents.
"Undevit" is recommended to improve the general condition of the body of an adult, elderly person.
The manufacturer notes that Undevit (like other multivitamin complexes) does not have a specific pharmacological effect. The composition of the drug contains vitamins necessary for a person, and their dosage is close to the dailynorm. The ratios between the components are also maintained close to those required by the human body. The correct use of "Undevit" in accordance with the instructions allows you to saturate the body with various vitamins, creating an overall favorable background.
All components have a coenzyme function, which means that various biological and chemical reactions are simultaneously activated. Oxidative processes and reduction reactions are more active, the production of protein structures is stimulated, tissue respiration is accelerated. The use of "Undevit" allows you to increase the vital activity of the body, and therefore improve the well-being of a person.
Proper use of the composition shows the following effects:
- restoring he althy sleep;
- increase in physical, intellectual activity;
- feel better;
- activation of the liver;
- normalization of cardiac activity;
- growth of the body's resistance to aggressive external factors;
- immunity activation.
Contraindications and adverse reactions
"Undevit" can not be used if an allergic reaction or excessive sensitivity to any substance included in the medication is established. With caution, "Undevit" is prescribed if severe liver failure, hepatic pathologies, an ulcer in the stomach or intestines are detected.
Clinical trials have shown that the use of "Undevita" can cause an allergic recommendation. To minimize the likelihood of such an organism response, it should be clearlyfollow the manufacturer's recommended daily doses. If this amount is exceeded, you should seek the help of a doctor.
Usage rules
The manufacturer recommends using Undevit capsules after a meal. To prevent the lack of vitamins in the body, the remedy is used orally, one tablet daily. With significant loads, during the recovery period after an illness, surgical intervention, the use of two to three servings is recommended for a day. The manufacturer advises the same dosage for the elderly.
Duration of admission - 20-30 days. A pause is required between repeated courses; break - from a month to a quarter of a year.
"Undevit" is allowed from 14 years old. As a prophylactic composition, it is used in a capsule daily, as an element of complex therapy - 2-3 doses daily.
An overabundance of the drug can manifest itself as nausea, vomiting and stool disorders. Allergies, lethargy, irritability are possible. Against the background of an overdose of Undevit, the head and stomach may hurt, and hepatic functionality may be impaired. When such manifestations are observed, the reception is stopped, they turn to the doctor for a choice of symptomatic treatment.
Mutual influence
Studies have shown that retinol and tocopherol have a mutually stimulating effect. Vitamin A reduces the activity of glucocorticoids relative to the foci of inflammation. Do not use a multivitamin complex and nitrites, cholestyramines, which prevent the normal absorption of retinol. Vitamin A is incompatible withretinoids.
The high content of iron in some preparations does not allow tocopherol to affect the human body. Therefore, a multivitamin complex should not be combined with drugs on silver, iron. You should not combine "Undevit" and trisamine, sodium bicarbonate, since the increased alkalinity of the environment, which is formed under their influence, does not allow tocopherol to be absorbed. Inhibit the effectiveness of the vitamin and drugs that indirectly affect blood clotting.
Ascorbic acid activates penicillins, sulfonamides, leading to an increase in the toxicity of these compounds. The simultaneous use of heparin, indirect anticoagulants and vitamin C leads to a decrease in the effectiveness of the first two. Ascorbic acid stimulates the absorption of iron. The combination of a vitamin complex and oral contraceptives reduces the bioavailability of the vitamin.
