Drug "Bergolac" is an inhibitor of prolactin production, which is also a dopamine receptor agonist. The dosage form of this medication is tablets: white, biconvex oblong, with a risk. They are packaged in 8 or 2 pieces. in polymer bottles - 1 pc. in carton.
What is the composition of Bergolak? 1 tablet contains the active ingredient - cabergoline, as well as some excipients: anhydrous lactose (lactopress), leucine, magnesium stearate.
Pharmacological properties
Cabergoline is an ergoline derivative, a dopamine receptor agonist that inhibits prolactin secretion. This substance provides stimulation of dopamine D2 receptors located in the lactotropic cells of the pituitary gland.
According to the instructions for use, "Bergolac" in high dosages has a dopaminergic effect of the central type, reduces the content of prolactin in the blood, restores fertility and the menstrual cycle. In women, due to a decreasethe level of prolactin is restored by the pulsating production of gonadotropins, and in the middle of the menstrual cycle, luteinizing hormone is produced, with the help of which anovulatory cycles disappear, the estrogen content in the blood increases, the severity of hyperandrogenic (acne, hirsutism) and hypoestrogenic (osteoporosis, fluid retention, weight gain) symptoms decrease.
In men, cabergoline reduces the factors caused by hyperprolactinemia: impotence (as a result of a decrease in the amount of prolactin, the concentration of testosterone increases), reduced libido, gynecomastia, lactorrhea. There is a reverse development of pituitary adenomas and the symptoms caused by them (headache, impaired fields and visual acuity).
This medication helps to reduce the concentration of prolactin in people suffering from pseudoprolactinoma or prolactinoma. The concentration of prolactin decreases already 3 hours after ingestion, remaining for 14-21 days. The drug provides a stable decrease in the level of prolactin at 2-4 weeks of treatment.
Indications for use
"Bergolac" is prescribed for the following pathologies:
- suppression or prevention of postpartum lactation;
- treatment of conditions associated with hyperprolactinemia, including amenorrhea, anovulation, galactorrhea, oligomenorrhea;
- syndrome "empty Turkish saddle", which is combined with hyperprolactinemia;
- prolactin-secreting pituitary adenomas (micro- and macroprolactinomas), idiopathic hyperprolactinemia.
List of contraindications
The medicine is contraindicated in such cases:
- under 16;
- galactose intolerance;
- glucose-galactose malabsorption;
- lactase deficiency;
- high sensitivity to ergot alkaloids;
- intolerance to cabergoline and other substances in the formulation.
This must be considered before appointment.
Careful reception
According to the instructions for use, "Bergolac" is prescribed with caution in diseases of the cardiovascular system, arterial hypertension during pregnancy (including preeclampsia), simultaneous administration of antihypertensive drugs (risk of orthostatic hypotension), with severe insufficiency liver, gastrointestinal bleeding, peptic ulcers, severe forms of cognitive and psychotic disorders, in the presence of fibrotic changes in the respiratory system and heart (pleurisy, valvulopathy or pleural fibrosis).
When to start conception?
After taking the medication, conception can begin after one month. If the patient becomes pregnant during therapy, consideration should be given to the advisability of discontinuing the medication, taking into account the benefits and risks.
The product is not indicated for women who wish to breastfeed, therefore, if cabergoline therapy is necessary, feeding should be stopped.
Instructions
Pills are for oral use. Recommended dosage:
- In order to prevent postpartum lactation: on the first day after birth - 1 mg once.
- Breastfeeding suppression: 0.25mg twice a day 12 hours apart. Duration of admission - 2 days. Due to the potential for orthostatic hypotension, a single dose should not exceed 0.25 mg.
- Treatment of conditions associated with hyperprolactinemia: initial dosage - 0.5 mg per week, once or divided into 2 doses with an interval of 3 days.
Side effects of Bergolac
Medication may cause these side effects:
- CNS: excessive sleepiness, headaches, dizziness, fatigue, syncope, asthenia, paresthesia, depression.
- Heart, vessels: flushing, valvulopathy, palpitations, vasospasm, orthostatic hypotension, decreased blood pressure.
- Digestion: abdominal pain, constipation, dyspepsia, gastritis, liver dysfunction.
- Allergic reactions: hypersensitivity.
- Other: muscle cramps, epistaxis, mastodynia, alopecia, transient hemianopia, edema, respiratory problems, pleural fibrosis.
Cost
The price of "Bergolak" is approximately 860 rubles. It depends on the region and pharmacy chain.
Analogues of this medication
The main analogues of Bergolak are:
- Agalates.
- "Cabergoline".
- Dostinex.
It is important to understand that only a doctor should select a replacement.
Agalates
This is an Israeli-made drug, a dopamine receptor agonist based on cabergoline, a synthetic ergot alkaloid. The drug inhibits the production of prolactin. The principle of operation of the main element includes the stimulation of dopamine receptors in the hypothalamus. At higher doses than required to suppress prolactin production, the drug causes a central type of dopaminergic effect due to stimulation of dopamine D2 receptors.
The effect of the drug is dose-dependent. A decrease in prolactin content is usually observed after 3 hours and persists for 2-3 weeks, and therefore, in order to suppress lactation, a single dose of this medication is usually sufficient. When treating hyperprolactinemia, the level of prolactin in the blood stabilizes after 2-4 weeks. Normal levels of prolactin can persist in the body for several months.
It can be difficult to decide what to prefer - "Agalates" or "Bergolak". The main element of the first has highly selective properties and does not affect the basal production of cortisol and other pituitary hormones. The only pharmacodynamic phenomenon that is not due to therapeutic action is considered to be a decrease in blood pressure. The greatest hypotensive effect is usually noted 6 hours after ingestion. The degree of pressure reduction and the incidence of hypotensiveeffects depend on the dosages of the drug.
Indications for prescribing and a list of contraindications to this medication are absolutely similar to those indicated in the instructions for use of the drug "Bergolac".
The cost of this drug analogue is about 1150 rubles.
Cabergoline
What else is included in the list of analogues of "Bergolak"? The medicine "Cabergoline" (Russian drug) is produced on the basis of the active substance of the same name. It is an ergoline derivative, a dopamine receptor agonist that inhibits prolactin secretion. This substance provides stimulation of dopamine D2 receptors located in the lactotropic cells of the pituitary gland. An analogue of "Bergolac" "Cabergoline" in high dosages has a dopaminergic effect of the central type, reduces the content of prolactin in the blood, restores the cycle of menstruation and fertility.
In women, due to a decrease in the level of prolactin, the pulsating production of gonadotropins is restored and in the middle of the menstrual cycle, luteinizing hormone is produced, with the help of which anovulatory cycles disappear, the estrogen content in the blood increases, the severity of hyperandrogenic (acne, hirsutism) and hypoestrogenic (osteoporosis, fluid retention, weight gain) symptoms.
In men, cabergoline reduces the factors caused by hyperprolactinemia: impotence (as a result of a decrease in the amount of prolactin, the concentration of testosterone increases), reduced libido, gynecomastia, lactorrhea. The reverse development of pituitary adenomas and the symptoms caused by them is noted.(headache, field and visual acuity disturbances).
Taking this analogue of "Bergolac" helps to reduce the concentration of prolactin in people suffering from pseudoprolactinoma or prolactinoma. The concentration of prolactin decreases already 3 hours after ingestion, remaining for 14-21 days. The drug provides a stable decrease in the level of prolactin at 2-4 weeks of treatment.
What is better - "Cabergoline" or "Bergolac", the doctor will tell you. The price of the first varies between 680-770 rubles per pack.
Dostinex
Drug "Dostinex" is the Italian analogue of "Bergolak". Dopamine receptor agonist based on cabergoline, a synthetic ergot alkaloid. The drug inhibits the production of prolactin. The principle of operation of the main element includes the stimulation of dopamine receptors in the hypothalamus. At higher doses than required to suppress prolactin production, the drug causes a central type of dopaminergic effect due to stimulation of dopamine D2 receptors.
The effect of the drug is dose-dependent. A decrease in prolactin content is usually observed after 3 hours and persists for 2-3 weeks, and therefore, in order to suppress lactation, a single dose of this medication is usually sufficient. When treating hyperprolactinemia, the level of prolactin in the blood stabilizes after 2-4 weeks. Normal levels of prolactin can persist in the body for several months.
Many are also interested in what is better "Bergolak" orDostinex. These medicines are similar in many ways.
The main element of the Dostinex analogue has highly selective properties and does not affect the basal secretion of cortisol and other pituitary hormones. The only pharmacodynamic phenomenon that is not due to therapeutic action is considered to be a decrease in blood pressure. The greatest hypotensive effect is observed, as a rule, 6 hours after administration. The degree of pressure reduction and the frequency of occurrence of the hypotensive effect depend on the dosages of the drug.
This analogue of "Bergolak" price in the pharmacy chain is approximately 660 rubles.
Alaktin
This is a remedy that stops lactation. It is a synthetic ergot alkaloid and has a long and pronounced dose-dependent prolactin-lowering effect. Active ingredient: cabergoline (0.5 mg).
"Alactin" is used orally during meals.
Standard dosage for suppression of postpartum lactation is 1 mg once during the first day after delivery.
To suppress existing lactation, 0.25 mg every 12 hours for two days (1 mg total) is recommended.
Standard dosage in the treatment of hyperprolactinemic conditions is 0.5 mg once/week or 0.25 mg twice a week. If necessary, the dose can be gradually increased (under the supervision of a doctor) - by 0.5 mg / week at monthly intervals until a therapeutic effect is obtained. The standard therapeutic dose is 1 mg per week and can range from 0.25 mg to 2 mg per week.
Max dose - 3mg/day.
Reviews
The patients who left the bulk of the reviews about the drug "Bergolac" and its analogues are women who were prescribed these drugs for hormonal diseases of the genital area and in order to stop lactation. The rest are people who have been treated for other diseases caused by hyperprolactinemia.
Reviews are mostly positive. Patients note that the drugs of this pharmacological category are very effective, allowing you to quickly achieve the desired therapeutic result. The only disadvantage of these drugs is a large number of side effects, among which extremely unpleasant conditions of patients are often observed - severe dyspepsia, severe dizziness, tremor, impaired visual perception, stool disorders, attacks of vegetovascular dystonia, low blood pressure, asthenic syndrome, decreased appetite, cramps of the limbs and others.
