In a modern pharmacy, you can easily buy Actovegin gel, tablets or injections with instructions. The tool belongs to the class of antioxidants, prevents the lack of oxygen, is considered an effective reparant. The active components of the drug affect the transformation, movement of glucose in the body, thereby activating oxygen consumption by cells affected by ischemia. At the same time, the amount of ADP, ATP increases.
"Actovegin": ampoules
Presented in three types: 80, 200 and 400 mg of the active ingredient in one dose. Volumes - 2, 5, 10 ml, respectively. One package contains instructions for "Actovegin" (intravenously), 25 ampoules of the minimum dosage or five copies of 200 mg, 400 mg. The main substance from which the drug was created is hemoderivat obtained from the blood of young calves. Proteins have been removed from the substance. For eacha milliliter of the substance accounts for 40 mg of hemoderivat.
According to the instructions for Actovegin ampoules, the substance consists entirely of small physiological components. The molecular weight of the ingredients is strictly less than 5,000 Da.
"Actovegin" shows a pronounced metabolic effect, protects the cells of the nervous system. As a neuroprotector, the substance reduces the effects of stress associated with oxygen deficiency at the cellular level. Reduced neuronal apoptosis. Studies have shown non-specific effects on metabolism relative to the organs of the human body.
The manufacturer in the instructions for use for injections "Actovegin" intramuscularly indicates the effect of using the composition at the molecular level. Under the influence of the components of the product, oxygen is utilized faster, resistance to hypoxia increases, glucose is processed faster, which means that energy metabolism is stimulated. The mutual effect is that energy reserves at the cellular level increase. This is especially important in ischemia, oxygen deficiency. "Actovegin" has become almost a unique drug for the treatment of people who have polyneuropathy on the background of diabetes mellitus, as it exhibits activity similar to insulin regarding the movement, oxidation of glucose, while simultaneously stimulating metabolic processes involving oxygen.
In the second type of diabetes, studies have shown (this is recorded in the instructions for use), Actovegin reduces the severity of manifestations of polyneuropathy caused by metabolic disorders. Weakening:
- burning;
- paresthesia;
- pain;
- numbness of the legs.
Under the influence of the composition, vibration susceptibility disturbances become noticeably less. In general, as the reviews and instructions for use show, Actovegin (the price of ampoules is from 600 rubles) can significantly improve the quality of life of patients.
Kinetics
A distinctive feature mentioned in the instructions for the use of Actovegin intramuscularly, orally and externally is the inability to assess the kinetics of the drug using methods available to modern doctors. No mechanisms for rating:
- suction;
- distribution;
- eliminations.
This is due to the composition of the substance: "Actovegin" contains only physiological components present in the human body.
Terms of Use
In the instructions for use of Actovegin injections, the manufacturer mentions the following indications for the use of the drug:
- brain diseases caused by metabolic disorders, vascular conditions;
- peripheral circulation problems;
- complications associated with insufficiency of peripheral blood flow;
- polyneuropathy due to diabetes mellitus.
"Actovegin" shows a pronounced effect when:
- dementia;
- angiopathy;
- trophic ulcers.
The remedy can be used in violation of blood flow in both veins and arteries. In the instructions for use for injections "Actovegin" indicates a vast areadrug efficacy.
Injection solution injected into a vein:
- under a drip;
- jet infusion.
You can inject "Actovegin" into the artery. The optimal dosage is 5-20 ml per day.
The instructions for Actovegin indicate the possibility of using the composition intramuscularly, while observing the rules:
- injection is done very slowly;
- maximum dose per day - 5 ml.
For infusion into a vein "Actovegin" is diluted with glucose or sodium chloride. The maximum concentration is 2 g per 250 ml of liquid.
Dosage rules
In the instructions for Actovegin, the manufacturer recommends choosing a dosage, assessing the clinical manifestations of the disease. Usually they start with 5-10 ml, the injection is made into a vein or artery. Continue the course, inject 5 ml into a vein or muscle every day. It is possible to reduce the frequency of use to several times a week. The specific format is chosen by the doctor, analyzing the disease, the response of the patient's body to therapy.
If the patient is in serious condition, "Actovegin" is shown to be administered under a dropper into a vein in an amount of 20-50 ml per day. The duration of treatment is several days, until a pronounced progress is made.
In the instructions "Actovegin" with moderate severity of the patient's condition is recommended for injection into a vein or muscle. Dosage - 5-20 ml per day. Duration of treatment - from two weeks to 17 days. A similar program requires exacerbation of chronic pathology.
As part of the planned therapeutic program "Actovegin" is used fromone to three times a week for a month or a half. The Actovegin instructions indicate that the agent is injected into a vein or muscle. Dose - from two to five milliliters. The specific frequency and amount is chosen by assessing the severity of the pathology.
If polyneuropathy is established against the background of diabetes mellitus, Actovegin is started to be used in an amount of 2 g per day. The drug is injected into a vein. The duration of the course is three weeks. After that, they switch to the form for oral administration. For 4-5 months (and more), the patient is prescribed Actovegin tablets. According to the instructions, they are taken three times a day, 2-3 doses.
Forbidden
The contraindications listed in the instructions for "Actovegin" (tablets, injections, ointments) are primarily hypersensitivity to the components of the composition, the susceptibility of the ingredients. You can not use the medication if hypersensitivity to other drugs with similar components in the composition is detected. In addition, the drug in the form of injections is not used for:
- decompensated heart failure;
- pulmonary edema;
- oliguria;
- anuria.
These conditions do not allow the infusion of medications, as there is a possibility of overhydration.
Adverse reactions
The instructions for "Actovegin" (intramuscularly) lists the possible negative responses of the patient's body. There is a possibility of an allergic reaction. The manufacturer warns of the risk of developing the following conditions:
- increased sensitivity, affecting the condition of the skin;
- anaphylactic, anaphylactoid responses;
- anaphylactic shock;
- heat;
- chill;
- angioedema;
- itch;
- skin rashes;
- urticaria;
- hyperemia of the skin;
- activation of sweat glands;
- swelling of mucous membranes, skin;
- tides.
Tissue changes may occur at the injection site.
Also in the reviews and instructions for "Actovegin" (the price of the form for injective administration - from 600 rubles) negative responses of the body are mentioned:
- dyspepsia, stool disorder, nausea, vomiting, epigastric pain;
- pale skin, decreased or increased pressure, shortness of breath, irregular heart rate and rhythm, acrocyanosis, heart pain;
- suffocation, difficulty swallowing, difficulty, rapid breathing, chest constriction, sore throat;
- trembling, paresthesia, agitation or weakness, head may ache and dizziness, loss of consciousness;
- pain in the joints, muscle tissue, lower back.
When side effects appear, "Actovegin" is canceled, therapy is carried out to eliminate the symptoms.
Features of introduction
In the instructions for use of "Actovegin" (the price of injections mentioned above), the manufacturer recommends using the drug in muscle tissue in an amount of no more than 5 ml due to a pronounced hypertonic effect. The substance intended for infusion is combinedonly with glucose and sodium chloride. It is very important to observe the sterility of the conditions, otherwise "Actovegin" can become a source of danger to the he alth and even the life of the patient.
The product does not contain preservatives, it is based only on natural ingredients, which partly explains its rather high price. Instructions for use "Actovegin" draws attention to the following limitation associated with such a set of ingredients: the drug must be fully used at a time. The opened ampoule cannot be stored, as well as the prepared solution. If the medicine has not been used on time, it must be disposed of, as well as any waste associated with the administration procedure. At the same time, the requirements and rules established by laws must be observed.
Manufacturer draws attention to the risk of an anaphylactic response. To prevent a serious condition of the patient before starting the procedure, it is reasonable to conduct a test injection to check the sensitivity. If the balance of water, electrolytes is disturbed, the dosage is adjusted, a specific therapeutic course is selected.
Patients who need to control the intake of sodium in the body should take into account that the drug contains this substance.
The infusion solution is colored a slight shade of yellow. The strength of the color depends on the original product used in the preparation, therefore it varies significantly. The shade, as the manufacturer assures, does not indicate the quality component of the drug, does not lead to greater or lesser sensitivity, activity. In addition, attention is paid to what to enteronly a uniform transparent solution is allowed, in which there are no inclusions visible to the eye.
Mother and child
If you need to use "Actovegin" during the period of bearing a child and breastfeeding, you should consult a doctor. The doctor will assess the condition of the mother, the fetus, analyze the possible dangers and obvious benefits, and warn the woman about the risks associated with such therapy. Only with the obvious dominance of benefits, a decision is made to use Actovegin. In medical practice, there are cases when the combination of "Actovegin", pregnancy and placental insufficiency led to death, but there is no official information about what exactly provoked this result: the drug or the underlying disease.
The use of "Actovegin" during breastfeeding under the supervision of doctors showed no negative effects for the mother or child.
There is no information on the use of Actovegin for minors. The manufacturer does not recommend the use of ampoules for the treatment of this category of patients. At the same time, children's age is not an absolute contraindication to the use.
Work and Therapy
Like many analogues, the Actovegin instructions indicate that the agent can only slightly affect the rate of human reaction, in most patients this effect was not observed at all. When working with high-precision machines and units, transport management, it is important to take into account not only the direct impact of "Actovegin" on the ability toto concentrate and respond, but also to the risk of a negative response of the body to the therapeutic course, in particular, from the nervous system.
Usage nuances
There is no information confirming the interaction with other medicinal formulations about Actovegin. There are no known cases of overdose.
"Actovegin"-gel
The active component of the product in this form is also hemoderivat obtained from calf blood, from which the protein component was extracted. There are 20 ml of the component per 100 g of gel. Auxiliary ingredients were also used in the production:
- carmellose;
- calcium lactate;
- water;
- propyl parahydroxybenzoate;
- propylene glycol.
The most pronounced difference from the already described ampoules is the price of Actovegin. The instructions for the analogue of injections (gel) are in many ways similar to those given above, however, the composition is used differently. Another difference is the availability in pharmacies. Ampoules are available in most modern pharmaceutical outlets, but finding a gel is somewhat more difficult.
General information
"Actovegin" is produced in the form of a homogeneous transparent mass. Has no hue or is colored yellowish. The tool belongs to the group of drugs that prevent hypoxia, stimulates metabolic processes involving glucose, oxygen. Under the influence of the drug at the cellular level, energy reserves increase. Stimulates ATP metabolism. With Actovegin, regenerative processes proceed faster, which require impressive energy reserves.
In the instructions for use of the analogue of "Actovegin" in injections - gel - the following indications are indicated:
- inflammation;
- wounds, cuts, scratches;
- burns;
- cracks;
- weeping ulcers.
"Actovegin" is indicated for sunburn, steam burns or scalding, as it stimulates cell regeneration. With a weeping ulcer, it is used only at the initial stage. In case of violation of the integrity, an equally pronounced effect is shown in the treatment of mucous membranes and skin.
"Actovegin" in the form of a gel is used as a prophylactic agent to prevent the negative effects of radiation, as a therapeutic agent for damage caused by this factor.
You can use the composition as a preliminary for the treatment of a wound with burns, if the patient is shown transplantation.
No way
Like injections, Actovegin gel is not applied if hypersensitivity to the substance is established. Similar medicines can also be dangerous.
Subtleties of use: instructions for use "Actovegin"
The price of analogue injections is attractive - about 150 rubles per pack, but the product has serious differences, so it is far from always possible to replace one with another. Like injections, the ointment can be applied during gestation, while breastfeeding, but the mechanics of application are completely different: the gel is intended for external use.
In the instructions, the manufacturer recommends distributing the composition with a thinlayer, treating diseased skin several times daily. If it is necessary to clean the surface of the ulcer, the drug is applied in a thick layer, then covered with a compress with an ointment or gauze bandage soaked in medication. Bandage change frequency - daily. If the surface gets very wet, replace it several times a day.
As clinical trials show, most patients tolerate the medication very well. There are cases when, at the beginning of use, patients felt pain at the site of application. The syndrome is explained by swelling of the tissues, but does not indicate intolerance to the agent. If the pain persists for a long time, and the therapy does not show a pronounced result, it is necessary to consult a doctor.
An allergic reaction to the composition is possible if there is a mention of hypersensitivity that bothered the patient earlier in the medical history.
There is no information about the possibility of interaction between Actovegin gel and other medicines.
What's on the pharmacy shelves?
In a pharmacy you can buy a remedy at an affordable price, as evidenced by the reviews. Instructions for use and an analogue of "Actovegin" in injections - gel - are on sale at a price of 150 rubles and more. The manufacturer always puts an accompanying document in a cardboard box with the composition, which indicates the composition, action, contraindications and features of the use of the substance.
There are four packaging options: 20, 30, 50 and 100 g. The gel is sealed in an aluminum tube, protectedmembrane removed at the first opening. The cover is made of plastic. The concentration of the active compound in all forms of release is 20%.
"Actovegin" in the form of a gel is sold without a doctor's prescription.
The drug has several analogues similar in pharmacological action (and relatively close in price). Reviews of Actovegin, instructions in the parts relating to indications, allow us to conclude that the drug can be replaced with medicines:
- Artra.
- Arcalen.
- Aekol.
The choice of replacement should be agreed with the doctor.
Tablets "Actovegin": instructions for use
The price of a tablet form is quite high - for a package containing fifty doses, pharmacies ask about 1,600 rubles. One capsule contains 200 mg of the active ingredient. The product is made in a round shape, the shell is greenish, yellowish. All copies are shiny. The active compound, as in the cases listed above, is hemoderivative obtained from calf blood. Protein structures are extracted from the substance. As auxiliary components, the manufacturer used:
- talc;
- povidone;
- magnesium stearate;
- cellulose;
- sucrose;
- dyes;
- wax;
- macrogoal;
- gum;
- phthalates.
Pills are packed in tinted glass bottles placed in a cardboard box along with instructions for "Actovegin". Reviews about the price of an analogue of injections - tablets - basically confirm that the remedy is effective, but it is expensive, so it is available farnot every patient. The drug is produced by the Japanese pharmaceutical company Takeda GmbH, which has a good reputation, so many agree that Actovegin is worth the money that they ask for it in pharmacies.
Pharmacology
"Actovegin" in tablet form activates metabolism at the cellular level, increases trophism, stimulates regenerative processes, prevents oxygen starvation of cells. Under the influence of the drug, oxygen and glucose are more efficiently transferred, accumulated, and utilized at the cellular level. Actovegin initiates ATP production reactions, thanks to which the cells receive the energy volumes necessary for normal life activity.
"Actovegin" is indicated if there are conditions that prevent energy metabolism or require an increase in its activity, such as:
- lack of oxygen;
- lack of substrate;
- regeneration;
- healing.
The active component of the substance stimulates anabolism, metabolism. The secondary effect is the activation of blood flow.
The tablets contain only physiological substances. The molecular weight of each of the components is up to 5,000 Da. The agent acts at the molecular level, increases the resistance of tissues to oxygen deficiency, stimulates energy production, glucose transformation. All the effects shown by "Actovegin" in total allow you to increase energy reserves, which is especially important during ischemia, hypoxia.
The primary effect can be seen within half an hour after using the drug in food. Maximumthe result is achievable in three hours from the moment the substance enters the body.
Kinetics
As with injections, ointments, and tablets, it is not possible to evaluate and investigate how Actovegin is absorbed, how it is distributed throughout the body tissues and in what ways it is excreted. This is due to the presence of exclusively physiological compounds that are already present in the human body.
Usage rules
The instructions list the following indications for taking Actovegin tablets:
- disturbances of metabolism, activity of brain vessels;
- acute forms of impaired blood flow in the brain;
- dementia;
- trauma of the skull, brain, the consequences of such injuries;
- hypoxia provoked by various factors;
- polyneuropathy due to diabetes mellitus;
- disturbances in the work of veins, arteries;
- trophic ulcers;
- arterial angiopathy.
"Actovegin" is prescribed, assessing the patient's condition, diagnosis, severity of the disease. The classic course involves the use of tablets three times a day in the amount of 1-2 capsules. The integrity of the shell should not be violated. "Actovegin" is washed down with clean water. The duration of the course is from a month to one and a half.
Polyneuropathy requires the first use of a solution for injection into a vein for three weeks in an amount of 2 g, after which they begin to take pills. Duration of the program - from five months and more, frequency of use - three times a day, one-timedosage - 2-3 capsules.
Negative effects and contraindications
Using Actovegin tablets can cause:
- urticaria;
- heat.
You can not use the composition if an increased susceptibility is established in any substance used in the manufacture of the drug.
Special Occasion
If indicated, it is allowed to take "Actovegin" during gestation and breastfeeding.
In the manufacture of the composition, a quinoline dye was used, products with which are not recommended for use until reaching the age of majority. This aspect should be taken into account if it is planned to prescribe treatment with Actovegin to a child.
Clinical observations have shown that "Actovegin" does not correct a person's ability to concentrate, respond, drive vehicles and high-precision mechanisms. No effect on the psyche and motor skills.
When taking an overdose, stomach pains are possible. When such a symptom is observed, Actovegin is canceled, the stomach is washed, therapy is prescribed based on the symptoms. The patient is shown to drink a lot.
Failed to detect the effects of the interaction of "Actovegin" and other medications.
What to replace?
There are several known means that, to one degree or another, are analogues of Actovegin. Before replacing the drug with an alternative, you should consult with your doctor to clarify the effectiveness of other formulations.
One of the options is Cortexin. In pharmacies it costs 800-1200 rubles,is a water-soluble polypeptide. Differs in the increased speed of penetration into cells, effectively restores functions of a brain. You can not use the drug during childbearing, breastfeeding. "Cortexin" is contraindicated if hypersensitivity to any of the compounds used in the production is established.
A fairly affordable analogue of "Actovegin" is presented in pharmacies under the name "Vero-trimetazidine". For one package they ask for about a hundred rubles. The drug prevents hypoxia, is used for ischemia, strokes, cardiac hypoxia. Not intended for pregnant women and nursing mothers.
Another analogue of Actovegin is Noben. It costs a little more than 500 rubles per pack. Active ingredients protect brain neurons, stimulate regenerative processes, and allow cells to recover. The substances on which the composition works are antibodies of one of the brain proteins. The product is not intended for the treatment of pregnant women and minors.
