"Actovegin" - an extract taken from calf blood protein, refers to drugs with a wide spectrum of action. The drug has a nootropic and stimulating effect on the human body. It is used for metabolic and vascular changes in the brain (neuralgic disorders), as well as for other diseases. The medicine is absolutely safe for children, it has no serious side effects on the body, the drug is recommended to all patients who are suitable for the list of pharmacological properties. Why is Actovegin prescribed in ampoules?
Issue form
"Actovegin" is available in the following forms:
- injections;
- pills;
- gel.
The solution is usually used in the treatment of neurological diseases. The composition of injections "Actovegin" includes the following components:
- calf blood extract (deproteinized hemoderivat);
- water;
- sodium chloride.
Drugavailable in different strengths:
- injections of 400 milligrams, in a package of 5 ampoules of 10 milliliters;
- solution of 200 milligrams, in a package of 5 ampoules of 5 milliliters;
- solution of 80 milligrams, 25 ampoules of 2 milliliters in a pack.
All ampoules are placed in a plastic container. The color of the solution is yellow with different shades, the saturation of the color does not affect the effectiveness of the drug.
In rare cases, when taking the medicine, pain may occur associated with an increase in secretion. Therapy should be stopped if the pain persists and there is no effect.
Pharmacological actions
The drug, getting inside, carries out its action by enhancing the process of metabolic decay, decomposition into simpler substances. It increases the processing of oxygen, thereby increasing resistance to oxygen starvation (a state of the body in which the normal supply of oxygen to the brain is disrupted). The drug in the form of a solution quickly penetrates the circulatory system, spreading the active substance throughout the body, which explains its quick result.
Actovegin has been on the pharmaceutical market for more than thirty years, and the feedback about this drug is extremely positive both from the patients themselves and from the doctors, which means that there is no reason to consider the drug ineffective in the treatment of diseases. "Actovegin" can be administered intra-arterially, intravenously and intramuscularly.
Indications
According to the instructions for use, Actovegin ampoules can be used in the presence of the following diseases:
- diabetes mellitus (an endocrine disease caused by a deficiency in the body of the hormone insulin or its low biological activity);
- ischemic stroke (impaired cerebral circulation with damage to brain tissue, disruption of its functions due to difficulty or cessation of blood flow to a particular department);
- hypoxia (reduced oxygen content in the body or individual organs and tissues);
- traumatic brain injury;
- blood supply problems;
- metabolic disorders;
- varicose veins (veins dilate, valves are not able to distill blood, which causes a gradual disruption of the entire blood flow in the human body);
- imbalance of vascular tone (vegetovascular dystonia - a complex of functional disorders, which is based on a violation of the regulation of vascular tone of the autonomic nervous system).
- hemorrhagic stroke treatment;
- encephalopathy (chronic hypoxia of the brain as a result of exposure to various pathological factors);
- trophic damage;
- wounds of various origins;
- ulcerative skin lesions;
- occurring bedsores;
- damage to mucous membranes and skin caused by radiation damage.
The drug is effective in healing burns and wounds. Actovegin injections have no contraindications, but it is not recommended to use them forallergic reactions.
Instructions for use
Actovegin ampoules are administered intravenously by drip or jet. How to use the drug correctly?
Before injecting the drug into a vein, it is necessary to dissolve the drug in a solution of sodium hydrochloride 0.9 or in a five percent glucose solution. The maximum daily dosage of "Actovegin" is 2000 milligrams of dry or 250 milliliters of the drug.
For intravenous administration, the dose of "Actovegin" is from five to twenty milliliters per day.
For intramuscular administration, the dosage of "Actovegin" in ampoules is 5 ml per day, the procedure is carried out slowly.
After examining the patient's condition, selects the required dose. The initial amount of the drug is from five to ten milliliters intramuscularly or intravenously. In the future, five milliliters (several times a day) daily for one week.
In severe cases of the disease, it is recommended to use the drug intravenously in a dosage of twenty to fifty milliliters per day for three days.
With exacerbation of some chronic diseases of moderate severity, the drug is prescribed intravenously or intramuscularly from five to twenty milliliters for two weeks. The dosage is selected only by the doctor.
If it is necessary to conduct a planned course of treatment, then "Actovegin" can be administered at a dose of two to five milliliters per day in any way. The duration of the course is from four to sixweeks.
The number of injections should be from one to three times. The multiplicity varies from the severity of the disease.
For the treatment of patients with a complicated form of diabetes, it is better to start the administration of "Actovegin" intravenously. Dosing in this situation will be two milliliters per day, the duration of therapy is twenty-one days.
Side effects
Given the numerous reviews, Actovegin injections are well tolerated by patients. In rare cases, anaphylactic shock and allergic reactions may occur. According to the instructions for use, Actovegin ampoules sometimes cause the following adverse reactions:
- Soreness at injection site.
- Pain in the head.
- Feeling dizzy.
- General weakness in the body.
- The appearance of trembling.
- Loss of consciousness.
- Vomiting.
- Diarrhea.
- Cut in the abdomen.
- Feeling nauseated.
- Tachycardia (rapid heartbeat).
- Sudden blanching of the skin.
- Rash on the body.
- Itchy skin.
- Flushing.
- Angioedema.
- Joint pain or muscle pain.
- Acrocyanosis (bluish discoloration of the skin associated with insufficient blood supply to small capillaries. In circulatory disorders, cyanosis is expressed in the most distant parts of the body from the heart: fingers and toes, tip of the nose, lips, ears).
- Decrease or, conversely, increase blood pressure.
- Soreness inlumbar region.
- Paresthesia (a type of sensory disorder characterized by sensations of numbness, tingling, crawling).
- Excited state.
- Suffocation (a serious condition characterized by lack of air and fear of death).
- Breathing problems.
- Difficulty swallowing.
- Pain in the throat.
- Chest pressure.
- Pain in the heart.
- Temperature increase.
- Excessive sweating.
Features of the drug
"Actovegin" in ampoules is hypertonic, so intramuscular injection should not exceed five milliliters.
There is a risk of anaphylaxis (immediate type allergic reaction, a state of sharply hypersensitivity of the body that develops with repeated administration of the allergen). To minimize this condition, it is necessary to conduct a test for the perception of the drug by the human body. To do this, a test of two milliliters of the solution is performed intramuscularly with further monitoring of local reactions.
Injections "Actovegin" during pregnancy and lactation are prescribed only for he alth reasons. In pediatrics, the medicine is not used.
The drug in ampoules is perfectly combined with isotonic solutions of glucose and sodium chloride. Apart from this compatibility, the drug does not interact with anything else.
How to store "Actovegin" in ampoules?
Injections must be kept away fromsunlight, at a temperature not exceeding twenty-five degrees. The price of ampoules "Actovegin" is:
- injections 2 milliliters (5 pieces) - 580 rubles;
- injections 2 milliliters (10 ampoules) - from 790 to 870 rubles;
- injections 5 milliliters (5 pieces) - from 550 to 670 rubles;
- injections 5 milliliters (10 pieces) - from 1100 to 1300 rubles;
- injections 10 milliliters (5 ampoules) - from 1050 to 1250 rubles.
Substitute drugs
An analogue of "Actovegin" in ampoules is the drug "Solcoseryl" (injections).
Generic improves tissue repair processes, is effectively used for the pathogenetic treatment of various pathological conditions that are accompanied by cellular nutrition disorders.
"Solcoseryl", like "Actovegin", has a yellowish tint. The solution is clear, has the aroma of meat broth. The active substance is the same as that of the first drug - deproteinized dialysate from the blood of he althy dairy calves. Water is an additional substance. Injections for parenteral administration are available in two and five milliliter dark glass ampoules.
Analogue of "Actovegin" in ampoules is packaged in contour cells of five pieces. The package may contain from one to five cells, as well as instructions for use.
Action "Solcoseryl"
The drug has the following effects:
- Improves the condition of arterial vessels and microcirculation structures, which leads to an increase in the saturation of blood flow in tissues.
- Increases the consumption of glucose and oxygen by cells.
- Enhances energy production in cells by improving the activity of the metabolic pathway process.
- Adds the intensity of the synthesis of fibrillar protein, which is considered the main structural substance of the intercellular substance of tissues.
- Increases tissue growth.
Indications for use are the same as for Actovegin.
Does Solcoseryl have any contraindications?
There are several physiological conditions of the patient in which the administration of the drug is prohibited:
- pregnancy;
- breastfeeding;
- individual intolerance;
- children's age of the patient (up to eighteen years);
- hypersensitivity to the components that make up the drug.
Caution should be taken by people with kidney failure. In addition, the drug is contraindicated in the patient's condition, when the level of potassium ions increases in the body (hyperkalemia). And also, the drug should not be used by people who have a violation of the rhythm of heart contractions (arrhythmia) and with pulmonary edema.
How to use Solcoseryl correctly?
The solution is intended for intravenous administration, the dosage and mode of use of the drug depend on the indications for use:
- In case of traumatic brain injury, 10 milliliters should be injected intravenously for ten days.
- In case of chronic insufficiency of vein activity, the drug must be administered intravenously in 10milliliters three times a week, the course of treatment should not exceed four weeks.
- When blocking the blood flow of peripheral arteries, it is recommended to inject 20 milliliters intravenously, the duration of therapy is at least one month.
Cost
The price of Actovegin ampoules is somewhat cheaper than that of Solcoseryl. The cost depends on the volume of injections and the number of ampoules in the package:
- injections of 2 milliliters (25 pieces) - from 1400 to 1500 rubles;
- injections of 5 milliliters (5 pieces) - from 800 to 900 rubles.
What is the difference between Actovegin and Solcoseryl?
The question of which is better of these two drugs is difficult to answer, since they are analogues of each other. Solcoseryl has a longer shelf life - 5 years, the analogue - 3 years.
Is "Actovegin" effective in the treatment of diseases?
According to reviews, "Actovegin" in ampoules causes a positive impression in patients. People note positive dynamics in the treatment of varicose veins, encephalopathy, imbalance in vascular tone, and traumatic brain injuries. Women who used "Actovegin" during pregnancy did not experience negative sensations and the medicine did not affect the development of the fetus. The drug during pregnancy is prescribed in the presence of placental insufficiency.
According to reviews and instructions for use, Actovegin ampoules improve microcirculation, help oxygen and glucose penetrate faster into damaged areas of the body. The drug is well tolerated by patients, has no serious consequences andused in the treatment of most known diseases. The drug works great in anabolism (the process of creating new substances, cells and tissues of the body).
