In what form is Nadroparin Calcium produced? The release form of this medication is presented in this article. It also contains information about the features of the said remedy, its indications and side effects.
Form, composition
"Nadroparin Calcium" - a solution intended for injection under the skin. The drug in question is a clear, light yellow or colorless, slightly opalescent drug liquid. Its active component is the substance of the same name - calcium nadroparin. Also, the composition of this medication includes the following additional ingredients: water for injection, calcium hydroxide solution or hydrochloric acid (diluted).
Nadroparin Calcium is on sale in single-dose syringes, which are packed in blisters and paper packs.
Drug properties
"Nadroparin Calcium" is an antithrombotic and anticoagulant agent. According to the instructions, this drug is a low molecular weight heparin, which was produced from standard heparin by depolymerization. It has a high affinity for the blood protein antithrombin 3 and suppresses factor Xa well.
It is impossible not to say that thethe drug changes the rheological parameters of the blood, that is, reduces its viscosity, increases the permeability of the membranes of granulocyte cells and platelets, and also prevents the development of such a pathological process as vascular occlusion.
Compared to unfractionated heparin, this solution has a weaker effect on platelet activity, primary hemostasis and aggregation.
Kinetics of the product
What is the kinetic ability of Nadroparin Calcium? After subcutaneous administration, the greatest anti-Xa activity of this agent is observed after 5 hours. Moreover, its half-life is 2 hours. This medication is metabolized in the liver through depolymerization and desulfation.
Prescribing the drug
Clogged veins can happen for a variety of reasons. To prevent the development of such a pathological and rather dangerous process, many doctors prescribe the drug Fraxiparin to their patients, the active component of which is calcium nadroparin. Thus, the mentioned tool is shown for use:
- in the treatment of thromboembolism;
- for the prevention of thromboembolic complications (for example, during orthopedic and surgical interventions, in people with a high risk of thrombosis, including in case of (acute) heart or respiratory failure);
- in the treatment of myocardial infarction and unstable angina;
- for preventionblood clotting
Prohibited appointments
Clogging of blood vessels is a rather dangerous phenomenon. However, even with this condition, the drug "Fraksiparin" is not always prescribed to patients. According to experts, this medicine has the following contraindications:
- intracranial hemorrhage;
- thrombocytopenia when using nadroparin;
- organic lesions of internal organs with a tendency to bleed;
- symptoms or high risk of bleeding associated with impaired hemostasis;
- surgical interventions and injuries of the brain, spinal cord, and visual organs;
- acute septic endocarditis;
- minor age;
- severe kidney failure;
- high sensitivity to nadroparin.
Careful use
With caution, Fraxiparine is prescribed only in cases associated with a high risk of bleeding, including:
- kidney failure;
- severe arterial hypertension;
- in the postoperative period;
- liver failure;
- in people weighing less than 40 kg;
- peptic ulcers;
- circulatory disorders in the retina or choroid;
- in combination with drugs that increase the risk of bleeding.
Drug "Nadroparin Calcium": instructions for use
According to the instructions, the agent in question shouldinjected subcutaneously into the abdomen (alternately to the left and right side). In this case, the patient must be in a supine position. It is also allowed to inject into the thigh.
The dosage of this remedy is selected only by a doctor, depending on the indications. For example, in order to prevent thromboembolism in surgical practice, a dose of Fraxiparine equal to 0.3 ml is used. In this case, the drug is administered 4 hours before the planned operation, and subsequently - once a day.
The duration of treatment with this remedy also depends on the existing disease (usually 6 days).
Side Effects
The use of the drug in question can cause a number of negative effects, in particular:
- bleeding of various localization;
- increase in liver enzymes;
- thrombocytopenia and eosinophilia;
- hypersensitivity reactions;
- local reactions such as the appearance of subcutaneous hematoma at the injection site, the formation of hard bumps that disappear after a few days, necrosis of the skin in the injection area;
- hyperkalemia and priapism.
Reviews
Clogged veins can happen to anyone. Therefore, people with impaired blood circulation are often prescribed the drug Fraxiparin or the so-called Nadroparin Calcium. Patients claim that this remedy copes well with its direct task. However, it should be noted that this medication often causes the development of negative reactions. In this caseexperts recommend replacing it with a safer drug.
