"Don't complain about the pain - that's the best medicine." These words belong to Omar Khayyam. It is likely that this is the case when it comes to mental suffering. If we are talking about diseases of the body, there is no need to complain, you need to help your body. One of the fairly effective painkillers at the present time are Ketorolac injections. The instructions for use contain the most complete information about this medication.
Composition and pharmacodynamics
Belonging to the drug - non-steroidal anti-inflammatory drugs. It is a derivative of pyrrolysine-carboxylic acid. The main active ingredient is ketorolac tromethamine (1 ml of solution contains 30 mg), auxiliary substances are disodium s alt and sodium chloride, ethylenediaminetetraacetic acid, rectified ethyl alcohol, tromethamine.
Ketorolac painkillers have a pronounced analgesic effect. Characteristic of this drug is also an anti-inflammatory effect and moderateantipyretic effect.
The mechanism of action is based on the suppression of COX activity. This is the main enzyme of arachidonic acid, which, in turn, is the precursor of prostaglandins, which play the "main violin" in the pathogenesis of inflammatory processes, pain and feverish conditions.
"Ketorolac" (shots) reviews of medical professionals in terms of the strength of the analgesic effect are considered comparable to morphine and significantly superior to other NSAIDs.
Indications for use
The main field of application of this drug is pain syndromes with moderate or severe severity. A medication is used for symptomatic therapy in order to reduce pain and inflammation at the time of administration. It has no effect on the progression of the disease.
Prescribe this remedy in cases of postpartum and postoperative pain. These injections also effectively treat joint pains provoked by injuries and torn ligaments, toothaches.
Also, Ketorolac injections are recommended for the treatment of dislocations, sprains, muscle pain and back pain. This medication is prescribed for oncological diseases, myalgia, arthralgia, neuralgia.
Contraindications for use
Should not use the drug for the treatment of those patients who have recorded hypersensitivity to any of the components. The basis for refusal is also the presence of the "aspirin triad" andhypovolemia (the cause that provoked the disease is not important). Also, "Ketorolac" (injections and tablets) is not prescribed for those who have any erosive and ulcerative lesions of the gastrointestinal tract in the acute stage.
These injections should not be used for treatment by those with hemophilia, hypocoagulability and bleeding or high risk of bleeding.
Also, a contraindication is the presence of severe forms of renal and hepatic insufficiency.
Ketorolac is not prescribed for use immediately after coronary artery bypass surgery, during the course of the 3rd trimester of pregnancy, during childbirth and lactation. Injections are contraindicated for children under 16.
Use and dosage
The dose for injection is selected individually, based on the severity of the pain syndrome. Injections "Ketorolac" instructions for use allows you to enter in / m and / in. With the intramuscular method, a single volume is from 10 to 30 mg. The interval between procedures should not be less than 4-6 hours. The maximum course of therapy is 5 days.
The IM daily dose is 90 mg. However, for patients weighing up to 50 kg, for those suffering from impaired renal function and for patients over 65 years of age, the dosage should not exceed a volume of 60 mg.
To enhance the analgesic effect, Ketorolac injections and tablets are often prescribed in combination.
Pregnancy, childbirth and lactation: is it permissible to use Ketorolac?
Injections "Ketorolac" instructions for use prohibits the use for the treatment of pregnant womenwomen. The use of this medication is possible only for he alth reasons, when the expected positive effect for the mother outweighs the potential risk for the baby.
If for any reason there is a need to be treated with "Ketorolac" during lactation, it is necessary to discuss with the doctor the issue of not breastfeeding.
Medical specialists also do not recommend the use of "Ketorolac" for pre-meditation, supporting anesthesia and labor pain relief, since this medication can prolong the course of the first stage of labor. In addition, "Ketorolac" can depressingly affect the contractility of the uterus and the blood circulation of the child.
Possible side effects
Side effects on Ketorolac injections, the use of which was described above, are also quite diverse and can follow from a variety of body systems. The gastrointestinal tract most often can respond with the development of diarrhea and the appearance of symptoms of gastralgia. Less often you can hear about constipation, vomiting, flatulence, the development of ulcerative foci.
The urinary system reacts to Ketorolac quite rarely, but here you can also hear about hematuria, back pain, nephritis and edema of renal origin.
Also quite rarely, in response to injections, the respiratory organs (bronchospasm, rhinitis, swelling of the lungs and larynx) and sensory organs (impaired vision, impaired hearing, ringing in the ears) declare themselves.
Often, patients talk about the reaction of the central nervous system to Ketorolac, manifested by drowsiness,dizziness, headaches. Less often you can hear about the symptoms of aseptic meningitis and hyperactivity, about the appearance of psychoses and hallucinations.
From time to time there is information about undesirable manifestations from the cardiovascular system (increased blood pressure), hematopoietic system (leukopenia, anemia), hemostasis system (bleeding - nasal, rectal, postoperative).
Often, patients report swelling of the face, shins, ankles, fingers, weight gain, increased sweating.
Overdosing
Symptoms of an overdose for the drug "Ketorolac" (a single injection into a vein or intramuscularly) is most often expressed in pain in the abdomen, in nausea and vomiting. Also, patients and he alth workers talk about possible erosive and ulcerative lesions of the digestive tract, impaired kidney function, metabolic acidosis (develops due to the accumulation of acidic products in the tissues, their insufficient binding or destruction).
Therapy in such cases is symptomatic and is aimed at maintaining important body functions. Hemodialysis will not give a significant effect.
What to look out for?
Before starting treatment with Ketorolac, it is important to find out if there have been previously recorded cases of allergic manifestations to the drug or other NSAIDs. It is advisable to carry out the first injection in the presence of a doctor (to avoid the manifestation of allergies).
If the need arises, you can use "Ketorolac"(injections) in combination with narcotic analgesics. Patients suffering from abnormalities in blood clotting, "Ketorolac" is prescribed for use only with the condition of constant monitoring of platelet count. This is a particularly pressing issue for people who have undergone surgery and require careful control of hemostasis.
In people with chronic diseases and pain, an increase in the period of therapy may cause the development of drug complications.
During the treatment with Ketorolac, it is important to be careful when driving and avoid potentially hazardous work activities associated with increased attention and increased speed of psychomotor reactions.
Interaction with other drugs
Parallel intake of "Ketorolac" with paracetamol enhances the nephrotoxicity of the first. Often patients are interested in the question of whether it is possible to combine Dicloberl and Ketorolac injections. The answer is no: the combination of "Ketorolac" with any other NSAIDs increases the likelihood of ulceration of the gastrointestinal mucosa and may cause gastrointestinal bleeding.
Concurrent use with anticoagulants, antiplatelet drugs, valproic and acetylsalicylic acids, cephalosporins increases the likelihood of bleeding.
Ketorolac reduces the effectiveness of blood pressure lowering drugs and diuretics. "Methotrexate"increases hepato- and nephrotoxicity of Ketorolac. The same effect will be when taken in parallel with any other nephrotoxic drugs. Medications that block tubular secretion lower the clearance of Ketorolac and thereby increase its plasma concentration.
In addition, Ketorolac injections increase the effectiveness of narcotic analgesics.
Medicines - analogues and price range
Ketorolac (injections) has a fairly large number of medicines similar in effect on the human body. Instructions for use describe analogues for each form of release, i.e. for both injections and tablets. Of the most famous and popular solutions for injections by consumers, one can indicate such medicines as "Ketanov", "Ketalgin", "Ketorol", "Ketofril", "Ketorolac-Eksmo", "Ketorolac-Tromethamine", "Dolak", "Dolomin", Toradol.
As for the price, the cost of a package of 10 ampoules with a dosage of 30 mg/ml ranges from 63 to 144 rubles.
Consumer Reviews
Most consumers are very satisfied with the effect. Positive results are observed in most variants of pain sensations, in which Ketorolac treatment is recommended by the instructions for use. Injections reviews of female patients are characterized as very effective for menstrual pain. In general, injections were used for toothaches, and to anesthetize the process of movement of stones in the kidneys, and in the postoperative period, andin many other cases.
The positive effect of the drug significantly alleviated the condition of patients, however, there were side effects. So, a separate group of people talks about the appearance of skin reactions and abdominal pain. However, this does not detract from its high effectiveness as an analgesic and anti-inflammatory agent.
In addition to all of the above, patients are satisfied with the price of Ketorolac injections, which is significantly lower than the cost of almost all of its analogues.
Expert Opinion
Doctors' opinions about Ketorolac also have both positive and negative sides. The bulk of experts believe that if you follow all the recommendations that the instruction contains for the Ketorolac medication (injections), then this NSAID will perform all its functions with the proper positive effect and will not cause the development of side effects.
The drug does not penetrate into the cerebrospinal fluid, as it is a drug of limited effect - only in the area of inflammation. There is also no addictive effect.
As for the negative feedback from specialists, we can say that a separate group of doctors believes that Ketorolac has a weak anti-inflammatory effect. Doctors also talk about the negative impact on the pancreas (provoking the development of diabetes) and on the functioning of the kidneys.
In general, we can say that following the instructions and following the recommendations of the attending doctor will allow you to get the most positive effect from the use of injectionsKetorolac without the risk of developing serious side effects.
