The instruction refers to the drug "Minirin" as a drug with a vasopressin-like effect. The active substance is desmopressin, a structural analogue of arginine-vasopressin, a human pituitary hormone.
Medication "Minirin" (instruction contains such information) increases the permeability in the epithelium of the distal parts of the convoluted tubules, enhances water reabsorption. This provokes a decrease in the volume of urine excreted, an increase in its osmolarity while reducing plasma osmolarity. As a result, the frequency of urination decreases. During the first 30-120 minutes after administration, an increase in concentration to a maximum is noted. The content of the drug in the body is directly proportional to the dosage. The ability of the drug to pass the BBB is not noted. Excretion occurs through the kidneys.
Means "Minirin". Instruction. Destination
The drug is recommended for primary enuresis (nocturnal) in children from six years of age, diabetes insipidus. With symptomatic therapy, the drug is used for nocturnal polyuria.
Contraindications
The medicine "Minirin" is not prescribed (the instruction confirms this) whenpsychogenic or habitual polydipsia (with a volume of urine formation of 40 ml / kg / day), hypersensitivity, insufficiency of the heart and other conditions that may require the use of diuretic medications. Contraindications include age up to 6 years, syndrome of inadequate production of antidiuretic hormone. Caution in the treatment should be shown to patients with renal insufficiency, disorders of water and electrolyte metabolism, fibrosis in the bladder. Dose adjustment is required if there is a potential for increased intracranial pressure in the elderly. Despite the absence of a negative effect on the condition of the mother and fetus, during the bearing of a child, the medication "Minirin" allows the instruction to be prescribed for he alth reasons. Treatment during these periods may require dose adjustments and should therefore be monitored by a physician.
Means "Minirin". Instruction. Adverse reactions
As a rule, undesirable effects of treatment are observed in cases of uncontrolled fluid intake by the patient. In these cases, water retention in the body, hyponatremia is likely. These phenomena may be asymptomatic or manifest as dry mouth, nausea, weight gain, dizziness, peripheral edema, and headache. In some cases, convulsions are noted.
Medication "Minirin". Instructions for use
The medicine is administered sublingually (for resorption). The required dosage is selected individually. The drug is taken after a meal. Atin diabetes insipidus, the recommended initial dosage is 60 mcg three times a day. In accordance with the onset of the effect, the amount of the drug can be adjusted. The optimal therapeutic dose per day is 120-720 mcg, prophylactic - 60-120 mcg / 3 rubles / day. With primary enuresis, 120 mcg is prescribed. The drug is given at night. In the absence of a result of therapy, the dose can be doubled (up to 240 mcg). During therapy, fluid intake should be limited.
Means "Minirin". Instruction. Price
The cost of the medication is from 1300 rubles.
