Diseases of the gastrointestinal tract are a human problem in the modern world. People are forced to turn to doctors with pains that torment them in the abdomen, and they, in turn, prescribe various procedures and medicines for them. "Creon 10000" is prescribed to patients more often than many other medicines. Sometimes it may seem that this drug is the solution to all problems associated with the digestive system. In this article, we will answer the most frequently asked questions about Creon 10000.
Composition and form of production
In the instructions for use for "Creon 10000" it is written that it is available in gelatinous, hard capsules that dissolve in the intestines. They are divided into two halves: one is brown opaque, the other is colorless, transparent. The capsules contain small, light brown granules. Twenty, fifty or one hundred capsules are packed in polyethylene bottles.
In the instructions for use "Creon 10000" in tablets is not described.
Active ingredient
In the instructions for use for "Creon 10000" it is written that the active substance of the drug is pancreatin. One capsule contains one hundred and fifty mg of the active ingredient, corresponding to the content of the following number of units:
- lipase – 10000;
- amylase – 8000;
- protease – 600.
Pharmacodynamics
In the instructions for the use of capsules "Creon 10000" it is written that the drug contains pacreatin enzymes. It is a substance that improves digestion processes, namely:
- relieves symptoms of digestive enzyme deficiency,
- normalizes the digestion of nutrients, due to which they are completely absorbed in the small intestine.
Creon 10000 contains pancreatin of porcine origin. Getting into the stomach with food, the shell of the capsules disintegrates, releasing hundreds of microgranules. This form is designed so that the granules are mixed with the contents of the intestine and pass through the digestive tract with food. As soon as the microgranules enter the intestine, the capsule shell is rapidly destroyed, enzymes are released. Substances produced as a result of breakdown are absorbed or broken down further in the intestine.
Pharmacokinetics
In the instructions for use of the drug "Creon 10000" it is written that its therapeutic activityimplemented in the lumen of the gastrointestinal tract. The structure of pancreatitis enzymes are proteins. As they pass through the digestive tract, they are broken down into amino acids and peptides.
Using the drug
In the instructions for use of "Creon 10000", it is written that it can be used for alternative therapy of digestive enzyme deficiency due to a reduction in its active activity due to dysfunctions in the production and transport of pancreatitis enzymes or due to their too much destruction in the lumen intestines, provoked by various diseases of the digestive system.
According to the instructions for use, "Creon 10000" is most often prescribed in the following situations:
- recovering from an attack of pancreatitis;
- chronic pancreatitis;
- damage to the glands of external secretion;
- underdevelopment of the pancreas;
- partial removal of the stomach;
- rupture of the ducts of the gland under the stomach or bile duct;
- malignant growths on the gland under the stomach;
- postoperative recovery on the pancreas;
- recovery after gastric extirpation;
- preparation for a hardware examination of the abdominal cavity.
Sometimes a medication is recommended for dietary or sedentary problems, even for patients with a well-functioning digestive system.
Opt-out
The use of "Creon 10000" according to the instructions is contraindicated in case of personal sensitivity to itcomponents. It is not recommended to take medication during an acute attack of pancreatitis.
Method and dosage of intake
Capsules "Creon 10000" are taken orally during or after a meal. They must be consumed whole, washed down with the necessary amount of water. If a person has trouble swallowing, the capsule can be opened and added to food that does not require chewing (mashed potatoes, yogurt, juices and drinks). Food with the addition of "Creon 10000" is not subject to long-term storage, so it must be consumed immediately. It is not recommended to mix the contents of "Creon 10000" with hot food.
According to the instructions for use, the dosage of "Creon 10000" is selected individually for each patient, taking into account the symptoms, severity of the course of the disease, diet, diet and body weight of the patient. In case of genetic diseases, at the beginning of therapy, adults and children from four years old are prescribed 500 units / kg, children under four years old - 1000 units / kg with each meal. Based on the symptoms of the disease, the dosage can be reduced or increased according to the recommendations of the doctor.
For many patients, the dosage per day of the drug "Creon" according to the instructions for use is 10,000 units / kg of body weight or 4,000 units / g of fat consumed. In other diseases accompanied by insufficiency of digestive enzymes, the dosage is determined based on the personal characteristics of the person, containing the degree of insufficiency in digestion of food and the content of fatty foods in the diet. Withthe main meal usually requires a dose of 25,000–80,000 units of lipase, with snacks half the therapeutic dose.
According to the instructions for use, the dosage of "Creon 10000" for children is used in accordance with the doctor's recommendations.
Side effects
Possible side effects, according to the instructions for use of "Creon 10000", in adults from the digestive system:
- pain in the abdomen;
- bloating;
- fibrosis of the submucosal layer of the colon with the formation of its strictures.
Sometimes there are negative effects on the skin in the form of rashes, hives and itching.
Possible side effects in the form of anaphylactic reactions and from the exchange of useful elements with prolonged use of the drug in too high doses in the form of an increase in the level of uric acid in the patient's blood plasma.
According to the instructions for use of "Creon 10000", in children, when using the drug in high doses, it may occur:
- inflammation of the skin around the anus,
- disorder of the digestive system,
- diarrhea and abdominal pain,
- allergic skin reactions.
According to the instructions for use, for children "Creon 10000" is prescribed only by the attending physician.
Too much drug
Overdose may show up as an increase in uric acid in the blood. Then the drug is canceled and the therapy is replaced insymptoms.
Special Instructions
If the patient, when taking Creon 10000, chewed and did not swallow the capsule, pancreatin enzymes will be released in the oral cavity. This can, firstly, cause irritation of the oral mucosa, and, secondly, reduce the effectiveness of the active substance. A similar situation can also occur when mixing the drug with food or drinks with an acidity level above 5.5. It is recommended to avoid negative side effects when using the contents of Creon 10000 capsules without a shell, rinse the mouth thoroughly after taking the medication.
During treatment with "Creon 10000" it is important to provide the patient with a sufficient amount of fluid to drink on an ongoing basis, especially in case of excessive loss (vomiting, diarrhea). Patients may develop constipation due to low fluid intake.
"Creon 10000" doctors do not recommend taking during an exacerbation of pancreatitis. Patients with a genetic disease of the pancreas who take high doses of pancreatin are at risk of forming strictures in the colon. It is worth remembering that the dose should be comparable to the amount of enzymes required for fat absorption and should not be more than 10,000 units / kg per day.
When negative symptoms appear, it is recommended to conduct an examination, especially in patients using "Creon 10000" in doses exceeding 10,000 units / kg per day. Digestive disorders may occur in patients withpersonal hypersensitivity to the active substance "Creon 10000".
Impact on the ability to adequately drive a vehicle, according to the instructions, "Creon 10000" does not. There is no tangible negative impact on the ability to work with complex apparatus and to perform functions that require concentration and speed of reactions.
Use during childbearing and breastfeeding
In clinical studies on animals, no negative effects on reproductive functions and the development of the unborn child were found. To date, there is no data on therapy with drugs containing digestive enzymes of animal origin, women in a state of pregnancy, so they are prescribed medication with caution. According to the instructions for use, Creon 10000 is prescribed during pregnancy if the benefits of treatment outweigh the potential negative risks. In this condition, women should be careful when taking medicines.
Similarly, no harmful effects are expected, according to the instructions for use of "Creon 10000", for infants through mother's milk. The drug can be used during breastfeeding.
Use in children
Irregular or loose stools, increased gas production, food allergies are all signs of a digestive disorder. Typically, this problem occurs in toddlers and young children. The causes of disorders are as follows:
- unfavorable ecological situation;
- regularnervous breakdowns in children due to difficult relationships in the environment of the child;
- weak muscle structure;
- enzyme deficiency.
Children begin to eat poorly, not gaining enough weight, complaining to their mothers about abdominal cramps and a feeling of heaviness after eating. According to reviews and instructions for use for children, "Creon 10000" in this case is an indispensable drug. It normalizes the digestive processes in the body, because the structure of the drug contains those enzymes that are most actively involved in such activities. The rational enzyme composition of the drug helps to digest the incoming food, ensuring the normal absorption of these beneficial substances. Creon 10000 tablets stimulate the production of enzymes by the pancreas.
According to the reviews and instructions for the use of "Creon 10000" by children, the drug can be taken by young patients, subject to the dosing regimen. In children, the likelihood of constipation increases with a high activity of the lipase contained in the enzyme, so increasing the dosage should be carried out in stages.
Interaction with other drugs
An analysis of the interaction of pancreatin with other medicines has not been conducted in a clinical setting. Here are the main points to pay attention to:
- Pancreatin may reduce the absorption of concomitant iron preparations.
- The drug may reduce the effectiveness of acarbose.
- Drugs intended for the treatment of gastrointestinal diseases by neutralizing hydrochloricacids, may reduce the effectiveness of pancreatin.
Storage conditions
Tablets "Creon 10000" according to the instructions for use must be kept in a sealed vial, out of the reach of small children, at temperatures up to 25 ° C. Shelf life - two years, after the initial opening of the bottle - three months. The drug is dispensed from pharmacies without a prescription.
Reviews
Many doctors prescribe "Creon 10000" for the treatment of digestive enzyme deficiency in the body in children, because they believe that only symptomatic treatment is not enough. According to the results of the analysis of feces, after taking a course of medication, as a rule:
- significantly reduces the amount of undigested food leftovers in the stool,
- stool quality improves,
- becomes clear skin.
Reviews about Creon 10000 from patients are usually very positive:
- there is an improvement in the general condition of the patient after a few days of therapy;
- emphasizes the normalization of digestion and stool, the disappearance of pain and discomfort in the abdomen and sides, nausea after eating.
Many patients take this medication on their own and advise other people to take this medicine as an emergency remedy for malnutrition. Despite the fact that there are many other drugs, including an order of magnitude cheaper, patients do not recommend rushing to replace Creon 10000 with other medicines, as they believe that the analogues are not effective enough compared to those describeddrug.
It is worth mentioning that there are negative reviews about "Creon 10000" from people in whom it caused negative effects.
Analogues of the drug
Drugs similar in action, analogues of "Creon 10000" are:
- "Gastenorm forte" and "Gastenorm forte 10000". The drugs are available in tablets. They are indicated for diseases of the pancreas that affect its main function: pancreatitis, cystic fibrosis.
- "Creon 25000".
- "Mezim" and "Mikrazim". Medicines are produced in capsules.
- "Pangrol 25000". German medicine produced in capsules. He performs replacement therapy for exocrine pancreatic insufficiency in adults and children.
- "Pancreasim". The drug is produced in tablets. Not applicable for cystic fibrosis.
- "Pancreatin". Means that promote the digestion of the contents of the stomach, including enzymes. The drug is available in both tablets and dragees.
- "Pancreatin forte". Tablets for the restoration of disorders of the exocrine function of the pancreas, accompanied by indigestion.
- "Penzital". Indian enzyme drug designed to normalize digestion. It comes in tablets.
- "Enzistal-P". An enzyme medicine that improves digestive processes. The drug contains digestive enzymes that break down useful elements, contributing to their fullabsorption in the small intestine.
- "Ermital". Digestive enzyme agent in capsules with various dosages of active ingredients of the pancreas. The active ingredient of the drug is pancreatin.
Problems with the stomach - the modern problem of mankind. Improper nutrition, an uncorrected meal schedule - all this leads to indigestion, discomfort in the pancreas or the stomach itself after eating. Quickly get rid of the problem will help "Creon 10000". Varieties of the drug "Creon 10000" and "Creon 25000" are dispensed at the pharmacy without a prescription from the attending physician.
