The article will talk about PDE-5 inhibitor drugs. It is known that due to erectile dysfunction, the work of other organs and systems is not disturbed, it does not harm the he alth and life of a man, but such a sexual disorder is very difficult to perceive from a psycho-emotional point of view. A man has to worry about the quality of erection and potency for almost his entire adult life, even if there are no visible reasons for concern.
Currently, there are a large number of natural remedies that help prevent erectile disorders, and strong erection stimulants with complete dysfunction. The most effective are PDE-5 inhibitors, or phosphodiesterase type 5, which provide a man with a 100% erection, regardless of the etiology of the disorder and its severity.
What are the causes of erectile dysfunction?
If earlier various psychological problems were considered the main causes of erectile dysfunction, now the opinion has changed. It is now known that the violation in 80% of cases is of organic origin and appears as a complication of various somatic diseases.
Main organic causes: hypogonadism (dyshormonal conditions); angiopathy; neuropathy.
The prevalence of pathology of the heart and blood vessels is very high, more than 50% of the stronger sex with such diseases have erectile dysfunction, but not every patient uses PDE-5 inhibitors - a kind of "gold standard" in the treatment of defects in sexual function. Why is it so? Unfortunately, until now, patients are extremely wary of such drugs, despite the fact that their effectiveness has already been proven.
General Therapeutic Principles
Before selecting tablet type 5 phosphodiesterase inhibitors for the treatment of disorders of the reproductive system, each man must determine the mental and somatic prerequisites for such disorders. The following factors can affect an erection:
- presence in the body of concomitant systemic pathologies;
- use of strong drugs;
- lifestyle (bad habits, passive pastime, overeating);
- frequent depression and stress.
Expert Help
If, after the elimination of such prerequisites of dysfunctionthe violation does not go away, you can first use the help of a sexologist or psychotherapist. A conservative treatment method can be a correction of nutrition, playing sports, giving up addictions, losing weight, and eliminating stressful situations that lead to depression. Among other things, an erection can be restored by treating the underlying disease, such as hormonal disorders, diabetes, etc.
What is the treatment?
Medicated treatment involves:
- sublingual and oral use of tablets;
- injections into the urethra or cavernous bodies of vasoactive drugs.
Alpha-1-blocker medications or PDE5-type inhibitors shortly before intercourse may also help achieve a stable erection.
Special Instructions
It should be noted that taking such medications is possible only after consulting a doctor. He will determine the dosage acceptable in each case, since if used irrationally, the drug may be ineffective or cause side effects.
Appropriateness of use
The use of PDE-5 inhibitors is reasonable, as evidenced by the following facts:
- these drugs are first-line adapted treatment;
- the use of such funds continues for more than 30 years;
- repeated clinical trials have proven their effectiveness;
- drugs are easy to use;
- in practice by the millionsmen have been shown to be safe.
Instructions for the use of drugs
Phosphodiesterase type 5 inhibitors are currently the most sought after in the treatment of erectile dysfunction, which have valuable pharmacokinetic properties, are clinically effective and have a relative lack of harm.
Pharmaceutical companies produce a large number of drugs that stimulate erection. PDE-5 inhibitors include the following drugs.
"Sildenafil". It is also a selective PDE5 inhibitor, which was first produced in 1996. Film-coated, almost white or white, round, biconvex tablets with an almost white or white core in cross section.
The active ingredient is sildenafil nitrate, in one tablet - 28.09 mg, which corresponds to 20 mg of sildenafil. Inactive ingredients: microcrystalline cellulose, anhydrous calcium hydrogen phosphate, croscarmellose sodium, magnesium stearate.
Film coating contains talc, hypromellose, titanium dioxide, polyethylene glycol 4000 (macrogol 4000).
The tablet should be taken one hour before sexual intercourse, the approximate daily dosage ranges from 50 to 100 mg. The effect of the drug lasts for four hours.
Phosphodiesterase type 5 inhibitor "Vardenafil". This is an improved and new highly selective inhibitor, which has confirmed its highefficacy to biological equivalents in multiple clinical studies (as monohydrochloride trihydrate).
This drug is taken once a day thirty minutes before intimacy, its action lasts 4-5 hours. The daily dosage is approximately 10-20 mg of vardenafil.
Tadalafil is a selective inhibitor that has been marketed recently but is highly effective in restoring erectile dysfunction. "Tadalafil" is currently produced in the form of tablets, in which the active ingredient is contained in 2, 5; 5; 20 and 40 mg. As an active active element, the drug "Tadalafil" includes a chemical substance of the same name. In the form of excipients, the preparation contains the following components: giproloza; lactose; croscarmellose sodium; microcrystalline cellulose; magnesium stearate; sodium lauryl sulfate; titanium dioxide; triacetin.
The principle of action and structure are somewhat different from Sildenafil, its selectivity is less than that of the first remedy. The effectiveness of the composition of the tablets lasts 36 hours. The drug should be taken in an amount of 10-20 mg shortly before intimacy. In addition, such a remedy is allowed to be combined with alcohol and food, which is an indisputable advantage for patients.
Udenafil. A modern reversible selective inhibitor that makes it easy for a man to achieve an erection. Tablets should be taken 30-90 minutes before possiblesexual contact, and its effect will persist for 12 hours. It is very important to comply with all the conditions that are specified in the instructions, since drugs of this type have contraindications and side effects.
"Avanafil". The next representative of the group of PDE-5 inhibitors, which also promotes vasodilation and allows blood to flow to the intimate organs more easily, providing an erection by 100%. The tablets contain avanafil as an active ingredient. The composition of the drug also includes mannitol, hydroxypropyl cellulose, fumaric acid, calcium carbonate, iron oxide and magnesium stearate.
The medicine should not be taken if there is an allergic reaction to at least one of the components listed above. The therapeutic efficacy of the drug is 80%, the tablet must be taken 15-20 minutes before the upcoming sexual contact. The effectiveness of the drug lasts for six hours, it can be combined with alcohol and food. In this case, the average dosage is approximately 100 mg per day.
What can be achieved?
It is worth noting that most of these types of drugs to stimulate erectile function allow for vasodilation, muscle relaxation, and thanks to this, it will be much easier to achieve an erection.
In addition, such products are not recommended to be combined with the intake of alcoholic beverages or fatty foods, as this may to some extent reduce the absorption and effectiveness of the composition of the tablets.
Before taking the erectile-restoring pills listed above, every man should consult the optimal dosage of a particular inhibitor, as overdose can cause significant side effects.
Contraindications for taking PDE-5 inhibitors
It is known that drugs with synthetic components in any case have a well-defined list of contraindications, can cause a number of side effects. The same can be said for PDE-5 inhibitors contraindicated in the following situations:
- person under legal age;
- hypersensitivity to ingredients;
- parallel use of tablets containing organic nitrates;
- disorders and pathologies of the functionality of the heart and blood vessels, in which increased sexual activity is unacceptable;
- taking Doxazosin and other erection drugs;
- vision loss due to anterior non-arterial ischemic optic neuropathy;
- chronic kidney failure and use of similar stimulants more than twice a week;
- alabsorption, lactase deficiency or lactose intolerance;
- glucose-galactose malabsorption.
Side effects
The most typical adverse effects of the inappropriate use of type 5 phosphodiesterase inhibitors are vomiting, nausea, headaches, visual disturbances (light perception and lack of concentration),dizziness, rhinitis and swelling of the nose, shortness of breath, redness of the face. Seek medical attention if these symptoms occur.
Interaction between Trazodone and phosphodiesterase type 5 inhibitors
Trazodone is a selective serotonin reuptake inhibitor, it also blocks 5-HT2A receptors and moderately inhibits serotonin reuptake.
"Trazodone" can be used as a separate treatment course, and in combination with other drugs to get rid of erectile dysfunction, including androgens and type 5 phosphodiesterase inhibitors, that is, they are combined with each other, their interaction is effective.
