An effective antihypertensive drug, a selective imidazoline receptor agonist, is Physiotens. Patient reviews say that the tool helps to reduce the pressure of diabetics and people with overweight.
Features of hypertension
Diseases of the heart and blood vessels are susceptible to many people. However, in women, these deviations develop later than in men. But they are much more complicated and are characterized by increased blood pressure, more pronounced painful symptoms. Hypertension often develops along with other pathologies: obesity, diabetes mellitus, liver and kidney abnormalities, lipid metabolism failure.
Along with an increase in body weight, there is a disruption of the SNS, which is the main cause of high blood pressure and the formation of hypertension. Hormones secreted by the symptomatic nervous system contribute to the narrowing of the lumen of blood vessels, inAs a result, to deliver oxygen to tissues and organs, the heart has to push blood with effort, under high pressure, thus developing hypertension, which has to be treated with medication. One of the drugs that help curb high blood pressure is Physiotens.
Composition and release form
The drug is produced in the form of film-coated tablets. The main active ingredient is moxonindine. The auxiliary components include magnesium stearate, crospovidone, povidone, lactose monohydrate.
Pharmacological properties
The active substance of the drug has a central hypotensive effect. Moxonidine in brain stem cells selectively stimulates sensitive receptors that are involved in the reflex and tonic regulation of the nervous symptomatic system. The result is a decrease in peripheral symptomatic activity and blood pressure. Numerous studies (placebo-controlled, randomized, double-blind) prove the effectiveness of Physiotens. Patients' reviews confirm that the drug differs from other antihypertensive sympatholytic drugs in that it does not cause dry mouth, and there is no sedative effect when using it.
Pharmacodynamics and pharmacokinetics
After internal administration, the drug is 90 percent absorbed from the gastrointestinal system. The maximum concentration of the active substance in blood plasmaseen after an hour. Meal does not affect the pharmacokinetics of moxonidine.
The main metabolite of the active substance is dehydrated moxonidine, as well as guanidine derivatives. The half-life of moxonidine occurs within 2.5 hours, and after a day, the element is 90% excreted by the kidneys and through the intestines.
In patients with arterial hypertension, compared with he althy people, no changes in the pharmacokinetics of moxonidine were noted. Slightly kinetic parameters may change in elderly patients, which is associated with a decrease in the intensity of moxodinine metabolism, as well as its higher bioavailability.
Due to the lack of pharmacokinetic studies, the use of the drug in patients under the age of majority is not recommended.
The drug "Physiotens" instructions for use
Reviews of patients say that the pills must be taken orally, regardless of eating. Usually the drug is used in the initial daily dosage of 200 mcg. The maximum single volume of the drug should not exceed 400 mcg, the daily amount divided into two doses should not exceed 600 mcg. Patients with moderate to severe heart failure who are on hemodialysis are recommended to take up to 200 mcg of the drug per day. With good tolerance, the volume of the drug can be doubled.
Overdose
With excessive use of the drug, various negative symptoms may occur. So, tablets for pressure "Physiotens" (reviews indicateto this) can provoke headache, drowsiness, sedation. If the dosage is exceeded, pressure can drop significantly, pain develops in the epigastric region, dry mouth, bradycardia, vomiting, asthenia, increased fatigue, dizziness are observed. In addition, patients may be disturbed by hyperglycemia, tachycardia, as well as a short-term increase in pressure.
No specific antidotes have been developed to treat signs of overdose. With arterial hypotension, it is necessary to introduce dopamine and increase the fluid content in the body. Symptoms of bradycardia can be treated with atropine. In case of an overdose, it is recommended to reduce or eliminate arterial paradoxical hypertension by using alpha-adrenergic receptor antagonists.
Drug Interactions
The combination of drugs is not always given due importance. However, when taking two or more drugs, there may be a weakening or strengthening of the mutual action. In the first case, the medicine will not give the expected result, in the second situation there is a risk of overdose and even poisoning.
So, when combined with the use of antihypertensive drugs (thiazide diuretics, calcium slow channel blockers) with the drug "Physiotens" (reviews warn about this), an additive hypotensive effect may develop. Simultaneous use of tricyclic antidepressants reduces the effectiveness of central antihypertensive drugs, so they should not be used together with the drugPhysiotens.
In addition, the tool can improve cognitive impairment in patients taking the drug "Lorazepam". The use together with benzodiazepines may cause an increase in the sedative effect. When administered with Digoxin, Glibenclamide, Hydrochlorothiazide, there is no pharmacokinetic interaction.
Use during pregnancy
Various drugs have a negative effect on the fetus or embryo, leading in some cases to malformations of the child. Also, the components of drugs taken with mother's milk can enter the infant's body and act on it. Therefore, during pregnancy and lactation, it is necessary to take medicines with extreme caution.
Physiotens is no exception. Its reception is permissible only after consultation with a specialist, carefully weighing the possible benefits for the mother and harm to the child. Since the active ingredient passes into breast milk, it is necessary to stop using it or stop feeding the baby while breastfeeding.
Experimental studies conducted on animals have not revealed a direct or indirect effect of the drug on pregnancy, embryonic (embryonic) or postnatal development.
Side effect
Like most medicines, Physiotens tablets (reviews indicate this) cause negative reactions from the body. This usually happens when usingin maximum quantities, for a long period or with individual intolerance to the active ingredient.
The nervous system reacts to the use of the drug with a headache, drowsiness or insomnia, dizziness. These symptoms are observed quite often. From the side of the cardiac and vascular system, negative reactions occur in rare cases, manifested by a sharp drop in pressure, orthostatic hypotension. In addition, patients after taking the medicine experience dry mouth, nausea, they may experience dermatological reactions in the form of angioedema, itching or skin rash. In the presence of side effects, the medication should not be canceled; negative symptoms usually disappear after three weeks of use. However, it is still necessary to contact a specialist.
Contraindications
Not in all cases you can take the medicine "Physiotens". Reviews of doctors say that it is not recommended to take medication when:
- expressed bradycardia (heart rate less than 50 beats per minute);
- SSSU;
- hereditary galactose (glucose) intolerance or malabsorption
- lactase deficiency;
- hypersensitivity to the components of the remedy;
- children and adolescents up to the age of majority.
Carefully prescribe the drug in the terminal stage or severe renal failure, patients who are on hemodialysis, with severe liver failure.
Physiotens tablets:indications for use, reviews, special instructions
The main diagnosis for which doctors prescribe medication is arterial hypertension. It should be borne in mind that during therapy it is necessary to systematically monitor the state of blood pressure, ECG and heart rate. If you need to cancel the medication, then this should be done gradually.
The product does not adversely affect the ability to drive machinery and vehicles. However, the drug "Physiotens" (patient reviews indicate this) must be taken with caution, as it can cause dizziness and drowsiness. This fact must be taken into account by people involved in dangerous activities that require constant concentration of attention.
Storage conditions, analogues and price
Pills should be kept out of reach of children. If the storage rules are observed (temperature up to 25 degrees C, dark dry place), the medicine will not lose its pharmacological properties for two years. You can buy the medicine "Physiotens" (reviews confirm this) by prescription in pharmacies. The price of a pack of tablets (0.2 mg) is 275 rubles. If for some reason there was no medicine in the pharmacy, then you need to look at the analogues: Cint, Moxonitex, Moxonidine, Moxogamma.
Reviews about the drug "Physiotens"
Many patients speak of this medicine as a quality effective remedy. People say that they have been taking it for many years, the drug lowers blood pressure well, whilethere is no side effect. Some attribute the high cost of Physiotens tablets to the disadvantages. Reviews indicate good compatibility with other hypertensive drugs.
