In the article, we will consider the instructions for use, price, reviews and analogues for the drug "Reserpine".
It is a complex sympatholytic drug that has antihypertensive, antipsychotic and sedative effects. The active substance of this drug is one of the alkaloids of such a rare plant as snake rauwolfia.
Pharmacokinetics
The drug "Reserpine" is an antispasmodic that mostly affects the nervous sympathetic system, the reduction of which allows you to activate the parasympathetic. It has a compensatory effect.
This remedy can cause a persistent decrease in blood pressure. This is indicated by the instructions for use. At what pressure it is permissible to prescribe "Reserpine" is of interest to many. It is effective in high.
The antipsychotic action is based on a decrease in the concentrations of certain neurotransmitters in the neurons, these include serotonin and dopamine. ATthe composition of the drug includes the active substance - reserpine, hydrochlorothiazide, dihydralazine sulfate.
"Reserpine" produces the following therapeutic effect on the human body:
- depresses heart contractions;
- reduces total peripheral vascular resistance;
- deepens and enhances physiological sleep;
- slows down metabolism in patients suffering from hypertension and coronary atherosclerosis;
- strengthens the influence of such a group of drugs as sleeping pills and painkillers;
- stabilizes the metabolism of fats and proteins;
- normalizes breathing, it becomes rarer and deeper;
- pupil constricts, temperature drops;
- activates the production of hydrochloric acid by the stomach;
- intestinal peristalsis increases;
- blood supply to the kidneys improves;
- renal glomerular filtration increases.
What else does the instruction manual for Reserpine tell us?
The drug also has a cumulative effect, since the primary effect is observed after a few days of its use, the maximum effect is achieved after 2-6 weeks if taken regularly.
The time for complete elimination of the drug from the body is approximately 4-6 weeks.
What are the indications for Reserpine according to the instructions for use?
Indications
"Reserpine" is used for the following pathologies:
- mental illness of vascular origin;
- hypertension, when there is a persistent increase in blood pressure;
- psychosis that occurs with high blood pressure;
- neuroses;
- hypertension;
- thyrotoxicosis;
- manic arousal in cycloid psychosis;
- psychomotor agitation in patients with schizophrenia.
Possible contraindications
According to the instructions for use, "Reserpine" may not be used by all patients who need it, so you should avoid using it when:
- peptic ulcers of the duodenum and stomach;
- depressions;
- bronchial asthma;
- serious diseases of the heart and blood vessels;
- bradycardia;
- nephrosclerosis;
- Parkinson's disease;
- cerebrovascular atherosclerosis;
- prescribing therapy with electrical impulses;
- hypersensitivity to the components of this drug;
- lack of breath;
- gallstone disease;
- pheochromocytoma;
- angle-closure glaucoma;
- chronic heart failure;
- breastfeeding and pregnancy.
Side symptoms
The price and reviews for "Reserpine" will be presented below.
Instructions for use indicate that the use of the drug may also cause unwanted symptoms:
- digestive system: patientsnote pain in the epigastric region, symptoms of dyspepsia, a feeling of dryness in the mouth, a strong decrease in appetite, bleeding from the intestines and stomach is rarely observed;
- nervous system: headaches, sleep disturbances, patient anxiety, excessive fatigue, decreased libido, hyporeflexia;
- vessels and heart: there is arrhythmia, bradycardia and pain in the space behind the sternum;
- urinary system: responds to the Reserpine drug with s alt and water metabolism disorders, manifested in dryness and peripheral edema of the mucous membranes, in addition, dysuria and anuria may appear;
- epidermal integument: urticaria, pruritus, exacerbation of herpetic infection;
- There have been cases of liver dysfunction and human weight gain.
Instructions for the use of "Reserpine"
The drug is taken orally after meals and washed down with water or any liquid in sufficient volume. In accordance with the instructions, the drug is prescribed for the treatment of the initial stage of hypertension at a dosage of 0.1 mg twice a day. The duration of its use is approximately seven days. In the absence of a therapeutic effect during this period, it is recommended to increase the dose of the drug to 0.5 mg, also divided into two doses.
If a stable condition of a person has been achieved and blood pressure has reached the required levels, then the dosage is gradually reduced to 0.1 mg. Medicinetaken thereafter for maintenance therapy.
The full treatment course lasts from two to four months.
Also, the drug can be prescribed for complex therapy for other indications (tachycardia, thyrotoxicosis, late preeclampsia) and used along with other drugs. In such cases, it is assigned strictly individually.
Overdose
According to the instructions for use for Reserpine tablets, during their use with excessive dosage, symptoms such as:
- sudden drop in blood pressure;
- diarrhea;
- bradycardia;
- nightmares;
- parkinsonism;
- coma;
- vomit;
- hypothermia;
- tremor;
- liver disorders.
Therapy for such symptoms is symptomatic, it consists in the introduction of an intravenous drug. In special situations, intravenous infusion of pressor amines is required.
Drug interactions
Instructions for use for "Reserpine" also reports that with the parallel use of the drug and other medications, specialist supervision is always required, because this substance can interact with many of the drugs, weakening or enhancing their therapeutic effect. Let us describe such interactions in more detail.
- Foxglove remedies increase the possible risk of bradycardia.
- Sharing with ethanol,barbiturates, tricyclic antidepressants, inhalation anesthesia drugs enhances their effect.
- "Reserpine" can reduce the effectiveness of antiepileptic drugs and anticholinergics, as well as reduce the analgesic effect of morphine.
- "Reserpine" contributes to a longer effect of direct adrenomimetic drugs.
- When prescribing eye drops, an increase in blood pressure is recorded.
- When using tricyclic antidepressants, the hypotensive effect of "Reserpine" decreases.
- The drug "Fenfluramine" enhances the hypotensive effect of the drug, and "Methyldopa" develops a state of depression.
Cost
The price of the drug ranges from 380-420 rubles. It depends on the pharmacy chain and the region.
Analogues
Reserpine has analogues such as Christoserpin, Eskaserp, Rausedil, Raupazil, Alserin, Raused Serfin, Tenserpin, Questsin, Rausedan, "Serpin", "Roxinoid", "Serpiloid", "Sedaraupin", "Tenserpin", "Serpat".
Reviews
The Reserpine drug has collected mixed reviews from people: some patients believe that it has a positive therapeutic effect, others note that many undesirable side symptoms appear.
Some patients with high blood pressure, taking "Reserpine" instead of their usual means, notice that his performance returns to normal, nervous conditions are observed less and less. Moreover, the drugwas taken at first in the minimum dosage, and then it was increased in accordance with the scheme developed by the doctor. Positive changes were observed after two months.
Others note that Reserpine helped to normalize blood pressure, but after two days long headaches began to appear, which disappeared only by the fifth week of treatment with this drug.
We reviewed the instructions for use for Reserpine, price, reviews and analogues.
