Medication "Indapamide" affects the vascular walls, relaxing them and normalizing the elasticity of the muscles. Thanks to this drug, arterioles increase, which leads to the unhindered movement of blood in the body. Tablets "Indapamide" - a medicine for pressure. It is a vasodilator, pharmacodynamically similar to a thiazide diuretic. During the day, the amount of urine produced increases slightly. Together with it, the predominant ions of sodium, chlorine, and potassium are removed from the body. While taking the drug, carbohydrate and fat metabolism remain normal, which makes it possible for patients suffering from obesity or diabetes to take the drug. With a pronounced increase in the left ventricle of the heart, the drug "Indapamide" significantly reduces the level of hypertrophy. With regular use of the drug, the effect is achieved after 2 weeks, and after 10 weeks, the maximum beneficial effect is noted. A single dose of the drug "Indapamide" retains its therapeutic properties for up to 24 hours.
Pharmacokinetics
The pressure drug "Indapamide" is rapidly absorbed in the gastrointestinal tract and excreted from the body mainly in the urine. The content of inactive metabolites in feces is about 20%. The diuretic interacts with plasma and red blood cells, penetrates into breast milk. With regular use of the drug, cumulation was not observed. Patients with hepatic insufficiency should use this medicine with caution to avoid the formation of hepatic encephalopathy.
Indications for use
What does the medicine "Indapamide" help from? The indications for its use are:
- Hypertension.
- Chronic heart failure (sodium and water retention in the body).
Contraindications
The drug is limited to the following diseases:
- Impaired liver function.
- Impaired kidney function.
- Intolerance to drug components.
- Hypokalemia.
- Impaired circulation in the system of the brain and spinal cord.
- Gout.
In what cases can there be complications when using the drug "Indapamide"
From what it is recommended to take this drug, we have already found out. But when do you need to be especially careful when using it? These cases include:
- Lactose intolerance.
- Pregnancy and lactation.
- Under 18 years of age.
- Unstable waterelectrolyte balance.
Method of application, dosage
The drug is taken orally 1 time per day, 2.5 mg. Morning intake is more effective, since a large amount of food slows down the absorption of the drug. Tablets should be swallowed without chewing, drinking plenty of water. An increase in the dose of the drug "Indapamide" does not lead to an acceleration of the therapeutic effect, but causes a number of side effects. Patients suffering from heart failure, in the absence of improvement, are prescribed a dose of 5 mg per day.
Adverse reactions
When taking the drug "Indapamide" (from which it is prescribed, we already know) there may be a side effect. First of all, this happens when using an increased dose of the drug, intolerance of the substance by the body, the impact of individual components on a specific organ system. Side effects can manifest themselves in different ways.
- Central nervous system: headache, drowsiness, asthenia, insomnia, irritability.
- Respiratory system: pharyngitis, acute cough.
- Digestive system: nausea, vomiting, diarrhea.
- Urinary system: nocturia, infectious inflammation.
- Cardiovascular system: arrhythmias, palpitations, hypokalemia.
- Skin diseases: itching, hives, rash.
Cost
The average price of the drug "Indapamide" in Russia is 12 rubles. Pack of 30 tablets of 2.5 mg.
Interaction with other drugs
Anti-inflammatory drugs reduce the effect of the drug "Indapamide", quickly consume fluid in the body, which is why it has to be constantly replenished. When taking Indapamide tablets, what determines the compatibility with other drugs? The composition of the diuretic is quite complex, so complex treatment is selected by a specialist strictly individually, based on the prescribed drugs.
- Medicines containing lithium are rapidly excreted in the urine, so serum levels need to be monitored.
- GCS, on the contrary, retain water in the body, reducing the antihypotensive effect.
- Cardiac glycosides reduce the amount of potassium in the body, which can lead to hypokalemia.
- Calcium: increase the body's s alt content.
- Radiocontrast products containing significant amounts of iodine can lead to kidney failure.
- Tricyclic antidepressants cause a risk of orthostatic hypotension.
Special Instructions
Which patients need careful monitoring of their condition while taking the drug "Indapamide"? What do they need to watch out for? Patients with cirrhosis of the liver, heart, kidney, liver failure are required to undergo treatment with the drug "Indapamide" strictly under the supervision of doctors. The possible occurrence of dehydration in the body leads to an exacerbation of organ dysfunction. It is important to control the fluid content in the body and compensate for it in time.
