What is a drug like "Ganaton"? What does this remedy help with? You will find the answer to these questions in this article. You will also learn about what patients think about this medicine, whether it has contraindications, and how it should be taken correctly.
The form of the drug, its packaging, composition, description
In what form is the drug "Ganaton" made? Instructions, reviews claim that such a tool can be purchased in the form of tablets that are white, shell (film), round, engraved "HC 803" on one side and at risk on the other.
The active ingredient in the drug in question is itopride hydrochloride. As auxiliary components, this medicine includes lactose, carmellose, corn starch, anhydrous silicic acid, macrogol 6000, magnesium stearate, titanium dioxide, hypromellose and carnauba wax.
Such tablets are sold in blister packs, which, in turn, are packaged in cardboard packs.
How the drug works
What is Ganaton? What helps this drug? It is used for the purposeincrease motility and tone of the gastrointestinal tract.
The active ingredient in this product is itopride hydrochloride. This substance specifically affects the upper tracts of the digestive system, and also accelerates the removal of food from the stomach. It should also be noted that the component in question is able to have an antiemetic effect.
Drug properties
What is remarkable about such a tool as "Ganaton"? From what it helps, we will tell further.
The drug in question is a stimulator of the release of acetylcholine. Its main substance activates gastric motility (propulsion). This happens due to antagonism with dopamine D2 receptors, as well as dose-dependent inhibition of acetylcholinesterase activity.
Itopride hydrochloride activates the release of acetylcholine and also inhibits its destruction.
Kinetic features of the drug
Where is the absorption of a drug like "Ganaton"? Instructions for use, reviews claim that the active ingredient of this medicine is very quickly and almost completely absorbed from the intestine. Its relative bioavailability is approximately 60%. This is due to the metabolism of the drug, which occurs during the first passage through the liver. Food intake has no effect on the bioavailability of the product.
After taking (oral) 50 mg of itopride hydrochloride, its peak concentration is reached after 0.5-0.75 hours and is about 0.28 mcg / ml. Repeatedtaking the drug at a dosage of 50-200 mg three times a day for a week causes linear pharmacokinetics. In this case, the cumulation is minimal.
Communication of the drug with plasma proteins is approximately 96%. It is actively distributed in all tissues, and is also found in high concentrations in the liver, kidneys, adrenal glands, small intestine and stomach. The drug penetrates through the BBB in small quantities. It is also excreted in breast milk.
Itopride hydrochloride and its derivatives are excreted in the urine. Renal excretion of the active substance after a single dose in therapeutic doses is about 75%. The terminal half-life of this agent is approximately six hours.
Ganaton drug: what helps?
This remedy is actively used in the treatment of gastrointestinal problems that are associated with non-ulcer functional dyspepsia (including chronic gastritis), as well as slow gastric motility.
So in what cases should the drug "Ganaton" be used? The use of this tool is shown when:
- anorexia;
- bloating;
- heartburn;
- vomit;
- feeling of fullness in the stomach after a meal;
- pain or discomfort in the epigastric region;
- nausea.
Prohibitions to take medication
Now you know what is remarkable about such a tool as Ganaton. What this drug treats, we also found out. It should be especially notedthat the medication in question is contraindicated for:
- pregnancy;
- gastrointestinal bleeding, mechanical obstruction or perforation of the gastrointestinal tract;
- under the age of 16;
- breastfeeding;
- Hypersensitivity to itopride or another auxiliary ingredient of the drug.
Careful drug use
This remedy is used with caution in the elderly due to the frequent decrease in kidney and liver function, as well as the presence of concomitant diseases or other treatment.
Due to the enhanced action of acetylcholine, the medication in question is recommended with extreme caution to patients in whom the development of cholinergic side effects can aggravate the course of the underlying disease.
How to take Ganaton?
The tablets in question should be taken orally before meals. They are washed down with plain water.
The drug does not have any effect on a person's ability to drive vehicles, as well as complex mechanisms. When using Ganaton by the elderly or people with impaired kidney and liver function, they require constant medical supervision.
Sometimes the doctor may need to adjust the recommended dosage. In case of accidental ingestion of a large amount of the drug, standard measures such as symptomatic treatment and gastric lavage are required.
In what dosage should the patient take the drug "Ganaton"?The use (reviews about the medicine are discussed below) of this remedy should be carried out only after consulting a doctor. The daily dosage of the drug in question for adults is 150 mg. If necessary, the indicated quantity can be changed by a specialist.
As a rule, this remedy is recommended to be taken three times a day, one tablet before meals (50 mg). The duration of treatment is determined by the doctor and can be approximately 5-8 weeks.
Side actions
What side effects can the drug "Ganaton" cause? This remedy helps with many diseases of the digestive tract, but it can provoke the appearance of the following undesirable effects:
- Endocrine system: gynecomastia, elevated prolactin levels.
- Hematopoietic system: thrombocytopenia, leukopenia.
- Allergic reactions: skin itching, skin hyperemia, anaphylaxis, rash.
- CNS: headaches, dizziness, tremors.
- Gastrointestinal tract: jaundice, diarrhea, increased salivation, constipation, nausea, abdominal pain.
- Changes in laboratory tests: increased levels of bilirubin and alkaline phosphatase, as well as the activity of ALT, AST and GGT.
Drug interaction
Metabolic interaction is not possible with this drug. This is due to the fact that itopride is metabolized not under the influence of isoenzymes of the cytochrome P450 system, but under the action of flavin monooxygenase.
The active substance of the drug in question enhancesgastric motility, which may affect the absorption of other concurrent oral medications. Caution must be observed when taking medicines with a low therapeutic index. The same applies to preparations with enteric coating and sustained release of the main component.
When Ganaton was combined with Diazepam, Warfarin, ticlopidine hydrochloride, diclofenac sodium, nicardipine hydrochloride and Nifedipine, there were no changes in the binding of itopride to plasma proteins.
Antiulcer drugs such as Ranitidine, Cimetidine, Cetraxate and Teprenon have no effect on the kinetics of itopride.
Anticholinergic medicines weaken the effect of the active substance of the agent in question.
Feeding and pregnancy
There are currently no sufficient data on the use of itopride hydrochloride during pregnancy. The use of this drug in the process of gestation is possible only in the absence of alternative therapy, as well as with the potential benefit to the mother, which outweighs the risk to the fetus.
It should also be noted that against the background of the use of this drug, there is a risk of side effects in an infant. In this regard, if it is necessary to use the drug during breastfeeding, lactation must be stopped.
Similar drugs and drug cost
Do you know how much the drug we are considering costs? If you do not have such informationif you own it, we will provide it to you. The price of this product depends on the mark-up of the chain's first-aid kit and is approximately 250 rubles for 10 tablets.
If a drug with this name could not be found, then it can be replaced with an analogue. Such medicines include products with the same active ingredient, that is, with itopride. As they are very often used "Itomed", "Itoprid", "Itopra" and "Primer".
Reviews from patients and specialists
Does Ganaton help with Helicobacter pylori? Experts report that the remedy in question is a drug that improves the tone and motility of the digestive tract. This is not an antibacterial medicine that can fight the bacterium mentioned above. However, in some cases, it is still prescribed for such a disease, but only in complex therapy together with antibiotics and other antiulcer drugs.
Almost all patients who have ever taken the drug in question speak of its high effectiveness. According to them, after the completed course of therapy, this drug completely eliminates the feeling of nausea and discomfort in the epigastric region, as well as heaviness and pain in the stomach.
Some patients speak well of this medication as an occasional remedy for heartburn and vomiting.
As for reports of adverse reactions of Ganaton, they are rare. As a rule, while taking this remedy, some patients experience increased salivation, drowsiness or dizziness.
Reviews of cases of overdose of this remedy have not been recorded so far. The price of a drug like Ganaton is perceived by consumers as acceptable or high.
