Duodenogastric reflux is a pathological condition in which bile enters the stomach from the duodenum due to various pathologies of the gastrointestinal tract. As a result of the disease, the digestive process is disturbed, which patients feel by characteristic symptoms.
One of the drugs used for bile reflux is Ganaton. Patient reviews about him are mostly positive. Consider the instructions for this drug, its advantages, disadvantages and analogues.
Bile in stomach
According to experts, duodenogastric reflux (it is also called bile) is observed in every second inhabitant of the planet. However, most people with this pathology do not notice any symptoms that bile from the duodenum enters the stomach. Many doctors even consider them absolutely he althy in terms of the digestive tract.
There are doctors who claim that duodenogastric refluxobserved in every person (sick and he althy), and bile is in the lower parts of the stomach for about 8-9 hours a day. Reflux is activated at night, and during the day its intensity decreases. At the same time, people do not experience any discomfort. Of course, in this case, when throwing bile, "Ganaton" is not prescribed.
Duodenogastric reflux becomes dangerous to he alth when bile is in the stomach for a longer time, which leads to the development of chemical-toxic gastritis. It is this disease that makes itself felt by the characteristic symptoms, which we will discuss below. When they begin to disturb the patient, doctors prescribe Ganaton for bile reflux.
Reasons why bile enters the stomach cavity
Why does it happen that bile ends up in the stomach? The main reason is the weakening of the closing function of the pylorus. Also, pathology can occur with chronic duodenitis and increased pressure in the duodenum, which often occurs in the organ if there is inflammation of its membrane.
The above pathologies can be triggered by many reasons, among which are the following:
- Unbalanced diet.
- Alcohol abuse.
- Excessive exercise associated with heavy lifting.
- Abuse of coffee and strong black tea.
- Eating very spicy food regularly.
- Taking pharmacologicaldrugs.
- Regular overeating.
- Hereditary predisposition.
- Tobacco smoking.
There are a number of diagnoses in which duodenogastric reflux becomes a concomitant pathology. This is:
- Pyloric stenosis.
- Obesity and type 2 diabetes.
- Dyskinesia of the gallbladder and biliary tract.
- Ascites.
- Swelling of internal organs.
- Diaphragmatic hernia.
- Neoplasms of various etiologies.
Normally, bile should enter the duodenum. Why does reflux occur in the stomach? To get into it from the intestines, she needs to pass the pyloric sphincter, which is a kind of valve that separates the stomach and duodenum.
In some people, not only the pyloric but also the cardiac sphincter is weakened. Its function is to prevent the contents of the stomach from entering the esophagus. If the second "damper" does not work well, then the patient has gastroesophageal reflux (bile and acids enter the esophagus). Reviews of "Ganaton" with bile reflux report that regular use of the drug can save the patient from unpleasant symptoms in these painful conditions.
When bile becomes dangerous
Bile in relation to the mucous membranes of the lower part of the stomach and esophagus is an aggressive environment. This feature helps to digest food. However, bile can disrupt the integrity of the inner membranedigestive tract, causing erosion and ulceration.
At the same time, patients report abdominal pain, a feeling of heaviness and fullness in the stomach (food is poorly digested and takes a long time), heartburn, belching, nausea, a characteristic yellow coating appears on the tongue. The reflux of bile into the esophagus is especially dangerous, since its mucous membranes have practically no protection from contact with aggressive environments, because its function is only to transport food from the oral cavity to the stomach.
General information about "Ganaton"
This drug belongs to the group of prokinetics. These are medicines that help improve the process of digestion of food, improve the motility of the digestive tract (food moves faster, which makes it possible to avoid stagnation). They also affect the contractile function of the sphincters and the reduction or complete elimination of the gag reflex.
Produced "Ganaton" in tablets. The main active ingredient is itopride hydrochloride. One tablet contains 50 mg of this substance. The following substances are used as auxiliary components:
- Lactose.
- Carmellose.
- Silic acid.
- Magnesium stearate.
- Hypromellose.
- Titanium dioxide.
- Carnauba wax.
Pills are packed in blisters. Each can contain 7, 10 or 14 pills. Blisters are placed in cardboard packs, in which they can contain from 1 to 5 pieces.
Pharmacodynamics and pharmacokinetics
Once in the stomach,the shell of the tablet "Ganaton" dissolves very quickly. The active substance (itopride hydrochloride) acts on dopamine receptors (is their antagonist) and inhibits acetylcholinesterase. This leads to the activation of motility and increased sphincter tone. As a result, the stomach empties faster and gastroduodenal coordination improves. Therefore, all symptoms of the disease in patients are quickly stopped.
The active substance is absorbed very quickly. Its bioavailability is 60%. Food has no effect on this. The maximum plasma concentration is reached within 30-40 minutes after taking the pill.
In the liver, itopride hydrochloride undergoes biological transformation with the formation of metabolites. They are excreted primarily in the urine.
Indications for use
Instructions for use for "Ganaton"reports that the remedy is effective in treating symptoms caused by impaired motility in the digestive tract, such as:
- Bloating.
- Feeling of heaviness and fullness in the stomach.
- Quick satiety.
- Decreased appetite.
- Abdominal pain.
- Heartburn.
- Nausea.
It is undeniable that while taking the drug, appetite improves significantly. What helps "Ganaton"? Reviews of patients who took this medication report that they had pain in the stomach, the feeling of heaviness, fullness, as well as nausea, belching, rumbling in the gastrointestinal tract disappeared.
Dosage
Instructions for the use of "Ganaton" recommends taking this medicine orally at 50 mg (1 tablet) three times a day before meals. The optimal time interval between taking the pill and eating is about 20 minutes. The recommended daily dosage can be reduced. This decision should be made by the doctor based on the patient's condition. It can be reduced based on the age of the patient.
Possible side effects
Reviews of Ganaton tablets report that patients during treatment noted the presence of the following side effects:
- Drawing pains in the stomach.
- Nausea.
- Diarrhea.
- Gynecomastia (long-term treatment).
- Hormonal imbalance (more common in men).
- Dizziness.
- Rash, itching.
- Decrease in white blood cells.
- Thrombocytopenia.
- Leukopenia.
- Patients with weakened livers may develop jaundice.
- Swelling of tongue and palate.
If side effects are obvious, then you should stop taking this drug. Reviews of "Ganaton", with bile reflux prescribed by doctors, report that in some cases the manifestations of reflux do not alleviate, but side effects appear. In this case, it is also better to stop taking these pills.
Contraindications for taking the drug
The instructions for the drug informs that there are the following contraindications for use:
- The period of pregnancy and breastfeeding.
- Under 16 years of ageyears.
- Mechanical obstruction.
- Internal bleeding;
- Exacerbation of chronic diseases of the gallbladder, liver (in this case, the reception is possible only as directed by a doctor).
- Intolerance to the components included in "Ganaton".
With caution, the drug can be taken by the following categories of patients:
- Elderly.
- Suffering from kidney and/or liver failure.
The drug can be purchased without a prescription. However, before you start taking, you should carefully study the instructions and, if there are contraindications, refuse the medication.
Drug interaction "Ganaton" with other medicines
When taken simultaneously with "Diazepam", "Warfarin", "Diclofenac" violations of the interaction of "Ganaton" with blood proteins are not observed, but the patient's condition should be monitored.
Since taking the medication in question improves gastric motility, it affects the absorption of concomitantly used drugs. Particular care must be taken when using drugs with a low therapeutic index, prolonged release of the active substance and enteric coating.
Analogues
Not always the patient can afford to take the described drug, as it has a number of contraindications and side effects. This is confirmed by the instructions. Reviews of analogues of "Ganaton" reportthat they often fit the patient better. List of such drugs according to the principle of action:
- "Passage".
- "Aceclidine".
- "Domrid".
- "Motilium".
- "Itomed".
- "Zirid".
Perhaps the most commonly used drug as an analogue of Ganaton is Motilium. This medication has antiemetic properties and also activates gastrointestinal motility.
"Domrid" is one of the cheapest analogues of "Ganaton". Instructions for use and reviews of the drug report that it helps with stomach pain, nausea, bloating, heartburn, and vomiting. An important advantage is that this drug can be given to children from the first days of life.
Reviews about "Ganaton" when bile is thrown into the stomach or esophagus
With this pathology, patients often feel a bitter taste in the mouth, which creates some discomfort. Reviews of "Ganaton" with bile reflux indicate that the drug is effective only if you give up bad habits and normalize nutrition. It is important to understand that the drug helps only with complex treatment, which includes a diet. Don't starve or change your diet significantly. It is enough to refuse fatty meat, fried foods, mayonnaise and similar high-calorie sauces.
There are also negative reviews about "Ganaton". When bile is thrown into the stomachthere are a number of processes that contribute to the development of gastritis, and later ulcers. To cure these ailments, the medicine must be used for a long time or repeat the course after a break. That is, at one time the drug may not have the expected result.
In reviews of Ganaton, patients also report that the drug is too expensive. The price is from 330 rubles for 10 tablets. Therefore, not everyone can use it for a long time.
Reviews of doctors about "Ganaton" when bile is thrown into the stomach
Many gastroenterologists believe that taking this drug when bile is thrown into the stomach does not have a therapeutic effect, that is, it does not eliminate the cause of reflux, but only reduces the symptoms. If the sphincters of the gastrointestinal tract are weakened, then you should undergo a diagnosis and determine the cause of this condition. After that, we can talk about the appointment of certain pharmacological drugs that will act directly on the cause of the pathology.
Doctors in the reviews of "Ganaton" with bile reflux are skeptical. They believe that the drug can only be used as part of complex therapy to reduce discomfort in the stomach in patients.
It should be noted that the drug is often prescribed to people with poor appetite. Reviews about "Ganaton", when bile is thrown into the stomach, prescribed by specialists, are ambiguous. What do doctors think about the effectiveness of its use in anorexia?
Doctors say to get rid ofthis condition, the medication is quite suitable. Patients in their reviews write that their appetite has improved already on the first day after taking the pill. At the same time, "Ganaton" does not cause psychological and pharmacological dependence.
Proper nutrition and taking "Ganaton"
In parallel with the use of pharmacological preparations, the patient must adhere to the principles of proper nutrition:
- Refuse to eat spicy and s alty foods.
- Prefer stews, avoid fried, smoked and fatty foods.
- Completely stop drinking alcoholic, sugary carbonated drinks.
- Reduce coffee and black tea.
This restores bile production. Reviews of "Ganaton" indicate that the medicine works better if you eat right.
