This article provides a complete description of the drug "Neurubin". The price of the drug will also be indicated in the review. Here you will learn about the composition of the drug, its properties, indications for use, adverse reactions, features of use, and more.
Attention! Information about this pharmacological agent is provided for informational purposes only and is not recommended for use in the process of self-treatment. The article presents not an official instruction for the use of "Neurubin", but its simplified version. Before you buy and start using the medicine, you should consult with your doctor. Only a specialist can decide on the appointment of this drug, determining the optimal dosages and methods of application for you.
Neurubin dosage form
Neurubin is produced as:
1. Tablets - round, convex on both sides, having a pink color, the inscription "TR" and a film shell. Packed 10 pieces in blisters, which, in turn,packaged 2 in cardboard boxes.
2. Solution for injection (transparent, red in brown glass ampoules). Each contains 3 ml of the drug and is packed in an amount of 5 pieces in a cardboard box.
Composition of the drug "Neurubin"
The drug "Neurubin" (ampoules) contains: 3 ml - vitamins B1 (thiamine hydrochloride) and B6 (pyrodoxine) 100 milligrams each, B12 (cyanocobalamin) - 1 mg. The solution contains excipients - benzyl alcohol, potassium cyanide (0.25 mg), as well as water for injection.
The drug "Neurubin Forte Lactab" (tablets) contains thiamine mononitrate - 200 mg, cyanocobalamin - 1 mg, pyridoxine hydrochloride - 50 mg. Also in the drug of this form of release there are auxiliary components. The number of components is indicated based on 1 tablet. Auxiliary compounds include: colloidal silicon dioxide, microcrystalline cellulose, pregelatinized starch, magnesium stearate, hypromellose, powdered cellulose, mannitol. The film shells of Neurorubin tablets contain talc, erythrosin, macrogol-6000 and titanium dioxide.
Pharmacological action of the drug "Neurubin"
What is the drug "Neurubin" for? The instruction of the drug explains that it is a drug consisting of a complex of neurotropic B vitamins, which are important for the process of metabolism of proteins, fats and carbohydrates.
Pharmacokinetics and pharmacodynamics of the drug"Neurubin"
Next, we will talk about what processes in the human body are affected by the components of the drug. The official instructions for the use of Neurorubin provide a clear description of the action of each of them. Despite the fact that the complex compounds of the drug belong to the same group of vitamins, each of them differs in its spectrum of biological activity. Acting in a complex way, they stabilize the functioning of the nervous system and have a beneficial effect on carbohydrate, fat and lipid metabolism.
Vitamins B1, B6 and B12 dissolve in water and are absorbed by the human body completely immediately after injection into muscle tissue.
Vitamin B1
Vitamin B1 is actively involved in the metabolism of proteins, fats and carbohydrates. With a lack of thiamine in the human body, the level of lactic and pyruvic acid increases. In this case, vitamin B1 comes to the rescue. Thanks to him, the process of re- and deamination of lactate and pyruvates starts.
Thus, vitamin B1 normalizes protein metabolism. It also acts as a catalyst during the process of metabolism of fats and their acids, activates ion channels, interacting with cell membranes, stimulates peristalsis and secretory function in the intestine.
Vitamin B1 is excreted from the body partially unchanged, the rest is evacuated in the form of pyramine and thiaminecarboxylic acid.
Vitamin B6
Vitamin B6 actively affects the metabolism of fats and proteins. It is also involved in the synthesis processenzymes and hemoglobin. Pyridoxine favors the formation of the myelin neuronal membrane and is an integral part of lipid metabolism. In addition, vitamin B6 is involved in the process of connecting neurotransmitters and hemoglobin in the synapses of the nervous system. Pyridoxine hydrochloride also acts as a coenzyme in enzyme reactions.
Vitamin B6 accumulates mainly in muscle tissues in the form of phosphoric ester. Excreted from the human body mainly in the state of pyridoxine acid.
Vitamin B12
Vitamin B12 is an indispensable participant in protein metabolism, regulates the production of nucleic and amino acids, purines. Cyanocobalamin is vital for the human body, as it affects the process of myelination of neurons and the production of acetylcholine. In addition, vitamin B12 has a positive effect on the restoration of the fibers of the nervous system and stimulates the production of impulses in its peripheral structures.
Cyanocobalamin is a hematopoietin. This means that it contributes to the formation in the human body of substances that stimulate the maturation of blood cells and normalize the rate of its clotting.
Vitamin B12 accumulates mainly in the liver and is excreted from it within about one year.
Drug "Neurubin": indications for use
The drug "Neurubin" (tablets) is used to prevent such human he alth conditions when there is a lack of B vitamins. The drug is also used to treat the followingailments: diabetic polyneuropathy, neuralgia, intoxication (including alcohol), polyneuritis.
Neurubin (injections) is used as a separate therapeutic agent and in combination with other medicines. By injection, the medicine is administered for the following diseases: neuritis (including chronic and acute), beriberi disease (with wet and dry form), diabetic polyneuropathy.
Contraindications for use
Instructions for the use of "Neurubin" informs about the contraindication to the use of both forms of the drug in such ailments and conditions: during pregnancy and lactation, under the age of 18, with allergic diathesis, in case of hypersensitivity to the components of the drug. The use of both tablets and Neurorubin injection can lead to aggravation of psoriasis and worsening of acne.
Side effects
Are there any side effects when using the drug "Neurubin"? The instruction warns of the possible occurrence of the following deviations:
- headache;
- nausea;
- vomit;
- increased irritability;
- gastric bleeding;
- increased hepatic transmiases;
- of causeless anxiety;
- tachycardia;
- feelings of anxiety;
- sensory neuropathy;
- pulmonary edema;
- itching, rashes on the skin;
- circulatory collapse;
- urticaria;
- excessive sweating;
- Quincke's edema;
- cyanosis;
- development of acne;
- anaphylactic shock.
Neurubin drug: application (dosage and method of use)
The dosage of the drug "Neurubin" and the duration of therapy is determined by the attending physician, who, when prescribing the drug, is based on the patient's condition and the nature of the disease.
According to the instructions, the tablet form of the drug is used before, after or during meals. The drug should be swallowed without chewing, washed down with boiled water at room temperature. The therapeutic dose of Neurorubin tablets is 1-2 pieces per day.
In the form of injections, the drug "Neurubin" is administered to relieve pain. Depending on the severity of the disease, injections are given daily or once every two days. The solution for injection is injected into the muscle tissue of the buttocks. When the patient's condition improves, Neurorubin is used to maintain the therapeutic effect twice during each week.
The duration of the course of taking this medication is one month.
Overdose
In case of exceeding the dosage of the drug "Neurubin" usually there is an exacerbation of side effects. In this case, the patient is prescribed gastric lavage and therapy depending on the symptoms.
There are, however, isolated cases when, with excessive use of this drug, reversible sensory peripheral neuropathy occurred. After discontinuation of the drug, the patient's conditionback to normal.
Interaction of Neurorubin with other drugs
About the parallel use with other drugs, the instruction for the use of "Neurubin" says about undesirable joint therapy with the substances altretamine and levodopa. The reason is the decrease in their effectiveness with B vitamins.
Neurubin should not be taken concomitantly with any form of Isoniazid therapeutic agent. Otherwise, the toxic effect of the latter is enhanced.
Medications "Fluorouracil" and "Thiosemicarbazone" have opposite acting abilities relative to vitamin B1. Therefore, their parallel use is not recommended.
It is also unacceptable to use the drug "Neurubin" simultaneously with drugs that have antacid and enveloping properties, as they reduce the absorption of the drug we are describing.
Terms of sale and storage of the drug "Neurubin"
Neurubin is being sold, the price of which will be indicated below, in pharmacies without a prescription.
Store tablets should be at a room temperature that is not lower than +15, but does not exceed +25 degrees Celsius. The drug must be out of the reach of children. The place where it is located must be dry and protected from direct sunlight. Ampoules with Neurorubin injection solution should be stored at +2 to +8 ºС.
The shelf life of the drug "Neurubin" - 48 months from the date ofproduction.
Features of the use of the drug "Neurubin"
Care should be taken when using Neurorubin for people with angina or heart failure.
Extremely rare, but there are cases of development of sensory neuropathy with prolonged use of the drug in large quantities. After stopping the Neurorubin tablets, the patient's condition noticeably improves.
Due to side effects such as dizziness, restlessness, weakness, anxiety that occur when using the drug, care should be taken when driving vehicles and when performing work that requires a high concentration of attention.
Use of Neurorubin during pregnancy and lactation
As mentioned above, during pregnancy and while breastfeeding, the use of both tablets and Neurorubin injection solution is prohibited. In fact, there is no data on the safety of the drug in such cases.
But despite the ban, there are exceptions. The doctor may prescribe the drug "Neurubin" to a woman during pregnancy or lactation. Sometimes this is acceptable in case of emergency, provided that the expected help to the body exceeds the likely harm from the drug. Then, during lactation, it is necessary to interrupt the feeding of the child. Otherwise, the complex of vitamins of group B will overcome the hematoplacental barrier and under their influence the composition of milk will change. This, of course, will affect the statechild's he alth is negative.
Neurubin drug: price (tablets and ampoules)
The cost of the Neurorubin vitamin complex depends on the region of the country in which it is sold, and on the form of the drug. On average, the price of tablets in various regions of Russia starts from 605 rubles.
That's all the reference and general information about the drug "Neurubin". The instruction, the price of the drug indicate the high effectiveness of the drug and its availability for each patient. The main thing - do not self-medicate, and he alth will be in order.
