One of the most important functions in the human body is the respiratory system. In addition to participating in the process of voice formation, thanks to its well-coordinated work, the inhaled air is humidified and all tissues and organs are filled with oxygen.
Also, the respiratory system is involved in thermoregulation, the synthesis of hormones and protects the human body from external factors of aggressive environment. That is why the respiratory organs are more often than others susceptible to various diseases. There is not a single person on the planet who would not encounter influenza or SARS, as well as such serious pathological conditions as sinusitis, bronchitis and tonsillitis. Each of the listed diseases has its own symptoms and, accordingly, the principles of treatment.
According to medical statistics, most often in children and adults there are such painful conditions of the respiratory tract, which are accompanied by the release of viscous sputum or difficulty in its discharge. In such cases, most specialists prescribe Ambrobene solution to their patients. How many drops should be given to adults and children, how to use this drug, does it havecontraindications and adverse reactions are listed below.
Composition of the drug, its release form, description and packaging
"Ambrobene" - drops (solution), which are a transparent colorless liquid (may be light yellow), which is placed in dark glass bottles to prevent the destruction of its active ingredient under the influence of light. The medication kit includes a special measuring container, which ensures the convenience of dosage during its use.
"Ambrobene" - drops for inhalation and oral administration. Before using such a drug, a mandatory consultation with a specialist is required. If necessary, the doctor may prescribe a solution for inhalation procedures. Such therapeutic measures should be carried out with the help of special means - inhalers. Such procedures contribute to the good penetration of Ambrobene drops into the lungs and bronchi, where their active ingredient has a high therapeutic effect.
The main active ingredient of the drug in question is Ambroxol. This ingredient belongs to the group of expectorants or so-called mucolytics. Its concentration in drops is 7.5 mg/ml. As for excipients, their concentration in 1 ml solution is as follows:
- 0.6 mg - hydrochloric acid;
- 1 mg - potassium sorbate;
- 991, 9mg purified water.
Medication action
What are Ambrobene drops? According to statementsexperts, such a drug is an effective and efficient mucolytic and expectorant.
Ambroxol is the active metabolite of Bromhexine. Such a substance helps to improve the rheological properties of sputum, reduce its viscosity and adhesive properties, as well as its removal from the respiratory tract.
Getting inside the body, Ambroxol stimulates:
- production of enzymes that break down bonds between polysaccharides of viscous secretion;
- activity of serous cells of bronchial mucosa;
- surfactant formation;
- active bronchial cilia (prevents them from sticking together).
How quickly do Ambrobene drops start to act? The instructions say that after taking the drug inside, the therapeutic effect is observed after half an hour and lasts for 6-12 hours (depending on the dosage).
Inhalation results
According to the instructions, Ambrobene drops used for inhalation contribute to the development of secretomotor and secretolytic effects. As a result of this exposure, expectoration of sputum occurs. In this case, the patient's cough becomes wet gradually. Together with viscous mucus, bacteria are excreted, as well as other foreign agents that caused inflammation of the mucous membrane of the bronchi and bronchioles.
When using Ambrobene drops for inhalation, the expectorant effect is observed after 10 minutes and lasts about 8-10 hours.
Pharmacokineticproperties
What pharmacokinetic features are inherent in drops of "Ambrobene"? The instructions for use say that after ambroxol enters the human body, it is metabolized in the liver. In this case, metabolic products are formed, which are subsequently excreted by the kidneys.
The half-life of the drug in question is 6-12 hours. The active ingredient of the drug for inhalation and oral administration passes into breast milk, which should be taken into account when breastfeeding.
Indications for use
Ambrobene drops for children and adults are indicated for use in order to improve the removal of viscous secretions from the organs of the respiratory tract in pathological conditions that are accompanied by an inflammatory process, as well as sputum accumulation. These diseases include:
- Infectious bronchitis, acute or chronic (inflammation of the bronchial mucosa caused by viruses or bacteria, accompanied by secretion of viscous sputum and cough).
- Asthma as a result of an allergic reaction, accompanied by the secretion of viscous sputum and bronchospasm.
- Bronchiectasis or pathology of the bronchi of a chronic nature with the expansion of the bronchial tree, impaired external respiration, the formation of thick sputum and re-infection.
- Pneumonia or inflammation of the lungs of infectious origin.
- Tracheitis or inflammation of the trachea of any origin.
- Obstructive chronic bronchitis or prolonged inflammation of the bronchi that has been caused bytoxic effects of various chemicals, including long-term smoking.
- Cystic fibrosis or a severe hereditary pathological condition in which the synthesis of sputum is impaired, as a result of which it becomes very viscous and regularly accumulates in the respiratory organs.
Contraindications for use
Only a specialist knows how many drops of Ambrobene should be used in certain cases. It is forbidden to use such a drug at your own discretion. It is also contraindicated in the following cases:
- epileptic syndrome;
- peptic ulcer of the gastrointestinal tract (stomach, duodenum);
- high sensitivity to Ambroxol, as well as to other components of the drug.
The drug in question should be used with caution in patients with impaired kidney function or severe liver disease. In such cases, it is recommended to reduce the dose of the drug and increase the period between doses (treatment in such conditions should be carried out under the supervision of a doctor).
With extreme caution and only in the hospital "Ambrobene" should be used for impaired bronchial motility, as well as large volumes of sputum (in order to avoid the development of secretion stagnation).
Medication dosage, method of administration
How should Ambrobene be used? How many drops should be given to adults and children? The instructions say that such a solution should be taken orally only after eating. For the rightdosing medication, it is advisable to use a measuring cup.
Given the fact that 1 ml of the solution in question contains 7.5 mg of ambroxol, the drug "Ambrobene" is prescribed in the following dosage:
- babies under 2 years - 1 ml, 2 r/d;
- from 2 to 6 years - 1 ml, 3 r/d;
- from 6 to 12 years - 2 ml, 2-3 r/d;
- from 12 years old and adults - in the first three days, 4 ml, 3 r / d, and in the next - 4 ml, 2 r / d.
How should I use "Ambrobene" in inhalation? How many drops are required to achieve the desired effect? For such treatment, any modern equipment should be used (but not steam!).
Before inhalation procedures, the medication must be mixed with a 0.9% NaCl solution (for optimal hydration, the drug is diluted in a 1:1 ratio), and then heated to the patient's body temperature.
Therapeutic measures must be carried out in normal breathing mode, so as not to provoke a cough attack.
To avoid non-specific irritation of the respiratory organs, as well as their spasm, people with bronchial asthma should definitely use bronchodilators before inhalation of ambroxol.
How many drops (in ml) of Ambrobene are prescribed for inhalation procedures? The dosage in this case is as follows:
- Baby up to 2 years - 1 ml, 1-2 r/d.
- From 2 to 6 years - 2 ml, 1-2 r/d.
- From 6 years old and adults - 2-3 ml, 1-2 r/d.
Adverse reactions after applicationdrops "Ambrobene"
How many drops (for children and adults) should be prescribed for certain diseases? The answer to this question can only be obtained from a specialist. If a visit to the doctor is postponed for good reasons, then such information is contained in the attached instructions. It also lists all the side effects that may occur during the use of the drug. These include the following:
- nausea, urticaria, vomiting, abdominal pain, diarrhea, change in taste;
- skin itching, dry throat and mouth mucosa, delayed hypersensitivity, bloating, rash, Quincke's edema.
In more severe cases, the patient may experience anaphylactic shock while using the drug in question.
Overdose cases with Ambrobene solution
The instructions say that such an active substance as ambroxol is well tolerated by patients, but only when taken orally at a dosage of up to 25 mg / kg per day. If the drug was used above the specified value, then the patient may experience the following overdose symptoms: nausea, increased salivation, vomiting and a significant decrease in blood pressure.
For the treatment of such conditions, the patient is prescribed gastric lavage. It is desirable to carry out such a procedure in the first 1-2 hours after taking an excessive amount of the drug. Also, the victim is recommended to take fatty foods.
In case of an overdose, it is imperative to monitor all indicatorshemodynamics. If required, symptomatic therapy should be carried out.
Interaction with other drugs
Simultaneous use of Ambrobene solution with medicines that have antitussive activity (including those containing codeine) is highly undesirable due to the difficulty in removing secretions from the bronchi while reducing coughing.
Parallel use of the agent in question with antibiotics (including Amoxicillin, Cefuroxime, Erythromycin and Doxycycline) significantly improves the flow of the latter into the pulmonary tract. This interaction with "Doxycycline" is actively used for medicinal purposes.
Important to know
Before using the Ambrobene solution for inhalation and oral administration, you should carefully study the attached instructions. It describes the following features of the use of the drug:
- The drug is undesirable to take on an empty stomach, otherwise it may adversely affect the mucous membrane of the digestive tract.
- Children under 2 years old "Ambrobene" is assigned individually.
- The duration of treatment with the drug should be determined by the attending physician.
- If negative reactions develop, stop using the drug.
- Not recommended for breastfeeding mothers.
- The use of a mucolytic does not affect the reaction rate of the patient in any way, so it can be used even when performing work that requires a quick reaction and increased attention.
- Ambrobene is an over-the-counter drug, soit is freely available in pharmacies.
Reviews about the drug, its cost and similar products
What do patients say about Ambrobene solution? Reviews about this tool are mostly positive. Both doctors and patients rate the effect of this medication quite high (on a five-point scale - by 4, 5-4, 6 points).
The main advantages of the drug in question include:
- quick therapeutic action;
- high drug efficacy;
- ease of use;
- good taste for baby;
- possible use in early childhood;
- a large number of different dosage forms (except for drops, there are tablets, capsules, intravenous solution, Ambrobene syrup).
Also in the World Wide Web there are neutral and negative reviews about the drug. The latter are associated with the low effectiveness of the drug.
What can replace the solution "Ambrobene"? Similar drugs (according to the mechanism of action) are such drugs as Ascoril, Bronchostop, Libeksin Muco, Acestine, Kofasma, Acetylcysteine, Erdomed, ACC, Fluimucil, " Bromhexine, Fluifort, Sinupret, Bronchosan, Fluditec, Bronhobos, Solvin, Pulmozim, Joset, N-AC-Ratiopharm, Cashnol.
The cost of the Ambrobene solution for inhalation and oral administration is about 176 rubles (per 100 ml capacity).
