For the treatment of schizophrenic and bipolar disorder, drugs based on the substance olanzapine are used. There are many drugs with different trade names, but the same antipsychotic effect. One of these drugs is the drug "Olanzapine", its analogues contain a common active ingredient in their composition.
Medication description
This antipsychotic drug is produced by ALSI Pharma CJSC in the form of light yellow tablets, the shape of which resembles a biconvex cylinder.
There is a medicine in four dosages. The tablets of each dose differ externally with an engraving inscription. For a dosage of 0.0025 g, the inscription "L" is provided, for a dose of 0.005 g, the designation "FA20" is used. Tablets with 0.0075 g of olanzapine are engraved with "F20C", and with 0.01 g of the active ingredient they contain "N30C".
The structure of the drug is formed by inactive ingredients, which include microcrystalline cellulose, lactosemonohydrate, crospovidone filler, magnesium stearate. Their number increases two, three and four times depending on the dosage of olanzapine.
Pills of all doses are packaged in blister packs of 7 pieces, which can be 4 or 8 pieces in a pack.
Means "Olanzapine" instructions for use refers to antipsychotic neuroleptic drugs that show affinity for serotonin, dopamine, muscarinic, adrenergic and histamine receptor formation.
The excitatory activity of the mesolimbic dopaminergic neuron is selectively reduced, there is a slight activity on the striatal nerve conduction, which regulates motor functioning. Decreases strength in conditioned defense reflex if low dosing is used that does not induce cataleptic sleep.
The drug "Olanzapine" increases the anti-anxiety efficacy in the "anxiolytic" test task when it is performed. Relieves negative and productive symptoms in the form of delusional ideas and hallucinogenic visions.
What is used for
Olanzapine tablets act on schizophrenic conditions in adulthood in the acute stage, as a holding and long-term anti-relapse treatment. They are used for psychotic disorder with fruitful symptoms in the form of delusional ideas, hallucinogenic visions and for negative symptoms such as emotional flattening, reduction of socially significant actions, impoverishment of the speech apparatus.
Medication eliminates repetitionseizures with bipolar disorder if the pills successfully treat the manic stages.
Olanzapine is prescribed for adults with bipolar affective disorders as monotherapy or in conjunction with medications containing lithium ions or valproic acid. The drug is used to relieve the acute form of manic or mixed action, which may present with psychotic symptoms, as well as have a rapid change in stages.
Combined with fluoxetine medication for depressive conditions that are associated with bipolar disorders.
Terms of use
Drug "Olanzapine" instructions for use recommend taking a day from 0.005 to 0.02 g orally, without adhering to the diet.
Adult schizophrenic condition is treated with an initial daily dosage of 0.010g
Acute adult mania characterized by bipolar disorder is treated with a daily dose of 0.015 g of olanzapine administered once. If tablets are used for holding effects in conjunction with drugs based on lithium ions or valproic acids, then a daily dose of 0.010 g at a time is prescribed.
Depressive processes in adulthood caused by bipolar disorder are removed with a daily amount of 0.005 g, which is combined with 0.020 g of fluoxetine substance. If necessary, adjustment of medication dosage is allowed.
For the elderly, patients with a possible threat of severe insufficiencykidneys or liver in a chronic form, when there are risks associated with the female sex, senile age characteristics, with a slowdown in the exchange of olanzapine, its initial daily amount is reduced to 0.005 g.
Similar products
Medication "Olanzapine" has analogues with different trade names. They are produced by both domestic and foreign manufacturers.
Among Russian manufacturers, the company "Technology of Medicines" LLC with the drug "Olanzapine-TL", in tablet form of 0.0025 g with a film coating, is distinguished.
Another domestic drug is Olanzapine, manufactured by Severnaya Zvezda CJSC. Available as a 0.005 g film-coated tablet.
The Russian plant "Canonpharma production" CJSC produces the drug "Canon Olanzapine".
The Israeli drug is Olanzapine-Teva, manufactured by Teva Pharmaceutical Enterprises Ltd.
The Slovenian counterpart is the Zalasta Ku tab, in tablets of 0.015 g, intended for resorption. Produced by the enterprise "Krka, Novo Mesto". Also, this plant produces the drug "Zalasta", in tablets.
The Swiss analogue is the Zyprexa medicine in the form of a lyophilisate in vials, from which a solution for intramuscular injection is prepared, with a dose of 0.010 g. In the form of dispersible tablets of 0.005 g, there is the drug Zyprexa Zidis. They are produced by Eli Lilly Vostok S. A. The pharmaceutical market haspowder medication "Zyprexa Adera" with a dosage of 0.21 g.
Polish company JSC "Polpharma" produces the drug "Normiton" in coated tablets of 0.005 g.
The Hungarian analogues of Olanzapine are produced by Gedeon Richter under the name Parnasan tablets, and the EGIS pharmaceutical plant has developed the Egolanza medicine.
Description of Zalasta
This antipsychotic drug belongs to neuroleptics. Light yellow tablets have a round, slightly biconvex shape with dark patches. There are six dosages: 0.0025 g, 0.005 g, 0.01 g, 0.015 g, and 0.02 g of olanzapine. Cellactose, pregelatinized starch and corn dehydrated aerosil ingredient, magnesium stearate are considered additional inactive components.
For marking the Zalasta tablet form, the instructions for use describe the designations in the form of engravings indicating the dosage. Consumer packaging is 7-tablet contour strips. A pack may contain 4 or 8 of these blisters.
This antipsychotic agent exhibits broad pharmacological activity. The antipsychotic effect is associated with the blocking of dopamine-type receptor formations. Sedative activity is caused by inhibition of adrenoreceptor sites that form a reticular formation in brain stem cells.
Antiemetic activity is possible when the D2-dopamine receptor site is stopped intrigger-type zone, which is located in the vomiting center.
Hypothermic role is carried out by blocking dopamine-type receptor formations in the hypothalamus.
The medicine "Zalasta" instructions for use advises the use of schizophrenic manifestations. Tablets are able to actively keep changes in clinical symptoms during long-term treatment of patients with an initial positive effect on the drug.
Means eliminate episodic mania in a medium or complex form. Pills are used to prevent the recurrence of insanity in bipolar disorders in people who have manic episodes.
The medicine is intended for oral single daily administration. Food particles do not affect the absorption of olanzapine, which allows the tablets to be used at any time. If the drug is discontinued, the dose should be gradually reduced.
For the treatment of schizophrenic disorders, an initial dosage of 0.010 g per day is used.
Episodes of mania are started with a daily dose of 0.015 g administered as a single application or 0.010 g when combined with other antipsychotics.
Prevention of repetitions of bipolar disorder in the weakening stage is carried out by the initial dosing of the drug at 0.010 g per day. If people take this remedy for the elimination of episodic manic syndrome, then the same doses are used for retention therapy. The amount of the drug should be increased if new clustered or depressive episodic manifestations occur, andadd treatment for mood disorders.
The daily dose of the drug to eliminate schizophrenic disorders, manic attacks and prevent recurrence of bipolar disorders is used from 0.005 to 0.020 g, the value of which depends on the clinical parameters of the patient.
It is not advised for the elderly to reduce the initial dosage to 0.005 g, however, such actions are used for patients over 65 years old if there are risk factors.
Description of the drug "Olanzapine Canon"
This neuroleptic antipsychotic medication is available in film-coated tablet form. The tablets are round in shape with two convex yellow surfaces, the inner contents of the same color.
Available in two dosages: 0.005 g and 0.01 g of olanzapine. Auxiliary ingredients include low-substitution hydroxypropyl cellulose, calcium hydrogen phosphate, croscarmellose sodium, mannitol, magnesium stearate.
The shell film is formed by Type II Yellow Odra, Polyvinyl Alcohol, Macrogol, Talc, Titanium Dioxide, Iron Oxide.
Treatment with the drug is indicated for worsening, for holding and long-term anti-relapse use in adult patients suffering from schizophrenic disorders.
The drug is used as monotherapy, as well as combined combination with lithium-containing compounds in case of a strong form of manic or mixed attacks of bipolar affective disorder, which occur with psychotic expressions and with an early changestages. The drug prevents recurrence in people with bipolar disorders if the drug helped to cope with the manic stage.
When treating adults with depression caused by bipolar disorder, as well as in a stable depressive degree, the drug "Canon Olanzapine", an antipsychotic, can be combined with drugs containing fluoxetine.
It is taken orally, without adhering to the diet. The instruction recommends taking into account the therapeutic dosage of the drug, which is 0.005-0.020 per day. The amount of this drug is selected for each patient separately, depending on the clinical signs.
Adult schizophrenic disorders are treated with an initial daily dose of 0.010g of medication taken at one time. Acute manic bipolar condition is treated with a daily dose of 0.015g or 0.010g olanzapine is combined with products containing lithium ions or valproic acid.
Maintenance use during bipolar disorder is carried out with an initial daily dosage of 0.010 g.
Depressive disorders associated with adult bipolar disorder are treated with a combination of olanzapine 0.005 g and fluoxetine 0.020 g given in the evening.
The antidepressant effect is manifested by the drug in an amount of 0.006 to 0.012 g with an average daily dosage of 0.0074. The dose of fluoxetine drugs ranges from 0.025 to 0.030 g. If necessary, the dosing of both drugs can be reviewed.
Therapeutic resistant form of depression is treated with a combination of olanzapine 0.005 g and fluoxetine 0.02 g administered once in the evening.
Description of Zyprexa
This antipsychotic is produced in tablet form coated with a shell. There are four dosages of the drug: 0.0025, 0.005, 0.0075 and 0.010 g, which have the corresponding designations on the surface of "LILLY 4112", "LILLY 4115", "LILLY 4116", "LILLY 4117 "".
Inactive components in the form of milk sugar, hydroxypropylcellulose, crospovidone, microcrystalline cellulose, magnesium stearate formed the structure of the drug.
Pills are packaged in blisters of 7 pieces, the pack contains 4 blisters.
There is also a lyophilized form intended for the manufacture of intramuscular solutions. Yellow liquid with a dosage of 0.01 g is packaged in vials. Lactose monohydrate and tartaric acid are considered inactive components.
The drug has an antipsychotic effect.
The active ingredient of the drug behaves as a ligand that binds to serotonin, dopamine, m-choline, H1-histamine and alpha1-adrenergic receptor formations. Olanzapine has a selective effect on the state of the limbic system.
Drug"Zyprexa" instructions for use advise using in severe stages of schizophrenic and psychotic disorders, which are accompanied by obvious signs in the form of delusions, hallucinations, mental disorders, hostile, suspicious mood or a negative type in the form of emotional and social alienation, disorders of the speech apparatus. The drug is prescribed to eliminate secondary affective symptoms caused by schizophrenic disorders.
Zyprexa tablet instructions for use recommends drinking orally, at any time. At the beginning of treatment, a single dosage is 0.010 g. Subsequently, daily dosage ranges from 0.005 to 0.020 g, which is associated with a symptomatic picture.
Medication is administered intramuscularly if it is urgent to stop psychomotor arousal in people with schizophrenic, bipolar affective disorders and dementia.
Before use, the lyophilisate is diluted in 2.1 ml of injection aqueous medium. It turns out the solution is transparent with a yellow tint.
Nervous emotional arousal of schizophrenic and bipolar disorder is removed with a single dosing of 0.010 g.
Given the therapeutic picture of the patient, re-administration of a dosage of 0.010 g is carried out 120 minutes after the first application, and the next 0.010 g is consumed 240 minutes after the second application.
For further treatment with Zyprexa, they switch to its tablet form with a dosage of 0.005 to 0.020 g.
Agitation in dementia is relieved with a single doseintramuscular at 0.0025 g. Considering the clinical picture of the patient, the second administration of a dosage of 0.005 g is carried out 120 minutes after the first application.
Description of Adera Zyprexa
There are medicines "Olanzapine" analogues, which are available in the form of a powder of 0.405 g of olanzapine in vials with a solvent, syringe and needle.
Adera Zyprexa is an antipsychotic drug with neuroleptic activity.
The drug stops deterioration, is used for the detaining and long-term anti-repetitive treatment of schizophrenic and mental changes with highly productive symptoms in the form of delusions, hallucinogenic visions and negative ones with emotional flattening, impoverishment of the speech apparatus.
The drug is used to treat severe manic and combined attacks of bipolar disorder, during which a psychotic manifestation and a rapid change in stages are possible.
The initial daily dosage is used at 0.010 or 0.015 g. The daily amount of the drug is selected for each patient separately, taking into account the clinical picture. Usually a therapeutic daily dose of 0.005 to 0.020 g is used.
Increase in dosage is possible only if the results of the examinations are available. The increase in the amount of the drug is carried out in stages, every day.
Elderly patients, in the presence of insufficient kidney and liver function, the initial daily dose is prescribed at 0.005 g.
Cost of analogues
A wide range of antipsychotics allows you to choose the righta drug that is suitable in terms of quality and cost. Medicines "Olanzapine" price is relatively small. A pack of pills can be bought for 290 rubles.
Medication "Zalasta" price is from 1370 rubles.
Zyprexa Zidis tablets are considered expensive. For the packaging of the drug you need to pay 2370 rubles. The cost of the analogue "Ku-tab Zalasta" is 1075 rubles.
The price of Zyprexa medicine gets negative reviews. A pack of 28 tablets costs 4,760 rubles.
For the unprotected segments of the population, the medicine "Olanzapine" will be available, the price of which is several times lower.
Patient opinions
About the drug "Olanzapine" reviews can be heard both positive and negative. For many, the drug helps to cope with depression and reduce the number of negative thoughts after a few days of taking. It is considered one of the strong antipsychotics that calms patients, eliminates fears and anxieties.
Among the disadvantages are undesirable consequences that are associated with a slowdown in metabolism, resulting in increased body weight of the patient. Drowsiness, asthenic syndrome, dizziness appear, arterial pressure of the orthostatic type may fall, swelling of the soft tissues and dryness of the mucous membranes may develop.
For some patients, even a small dose of the drug is a strong sleeping pill, from which they sleep for 12 hours a day.
The human body is individual, so the pills act differently for each patient. To select a suitablefunds need a doctor's consultation.
