The drug "Metromicon-Neo" is a drug that has an antiprotozoal, antibacterial and antifungal effect. Used to treat various gynecological diseases.
Description and release form
The drug is available in the form of white suppositories, the color may also have a yellow tint. Candles have a cylindrical-conical shape, which resembles a small torpedo. The cut may contain a porous rod with a funnel-shaped recess. The main active ingredient is metronidazole, one suppository includes 500 mg of this active ingredient, as well as 100 mg of miconazole. The preparation also includes auxiliary agents, such as semi-synthetic glycerides, which are used to achieve a suppository mass of 2000 mg. Candles are in blisters, two blisters in a cardboard box. In total, 14 candles can be counted in the package.
Pharmacological action
"Metromicon-Neo" is a drug that has a bactericidal type of action, it is capable of interacting withdeoxyribonucleic acid. The main substance biochemically restores the 5-nitro group, which inhibits the synthesis of nucleic acid, thereby killing bacteria. This drug is highly active against protozoan and obligate anaerobic bacteria: Entamoeba, Trichomonas vaginalis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Veillonella spp, Prevotella, Mobiluncus, Gardnerella vaginalis.
The second active ingredient - miconazole - has an antifungal effect. During intravaginal use, the agent is active against Candida albicans. Miconazole has a fungistatic and fungicidal effect, thereby inhibiting the plasma membranes of fungi and the biosynthesis of ergosterol shell. By changing the lipid composition, the active substance causes the death of the fungal cell.
Pharmacokinetics
Unlike ingestion, intravaginal administration of metronidazole has a bioavailability of 20%. The half-life of active substances from the body occurs in 6-10 hours. Approximately 20% of the main dose is excreted unchanged in the urine. Miconazole during intravaginal administration is slightly absorbed, therefore, it is not detected in blood plasma.
Indications for use
For the use of the drug "Metromicon-Neo" the instruction defines the following indications:
- Trichomonas vaginitis;
- vaginal candidiasis;
- bacterial vaginosis;
- vulvovaginitis;
- mixed vaginalinfections.
Contraindications
This drug has a fairly small number of contraindications. Virgins, in the first place, should not take Metromicon-Neo. The instruction also highlights other contraindications. For example, it is forbidden to use the drug for women who are breastfeeding the baby, as well as for pregnant women during the first trimester. It is forbidden to use the drug for girls who have not reached the age of majority (who are under 18 years old). Do not take the drug and those patients who have hypersensitivity to the individual components of this drug.
The drug should be taken with caution in people with hepatic and renal insufficiency, as well as in diabetes, porphyria, in violation of microcirculation and impaired hematopoiesis. In the second and third trimester of pregnancy, as well as in diseases of the nervous system, Metromicon-Neo should also be used carefully.
Using the drug
The drug is introduced into the body by the intravaginal route. To use, you need to release the suppository with scissors, cutting the film along the contour, and then insert the opened suppository as deep as possible into the vagina. In acute vaginitis or bacterial vaginosis, the drug is used for a week. Use the drug should be 2 times a day, 1 candle in the morning and evening.
During chronic vaginitis "Metromicon-Neo" (candles) should be used fortwo weeks, 1 suppository at night. With relapses of vaginitis, with treatment by other means, or in the absence of positive clinical dynamics, suppositories are used 2 times a day. It is necessary to apply suppositories 1 piece in the morning and in the evening for two weeks.
Adverse reactions
Quite different side effects can occur if you use "Metromicon-Neo" (candles). Instructions for use indicate several side effects. Of the local reactions, itching, burning and irritation on the vaginal mucosa can be observed, and swelling can also occur. With vaginitis, due to inflammation of the mucosa, irritation may increase after the first injection of the suppository. Also, increased irritation can be observed after the third day of treatment. To remove these symptoms, it is necessary to stop treatment.
In addition, there may be symptoms associated with the gastrointestinal tract. These can include constipation or diarrhea, stomach cramps or pain, nausea or vomiting, and dryness and a metallic taste in your mouth.
Regarding the central nervous system, dizziness or headaches, convulsions, psycho-emotional and motor disorders are possible. Skin reactions (eg, rash, itching, hives) may also occur.
Drug overdose
If you use "Metromicon-Neo" (candles) in the doses recommended by the instructions, there should not be an overdose, since the drug has low absorption. But when using the tool inlarge doses, symptoms such as abdominal pain, vomiting, nausea, diarrhea are possible. As well as dizziness, ataxia, dry mouth, paresthesia, dark urine, convulsions. When using a high dose of the drug for a long time, peripheral neuropathy is possible. To get rid of the symptoms of an overdose, symptomatic treatment is necessary. If the drug was taken orally under any circumstances, urgent gastric lavage is necessary.
Special Instructions
It should be noted that when using the drug "Metromicon-Neo", you should refrain from sexual intercourse. To avoid re-infection with the infection, simultaneous therapy of the sexual partner is necessary. When using the drug, as well as a couple of days after stopping the use, it is necessary to exclude the use of ethanol, as its intolerance is possible.
In case of severe irritation, stop treatment with Metromicon-Neo. Patient reviews show that irritation occurs relatively often, in which case the drug should be replaced. Suppositories must be used intravaginally, use in any other way is prohibited.
The drug has a slight effect on driving, but if you experience any side effects, such as dizziness, you should avoid working with mechanisms and do not drive a car.
Storage
The drug should be stored in the dark at room temperature. The storage location must be out of the reach of children. The shelf life of the drug is 36months, after its completion, the drug is prohibited to use.
Metromicon-Neo cost
The price of this drug depends on several factors, primarily on the country in which the goods are produced and the distance of transportation to individual points of sale. On average, the price ranges from 350 to 550 rubles. The price is considered low, since there are 14 suppositories in one package (for 1 course of treatment).
Opinions of patients about the drug "Metromicon-Neo"
Reviews of many women are only positive. Almost everyone is satisfied with this drug. Although this tool is an analogue of a more expensive one, it fully justifies itself. Symptoms of vaginal diseases disappear after 2 days, which makes patients very happy.
Many girls warn that panty liners must be used when using this medicine, as suppositories leak out of the vagina during the day. There were also negative reviews from people who used Metromicon-Neo (candles). The price, according to them, is affordable, but it does not quite heal. They also add that the drug only relieves the symptoms, but does not provide any treatment, so the infection is constantly in the body and reappears from time to time. But it should be noted that such reviews are much less than positive ones.
In any case, before use, you need to consult a doctor and accurately determine the diagnosis, since if you use the drug on your own, it can not only not work, but also harm the body.
