In what dosage is the drug "Pangrol" prescribed? Instructions for the use of this medication will be described in this article. It also provides information about the composition of the drug in question, whether it has contraindications and side effects.
Medication form and packaging
In what form is the drug "Pangrol" produced? Instructions for use, reviews of doctors indicate that this product goes on sale in the form of hard and opaque gelatin capsules of a cylindrical shape, as well as tablets.
This medication has a light orange shell and a yellow-green cap.
The contents of the capsules are cylindrical granules. They have a shiny surface and enteric coating, and are also distinguished by a light beige color.
In what package is Pangrol sold? Instructions for use along with the medicine (20, 100 or 50 capsules) are enclosed in a polypropylene bottle. under considerationmedication in tablet form is packaged in blisters and placed in cardboard packs.
Composition of the drug
What is included in the preparation "Pangrol" 10000? The instructions for use inform us that the active substance of this medication is pancreatin. Also, the composition of the drug includes such additional elements as croscarmellose sodium, magnesium stearate, hydrogenated castor oil, anhydrous colloidal silicon dioxide and microcellulose.
Pangrol 20000 and 25000 have a similar composition.
Pharmacological properties of the drug
What is Pangrol medicine? Instructions for use (the composition of this drug was described above) states that this medication belongs to the group of digestive enzymes. After oral administration, it helps to fill the deficiency of substances that are essential for the normal functioning of the pancreas.
Also, the drug in question is capable of exerting amylolytic, proteolytic and lipolytic effects.
Pharmacodynamics of the drug
How does Pangrol 25000 work? Instructions for use states that pancreatin, which is part of this drug, is a powder obtained by processing pig glands (pancreas). The enzymes contained in it have a favorable effect on digestion processes, and also accelerate the breakdown of carbohydrates, fats and proteins. This substance also contributesnormalization of the pancreas itself.
What properties does Pangrol have? Instructions for use says that by improving the digestion of food, this medication quite effectively removes such signs of digestive disorders as a feeling of fullness in the stomach, shortness of breath, pain and heaviness in the abdomen, accumulation of gases, flatulence, and so on.
Taking capsules and tablets, the patient stimulates the pancreas, as well as the stomach and small intestine, which subsequently produce all the necessary enzymes involved in the digestive process.
The bile extract, which is part of the preparation, acts on the human body choleretically, and also enhances the emulsification of fats. Thus, it increases the activity of lipase, improving the absorption and digestion of fat-soluble vitamins A, E and K by the stomach.
Pharmacokinetics of the drug
How does Pangrol 20000 work? The instructions for use give a lot of information on this. The drug "Pangrol" is coated with a special acid-resistant coating that helps protect the drug from the effects of gastric juice until the drug enters the small intestine. At the same time, the capsule shell dissolves rather quickly, after which it releases granules that contain digestive enzymes. Mixed with the contents of the intestine, they provide it with the necessary level of enzymes.
For a more effective effect, it is very important to maintain a slightly alkaline or neutral pH in the small intestine.
It should also be noted that Pangrol is not absorbed from the gastrointestinal tract. At the same time, it is excreted from the body only with feces.
Indications for use
The medication in question is actively used as a replacement therapy in adults and young children with impaired exocrine pancreas function.
In addition, the drug "Pangrol" is prescribed for relative enzyme deficiency, which was caused by one of the following diseases:
- pancreatitis (including chronic and acute stages of the disease);
- pancreatic cancer or narrowing of the duct, which was caused by the presence of a malignant tumor or gallstones;
- intestinal infections;
- Shwachman-Diamond syndrome;
- disorders of the gastrointestinal tract that are functional in nature;
- irritable bowel syndrome;
- cystic fibrosis.
It cannot be said that the drug in question is actively used to prepare the patient for an X-ray examination or ultrasound of the abdominal cavity, as well as to normalize the function of the stomach and pancreas after surgery (for example, after resection or in as part of complex therapy after irradiation in the presence of symptoms such as flatulence, indigestion of food or diarrhea).
Contraindications for use
Under what conditions is it not recommended to take Pangrol medication? Instructions for use (indicationsof this medicine were listed above) indicates the following prohibitions:
- acute pancreatitis;
- hypersensitivity of the patient to drug substances;
- exacerbation of pancreatitis.
Drug "Pangrol": instructions for use
According to the instructions, this drug should be taken with food. However, it is not recommended to chew it (should be swallowed whole).
Tablets and capsules should be taken with liquid at room temperature. The dose of the drug is determined by the doctor and depends on the patient's condition, as well as the form and severity of the disease.
When prescribing capsules, you must adhere to the following therapeutic doses:
- adults - 1-2 or 2-4 capsules of Pangrol 25000 or 10000 respectively;
- small children - calculated as follows: 500-1000 units of medicine per 1 kg of body weight at each meal.
As for tablets, they are taken 1-2 pieces during each meal. The average therapeutic dose of this medicine may vary depending on the disease, as well as the food that the patient consumes.
If necessary, the doctor may increase the daily dosage. However, the maximum allowable limit of 15,000-20,000 units of lipase per 1 kg must be adhered to.
How long should therapy with the agent in question last? The course of treatment depends on the type, severity of the disease and the state of he alth of the person.
If the patient cannot acceptwhole capsule (for example, the elderly or young children), then the contents can be poured into liquid or mixed with food that does not need to be chewed (for example, fruit puree). In this case, it should be especially noted that the mixture of food and tablets must not be stored. It must be consumed immediately.
For the treatment of cystic fibrosis, the dosage of the drug is also selected by the doctor. As a rule, it depends on the patient's body weight.
The initial dose of the drug for children under 4 years old should be 1000 units per 1 kg of body weight, and for children over 4 years old - 500 units.
When using the drug in pediatrics, it is imperative to follow a diet in order to exclude the development of steatorrhea.
Overdose cases
About an overdose of the drug "Pangrol" and an increase in the number of enzymes in the treatment of cystic fibrosis, diseases such as hyperuricosuria and hyperuricemia can signal. In this case, the drug should be discontinued and then immediately consult a doctor.
Side effects
During treatment with Pangrol, patients may develop side effects such as diarrhea, bloating, nausea, digestive system disorders, vomiting, abdominal pain, and others.
Very rare people who take this medicine have an allergic reaction (itching, hives, skin rash). If such symptoms are found, stop using the drug and consult a doctor.
Special Recommendations
During the treatment of cystic fibrosis inpeople receiving large doses of the drug may develop fibrosing colonopathy (that is, strictures of the blind, large and ileal intestines). To avoid such pathologies, before taking the medication, it is imperative to undergo a medical examination in order to exclude the presence of intestinal lesions in the patient.
Analogues and price of the drug
Now you know what Pangrol is prescribed for. Instructions for use (analogues of this medicine will be listed right now) of the mentioned remedy have been described in detail above.
If you could not purchase this drug in your region, then it can be replaced with one of the following analogues (after consulting a doctor): Gastenorm Forte, Ermital, Creon, Pancrelipase, Mezim”, “Enzistal-P”, “Mikrazim”, “Penzital”, “Mezim Forte”, “PanziKam”, “Pancreatin Forte”, “Panzinorm”, “Festal”, “Pancreatin”, “Pancitrate”, “Panzinorm Forte”, Pancreatin-LekT, Panzim Forte.
The cost of the drug in question depends on the form. A pack of 50 tablets can be purchased for 1,000 rubles, and 20 capsules for 250 rubles.
Reviews about the drug
In most cases, people taking Pangrol leave positive feedback. This medication effectively copes with the task. Its only disadvantage is the difficulty in calculating the dose. Due to the fact that digestive problems are always individual in nature, only an experienced specialist can choose the right dosage. This fact is significantlymakes self-medication difficult.
