Consider drugs such as Metrogyl and Metronidazole. This is the same? Among single-celled organisms that cause various diseases, bacteria and protozoa stand out. Antibiotics are widely used against the former, which are ineffective against the latter. To combat protozoa, antiprotozoal drugs are needed, such as Metrogyl and Metronidazole, the difference of which needs to be learned in more detail.
Description
These are antiprotozoal and antimicrobial drugs, derivatives of 5-nitroimidazole. The mechanism of action of these agents is the biochemical reduction of the fifth nitro group of metronidazole by transport intracellular proteins of protozoa and anaerobic microorganisms. The reduced 5-nitro group interacts with the DNA of microorganism cells, intensely suppressing their production of nucleic acids, which leads to the destruction of these bacteria.
Activity
Many patients believe that Metrogil gel and Metronidazole are one and the same. Both drugs are active against Entamoeba histolytica, Trichomonas vaginalis, Gardnerella vaginalis, Lamblia spp., Giardiai ntestinalis, as well as obligate anaerobic microbes Bacteroides spp., Fusobacterium spp., Prevolella spp., Veillonella spp. and some gram-positive microbes (Clostridium spp., Eubacterium spp., Peptostreptococcus spp., Peptococcus spp.). In combination with amoxicillin, these drugs are active against Helicobacter pylori (reducing the development of resistance).
To metronidazole, which is present in both medicines, facultative anaerobes and aerobic microorganisms are not sensitive, however, in the presence of mixed flora (anaerobes and aerobes), metronidazole acts synergistically with antibiotics effective against the most common aerobes. In addition, the main substance increases the sensitivity of tumors to radiation, provokes disulfiram-like reactions, and stimulates reparative processes.
Composition
Both drugs contain the active element metronidazole. In fact, "Metronidazole" and "Metrogil" are identical medicines, but they are produced by different pharmaceutical companies. "Metrogil" is manufactured by the Indian company "Unique Pharmaceutical", and under the name "Metronidazole" the products of various companies from various countries are sold.
Medication forms
The drug "Metronidazole" is available in different forms:
- Plano-cylindrical white tablets, each containing 250 mg of the active ingredient. They are packed in jars of 20 pieces or in blisters of 10 pieces.
- Candles that contain 0.1 g of the main substance. Pack of 10 candles.
- Solution for infusion - a yellowish transparent liquid in polyethylene bottles, which contains 500 mg of the active ingredient.
- Vaginal gel 1%. 100 g of colorless gel contains 1 g of the main active substance. Packaging - aluminum tubes of 30 g in combination with an applicator.
Metrogyl is produced in the following dosage forms:
- Film-coated tablets: round, biconvex, orange or pink (400 mg each). They are packaged in blisters of 10 pieces.
- Solution for injection into a vein: pale yellow, clear or colorless. Poured into polyethylene bottles of 100 ml, 1 bottle in a carton. In addition, the solution can be sold in ampoules of 20 ml, 5 ampoules in a cardboard box or in thermal containers.
- Vaginal gel: light yellow or colorless, homogeneous - in tubes of 30 g per tube, complete with applicator.
- Gel for external use: yellow to colorless, uniform. Packed in 30g aluminum tubes
- Suspension for oral use - 100 or 60 ml vials.
Differences in dosage forms
As can be seen from the list of medicinalforms, these drugs are somewhat different. In particular, Metronidazole is produced in the form of suppositories, while Metrogil is not, but the second medication is in the form of a gel for external use and suspension, which cannot be said about Metronidazole. Medicines have certain differences that allow you to choose the necessary dosage form in each case.
Metrogyl gel for external use is more popular. Instructions for both Metronidazole and Metrogil will be presented below.
Indications for prescription
Both medications have exactly the same indications for use - they include diseases provoked by protozoa:
- Amebic abscesses of the liver, brain, lungs and other organs.
- Leishmaniasis (an insect-borne disease that manifests itself as a lesion of the skin or internal organs).
- Amoebic dysentery (infection of the bowel characterized by frequent urge to defecate and discharge in the form of "raspberry jelly").
- Trichomoniasis (a sexually transmitted disease that causes abnormal discharge from the genitals, pain during urination and intimacy).
- Bacteroid-induced lesions (sinusitis, pneumonia, otitis media, oral and soft tissue lesions).
- Peritonitis (inflammatory process in the peritoneum).
- Liver abscess.
- Endometritis (damage to the functionallayer of the uterus).
- Pelvic Infection.
- Purulent lesion of the fallopian tubes.
- Skin infections.
- Gastritis, a gastric ulcer caused by Helicobacter pylori.
- Prevention of infectious complications in the postoperative period.
Contraindications
"Metronidazole" and "Metrogil" have identical contraindications. Therefore, these drugs should not be used in the following situations:
- intolerance to metronidazole;
- low white blood cell count;
- organic diseases of the central nervous system, including epilepsy;
- 1st trimester of pregnancy;
- pronounced liver dysfunction;
- lactation period.
Side effects
What else does the instruction manual for Metrogil and Metronidazole tell us? Since these medicines contain the same element, metronidazole, as the main substance, the side effects from their use are approximately the same. These include:
- disorder of digestive functions;
- metal taste in mouth;
- dyspepsia;
- headache;
- discoordination;
- dizziness;
- lowering mood;
- fainting;
- frequent urination;
- allergy;
- joint pain.
When using vaginal suppositories "Metronidazole" there may be a feeling of itching and burning in the vagina.
Cost
One of the main criteria according to which manypeople choose drugs, is their price. Which is better in this regard - "Metronidazole" or "Metrogyl"?
The cost of the drug "Metronidazole" varies depending on the manufacturer and form of release, and the maximum is 190 rubles. As for the Metrogil remedy, its price depends only on the dosage form, since there is only one manufacturer of this remedy. The cost of the drug is approximately 150-240 rubles.
Why does the question arise: "Metrogil" and "Metronidazole" is the same thing?
Difference
There is a lot of debate on the forums about which pharmacological agent is still better - Metrogil or Metronidazole. It should be noted that both drugs have identical pharmacological characteristics, which allow the use of these drugs in the same pathologies. This also applies to contraindications to these medications, and to the side effects that they can provoke. Thus, there is no fundamental difference between Metrogil and Metronidazole, both drugs can be used. Their difference is the form of release. For example, in the treatment of intravaginal lesions, as a rule, "Metronidazole" is used, since this drug is produced in the form of suppositories. At the same time, if there is a need to use the drug in liquid form, then in such a situation, the drug "Metrogil" is more suitable for the patient, since it is available in the form of a suspension.
Also "Metronidazole" and "Metrogil"differ in the way they are used. Systemic agents include oral tablets, solutions for infusion. They are used in the general therapy of infectious and inflammatory diseases of any of the body systems.
Metrogil and Metronidazole in the form of a gel, cream, vaginal suppositories belong to the local means with one active substance. They are used topically for the treatment of infectious and inflammatory pathologies in the field of dentistry, urology, gynecology, dermatology.
Which is better?
Prices for "Metronidazole" and "Metrogyl" are quite difficult to compare, since these drugs are available in different dosage forms. But their cost differs insignificantly, so there is no fundamental difference which drug to buy. So, gels for external use, vaginal and dental gels are suitable for topical therapy for the treatment of infections that occur easily. Tablets are mainly used in the treatment of stomach ulcers and intestinal infections. A solution for intravenous administration is necessary for sufficiently severe conditions of the patient. Which is better - "Metrogil" or "Metronidazole", you decide.
Similar drugs
These drugs have a wide range of analogues on the modern pharmaceutical market. These include:
- Bacimeks.
- Ergotex.
- Metrovagin.
- Metrolacare.
- Metroxan.
- "Deflamont".
- Klion.
- Orvagil.
- Rozamet.
- "Siptrogil".
- Trichopolum.
- "Trichosept".
- Flagil.
Despite such a variety of similar medications, they can also differ in certain parameters of quality and effectiveness. In addition, it is necessary to use such drugs in the dosages strictly indicated by the doctor, therefore it is not recommended to use them without the appointment of a specialist. This can provoke a deterioration in the condition and the development of adverse reactions.
We have described the preparations in detail. What do the reviews say? Which is better - "Metrogil" gel or "Metronidazole"?
Patient comments
Reviews of patients about these medications are quite contradictory. However, such a difference in views is due, by and large, to personal preferences. The release form plays an important role. Someone is more suitable for tablets or suspension, someone prefers a gel or ointment. Both "Metrogil" and "Metronidazole", judging by the reviews of experts, are quite good, effective means, the main thing is not to self-medicate and follow the doctor's instructions and recommendations. So what are the patients actually saying?
There are many positive reviews about the second medication, and patients characterize this remedy as highly effective and inexpensive. It is used for a variety of infectious diseases of non-bacterial origin, in which antibiotics do not produce the desired effect. For example, "Metronidazole" is often prescribed to women with various gynecological diseases. Patientsnote that the effectiveness of this drug is very high, it is well tolerated and practically does not cause adverse reactions if used in the form of vaginal suppositories. This often causes a burning sensation in the vagina, but this condition passes fairly quickly.
Patients who have treated diseases of the digestive organs with this drug say that it helped them cope well with the symptoms of the disease, but often caused a violation of the stool in the form of diarrhea, sometimes severe nausea and heartburn. At the same time, it was not necessary to cancel the medication, since such negative phenomena quickly disappeared on their own, without taking symptomatic drugs.
About the medicine "Metrogyl" there are also positive characteristics from patients. Many believe that this remedy has a lot of advantages over Metronidazole, and the main one is that it is produced by an Indian company that has long established itself as a conscientious and reliable manufacturer of pharmacological preparations. According to these people, Metrogil is a more modern and high-quality medicine, and it helps to intensively fight the diseases listed in the indications for use. Adverse reactions from this remedy are also available, but they are not pronounced and do not prevent the patient from leading a normal life. It is better to read reviews about Metrogil and Metronidazole in advance.
Specialists also draw the attention of patients to several points: there can be no one-component "Metronidazole" better than the drug "Metrogil". Since the drugs contain the same active substance, they are interchangeable in the treatment of infectious and inflammatory diseases, as they are structural analogues. In the treatment of complex pathologies, both drugs are considered auxiliary: they enhance the effect and expand the spectrum of action of macrolide antibiotics, III generation cephalosporins.
