In the article, we will consider the instructions for use for Diazolin.
The drug is a blocker of histamine H1 receptors. It is able to stop attacks of allergic reactions, have an anesthetic, anticholinergic, anti-exudative, antipruritic effect. Has a slight hypnotic and sedative effect.
Description and composition
The manufacturer produces the drug in two dosage forms - in the form of tablets and dragees. The dosage can be 50mg and 100mg.
Dragee spherical, white. Tablets are round, white in color.
According to the instructions for "Diazolin", the main component in the composition of the drug is mebhydrolin. Dragees, in addition to the active ingredient, contain auxiliary components: sunflower oil, talc, beeswax, molasses and sucrose.
The drug is able to have an anti-allergic effect, reduce swelling of the mucous membranes.
"Diazolin" stops the effect of histamine on the intestines, uterus, bronchi and other internalorgans with smooth muscles. Mebhydrolin reduces the hypotensive effect of histamines, eliminates increased vascular permeability.
The drug does not have a pronounced hypnotic and sedative effect. This is due to the fact that the active component penetrates the BBB in a small amount.
The drug is intended for oral administration. After ingestion, the active substance is rapidly absorbed in the digestive tract. The variability of bioavailability is 40-60%. Metabolism of the active ingredient occurs in the liver. As a result, the synthesis of microsomal hepatic enzymes is enhanced. The active substance is excreted from the body by the kidneys, along with urine.
Indications for admission
As the instructions indicate, "Diazolin" is indicated for admission at:
- Seasonal allergic rhinoconjunctivitis.
- Hives.
- Angeoneurotic edema.
- Allergic dermatoses, manifested in the form of itching and eczema.
- Allergic reaction to medications.
- Bronchial asthma as one of the drugs of complex therapy.
It can be prescribed for similar diseases in children from 3 years old - in the form of a dragee, from birth - in the form of tablets.
What else does the instruction for "Diazolin" for adults tell us?
Contraindications for taking
"Diazolin" in any pharmacological form is contraindicated for patients if they have one of the following diseases or conditions:
- Pregnancy.
- Violationsheart rhythm (mebhydrolin is able to have a vagolytic effect, resulting in an improvement in AV conduction, supraventricular arrhythmia develops).
- Epilepsy.
- Inflammation of the gastrointestinal tract, which is in the exacerbation phase.
- Prostate enlargement.
- Lactation period.
- Pyloric stenosis (pyloric stenosis).
- Gastrointestinal ulcers.
- Angle-closure glaucoma.
- Individual hypersensitivity to any of the components of the drug.
The use of "Diazolin" in the form of dragees is contraindicated in the treatment of children under 3 years of age. This is due to the difficulty in swallowing this form of the drug.
Dosage and methods of application
In accordance with the instructions, "Diazolin" in any dosage form is prescribed in a daily dose of 100-300 mg. The maximum dosage for a single dose is not more than 300 mg, the maximum daily dosage is not more than 600 mg.
Medication should be taken directly with meals or immediately after. It is recommended to swallow dragees and tablets whole, avoiding biting and crushing.
The duration of therapy should be determined by the attending physician, based on the tolerability of the medication and the clinical picture of the disease.
When treating children from birth, it is necessary to prescribe "Diazolin" in the form of tablets in the following dosages:
- Up to 2 years - per day from 50 mg. The maximum daily dose is not more than 100 mg.
- 2-5 years - per day from 50mg. The maximum daily dose is not more than 150 mg.
- 5-10 years - per day from 100 mg. The maximum daily dose is not more than 200 mg.
- From 10 years old - dosages are used the same as in the treatment of adult patients.
Instructions for Diazolin tablets are very detailed.
The drug in the form of a dragee can be administered to children over 3 years of age in the following dosages:
- 3-5 years - once or twice a day, 50 mg each.
- 5-12 years - 2-4 times a day, 50 mg each.
- From 12 years old - 1-3 times a day, 100 mg.
Side Effects
Against the background of taking the drug in the form of dragees or tablets, such negative effects can develop as:
- Allergies, manifested in the form of urticaria, angioedema, rash and itching - from the immune system.
- Drowsiness, tremor of certain parts of the body, increased fatigue, impaired sensitivity, headaches, dizziness - from the side of the National Assembly.
- Agranulocytosis from the hematopoietic system. Under the influence of the drug, the number of leukocytes in the blood may decrease, as a result, the body's susceptibility to bacteria and viruses increases.
- Urine retention, various urinary disorders - from the genitourinary system.
- Irritation of the gastric mucosa, difficulty emptying the intestines, epigastric pain, heartburn, vomiting and nausea, dry mouth - from the gastrointestinal tract.
In rare cases, against the background of the use of the drug in children, paradoxical reactions may be observed, such as excessiveexcitability, tremor, sleep disorders. This is confirmed by the instruction and reviews for the Diazolin tool.
Interaction with other medicines
Mebhydrolin significantly enhances the effects of ethyl alcohol. It also enhances the therapeutic effect of sedative drugs.
So it says in the instructions for Diazolin.
Special instructions for use
Mebhydrolin is ineffective in the treatment of anaphylaxis and bronchial asthma.
It is necessary to prescribe the drug with extreme caution to patients who have a lack of functionality of the liver and kidneys. If there are such diseases, it is necessary to adjust the dosage, as well as increase the time interval between two doses of the drug.
Therapy may be accompanied by the occurrence of negative reactions from the central nervous system. Dizziness is not ruled out. Therefore, for the period of treatment, it is recommended to refrain from driving and working with mechanisms that require attention.
Overdose
According to the instructions for use for "Diazolin" for adults, with an overdose of this medication, there is a significant increase in side effects. A specific antidote is not currently known to medicine. If signs of an overdose appear, you should immediately stop taking the drug, perform a gastric lavage, take diuretics, which will speed up the excretion of the active component from the body. To eliminatesymptoms of intoxication, symptomatic treatment is prescribed.
Analogues
There is no structural analogue of "Diazolin". Among analogues according to the therapeutic effect, there are:
- Erius. The main active substance in its composition is desloratadine. The effect occurs within half an hour after oral administration of the drug, lasts up to a day. The drug is produced by the manufacturer in the form of a syrup, which can be used in the treatment of children from one year old, as well as in the form of tablets indicated for admission to patients from 12 years of age. The drug is contraindicated for pregnant and lactating women.
- "Tavegil". The main active ingredient in its composition is clemastine. The drug has three dosage forms - tablets, syrup, injection. Tablets can be prescribed to children from 6 years old, syrup - from 1 year old. The drug is contraindicated for pregnant and lactating women. In addition, it should not be prescribed if the patient has individual intolerance, pathology of the lower respiratory system, or if he is undergoing therapy using MAO inhibitors.
- "Suprastin". The main active ingredient in its composition is chloropyramine, like mebhydrolin, which belongs to H1-histamine receptor blockers. "Suprastin" has two pharmacological forms - tablets and injection. The drug can be prescribed to pregnant women in the first and last trimester, if there is an urgent need. There are no reliable data on the effect of the drug on the fetus. If therapy is carried out during breastfeeding, it should be suspended for the duration of the medication.
- "Fenistil". The main component in the composition of the medication is dimethinlene. "Fenistil" in the form of oral drops is acceptable for use in children from 1 month. Use is contraindicated during lactation, in the first trimester of pregnancy, with individual sensitivity, prostate adenoma, angle-closure glaucoma, bronchial asthma. The drug can be prescribed from the 14th week of pregnancy, but only if there is an urgent need.
Next, after the information regarding the instructions for use for Diazolin tablets, we will consider reviews about this drug.
Reviews
This drug is deservedly considered one of the most effective in the treatment of allergic reactions. Patients report that the drug is of high quality and effective, and its cost is more than affordable. The main disadvantage that all patients note is that the drug has a sedative effect, which causes drowsiness.
We reviewed the instructions for use for Diazolin tablets for adults.
