The drug has an antioxidant effect. "Mexifin" is used to correct disorders in the body with alcoholism and drug addiction, as well as to eliminate various diseases of the central nervous system.
The drug has antihypoxic, as well as local anesthetic, nootropic, anti-anxiety and anticonvulsant effects. The same effect is exerted by its substitute Mexidol. The trade name for ethylmethylhydroxypyridine succinate is "Mexifin".
Issue form
A drug is produced in the form of a solution for intravenous and intramuscular use.
Ampoules are placed in the contour cells of five or ten pieces of 2 or 5 milliliters. Mexifin contains the following components:
- ethylmethylhydroxypyridine succinate;
- water.
Pharmacological actions
The drug has antihypoxic, as well as antioxidant, local anesthetic, nootropic and anticonvulsant effects. The drug belongs to the group of compounds of succinic acid and 3-hydroxypyridine.
According to the instructions, "Meksifin" acts as a free radical inhibitor. The main actions of the medication are:
- Increasing the activity of enzymes of the antioxidant system.
- Inhibition of the processes of oxidative degradation of lipids, which occurs, as a rule, under the influence of free radicals.
- Modulating effect on membrane-bound enzymes.
- Restoration of the functions and structure of membranes that are impaired in various pathological processes.
- Improve the transport of neurotransmitters, as well as neurotransmission and interconnection of brain structures.
- Increasing the concentration of dopamine in the brain.
For what diseases is the medicine used
According to the instructions, indications for the use of the drug "Mexifin" are the following conditions:
- Impaired cerebral microcirculation in acute course.
- Vegetovascular dystonia (a complex of functional lesions, which is based on a violation of the regulation of vascular tone by the autonomic nervous system).
- Dyscirculatory encephalopathy (a brain lesion that appears after a chronic slowly progressive disorder of the brain microcirculation of various origins).
- Cognitive impairment of atherosclerotic origin in the mild course (decrease in cognitive abilities compared to the higher premorbid level of the individual, which remains inwithin the average statistical age norm or slightly deviates from it).
"Mexifin" is also used for such ailments:
- Neurotic states (a psychogenic disease that appears under the influence of psycho-traumatic factors, subsequently violations of especially significant personality traits, manifested in the form of general neurotic clinical phenomena, as well as insomnia, migraine, various vegetative-visceral signs of a functional nature in the absence of psychotic phenomena).
- Acute neuroleptic intoxication.
- Withdrawal syndrome (a complex of pathological symptoms that occur in alcoholics when they refuse to drink alcohol).
- Ischemic heart disease (a pathological condition characterized by an absolute or relative impairment of myocardial blood supply due to damage to the coronary arteries).
- Acute myocardial infarction (source of ischemic myocardial necrosis, which develops as a result of acute impairment of coronary microcirculation).
Contraindications
According to the instructions for use, "Mexifin" is forbidden to take under the following conditions:
- Diseases of the kidneys or liver.
- Pregnancy.
- Children's age.
- Lactation.
- Individual intolerance to substances included in the preparation.
How to use the medicine
According to the instructions forapplication to Mexifin, it is known that the solution is administered intramuscularly or intravenously. Dosing is determined on an individual basis. The duration of the course depends on the severity of the disease and the effectiveness of the treatment.
Therapy should be started with 50-100 milligrams one to three times a day. Dosing is gradually increased until the pharmacological effect is reached. The maximum daily concentration of the drug is 800 milligrams per day.
When injecting "Mexifin" must first be diluted in physiological sodium chloride solution. Jet medicine is injected slowly over five to seven minutes; drip rate - sixty drops per minute.
Recommended scheme for using the drug:
- With dyscirculatory encephalopathy, the first two weeks of treatment, the drug is administered intravenously two to three times a day, 100 milligrams, the next fourteen days - 100 mg per day intramuscularly.
- In dyscirculatory encephalopathy, for preventive purposes, Mexifin therapy is carried out for two weeks, twice a day, 100 milligrams intramuscularly.
- In case of acute disorders of the microcirculation of the brain: the first four days, treatment should be carried out intravenously by drip, 200-300 milligrams, then injections are carried out intramuscularly three times a day, 100 milligrams. The duration of treatment varies from ten to fourteen days.
The dosage of "Meksifina", according to the instructions, under different conditions is as follows:
- Whenalcohol withdrawal syndrome, you must use the drug for seven days three times a day (100-200 milligrams intramuscularly or twice a day intravenously).
- For mild cognitive impairment, as well as for anxiety disorders and in people of retirement age, the medication is used for thirty days (100–300 milligrams intramuscularly).
- For neurotic disorders and vegetovascular dystonia: for two weeks (50-400 milligrams per day intramuscularly).
- In case of acute intoxication with neuroleptic drugs, treatment is carried out for two weeks (50–300 milligrams per day intravenously).
Pregnancy and Mexifin
When carrying a future baby, the appropriateness of using a therapeutic drug is determined by a medical specialist. The use of "Meksifina" is allowed only when absolutely necessary. During lactation, it is required to stop breastfeeding - replace milk with specialized mixtures for feeding a newborn.
Mexifin and alcohol
According to the instructions for use, it is known that the described drug can be administered eighteen hours before drinking alcohol (for men). A woman should take "Mexifin" a day before the feast. After taking alcohol, you can use the medication after eight hours, and for women - fourteen hours.
If the conditions are violated, the drug enhancesside effect of alcohol on the liver, possibly the occurrence of stomach ulcers. Less commonly, migraine occurs, as well as tinnitus and lethargy. In advanced situations, this combination leads to bleeding.
"Mexifin" is an excellent drug that helps fight the negative symptoms of a hangover. This fast-acting drug is highly effective and has antioxidant, antihypoxic and neuroprotective effects.
Adverse reactions
According to the instructions, "Mexifin" in ampoules can provoke the following negative effects:
- Xerostomia (insufficient salivation accompanied by increased dryness of the oral mucosa).
- Flatulence (a pathological condition of the body resulting from excessive gas formation and accumulation of gases in the gastrointestinal tract).
- Diarrhea (an illness in which frequent or single bowel movements occur, during which liquid stool is excreted).
- Nausea.
- Taste of metal in the mouth.
- Allergic reactions.
- Insomnia (a sleep disorder characterized by insufficient or poor quality sleep, or a combination of the two, over a significant period of time).
- Increased blood pressure (higher than normal blood pressure in a middle-aged person).
If you experience side effects, you should tell your doctor about it.
Analogues of "Meksifina"
The following medicines are considered to be drug substitutes:
- "Instenon".
- "Neurotropin".
- Metostabil.
- "Combilipen".
- "Borizol".
- "Mexidol".
- "Intellan".
- Rilutek.
- "Mexicor".
- "Keltikan".
- "Armadin".
- "Nycomex".
- "Antifront".
- "Medomexi".
- "Neurox".
- "Elfunat".
- "Glycised".
- "Hypoxen".
- "Mexiprim".
- "Trigamma".
- "Tenotin".
- "Astrox".
- "Mexidol".
- "Cytoflavin".
- "Cerecard".
- "Enerion".
- "Meksidant".
- "Glycine".
- "Cerecard".
According to the instructions, Mexifin should be kept away from light and moisture, at room temperature. Keep the drug away from children. Shelf life - three years. A prescription medication is dispensed.
"Mexifin" or "Mexidol"?
The spectrum of effects of both drugs is absolutely no different. Both drugs prevent the aging process of the body as a result of the suppression of free radicals. "Mexifin" and "Mexidol"have a positive effect on the performance of the myocardium, and also affect the metabolism. The main result of the use of both drugs is considered to be a strong reduction in the risk of acute vascular disease.
Considering the indications for use, composition, adverse reactions, it can be revealed that Mexifin or Mexidol is better. The second drug has a wider range of effects, it is produced in several dosage forms - tablets, solution. Therefore, it is prescribed much more often. "Meksifina" in tablets does not exist.
But the drug "Mexifin" contains absolutely no additives and preservatives, therefore it is suitable for the treatment of people who are prone to allergies of various etiologies. In any situation, what is best suited for the treatment of a particular disease, only a medical specialist should decide.
Both drugs activate metabolism and microcirculation of the brain. Thanks to their use, the quality of blood improves, degenerative processes in brain tissues are eliminated. "Mexifin" and "Mexidol" improve memory, as well as attention and well-being.
Reviews about Mexifin
Opinions about the drug are generally positive. Patients note that during therapy with this medication, the level of anxiety decreases, and brain function and sleep improve. In addition, the great advantage of "Mexifin" is its availability in pharmacies andgood tolerance.
There are also negative reviews about the medicine. This drug may cause side effects, usually drowsiness.
Medical workers characterize "Meksifin" only from the good side. According to doctors, the drug is one of the most successful products that are produced in Russia. The drug has established itself as an effective medication that helps reduce the severity of signs of chronic or acute disorders of the microcirculation of the brain.
