Complex edemas of soft tissues that are difficult to localize, provoking point disturbances in the blood supply system and accompanied by pain, are a rather serious challenge for the pharmacological industry. Injuries of this kind are most often the result of surgical and postoperative interventions or the result of mechanical damage to the musculoskeletal system, part of the brain and / or spinal cord (volumetric hematomas, complications of compression fractures in the form of progressive swelling, etc.).
Quality therapy and effective prevention of edematous-pain syndrome is the "responsibility" of diuretics, glucocorticoids, flavonoids, ergot alkaloids, as well as medicines obtained from the fruits of ordinary horse chestnut. In the latter case, of particular interest is Lysina Aescinat, whose analogues, despite the similarity of the pharmacological action algorithm, sometimes cannot provide the necessary therapeutic effect.
The reaction of the body to the active substance
"Lysina aescinat" instructions for useclassifies as a multifunctional angioprotector. The components of the drug, reacting with the cells of the body, reduce the likelihood of developing large-scale inflammation, extinguish the sensitivity of pain receptors and slow down the progress of swelling in the tissues (up to a complete stop of exudative processes).
This result is possible due to the inhibition of lysosomal hydrolases, which are responsible for the rate of breakdown of mucopolysaccharides inside the bloodstream and in adjacent connective tissues. Moderate hypoglycemic manifestations and a general increase in vascular tone against the background of normalization of their permeability is a natural result of the dosed use of this medication.
Indications for prescribing the drug
"Lysine aescinat" (the instruction presents it as one of the forms of the composite association of horse chestnut triterpene saponins) is prescribed if:
- diagnosed with swelling of the brain / spinal cord of severe and critical degree of development (including when the presence of intracranial hematomas with displacement is confirmed);
- detected local swelling of soft tissues that affect the functioning of the musculoskeletal system (the patient experiences acute pain during movement / physical exertion, and damaged areas of the body are supplied with blood in an atypical mode);
- suspicions regarding acute thrombophlebitis were justified (there is an imbalancevenous circulation of the legs, further aggravated by edematous-inflammatory processes).
"Lysina aescinate": instructions for use and recommended dosage
The use of the drug implies a slow intravenous administration (setting an intra-arterial drip is strictly prohibited). The optimal daily dose for adults is 5-10 ml of the drug diluted with 0.9% sodium chloride solution (NaCl volume - 15-50 ml). However, in cases of a real threat to the life of the patient (as a rule, with progressive cerebral edema), it is permissible to increase the daily norm to 20 ml of the active substance (two doses within 24 hours, 10 ml each). The maximum dose is 25 ml / day.
For children-patients "Lysine aescinat" the instruction predetermines to enter in such quantities:
- Child age 1-5 years: 0.22 mg per kilogram of body weight;
- age 5-10 years: 0.18mg/kg;
- age 10-15 years: 0.15mg/kg;
- Age 15-18: 0.12ml/kg.
Preparation of the active solution, that is, dilution of the drug with sodium chloride, should be done immediately before use. The total duration of therapy should not exceed 8 days (the course can be reduced to two days if the attending physician considers that the patient's condition has stabilized before the specified time).
Clinical study results
"Lysina aescinat" instructions for use are positioned as a drug that has passed clinical trials and has demonstrated high efficiency in the fight against edema of variousnature of origin. Thus, in particular, in patients with a traumatic brain tumor, after the administration of the drug through a dropper, a significant reduction in the area of inflammation was observed. Along the way, the structure of the edema also changed: undamaged areas ceased to shrink, which contributed to the acceleration of pressure stabilization inside the skull. It was also noted that timely injections of "Lysine aescinat", performed in the form of a smooth infusion with slow injection, often prevented the development of the above scenarios and had a positive effect on the patient's well-being.
Suppression of inflammatory reactions at the initial stage and prevention of bulk swelling is reflected in the stimulation of the functional activity of the brain, that is, in minimizing the regression of nerve endings.
Special Terms of Use
Despite the fact that the reviews of specialized specialists about the drug "Lysina aescinat" are predominantly positive, there is no reliable information regarding the reaction of the active components to the fetus during pregnancy (the situation is similar with breastfeeding newborns). Therefore, it is not recommended to prescribe a drug in such cases.
In addition, special attention should be paid to patients diagnosed with "hepatocholecystitis" - escinat plays the role of a natural catalyst for transaminases and can slightly load the liver. However, in the absence of other pathologies, this disease is not a reason to stop the drug.
Side effects and contraindications
In addition to pregnancy and lactation, the instructions for use impose the following prescription restrictions on the drug "Lysina aescinat":
- individual intolerance to components;
- acute renal failure;
- serious liver problems;
- internal bleeding (ulcers or other forms of erosion of organs and tissues).
Under the above conditions, allergic reactions to the drug are extremely rare. And yet they are not excluded:
- skin: itching, urticaria, the formation of bright "blush" on the face;
- nervous system: tremor alternating with convulsions, acute persistent headaches, fainting;
- GIT: nausea, sometimes diarrhea and vomiting;
- biliary system and liver: short-term increase in bilirubin and transaminase activity;
- blood vessels and heart: hypotension and hypertension, arrhythmia;
- respiratory organs: shortness of breath, severe dry cough.
Quite often, side effects are poorly expressed, which makes it difficult to diagnose allergies. For example, general weakness or fever may be perceived not as a result of an intravenous drug, but as a consequence of a cold.
Nature of interaction with other medicines
"Lysina aescinat" (patient reviews of this medicine, as a rule, come down to the topic of complications in the musculoskeletal system, since they cannot evaluate the therapeutic effect in case of brain injuries, due to the criticality of the situation)refers to alcohol-containing compounds. Therefore, it is necessary to select drugs for simultaneous use in course therapy with increased caution (alkaloids can neutralize active substances).
Contact of escinat with aminoglycosides is undesirable. The reason lies in the increased toxicity of the reagents. The presence of anticoagulants in the prescription makes it necessary to revise the dosage of the drug in the direction of reducing the daily norm. But the combination with analgesics and antimicrobial agents is going well (the anti-inflammatory properties of aescinate are enhanced against the background of the absence of additional stress on organs and systems).
Form of release and description
Being a representative of the group of angioprotectors, the drug "L-lysine aescinate", reviews of which are sometimes subjective and do not reflect the real picture of what is happening, is produced in the form of a clear, colorless solution. At the same time, 1 ml of liquid contains 0.001 g of the active substance. The role of auxiliary components is assigned to propylene glycol, ethyl alcohol and specially prepared (injection) water.
An overview of alternative drugs
The trade name of the described medicine is "Lysina aescinat".
Analogues similar in pharmacological action are presented below:
- "Furosemide" (tablets / solution) - the fight against edematous-pain syndrome in hereditary diseases of the cardiovascular system, the elimination of swelling onareas of the brain/spinal cord (hematomas of a mechanical nature of origin), stimulation of diuresis, etc.
- "Hypothiazid" (tablets) - for edema provoked by congenital heart failure, cirrhosis, hypertension.
- "Valusal" (tablets/capsules/cream/solution) - for localization and neutralization of musculoskeletal degenerative processes, relief of postoperative pain syndrome, etc.
"Lysina aescinat": reviews of doctors and patients
Edema of the interhemispheric tissues and swelling of the substance of the brain is evidence of a severe traumatic brain injury. According to experts, in such a situation, the structural displacement of cortical areas, which entails disability or death, is a matter of several hours, and sometimes minutes. To stabilize the situation, dehydration therapy is usually carried out. However, corticosteroids, saluretics and osmotics - the most common "tools" of influence - often provoke side effects or do not justify the hopes placed on them at all.
According to practicing neurosurgeons, Lysina Aescinat should become an alternative drug (instructions, expert reviews and important nuances regarding the method of using the drug are given above). Unlike analogues, the injection solution does not cause critical complications and accurately hits the target, thereby ensuring control of the dynamics of swelling (minimizes the amount of swelling of the brain/spinal cord).
