Dicynone tablets are a hemostatic drug used to stop bleeding of various kinds, with hemorrhages and diseases of the retina, too strong menstruation. The drug is available in the form of tablets and solution for drip infusions and intramuscular injections, produced in Slovenia.
Let's take a closer look at the Dicinon tablets. From what they are interesting to many.
Form and composition
The medicine is produced in two forms: injection solution and tablets. The latter are painted almost white or white, their dosage is 0.05 or 0.25 grams, they are in a cell package. The carton pack contains one hundred Dicinone tablets of 250 mg or 50 mg (children's dosage) of the main active ingredient of etamsylate, as well as excipients, including magnesium stearate, lactose, anhydrous citric acid, povidone K25, corn starch.
Pharmacological action
Dicynone tabletsare hemostatic. The hemostatic effect is based on the acceleration of the initial stage of hemostasis - there is a stimulation of the interaction between platelets and endothelium. Dicinon increases platelet adhesion to disturbed vascular walls, especially to capillaries, protects the endothelium, reduces the permeability of capillary walls, inhibits prostaglandin biosynthesis, which causes vasodilation and disaggregation, and therefore increases capillary permeability. Due to the influence of the drug, bleeding is greatly reduced, blood loss is reduced.
The drug has no vasoconstrictive signs. It does not affect either the normal blood coagulation procedure or fibrinolysis, so it does not have a thrombogenic effect. The drug inhibits the effects of both histamine and hyaluronidase, thereby reducing high capillary permeability in various diseases, for example, in inflammatory processes. "Dicynone" significantly reduces the frequency of bleeding inside the ventricles of the brain in babies with low birth weight. Infants whose mothers took the drug had lower brain hemorrhages than those whose mothers did not receive the drug.
How fast do Dicynon tablets work for bleeding?
Pharmacokinetics
During oral administration, the active substance is absorbed at a high rate from the gastrointestinal tract. When 50 milligrams of etamsylate is taken orally, its maximum plasma level is reached.in four hours. Its half-life from plasma is 3.7 hours. Approximately 72% of the dose consumed during the day is excreted in the urine.
The active substance is able to penetrate breast milk and the placenta barrier.
So, Dicinon tablets - what are they from?
Indications for use
"Dicynone" in tablets is prescribed in the following cases:
- To prevent and stop bleeding.
- With parenchymal capillary bleeding (traumatic, postoperative, intestinal, pulmonary, renal, after dental procedures).
- In case of bleeding of a secondary nature against the background of hypocoagulation, hematuria, thrombocytopenia, thrombocytopathy with hemorrhages inside the skull, drug-induced bleeding, hemorrhagic vasculitis, hemorrhagic diathesis.
- Recurrent retinal hemorrhage, Werlhof's disease, diabetic retinopathy.
- Dicynone tablets are often prescribed for menstruation.
Contraindications
Among the contraindications are:
- excessive sensitivity to the active ingredient of the drug - etamsylate, or any excipient;
- high sensitivity to sodium sulfite history;
- children's hemoblastosis (osteosarcoma, myeloid and lymphatic leukemia);
- acute porphyria;
- thromboembolism and thrombosis;
- breastfeeding.
Pregnancy and breastfeedingfeeding
Exposure of etamsylate to women during pregnancy. Etamsylat crosses the placental barrier, so its use is contraindicated in patients in the first trimester. Clinical use during pregnancy is not relevant for this indication.
The active substance passes into breast milk. While taking the drug, you should stop breastfeeding your baby.
Consider the instructions for use for Dicynon tablets for bleeding.
Method of application and dosage specifics
Use in children over 14 and adults:
- Pre-surgery: 1-2 tablets of 250 to 500 milligrams within an hour before surgery.
- After surgery: every 4-6 hours until there is a chance of bleeding - 1-2 tablets of the drug at a dosage of 250. Instructions for use for Dicinon tablets indicate that a dosage of 500 mg can also be used.
- Internal Diseases: General advice is to take two tablets three times a day with meals with a little water.
- With metro- and menorrhagia, in gynecology: drink 2 tablets of the drug three times a day with meals with a little water; therapy continues for ten days, five days before the expected bleeding.
For the treatment of children over six years of age:
- Dose during the day is 10-15 milligrams per kilogram of body weight, divided into three to four doses. The duration of use of the drug is determined by the volume of blood loss and ranges from three daysup to two weeks from the time bleeding stops in any patient.
- Take the pills during or after meals. Special categories of patients.
There are no studies on the treatment of patients with impaired renal or hepatic function. Thus, Dicinon should be used with caution in the treatment of these groups of patients.
If a dose is missed, do not take a double dose to make up for the missed dose.
Side effects
The following undesirable effects from Dicinon tablets may occur: dizziness, headache, transient skin disorders, hyperemia, epigastric pain, nausea, paresthesia of the lower extremities. These reactions are transient and not dangerous. There is evidence that in children with acute myelo- and lymphocytic leukemia, osteosarcoma, an active substance that acts to prevent blood loss caused severe leukopenia. According to a number of sources, the use of the drug for the treatment of children is not recommended.
There is evidence that women who took Dicinon before the intervention of the surgeon noted thrombosis on the cervix after surgery. But recent tests have not confirmed these data.
Specific application
Dicynone tablets for uterine bleeding should be prescribed with caution if patients have a history of thromboembolism or thrombosis, excessive sensitivity to drugs. Dicinone contains sulfites, and therefore you need to be careful whenits administration to patients with allergies or bronchial asthma. Before starting therapy, it should be borne in mind that the drug is not effective in treating people with thrombocytopenia.
Due to the fact that little patients who were prescribed Dicinon to prevent blood loss in myeloid and lymphoblastic leukemia, osteosarcoma, worsened, a number of experts believe that the drug is contraindicated in such situations.
This medicine should not be given to patients with rare genetic diseases such as galactose-glucose malabsorption or lactase deficiency.
The active substance does not affect a person's ability to drive or use complex machinery.
If you have an intolerance to carbohydrates, you should consult a specialist before taking the medicine.
Analogues
Dicinon has several analogues.
- "Tranexam" - this drug is a hemostatic agent. It is used for various bleeding, including postoperative, during pregnancy, with oncological diseases and liver pathologies. This analogue is characterized by anti-inflammatory and anti-allergic effects. It has contraindications and some side effects. Its active ingredient is tranexamic acid.
- "Etamzilat" - a drug used for the treatment and prevention of capillary bleeding, in gynecological and dentalsphere, after surgical interventions of any complexity, with pulmonary and intestinal bleeding. This analogue has its own contraindications, after its use, side effects may occur.
- "Vikasol" is a water-soluble synthetic analogue of vitamin K. The drug is used in surgical and gynecological practice to treat and prevent various bleeding. This analogue is approved for use in pediatrics and during pregnancy. Its use can cause side effects, which are especially pronounced against the background of an overdose. There are contraindications. The drug is not effective in Werlhof's disease and hemophilia.
The price of Dicinon tablets will be presented below.
Special Instructions
If the drug is prescribed to patients with a history of thrombosis and thromboembolism, then you need to be careful. In case of overdose, hemorrhagic complications occur, during the treatment of which specific antidotes are required. During pregnancy, Dicinon is also prescribed with caution.
The drug is also used in veterinary medicine, for example, for the treatment of cats.
Reviews on Dicinon tablets
The drug "Dicinon" is widely used for the treatment and prevention of bleeding during many extensive surgical manipulations and minimally invasive interventions. There are a lot of positive reviews from urologists, ophthalmologists, dentists and their patients.
"Dicinon" is used in the gynecological field with tooheavy menstruation that causes anemia, and complications after the introduction of an intrauterine device. Can be used to treat pregnant women.
The drug comes in a variety of forms, so it can be used for emergency stopping the flow of blood in an emergency or emergency setting, and for treatment with pills.
"Dicinon" is well tolerated by patients, does not cause negative consequences of use. Has a small number of contraindications. Given the duration of the course, the cost of the drug is adequate.
Price of Dicynon tablets
The cost of the drug in tablets is about 400 rubles. It depends on the region and pharmacy chain.
Conclusions
Dicynone is a hemostatic drug. It shows signs of an angioprotector.
Used to reduce bleeding in defects in clotting disorders and platelet function.
Used to reduce blood loss during surgical interventions. It stimulates the formation of platelets, increases their aggregation and adhesion. It is a component of the treatment of various kinds of hemorrhagic syndromes. It should be used with caution in patients with a history of thromboembolism and thrombosis. Strictly prescribed by a specialist, it is prescribed for pregnant women.
