Acne (or in other words - blackheads) is an inflammatory skin disease that is caused by changes in pilosebatory structures.
The causes of this disease are still unknown. In the mechanism of their development, the main role is played by seborrhea, which reduces the bactericidal effect of skin fat and leads to the reproduction of coccal flora.
Today there are many different drugs that effectively treat acne. One of them is the drug "Duak" (gel). The price, reviews of the external agent and the method of its use are presented below.
Shape, packaging, composition
Gel "Duak" goes on sale in tubes of 15 g. It contains active ingredients such as benzoyl peroxide and clindamycin. In addition, the composition of the external agent includes carbomer, disodium lauryl sulfosuccinate, dimethicone, glycerin, disodium edetate, colloidal aqueous silicon dioxide, sodium hydroxide, poloxamer, purified water.
PharmacologicalFeatures
Duak Gel is an external remedy used to treat acne. Its effectiveness is entirely due to the composition.
Clindamycin is a lincosamide antibiotic. It has a bacteriostatic effect against a wide range of anaerobic microorganisms and gram-positive aerobic bacteria.
By binding to the 23S subunit of the ribosome (bacterial), lincosamides, more specifically clindamycin, inhibits the early stages of protein synthesis. This component has a predominantly bacteriostatic effect. Although its high concentrations against susceptible microorganisms can also have a bactericidal effect.
Clindamycin's activity has been clinically proven in the treatment of comedones in people with acne. After applying this substance, the percentage of free fatty acids located on the surface of the skin decreased from 14 to 1.
What other properties are inherent in the drug "Duak"? The gel, the price of which is indicated below, contains a component such as benzoyl peroxide. It has a keratolytic effect (very mild) against comedones at any stage of their development.
This substance is oxidizing. It has bactericidal activity against Propionibacteium acnes, which is the cause of acne vulgaris. Also, this component is a sebostatic. It is good at counteracting the excessive sebum production associated with acne.
Adding this ingredient to Duak gel significantly reduces the potential for microbial growth,resistant to clindamycin.
Kinetic properties
Is the drug "Duak" (gel) absorbed? The instruction reports that the absorption of clindamycin through the skin is minimal. The presence of benzoyl peroxide in the composition of the drug does not have any effect on the absorption of the aforementioned substance.
Radiolabeled studies have shown that benzoyl peroxide is absorbed through the skin only after it has been converted to benzoic acid.
Indications
In what cases is the drug "Duak" used? Acne gel, judging by the reviews, helps very well. It is also used topically to treat acne.
Contraindications
Like any medical drug, Duak gel has contraindications. These include hypersensitivity, as well as the period of breastfeeding and age up to 12 years.
Duak preparation (gel): instructions
This medication is for external use only in adults and children over 12 years of age.
The gel is applied once a day (preferably in the evening) to the affected areas of the skin after they are thoroughly washed with water and cleansed. Apply the drug carefully (thin layer) until it is completely absorbed.
Treatment with this remedy should not exceed 12 weeks of continuous use.
Side effects
Gel "Duak" can cause side effects such as skin peeling, erythema, itching and dryness at the site of applicationmedicines, exacerbation of the disease.
Sometimes contact dermatitis and paresthesia may occur with its use.
With prolonged use of the drug, the development of bacterial resistance to clindamycin is possible. This may well be the cause of superinfection.
Also, Duak gel contributes to the development of allergic reactions.
Drug Interactions
Combining the gel with topical antibiotics, medical, conventional or abrasive soaps and cosmetics that have a drying effect, as well as with preparations with a high concentration of astringents and alcohol, the patient may experience a cumulative irritant effect.
Duac should be avoided at the same time as topical acne medications containing vitamin A derivatives.
Special Recommendations
Treatment with this drug should be used with caution in people with ulcerative colitis, regional enteritis and atopic dermatitis.
If diarrhea or abdominal cramps occur, treatment with Duak should be discontinued.
Duak drug (gel): reviews and cost
The price of this drug is quite high. It is about 550-650 rubles. Many patients are unhappy with this cost of the gel. Although experts say that this drug is one of the cheapest and most effective. It clears up blemishes very quickly, leaving skin clear and smooth.
The disadvantages of this tool include itinaccessibility (not available in all pharmacies) and the presence of a large number of side effects.
