The discovery of the antibacterial action of molds, from which penicillin was made, has become a real revolution in medicine. But over time, the pathogenic microflora adapted to the action of this drug. This forced scientists to develop synthetic analogues of penicillin, one of which was Flemoxin Solutab. Instructions, description of the drug will help to avoid its negative effects on the body and side effects.
The active substance of the drug
The composition of one tablet of "Flemoxin" includes acid-resistant amoxicillin in the form of amoxicillin trihydrate, 125, 250, 500 and 1000 milligrams. This substance has a strong bactericidal effect. Amoxicillin preparations are also used against gram-positive and gram-negative bacteria. Sometimes used to combat pathogens of intestinal infections. But in the latter case, it is less effective.
Dose form, composition
What is "Flemoxin Solutab" (500 mg)? Instructions for use describe the preparation of various dosages (125 and 250, 1000 and 500 mg) as oval tablets with a light yellow color. Each tablet has a company logo and a number on one side, and a risk mark on the other.
In the manufacture of the drug, excipients such as single-crystal cellulose, vanillin, dispersible cellulose, magnesium stearate, crospovidone, saccharin, flavors were used.
The drug is intended for systemic use and is a broad-spectrum medicine.
Pharmacological action on the body
How does "Flemoxin Solutab" (Flemoxin Solutab) affect the body? The instruction says that after taking the active ingredient of the drug - amoxicillin - almost everything is absorbed in the shortest possible time (almost 93 percent). Moreover, the absorption of the drug is in no way connected with food intake.
In plasma, the maximum amount of the drug is detected one to two hours after ingestion. After entering the digestive tract of the drug "Flemoxin Solutab 500 mg" (instructions for use confirms this), the maximum concentration of amoxicillin is noted by researchers after 2 hours. This maximum is 5 µg/ml. If, for any reason, the dose of a medical product is reduced or increased, then itsconcentration, respectively, decreases or increases.
Twenty percent of the substance binds to plasma proteins. The therapeutic effect is achieved almost always, since the drug penetrates perfectly into the intraocular fluid, bones, mucous membranes, and sputum. Amoxicillin enters the bile in two or even four times more than in the plasma. In the umbilical cord and amniotic substance, twenty-five to thirty percent of flemoxin is found from its concentration in the blood of a pregnant woman.
Poor penetration of the active substance through the blood-brain barrier was noted: in the cerebrospinal fluid, its amount does not exceed twenty percent when consumed.
The drug is excreted by the kidneys. Eighty percent of the active substance is processed by tubular excretion, the remaining twenty are filtered by the glomeruli. He althy kidneys half-remove amoxicillin for an hour and a half. In children under six months, the elimination half-life is three to four hours. Liver dysfunction does not affect the half-life of the drug.
Pharmacodynamics
"Flemoxin Solutab" (tab. 500 mg 20 pcs., Like other dosages of the drug) is an acid-resistant bactericidal antibacterial agent with a wide spectrum of action. It belongs to the group of semi-synthetic penicillins.
Deadly affects many gram-negative and gram-positive microorganisms, such as most varieties of streptococci, clostridia, staphylococci, helicobacteria, Escherichia coli, proteus, salmonella, cholera vibrio.
Whendrug is prescribed
In what cases is Flemoxin Solutab (500 mg) prescribed? The instructions for use confirm (this also applies to other dosages of the drug) that the drug is effective:
- with infectious processes in the respiratory tract;
- for infectious diseases of the genitourinary organs;
- for the treatment of gastrointestinal infections;
- for skin infections and infectious processes in soft tissues.
Who should not use the drug
"Flemoxin Solutab" (Table 500mg n20), the instruction confirms this, has not only advantages, it also has its own contraindications. This is also true for other dosages of the drug. The drug is not prescribed or prescribed with great caution in such cases:
- if the patient had allergic reactions to it or other antibiotics of this series;
- patients with lymphocytic leukemia or infectious mononucleosis;
- children under six years of age are prescribed with caution in the form of a suspension;
- for kidney failure;
- in diseases of the gastrointestinal tract, especially due to the use of antibiotics;
- pregnant women or during breastfeeding are prescribed if the need to use the remedy outweighs the possible risks.
Adult use of medication
Adults and children who have reached ten years and forty kilograms of weight are most often prescribed "Flemoxin Solutab" 500 mg. Instructions for use states the need to take the drug three times a day. If the infectious process is difficult and with complications, allow a dosage of 0.75 to 1 gram 3 times a day. Gonorrhea without complications in adults requires the appointment of three grams of the drug at a time. Women are given the same dose again.
Infectious diseases of the stomach, intestines and biliary tract, as well as gynecological diseases of an infectious nature are treated with a three-time dose in a dosage of one and a half to two grams or four times a day - one and a half grams at a time.
Adults with leptospirosis are treated with a four-fold intake of Flemoxin Solutaba, 0.5-0.7 grams each. Treatment should be continued for six to twelve days.
Carrying salmonella requires three doses of one and a half to two grams over two to four weeks.
To avoid endocarditis during minor surgery, prescribe three to four grams of the drug an hour before surgery. If there is a need to re-use the drug, then it is prescribed after eight to nine hours in the same dosage.
In case of kidney dysfunction, the interval between doses should be up to 12 hours. For more serious violations, reduce the dose. If the patient has anuria, the maximum dose should not exceed two grams.
"Flemoxin Solutab" for children - dosage
In most cases, this drug is used as a suspension for children. How is Flemoxin Solutab used for children? Dosage and administration depends on the age, weight of the patient, the severity of the infectious process. If the child is from five to ten years old, the drug is prescribed at a dose of 250 mg, from two to five years old - 125 mg, up to two years old - 200 mg. In severe cases of the disease, 60 mg / kg is used three times a day. The course of treatment with this medicine is six to twelve days.
For newborns and premature babies, the dose is reduced or the interval between doses is increased. For the prevention of endocarditis during minor surgical operations, one and a half to two grams are prescribed an hour before the procedure. If necessary, re-appointed eight to nine hours after surgery.
What side effects may be accompanied by the use of the drug
Whatever the perfect medicine, no matter what natural ingredients it is made from, there are risks of side effects that can affect the patient's condition.
- Allergic reactions can give any dosage of the drug, including "Flemoxin Solutab" 500 mg 20, the price, the instructions of which are almost the same in all dosage forms used. There may also be redness of the skin, rashes in the form of erythema, angioedema.
- Rarely, serum sickness and anaphylactic shock, fever, eosinophilia, arthralgia.
- Soon the part of the digestive organs, nausea, dysbacteriosis, diarrhea, vomiting, changes in taste sensations, pseudomembranous enterocolitis are possible. May increase ALT and AST.
- Changes in the nervous system: there may be sleep disturbances, anxiety, depressive phenomena, pain and dizziness, episyndrome, impaired consciousness, ataxia.
- Laboratory parameters are changing: the number of leukocytes, erythrocytes decreases, hemoglobin decreases, neutropenia is noted.
- Possible respiratory failure, increased heart rate, nephritis, vaginal candidiasis, even more infection (in patients with chronic processes and reduced immunity).
- Overdose of the drug is manifested in the form of diarrhea, vomiting and nausea, as a result of which there may be a violation of the water and electrolyte balance. Gastric lavage, saline laxatives, activated charcoal, and sometimes hemodialysis are prescribed.
"Flemoxin Solutab": reviews, analogues, application
This drug is rated by patients as very effective and relatively safe. It is bioavailable, so the effect of it is very quickly manifested. After the start of treatment, the condition of adults and children improves during the first day. Depending on the dosage and purpose, "Flemoxin Solutab" is very quickly absorbed into the blood. Its action lasts for eight hours. In this case, the concentration of the substance is noted 15 minutes after use.
According to experts, this antibiotic is one of the safest for children. It has been used since earlychildhood by doctor's prescription.
This drug has many synonyms, that is, drugs that are made on the basis of amoxicillin. But there are also some drugs with a different active ingredient, but used for the same he alth problems as Flemoxin Solutab. Such drugs are called analogues of the above. The active ingredients in them are also antibiotics, semi-synthetic penicillins. They are used for sepsis, abscesses, infections of the upper respiratory tract and respiratory tract, urinary tract, skin, gastrointestinal tract, soft tissues, and so on.
Such analogues of the drug include:
- "Azlocillin" - the active ingredient is azlocillin.
- "Ampik" - acts with the help of ampicillin.
- "Geopen" - the main substance carbenicillin.
- "Isipen" - the active substance piperacillin.
- "Penglob" - affects the body with the help of bacampicillin.
- "Flucloxacillin" - the active ingredient has the same name.
Analogues of the drug, especially the antibiotic, should be discussed with your doctor. This is very important, since only a specialist determines the dosage, nature of treatment and duration. He also knows better which active ingredient is suitable in a particular case.
Features of the use of the drug, price
For most patients, indications for the drug "Flemoxin Solutab", instructions for use,price, description, application features.
If drug treatment is carried out in courses, the function of the kidneys, liver, hematopoiesis should be monitored.
If the patient is sensitive to the penicillin group, cross-allergic manifestations may occur.
If mild diarrhea occurs during treatment, drugs that reduce intestinal motility should be avoided. If you experience severe diarrhea, you should seek advice from a medical institution. After the disappearance of clinical manifestations, it is recommended to take Flemoxin Solutab for another three to four days.
The drug may reduce the contraceptive effect of oral contraceptives, so you should take care of additional contraception while taking it. It also does not mix well with aminoglycosides, indirect anticoagulants, methotrexate, digoxin, alopurinol, diuretics, oxyphenbutazone.
Before use, it is important to familiarize yourself with the features of the use of the drug "Flemoxin Solutab". Instructions for use, reviews will help to avoid unwanted consequences.
Prices for a drug in different cities range from 176 rubles (in Nizhny Novgorod) to 228 rubles (in Novosibirsk). In the capital, "Flemoxin Solutab" can be purchased at a price of 191 rubles. In St. Petersburg, it costs an average of 184 rubles.
Do not forget that the instruction for the use of the drug "Flemoxin Solutab" is mainly compiled for the doctor. And only he can prescribe or cancel the drug. Avoid self-medication!
