The term "human chorionic gonadotropin" refers to a hormonal substance that can be found in the female placenta. In the blood of males, it is also present, but in meager concentrations. Currently, a drug under the trade name Chorionic Gonadotropin is being produced on the pharmaceutical market. It is a lyophilisate for solution for injection. As a rule, the drug is prescribed as a stimulating infertility treatment for both women and men.
Indications
Chorionic gonadotropin is a hormone designed to maintain the corpus luteum during pregnancy. Due to this, this female endocrine gland gets the opportunity to produce progesterone during the first 3 months of bearing a child. This hormone, in itsturn, contributes to the creation of a membrane of blood vessels in the uterus, due to which the developing fetus is successfully retained in it. In addition, human chorionic gonadotropin repels maternal cells produced by the defense system, thereby protecting the unborn child.
The most common source of the hormone is female urine. Some manufacturers collect the urine of pregnant women for subsequent extraction of human chorionic gonadotropin. In the future, the substance is used in the creation of drugs effective against infertility.
In addition, in women, the following diseases and conditions are indications for the use of the drug:
- Hypofunction of the gonads associated with disruption of the pituitary gland and hypothalamus.
- Dysmenorrhea. This term refers to pain in the abdomen, which are the result of spasms in the uterus during menstrual bleeding.
- Ovarian dysfunction. This is a pathology characterized by a violation of the work of this paired organ. In particular, hormonal function is suppressed.
- Anovulatory infertility. This is the inability to conceive a child due to the fact that the female body does not release the egg into the fallopian tube.
- Lack of corpus luteum. This is a pathological condition in which progesterone is produced in an amount insufficient to attach a fertilized egg to the endometrium and ensure its normal development.
According to the instructions, "Chorionic gonadotropin" is prescribed and with successfulthe onset of pregnancy, and during lactation. Its introduction is advisable only in case of insufficiency of the luteal phase. In the presence of this pathological condition, the active substance enhances the production of progesterone, which, in turn, has a beneficial effect on the state of the endometrium. If pregnancy and lactation are normal, the introduction of a solution containing hCG (chorionic gonadotropin) is not advisable.
The hormone also performs an important function in the male body. It is designed to normalize testosterone synthesis by the testicles. For men, chorionic gonadotropin is important during puberty and during hormone replacement therapy. The substance also controls spermatogenesis.
Indications for the administration of the drug for men:
- Hypogenitalism. This term refers to the insufficient development of the gonads or a significant deterioration in their functioning.
- Eunuchoidism. This is a disease in which there is a disproportion of the skeleton or a significant increase in body weight. The course of the disease is accompanied by inhibition of the functions of the gonads.
- Testicular hypoplasia. This is an underdevelopment of the male gonads, resulting in a decrease in the size of the testicles.
- Cryptorchism. This is a congenital disease in which the testicles do not descend into the scrotum.
- Adiposogenital syndrome. This is a pathological condition of a neuroendocrine nature, which has signs of underdevelopment of the gonads andobesity.
- Pituitary nanism. Another name for the disease is dwarfism (delayed physical development and growth).
- Sexual infantilism. This is a disorder in which the normal development of the reproductive system stops, and the formation of sexuality is inhibited.
- Oligoastenospermia. This is a decrease in the number of active germ cells.
- Azoospermia. This is a disease in which there are no active sex cells in the ejaculate.
Thus, the drug "Chorionic gonadotropin" is prescribed for both women and men. The active substance stimulates ovulation and spermatogenesis, has a therapeutic effect on various diseases of the reproductive system, and is also responsible for the development of the organs of the reproductive system.
Composition
The active ingredient of the drug is chorionic gonadotropin (1000 IU, 1500 IU, 500 IU and 5000 IU). Mannitol is used as an excipient. It is a six-hydric alcohol from the group of sugars.
The solvent is represented by sodium chloride and water for injection. 1 ampoule contains 1 ml of liquid.
Issue form
The drug is sold as a lyophilizate (dry powder) packaged in 5 ml vials. Each of them contains 500, 1000, 1500 or 5000 units of human chorionic gonadotropin.
The solvent for the powder is poured into 1 ml ampoules. Then the product is placed in secondary packaging - cardboard boxes. Each contains 5 dry powder vials and 5 solvent ampoules.
Contraindications
Chorionic Gonadotropin (1000 IU, 500 IU, 1500 IU or 5000 IU) is not prescribed for men and women with the following diseases and conditions:
- Hypersensitivity to one or more components of the drug.
- Pituitary tumors (both malignant and benign).
- ovarian cancer.
- Neoplasms on the gonads of a hormonally active nature.
- Early menopause.
- Absence of gonads (this can be either congenital or acquired pathology).
- Thrombophlebitis.
- Hyperprolactinemia.
- Adrenal insufficiency.
- Hypothyroidism.
"Horionic gonadotropin" (1000, 500, 1500, 5000 IU) is prescribed with caution to adolescents, as well as people suffering from frequent episodes of migraine, arterial hypertension, bronchial asthma, coronary heart disease and chronic renal failure.
In the course of an individual conversation with the attending physician, the list of contraindications can be expanded.
Method of application and dosing regimen
According to the instructions "Horionic gonadotropin" (1000, 1500, 500, 5000 IU) is intended for intramuscular injection. Injections are recommended to be carried out in a medical institution, but it is allowed to carry them out independently at home or in any other conditions comfortable for the patient.
Algorithm for intramuscularintroduction of "Horionic Gonadotropin" (1000, 500, 1500, 5000 IU):
- Initially, you need to prepare all the materials and tools that you need. These include: a drug solution (a lyophilisate mixed with a liquid from an ampoule), a sterile disposable syringe, medical alcohol or special wipes soaked in it (they can be replaced with ordinary cotton wool). Before handling, wash your hands thoroughly with soap and water.
- Then you need to choose the injection site. It can be the anterior thigh muscle or the gluteus maximus. The latter is the most developed. In addition, with the introduction of the drug into the anterior thigh muscle, the risk of various complications is higher (due to incorrect injection). In this regard, it is recommended to choose the gluteal.
- It is necessary to calculate the injection site. To do this, the gluteal muscle must be visually divided into 4 parts. The outer upper zone is the outer quadrant. The desired point is exactly in the middle of it. The introduction of the drug into this area is a guarantee that the needle does not touch the blood vessels, nerves or bone tissue.
- Open the syringe, fill it with the required amount of medicine. Then it is important to release the accumulated air from the medical device. Put the syringe on a clean tray, after closing it with a cap.
- Position yourself in front of a mirror in such a way that you can see your own buttock and the intended injection site. Bare this area. Transfer the weight to the other leg so that the necessary part of the body is relaxed as much as possible.
- Medical tissue orwith a piece of cotton soaked in alcohol, wipe the injection site. Take the syringe vertically in your hand, remove the cap and bring it to the buttock.
- With a quick movement, make an injection into the muscle so that the length of the open section of the needle above the skin is about 1 cm. Slowly press the plunger until the medicine runs out of the syringe.
- Sharply pull out the needle and apply cotton wool or an alcohol wipe to the injection site. Hold until the blood stops completely. The injection site is also recommended to be massaged. This will help to avoid seals and promote good absorption of the medicine.
The duration of the course and the dosage of Chorionic Gonadotropin (1500 IU, 500 IU, 1000 IU, 5000 IU) are determined by the attending physician on an individual basis. Unless the specialist has indicated otherwise, you must follow the standard recommendations:
- For men, the drug is administered twice or thrice a week. The course of treatment is 28 days. Then you need to take a break for 4 weeks. After that, the course must be repeated. There are 3 or 6 of them in total for 6 months or 1 year. If you enter "Chorionic gonadotropin" (1500, 500, 1000 or 5000 IU) without interruption and for a long time, the risk of antibody formation and dysfunction of the pituitary gland will significantly increase.
- The method of application for anovulation, the course of which is accompanied by normal maturation of the follicles, is as follows. The course of treatment should be started from the 10th or 12th day of the menstrual cycle twice or thrice a day at a dosage of 3000 IU. Then you needtake a break for 2 or 3 days. It is also allowed to administer the drug at a dosage of 1500 units 6 or 7 times a day.
- Use for pituitary dwarfism and sexual infantilism as follows. Chorionic gonadotropin (5000, 1500, 1000, 500) is administered 1 or 2 times a week at a dosage of up to 1000 IU. Course duration - 1-2 months. If necessary, it can be repeated.
- To induce ovulation, the drug is administered once at a dosage of 5000-10,000 IU. A similar pattern should be followed when carrying out additional reproductive activities.
- In case of pituitary insufficiency, it is advisable to start treatment only after preliminary follicle-stimulating therapy.
Often, the drug is prescribed to men for diagnostic purposes. In this case, the agent must be administered for 5 days at a dosage of 1500 or 3000 IU.
In children, treatment with Chorionic Gonadotropin is most effective until they reach the age of 10 years. The dosage regimen and the duration of the course of therapy are determined by the pediatrician on the basis of the existing disease, its severity, as well as the individual characteristics of the child's he alth. In the absence of recommendations from a specialist, it is necessary to follow the standard treatment regimen. According to the instructions for children, the drug must be administered twice a week for 1-1.5 months at a dosage of 1000 or 1500 IU.
Side effects
According to reviews, Chorionic Gonadotropin is well tolerated by most patients. However, the risk of adverse reactions remains.
To theminclude:
- Headache.
- Painful sensations, hyperemia at the injection site.
- Skin reactions.
- Fast onset of feelings of fatigue.
- Psycho-emotional instability.
- Inexplicable feeling of anxiety.
- Depression.
- Pituitary dysfunction.
In addition, men may additionally experience the following side effects:
- Swelling of the extremities.
- Retention of urination.
- High degree of nipple sensitivity.
- Increase in testicular size.
Against the background of long-term use, degenerative changes in the sex glands may occur. There is also a risk of developing atrophy of the seminiferous tubules and a decrease in the number of spermatozoa in the ejaculate.
Overdose
This condition may occur when taking the drug in an amount significantly exceeding the maximum allowable rate.
The following symptoms are alarming:
- pain in the abdomen;
- feeling of tension in the same area;
- vomit;
- shortness of breath;
- diarrhea.
In women with an overdose of Chorionic Gonadotropin, cysts form on the ovaries, which can burst at any time. In addition, fluid may begin to accumulate in the abdominal and pleural cavities.
The drug's antidote is unknown. Overdose treatment involves symptomatic therapy.
Analogues
Currently, several types of drugs are sold on the pharmaceutical market, the active component of which is human chorionic gonadotropin.
The most widely used drug analogues:
- "Prerotten". It is also a lyophilisate for solution preparation. The list of indications is identical to Chorionic Gonadotropin, but the drug has significantly more side effects.
- "Profazi". Available in two dosages - 2000 and 5000 IU. The tool has the same indications, while the list of restrictions is wider.
- "Horagon". The lyophilisate is sold complete with a solvent at a dosage of 1500 and 5000 IU. Among all analogues, it has the most impressive list of contraindications.
- "Choral". Instructions for use are identical to Chorionic Gonadotropin.
- "Ecostimulin". Available in the form of a lyophilisate for the preparation of a solution intended for both intramuscular and subcutaneous administration.
If, for any reason, the patient wishes to purchase an analogue of the drug, it is necessary to obtain the permission of the attending physician. This is due to the fact that each medication has certain contraindications, different dosages and treatment regimens.
Reviews
According to the opinions of patients, Chorionic Gonadotropin is well tolerated by most people. At the same time, the tool has a high degree of effectiveness.
Doctors most often prescribe Chorionic Gonadotropin to their patients due to the fact that the drug in a short timehelps to cope with the existing pathology or significantly improve its course. In addition, you can buy it at almost any pharmacy.
In closing
Chorionic gonadotropin is a hormone found in the female placenta. At the same time, manufacturers most often excrete the substance from the urine of pregnant women.
The drug "Chorionic gonadotropin" is intended for the treatment of disorders of the reproductive system in both women and men. The drug is administered intramuscularly in the dosage indicated by the doctor. In the absence of specialist recommendations, the standard treatment regimen should be followed.
