"Eliquis" - a drug manufactured in the USA, is a selective inhibitor of factor Xa blood clotting. Due to the relatively high price, people are often forced to look for an analogue. Eliquis has several.
"Eliquis" - instructions for use
The active ingredient in the composition of the drug is apixaban. Available in the form of tablets of 2, 5 and 5 mg, 20 or 60 pieces per pack. The mechanism of its action on the body is to slow down the activity of the blood coagulation factor. Indicated for use for the prevention of venous thromboembolism after prosthetic knee or hip joints. The drug is used under the strict supervision of a specialist, as there is a risk of bleeding. This is especially true for patients with bleeding disorders, peptic ulcers of the gastrointestinal tract, arterial hypertension, bacterial endocarditis, hemorrhagic stroke.
Also at risk are persons who have undergone surgery on the brain or spinal cord, ophthalmic surgery. Contraindications: allergic reactions, diseases of the liver, kidneys, pregnancy,lactation, age under 18 years, diseases associated with impaired blood clotting and the risk of bleeding. Patients note its high efficiency in the postoperative period. But the high price (about 2,500 rubles for a large package of 60 tablets) makes you choose cheaper analogues instead of Eliquis.
Xarelto. Description
"Xarelto" produced in Germany - the most popular analogue ("Eliquis" has a different active ingredient). The drug is a direct-acting anticoagulant. Available in the form of tablets of 5 and 10 pieces. The active ingredient - rivaroxaban, which is a direct inhibitor of blood coagulation factor Xa, has a high bioavailability when taken internally. During treatment, constant monitoring of blood clotting is not needed.
The drug is rapidly absorbed, the maximum concentration is observed 2-4 hours after ingestion, regardless of food intake. Excreted with urine and feces. Used to prevent venous thromboembolism after lower limb surgery.
Contraindications and side effects
A lot of contraindications has an analogue ("Eliquis" is also rich in them). These include:
• hypersensitivity to drug components, lactose intolerance;
• active bleeding (intracranial, gastrointestinal);
• disorders associated with the risk of bleeding (gastric ulcer, cancerous tumors, trauma to the brain or spinal cord, cerebral hemorrhage, and others);
• simultaneoususe of other anticoagulants;
• Liver disease with risk of bleeding (cirrhosis B and C classes);
• pregnancy, lactation;
• Under 18 years old.
Not recommended for severe renal failure. Just like the Eliquis drug, the analogue has a large list of possible negative consequences.
Side effects appear in the form of malfunctions:
- hematopoietic systems (anemia, thrombocythemia);
- cardiovascular system (hypotension, tachycardia);
- organs of vision (ocular hemorrhage);
- digestive system (gastrointestinal, gum, rectal bleeding; pain, nausea, constipation, diarrhea, vomiting);
- liver (jaundice);
- nervous system (dizziness, headache, rarely fainting);
- genitourinary system (bleeding);
- respiratory system (nosebleed);
- immune system (allergic reactions);
- skin tissue (itching, rash).
During treatment with the drug, pain in the limbs, fever, deterioration of the general condition of the body.
Warfarin
"Warfarin" is another analogue ("Eliquis", unlike it, is a direct-acting anticoagulant). Popular produced in Denmark "Warfarin Nycomed". Also in pharmacies you can find Latvian Varfarex, Finnish Marevan, Russian Warfarin. Compared to other substitutes for Eliquis, domestic analogues are the most affordable.
The active ingredient warfamin is an indirect anticoagulant, a derivative of coumarin. It is quickly excreted from the body through the gastrointestinal tract and skin. Indicated for use in the treatment and prevention of blood vessel embolism, postoperative thrombosis, recurrent myocardial infarction, and prosthetic heart valves. Used in the treatment of thrombosis (surgical or medical) as an additional therapy.
Warfamin contraindications
Due to the large number of side effects, the instructions for use should be carefully studied before taking Eliquis. Analogues do not lag behind in this and have the following contraindications:
- blood pathology, its change;
- diseases with a risk of bleeding;
- recent brain, eye surgeries;
- GI ulcer;
- diseases of the respiratory system;
- aneurysms;
- DIC;
- severe liver and kidney disease;
- diseases of the genitourinary system;
- arterial hypertension;
- pregnancy.
Whether it is safe for use by persons under the age of 18 has not been established.
Possible side effects:
- bleeding, anemia, skin necrosis;
- dermatitis, skin rash, itching, swelling;
- nausea, abdominal pain, vomiting, hepatitis, diarrhea;
- chills, vasculitis;
- headache, dizziness, feeling tired, taste disturbance.
Pradaxa
"Pradaksa" - made in Germany analogue ("Eliquis" differs in composition). It is a direct inhibitor of thrombin. The active ingredient is dabigatran etexilate mesilate. Available in the form of capsules of 10 and 60 pieces per pack. When taken, it is rapidly absorbed in the stomach. Pradaxa is used for prevention:
- venous thromboembolism after lower limb surgery;
- stroke and systemic thromboembolism;
- recurrent thrombosis;
- Pulmonary embolism.
It is also a treatment for acute thrombosis. Pradaxa reduces the death rate due to these diseases.
Contraindications to the use of "Pradaksa"
The presence of many side effects is said about the drug "Eliquis" reviews. Analogues also have their own contraindications and possible negative consequences. Contraindications include:
- hypersensitivity to active or auxiliary components of the drug;
- renal failure (severe);
- active bleeding, impaired hemostasis, hemorrhagic diathesis;
- organ damage due to bleeding;
- GI ulcers;
- malignant tumors;
- brain injury, spinal cord injury, recent surgeries;
- past intracranial hemorrhage;
- liver disease, impaired function;
- vascular aneurysms;
- taking other anticoagulants.
Data on the effect of the drug on patients under 18 years of age are not available. With caution, the drug is used with a decrease in kidney function, a patient weighing less than 50 kg, people over 75 years of age and in the presence of diseases with a risk of bleeding.
Side effects that may occur when taking are similar to previous drugs:
- bleeding;
- skin inflammation;
- disorders of the nervous, digestive, respiratory, genitourinary systems;
- chills, fever, headaches, muscle aches and more.
Compare prices
As it has already become clear, in pharmacies you can buy substitutes for the drug Eliquis. Analogues are cheaper, but no less high-quality, they are produced in different countries, with a different composition from each other. Therefore, their prices are different. So, the average cost of "Xarelto" is within 1500 rubles. Buying "Pradaksa" will cost 700-800 rubles. The most budget option is preparations based on warfamin. They are produced by pharmaceutical companies in several countries. "Warfarin Nycomed" Danish production - about 150 rubles. The price of the Finnish "Marevan" is in the same range. Unlike the expensive drug Eliquis, analogues are cheaper, but not inferior in quality. This is confirmed by numerous cases of successful completion of the postoperative period. The most economical analogues of domestic production, such as "Warfarin", its purchase will cost about 70 rubles.
