"Tubocurarine chloride" is a muscle relaxant and has a peripheral effect. The instructions indicate that it is able to block neuromuscular transmissions.
Composition and release form
The main component of this drug is tubocurarine chloride, which is contained in a dosage of 0.01 g. Glycerol - 0.3 g and special water for injection are added as additional substances.
The product at a concentration of 1% is poured into ampoules of 1.5 ml. Then they are laid out in packs of 25 pieces. Also, the drug is placed in 10 ml vials, which are packed in boxes of 5 pieces.
Pharmacological action
"Tubocurarine chloride" is a non-polarizing muscle relaxant that can block neuromuscular transmission. So, it acts on the H-cholinergic receptors of the skeletal muscles. The relaxation effect develops gradually and reaches a peak after about 5 minutes.
Relaxation of muscle mass occurs consistently. It all starts with the fingers of the upper limbs, and then the muscles of the eyes, lower limbs, back and diaphragm follow. Restoration of tone occurs in the reverse order andstarts with the muscles of the diaphragm.
Mechanism of action "Tubocurarine chloride" releases histamine from tissues and can provoke spasms of muscle tissue in the bronchi.
Indications for use
This drug is used for muscle relaxation while the patient is connected to a ventilator. It is also prescribed for pharmacological or electrically induced muscle cramps and during the diagnosis of myasthenia gravis.
In traumatology, it is used for repositioning bone fragments and repositioning dislocations. In psychiatry - for the prevention of schizophrenia and in the treatment of seizures. And in neurology - with status epilepticus and convulsions of a different origin.
Contraindications
The drug should not be used in case of individual intolerance and hypersensitivity to the components included in the composition. Also, "Tubocurarine chloride" is not prescribed to patients with insufficiency of the hepatic system in chronic renal failure and the elderly.
Instructions for use
The dosage of the drug depends on the type of anesthesia that will be administered to the patient. The instructions for "Tubocurarine chloride" say that it is administered intravenously.
In adults, the drug provokes temporary paralysis of the muscles of the respiratory tract at a dose of 16-26 mg. To achieve a long-term effect, the administration of the drug is repeated with a decrease in dosage by 2 or 1.5 times. For early termination of the drug, "Prozerin" is administered.
Side effects
Upatients after the use of the drug, a rash, swelling, collapse, bronchospasm, tachycardia and a decrease in pressure (arterial) may occur. Bradycardia, hypersalivation and allergic manifestations due to histamine liberation may also develop. Less common is cardiac arrest or arrhythmias.
Overdose
In case of an overdose of the drug, prolonged muscle relaxation may occur. Treatment in this case is carried out with the help of supporting the patency of the respiratory tract and the introduction of neostigmine or pyridostigmine into the body.
The described actions should be taken at the first symptoms of an overdose.
Interaction with other drugs
The effectiveness of "Tubocurarine chloride" is weakened by some substances. These include:
- acetylcholine;
- potassium;
- anticholinesterase drugs.
Cold temperatures and hypothermia can also reduce exposure.
Anesthetics (inhalation), calcium s alts, quinine, some antibiotics (streptomycin, kanamycin, neomycin) and other muscle relaxants can enhance the effect. Also, an increase occurs with hypokalemia.
Pharmacological group and special instructions
"Tubocurarine chloride" refers to drugs that act on the peripheral nervous system. It acts mainly in the zone of the respiratory nerves and tracts. It is an anti-depolarizing muscle relaxant.
Use the remedy can only be a doctor who has experience in using muscle relaxants in conditionspreparation for oxygen therapy and airway intubation.
Shelf life and dispensing from pharmacies
This drug is not sold in all pharmacies and is sold strictly by prescription.
Store and transport the drug in a cool and protected from sunlight place. Shelf life - 5 years.
After the expiration date or in case of improper storage, use the product is prohibited.
Analogues
The following drugs are used as substitutes for Tubocurarine Chloride:
- Amerizol;
- "Kukarin Asta";
- "Delakukarin";
- "Myostatin";
- "Tubokurine";
- Miricin.
The listed analogues have the same spectrum of action. But you can replace the drug only after consulting a doctor.
