The main purpose of Esperal is the treatment of alcoholism. As the review confirms, Esperal, when taken regularly, leads to the formation of a persistent rejection of alcohol. Structural analogues are the funds "Teturam", "Disulfiram", "Torpedo", "Antabus". Available as tablets for oral administration, subcutaneous implantation and as a gel.
Pharmacological properties
The active component of disulfiram promotes the inhibition of acetaldehyde hydrooxidase, a substance involved in the neutralization and breakdown of ethanol in the blood. With partial oxidation of alcohol, acetaldehyde accumulates in the body, resulting in toxic poisoning. General intoxication leads to nausea, general weakness, vomiting, tachycardia, a feeling of lack of air, lethargy, drowsiness or excessive excitement. Similar effects contribute to the formation of alcohol rejection.
As the review indicates, "Esperal" is used at the stage of dependence, in which the patient is no longer able to control the amount of alcohol consumed. The maximum effect is seen12 hours after ingestion. Esperal, which continues for another two weeks after the end of the dose, can act at lightning speed on some patients, causing toxic hepatitis.
Indications and method of administration
The drug is prescribed to prevent relapses during the treatment of alcohol dependence, to detoxify nickel poisoning. Tablets are taken in a volume of 0.5 grams once a day, it is recommended to do this during breakfast. After a 10-day application, an alcohol test is performed, after which the issue of increasing the dosage of the agent is decided. The tool must be used in a daily maintenance volume of 0.2 g for 1-3 years.
Esperal medication is not administered intravenously, implantation tablets are implanted into muscle tissue. Usually, the agent is implanted in the upper part of the buttock or iliac region to a depth of 4 cm. The gel acts and is implanted in the same way.
Contraindications
It is forbidden to use the medicine in case of hypersensitivity to components, renal failure, liver diseases. The tool is not prescribed for severe ailments of the cardiac and vascular system, epilepsy, diabetes. Do not use the medication during pregnancy and lactation.
Side effect, price
As evidenced by the review, Esperal, when used internally, can cause a metallic taste in the mouth, allergies, polyneuritis of the extremities, psychosis, and headache. Sometimes after taking the medicine, there may be a decrease in memory, confusion, optic neuritis, gastritis. In rare situations, asthenia, hepatitis, thrombosis of cerebral vessels of the head develop. With the simultaneous administration of the drug with oral anticoagulants, the likelihood of bleeding increases. As the review says, Esperal can be purchased at a price of 915 rubles.
