Sumamed forte 200 is a strong antibiotic effective against a wide range of diseases. The product is available in powder form for suspension. The product is effective in infections of the respiratory system, skin, it is used in the initial phase of Lyme disease and in the case of ulcers associated with colonies of Helicobacter pylori. In order for a pharmaceutical product to be effective, but not provoke complications, you need to use it correctly, strictly following the instructions drawn up by the manufacturer.
Technical info
As you can see from the instructions for "Sumamed forte" (200/5 ml), five milliliters of the finished product contains 0.2 g of the main active ingredient azithromycin. The antibiotic was used in the form of a dihydrate. As additional components, the manufacturer used flavoring agents and silicon dioxide. The product contains phosphate compounds, gum, sucrose, cellulose. If the patient's body is prone to reactionsensitization to any substances, before using drugs, you need to make sure that there are no dangerous components.
The drug is packaged in 50-100 ml vials. The kit comes with instructions for "Sumamed forte" (200 mg). 16.74 g of the medicinal product is packed into a smaller vial, 29.295 g is twice as large. Tinted brownish glass is used to make the container. In order for the bottle to be hermetically sealed, it is closed with a polypropylene cap. A measuring spoon or syringe is included with the bottle. In some cases, the manufacturer inserts both items for accurate dosing. The whole set is placed in a cardboard box. The exact weight of the medicine, the dosage of the active ingredient, the date of manufacture and the expiration date of the medicine are recorded on the outside.
Pharmacology
As you can see in the instructions for "Sumamed forte" (200 mg / 5 ml), the main ingredient that guarantees the effectiveness of the pharmaceutical product is azithromycin. The substance is assigned to the class of macrolides, is azalide. This is a bacteriostatic drug, which has a wide range of effectiveness when interacting with dangerous microflora. Azithromycin inhibits the process of generating microbial cell proteins. The substance reacts with the 50S ribosomal substance, inhibits the peptide translocase at the translational stage, and inhibits protein synthesis. Such a complex effect provides a slow growth of pathological microflora. The drug inhibits the ability of bacteria to multiply. If athe concentration is high enough, a bactericidal effect is observed.
The product has a pronounced effect in relation to gram-positive and negative bacteria, intracellular parasites, anaerobic life forms. You can use the drug to combat a number of other pathological microorganisms.
Names and effects
In the instructions for "Sumamed forte" (200 mg / 5 ml), the manufacturer indicates the reliability of the use of the drug in the treatment of diseases provoked by aerobic life forms, when tested by Gram showing a positive result. You can prescribe the product if infection with methicillin-susceptible staphylococcus, penicillin-receptive streptococcus has occurred. "Sumamed forte" is indicated for infection with pyogenic streptococcus.
It can be used if studies have shown aerobic infection, while the pathogen shows a negative result in the study by Gram. The drug is effective against Haemophilus influenzae, Legionella and Moraxella, Pasteurella and Neisseria.
In case of anaerobic infection, it is reasonable to prescribe a drug to combat Clostridium, Fusobacter, Prevotella. The tool shows a reliable effect when infected with porphyriomonads. Use the product if the tests showed some forms of chlamydia, mycoplasma, borrelia.
Working or not?
In the instructions for "Sumamed forte" (200 mg / 5 ml), the fact of possible resistance of pathological forms of life to the drug was recorded. Tests have shown that resistance to basican ingredient in a pharmaceutical product can develop penicillin-resistant strains of streptococcus from a species of pneumonia. Similar risks are inherent if infection with a strain characterized by an average degree of susceptibility to penicillin is detected.
By nature, enterococci, bacteroids are resistant to azithromycin. If methicillin is not dangerous for staphylococcus, it also does not accept Sumamed Forte.
From medical practice there are cases of cross-resistance between some forms of streptococci from type A beta-hemolytics, some staphylo-, enterococci. Cross-resistance covers erythro-, azithromycin, other macrolides, lincosamides.
Kinetics
As you can see from the accompanying documentation, "Sumamed forte" (200 mg / 5 ml, 15 ml and other forms of release) is made using azithromycin, which can be rapidly absorbed into the circulatory system after oral use. The maximum concentration in serum is achievable on average in a couple of hours. Bioavailability estimated at 37%.
Whey protein binding is inversely related to the content of the active ingredient in the blood, ranging from 12-52%. The volume of distribution is estimated at 31.1 L/kg.
The active ingredient is able to penetrate cell membranes, therefore it is effective in the case of intracellular microorganisms. Transportation is carried out by phagocytes, macrophages, leukocytes. With these cells, azithromycin penetrates to the infectious focus, is released due to the presence of bacterial invasion. Meansseeps through various barriers, penetrates into organic tissues. At the cellular level, in the tissues, the content of the active ingredient is approximately 50 times greater than in the blood serum. In the focus of infection, accumulation occurs more actively than in he althy areas, by 24-34%.
Kinetics: Continuing Consideration
In the documentation compiled by the manufacturer, attached to "Sumamed forte" (200 mg / 5 ml), the fact of processing of the active ingredient in the liver is specified. Here, chemical reactions of demethylation are localized, due to which azithromycin ceases to be therapeutically effective.
Elimination is relatively slow. The half-life from tissues is estimated at three days with a possible deviation up and down by a day. A therapeutically effective amount of antibiotic is observed in the body up to a week after receiving the last dose of the drug. Elimination is predominantly carried out by the intestinal tract in its original form. Up to 12% of the substance is excreted by the renal system.
Special Occasion
When using "Sumamed forte" (200, 15 ml and another version of the release) in case of weakness of the renal system, it is necessary to remember the possibility of changing the kinetic parameters. If the creatinine clearance is less than 10 units, the half-life increases by a third. If kidney failure is established, the case must be handled very responsibly. It is important to check the indicators regularly in order to control the concentration of the antibiotic in the body.
When shown?
"Sumamed forte" (200 mg) is recommended for use when an infection is detected, a disease accompanied by inflammatory processes. The drug is prescribed if the microflora that provoked the disease is susceptible to azithromycin. You can prescribe a remedy for tonsillitis, sinusitis, as well as other infectious diseases covering the upper passage of air into the lungs. It is allowed to prescribe the agent when an infectious agent enters the lower zones of the respiratory tract. In this case, among the indications, it is worth noting acute bronchitis, a relapse of the chronic course of this disease, as well as pulmonary inflammation that developed in a community-acquired form.
You can use the medicine for Lyme disease. The pharmaceutical product performed well at the initial stage. It is prescribed if erythema migrans is established. The suspension can be prescribed to a person suffering from infectious pathologies of the skin, soft tissues. Often, "Sumamed forte" is resorted to, if necessary, the treatment of erysipelas, dermatosis, secondarily affected by an infectious agent. The indication for prescribing the remedy is impetigo.
Terms of use
The drug "Sumamed forte" (200/5) is prescribed for internal use. The tool is used once a day. It is advisable to use the drug an hour or a couple of hours before a meal. Shortly after receiving the medication, the child should drink a few sips of water. This makes it easier to swallow powder residue. Before next usegently but thoroughly mix the contents of the container so that the substance becomes as homogeneous as possible. If the desired amount is not measured within the next third of an hour, you must first mix the product again, only then use it inside.
To measure the desired volume, use a syringe or a spoon that the manufacturer applies to the product. The division value is milliliter, the maximum volume is 5 ml. One spoon holds 2.5-5 ml. After use, the product is washed. If a syringe is used, it must first be disassembled. For washing use running water. The item is dried, left in storage in a clean place, protected from dust.
Cooking nuances
You can learn how to breed "Sumamed forte" (200/5) if you read the manufacturer's instructions attached to the product. If the vial is intended for the preparation of 15 ml of the drug, it is necessary to draw 9.5 ml of pure water with a syringe and enter it into the container. The agent is thoroughly mixed until the product becomes homogeneous. The finished product in volume will be about 20 ml - that is, 5 ml more than the nominal volume. This is necessary to avoid dosing losses. The prepared product is stored in an environment heated to a level of no more than 25 degrees. Shelf life - up to five days.
It is not more difficult to figure out how to dilute "Sumamed forte" 200 mg if a person has a bottle for 30 ml of the drug. 16.5 ml is measured with a syringe, this liquid is injected into the container. Everything is thoroughly mixed so that the product becomes homogeneous. The finished product will be in a volume of about 35 ml. The extra 5 ml is provided forcompensation for losses caused by measuring the dose. The finished product is stored for no more than ten days. Tempera - 25 degrees.
Finally, you can consider how to breed "Sumamed forte 200" if the volume of the container is 37.5 ml. In this case, 20 ml is injected into the vial with a syringe. The procedure is as described above, including thorough shaking. The finished drug will be larger than the nominal volume in order to prevent losses due to dosing. The product prepared for reception is stored no more than 10 days.
Dose and age
If infection, inflammation, "Sumamed forte 200" is prescribed for children, focusing on the weight of the patient. For each kilogram it is indicated to use 10 mg of the drug. The drug is taken once a day. Duration of application - a three-day program. In total, the patient receives 30 mg per kilogram of weight per course. To determine the optimal volume for one dose, it is taken into account that for a weight of up to 14 kg, 2.5 ml or 0.1 g of the antibiotic is indicated, for a weight of more than 10 kg, the dose is doubled. Children whose weight varies between 25-34 kg are prescribed 7.5 ml of the drug, which corresponds to 0.3 g of the antibiotic. For weights up to 44 kg inclusive, use 10 ml at a time, that is, 0.4 g of azithromycin.
If "Sumamed forte 200" is prescribed for children weighing more than 45 kg, it is necessary to use 12.5 ml of a pharmaceutical product containing 0.5 g of an antibiotic. This dosage is for adults.
Diagnoses and doses
In case pyogenic streptococcus caused tonsillitis, pharyngitis,"Sumamed forte 200/5 mg" is used in an amount of 20 mg / kg per day. Duration - three days, in total for the course the patient receives 60 mg of the drug for each kilo of mass. The maximum per day is 0.5 g. If treatment is indicated for children whose weight is less than 10 kg, the indicated form of release should be discarded and half as saturated should be used.
For erythema migrans, indicating the primary step of Lyme disease, you need to use the drug on the first day in an amount of 20 mg per kilo, from the second day to the fifth, use the product in half the amount. In total, during the course for each kilo, the patient receives 60 mg of the drug.
Do I need to adjust?
If "Sumamed forte 200/5 mg" is prescribed against the background of weakness of the kidneys, while creatinine clearance exceeds 10 units, specialized correction of volumes is not necessary. In case of mild or moderate liver failure, it is also not necessary to adjust the volumes of the pharmaceutical product received by the patient.
Elderly people "Sumamed forte" is prescribed in standard quantities. It is recommended to especially carefully manage such a patient, since there is a danger from the factors provoking arrhythmia. Together with the drug course, this can increase the risk of arrhythmia, including pirouette type.
Unwanted effects: what to be prepared for?
The use of the suspension "Sumamed forte 200" can cause candidiasis localized on the oral, genital mucosa. There is a risk of respiratorydiseases, runny nose, inflammatory processes in the throat, lungs. A vanishingly small percentage of those treated with the pharmaceutical product experienced pseudomembranous colitis. The antibiotic can cause neutro-, thrombocyto-, leukopenia. Its use can provoke anemia, eosinophilia. Occasionally, anorexia, anaphylactic, angioedema response, body sensitization were recorded.
After receiving the suspension of eosinophilia, some patients noted that they were sick and dizzy. There may be feelings of anxiety, irritation for no reason. Cases of sleep disturbance, paresthesia, temporary failure of the taste buds have been recorded. With an unknown frequency, fainting, deterioration of the sense of smell and perversion of this perception, delirium and hallucinations are possible. Occasionally, the patient's vision deteriorated. There is a danger of hearing impairment, palpable heartbeat, hot flashes, lowering pressure. Nosebleeds, heavy breathing are possible. The drug can provoke stool disorders, increased gas formation, abdominal pain, pancreatitis, hepatitis and jaundice.
Against the background of receiving the suspension "Sumamed forte 200", some people had itchy, reddened lesions on the skin. There is a risk of urticaria, activation of the sweat glands, sensitivity to light. Erythema, necrolysis, myalgia, arthralgia are possible. There is a risk of osteoarthritis. Occasionally, the product provoked dysuria, metrorrhagia, nephritis, asthenia, swelling of the face, fever.
Laboratory values and medication
Under the influence of azithromycin contained in Sumamed Forte, specific changes in quality indicators are possibleblood when studying them in the laboratory. There is a possibility of a reduced concentration of lymphocytes and an increase in the content of eosinophils. The number of neutro-, basophils, monocytes may increase. There are cases when, while taking the drug, the saturation of blood serum with bicarbonates decreased. Rarely, abnormal liver enzyme activity is observed. There is a possibility of an increase in the content of bilirubin, urea, creatinine. Some changed potassium, chloride, glucose, sodium concentrations in the blood serum. Possible increase in hematocrit.
Sometimes you can't
It is strictly forbidden to prescribe "Sumamed forte" to children under six months of age. The drug is not used if hepatic disorders are very pronounced. It is forbidden to prescribe a remedy for increased susceptibility to erythro-, azithromycin, macrolides, ketolides. You can not use "Sumamed forte" in case of a sensitization reaction to other components used by the manufacturer. The tool is prohibited in case of lack of isom altase, sucrase in the body. It is not suitable if the human body does not tolerate fructose. "Sumamed forte" is not used if glucose-galactose malabsorption syndrome is detected. You can not use the remedy if the patient is forced to receive ergotamine, dihydroergotamine.
In some cases, "Sumamed forte" is allowed to be used if there is no other alternative, safer. Such an application requires the utmost care. A similar attitude is necessary if the patient has moderate, mild hepaticfailures, myasthenia gravis, terminal weakness of the kidneys, proarrhythmic factors. It is necessary to prescribe Sumamed Forte with extreme care if the patient receives pharmaceutical products that prevent arrhythmia, uses antipsychotics, or is forced to be treated with fluoroquinolones. It is important to responsibly monitor the condition of the body of a patient suffering from fluid and electrolyte imbalances in the blood, bradycardia and cardiac arrhythmia. Severe weakness of the heart, diabetes require special care. You need to be extremely careful when prescribing the Sumamed Forte suspension if a person is receiving medicines containing warfarin, digoxin, cyclosporine.
Pregnancy
During pregnancy, "Sumamed forte" is prescribed if the obvious benefit is much greater than the possible harm. The doctor is obliged to warn the expectant mother about the risks associated with the use of an antibiotic. Strict restrictions are due to the lactation period. If a woman is breastfeeding a child, it is necessary to refuse to take the product in question. If this is not possible, the baby should be transferred to an alternative diet for the period of treatment.
Features and application rules
If there is a need to prescribe an antibacterial course to a diabetic, it is necessary to take into account the fact that the suspension "Sumamed forte" contains sucrose. This fact is important for everyone else who is forced to follow a low-calorie diet.
If an appointment is missed, you need to make up for the pass as soon as possible. Each next serving is consumed at daily intervals between doses.
It should be used an hour or a couple of hours after the patient receives antacids.
In case of weakness of the liver of a weak, moderate level, taking "Sumamed forte" is accompanied by the risk of developing hepatitis and aggravating the insufficiency of the organ. If symptoms of hepatic pathologies are observed, asthenia increases, urine darkens, encephalopathy of the organ is observed, the antibiotic course is stopped. The patient should receive an adequate clinical examination of the liver to assess functionality.
