Non-steroidal anti-inflammatory drug produced in Romania is one of the leading drugs prescribed for the treatment of diseases of the musculoskeletal system. It also has a pronounced antirheumatic effect. The medical drug "Diaflex", reviews of which are both positive and negative, is prescribed, in particular, for osteoarthritis. This disease affects the joints, resulting in a particularly severe deformity and changes in cartilage, which leads to painful consequences.
Tablets "Diaflex" are produced in the form of capsules with a dosage of the active substance diacerein 50 mg. In pharmacies, the medicine is dispensed exclusively by prescription, as it has a specific effect on the human body and interacts with other medicines.
Price policy of the drug is available to the average part of the population. It is included in the State Register, is certified, has parameters that meet the standards, and has the official trade name "Diaflex". Analogues, the price of which varies widely, have the same active ingredients and composition.
Quality andquantitative characteristics
Capsule "Diaflex Rompharm" has a shell of light brown hard gelatin, which contains a bulk substance. Chemical composition and weight content:
- iron oxide (III) - 2.2 mg;
- titanium dioxide - 750mcg;
- gelatin ~ 75 mg.
Active and auxiliary compounds of the drug:
- diacerein 50mg;
- magnesium stearate - 12.5mg;
- lactose monohydrate ~ 250 mg.
Pharmacological effects
The drug itself, as well as the analogue of "Diaflex" - the solution for injection "Vipraxin" - has an antidystrophic and anti-inflammatory effect on the human musculoskeletal system.
The main compound is reduced to an active metabolizing form, which is able to suppress the action of inflammatory mediators, in particular interleukin-1 and -6, tumor necrosis factor-alpha. The effect on the body begins to appear after taking the drug for 2-4 weeks. With the oral use of the Diaflex remedy, patient reviews of which fully confirm the therapeutic effect declared by the manufacturer, there is an anti-inflammatory and analgesic effect on the foci of the disease.
Chemical kinetics of ongoing processes
The drug, like the analogue of "Diaflex" - tablets "Artra Chondroitin" - is relatively quickly absorbed by the gastrointestinal tract, entering the bloodstream. It is recommended to take the medicine along with the main food intake, in thisIn this case, the absorption of the substance increases significantly by about 25%. With a single use of the drug, the maximum concentration of the active substance in the human body is 3.15 mg / l. With constant intake, accumulation occurs, therefore, the content of diacerein increases slightly. The highest concentration is reached after 144 minutes.
The active substance is completely reduced to rhein, which is almost completely bound to proteins. In addition, the drug has the ability to pass through the placental barrier and enter the central nervous system from the circulatory system. The half-life of rhein is 255 minutes. From the body, the substance is excreted in the urine in the form of sulfates, glucuranide and slightly unchanged.
Indications for use
The drug is prescribed for primary and secondary osteoarthritis. These are diseases that affect the tissues of the joints, mainly in women during menopause, as well as in people over sixty years of age. In some cases, as part of a complex of drugs for osteoporosis, the medicine also has a positive effect.
The strategy for the use of a particular medical device must be developed by a doctor without fail. Self-medication is strictly prohibited. It recommends that you carefully study all the information about the drug "Diaflex" instructions for use. Analogues may have other side effects, specific effects on the human body and different effectiveness of the active substance in the fight against the disease.
Prohibited use
Treatment with this drug during pregnancy and lactation is contraindicated, since the active substance, overcoming the placental barrier, has a detrimental effect on the fetus and, as part of mother's milk, adversely affects the he alth and development of the child. All analogues of such a drug are also prohibited for this category of patients. The active ingredients in their composition are harmful to the infant's body and may accompany the development of pathologies during the formation of the fetus.
Restrictions and contraindications
An analogue of "Diaflex" - "Actasulide" - in tablets is not prescribed for the treatment of adolescents under the age of eighteen. It is also not recommended to use the drug in the presence of individual intolerance to some of its components. If you have a syndrome of small absorption of glucose and galactose, as well as lactose deficiency, the drug is strictly contraindicated for you.
The use of the drug should be carried out under strict supervision and only as prescribed by a doctor in the presence of inflammatory processes in the gastrointestinal tract, kidney or liver failure or intestinal obstruction.
Dosage and treatment period
Taking the drug "Diaflex Rompharm", reviews of which say that in the first two weeks of using the drug there is an acceleration of intestinal motility, it is recommended to start with one capsule a day after the main meal, without destroying the capsule shell and drinking plenty of water. After four weeks, you need to increase the dosage intwice - in the morning and in the evening, therefore, you need to take 2 capsules per day, which is a total amount of the active substance 100 mg.
The result of the drug appears on average after a period of time from two to four weeks. The general course, which includes other analogues of drugs of a similar spectrum of action, should be at least four months. Based on the degree of effectiveness of the fight against the disease, the attending physician may prescribe a longer period of admission.
Side effects on the body
When using the drug, the following reactions from the gastrointestinal tract were noted: pain in the abdomen, nausea, vomiting, upset stool. Allergic manifestations: urticaria, bronchial spasms, anaphylactic shock, fever symptoms, mucosal edema. In addition, there may be a general malaise, as well as a change in the normal color of urine to brown due to an imbalance in the acid-base balance. Here is all the information that the instruction provides us with about the Diaflex preparation. Drug analogues may have similar and other side effects.
Overdose cases
Recorded data on exceeding the recommended concentrations of the drug. Patients experienced a general deterioration in well-being, lethargy, and indigestion. When you cancel the reception or restore the desired dosage, the symptoms, as a rule, were removed. More serious consequences were not recorded, unlike other drugs for osteoporosis. medication, evenin the event of an overdose, does not have a negative effect on the body that would not be subject to recovery.
Interaction with other medical devices
Antacids and any anti-diarrheal and poisoning agents that have absorption properties significantly reduce the absorption of the drug, as they absorb it. Any other analogue of "Diaflex", which includes an excellent active substance, may not depend on the intake of such funds. It is also contraindicated to combine the drug with a laxative or substances that increase the volume content of the stomach, for example, dietary supplements that have a lot of fiber in their composition.
Taking antibiotics, combining treatment with a course of chemotherapy, as well as other manipulations or drugs that disrupt the normal intestinal microflora, can lead to significant problems in the digestive system.
Other application tips
Duration of administration, changing the standardized dose and repeating the course can only be prescribed by a specialist doctor. The use of analgesic drugs is recommended to stop after the appearance of a pronounced therapeutic effect from treatment with diacerein.
While taking Diaflex Rompharm, the doctor is obliged to periodically monitor certain parameters, directing the patient to take blood, urine and liver tests. It is important that these characteristics are normal, since the results make a conclusion about the effectiveness of treatment, the required dosage, duration of therapy, repetition of the course or replacementanalogue drug. When taking tests, you need to inform the laboratory assistant about the treatment with diacerein, since urine has a specific color, and in the implementation of some studies, deliberately false conclusions are possible.
For patients with chronic kidney disease, the standardized dose of the active ingredient is half the amount stated in the instructions. In the further picture of treatment, it is possible to increase it under the strict supervision of the doctor.
Receiving "Diaflex" does not affect the patient's ability to drive a car, as well as work with potentially dangerous mechanisms and structures.
It is recommended to store the drug at a temperature not exceeding 25 degrees Celsius, in a dry place out of the reach of sunlight and children. Use the medicine as directed within 3 years.
Reviews about the drug "Diaflex"
Most of the Internet forums devoted to the issues of medicine and treatment with certain drugs contain a lot of reviews about the drug "Diaflex Rompharm". Patients often complain about the duration of treatment and the late effect, as well as the fact that they have to take additional painkillers. Although the instructions for the medicine indicate that the drug works that way.
Many times more you can find positive comments that confirm the effectiveness and efficiency of the remedy in the fight against the most severe joint disease - osteoarthritis. Users note that, on average, a positive effect occurs approximatelythe second week of admission, and the results are fixed for a long time. Many go to repeated courses with the drug "Diaflex", since the effectiveness of such treatment is justified by high efficiency.
Price policy of analog series
| Drug name | Average cost (in rubles) |
| "Diaflex Rompharm" | 1000 |
| "Artroker" | 1040 |
| "Arthrodarin" | 2200 |
| "Artra Chondroitin" | 885 |
The cost of "Diaflex Rompharm" and its analogues ranges from 800 rubles to 2500 thousand per pack. The price for the same drug may vary depending on the pharmacy where it is sold. There is no guarantee that a more expensive product will work better than a budget one. In this case, the individual parameters of the organism and the severity of the disease play a role.
