Today, many women suffer from infertility. Very often this is due to a violation of ovulation, which is caused by endocrine changes. In such cases, the drug "Klostilbegit" comes to the rescue. Reviews of the medicine indicate that this remedy has helped many women find the joy of motherhood. The drug does not contain hormones, but normalizes the production of estrogens and gonadotropins in the female body and is a powerful ovulation stimulator. Unlike other similar drugs, this medicine is much less likely to cause unpleasant side effects. Next, the properties and effects of the drug will be considered, reviews of "Klostilbegit" and the results for women in the treatment of infertility are given.
What is anovulation
A woman's ovaries produce follicles every month. One of them looks on ultrasound as the largest and most developed. Such a follicle is called dominant. In the middle of the menstrual cycle, an egg is released from it. This process is called ovulation. It is controlled by the pituitary and hypothalamus. Follicle-stimulating and luteinizing hormones (FSH and LH) are responsible for the formation of a dominant follicle and the release of an egg.
However, as a result of various pathologies and hormonal disruptions, ovulation may be absent, which makes conception impossible. In such cases, doctors talk about anovulation. In some cases, this may be due to natural causes. For example, the functioning of the ovaries stops in women during menopause, and the use of hormonal contraceptives also blocks the process of ovulation.
However, quite often, anovulation in a woman of childbearing age is associated with many diseases:
- Polycystic ovary syndrome (PCOS). This is a fairly common violation. In the body of a woman, the level of male hormones rises, because of this, the follicles mature, but do not reach the state of ovulation. An ultrasound of the ovaries reveals many blisters filled with fluid.
- Injuries and tumors of the brain. These pathologies can lead to dysfunction of the brain regions: the pituitary gland and the hypothalamus. As a result, a woman may not ovulate.
- Obesity or anorexia. Excess or lack of adipose tissue causes hormonal imbalance in the body.
- Diseases of the thyroid gland or adrenal glands. Pathologies of these organs can provoke hyperandrogenism - an increase in the level of male hormones in a woman's body. This results in a lack of ovulation.
How to understand that a woman has violations of the release of the egg from the dominantfollicle? Usually anovulation makes itself felt with the following symptoms:
- menstrual disorders (up to the complete cessation of menstruation - amenorrhea);
- male pattern hair growth on the body and face (hirsutism);
- intermenstrual uterine bleeding;
- lack of pregnancy with regular intercourse for 1 year without using contraceptives;
- growth of the endometrium (determined by ultrasound examination).
If a woman is planning a pregnancy, then in such cases, the drug "Klostilbegit" is prescribed. Reviews of doctors indicate that this remedy does not cure the disease itself, which caused infertility. The drug only stimulates ovulation and promotes pregnancy, so the drug is used in the treatment of only those patients who are planning to have a baby soon.
Pharmacological properties of the drug
Often the cause of anovulation is an excess of estrogen in the body. They block the formation of pituitary hormones that are responsible for the release of the egg. The active component of "Klostilbegit" is clomiphene citrate, which binds estrogens. The body increases the activity of gonadotropic hormones, which are responsible for the process of ovulation.
This medicine is produced in the form of tablets. Each of them contains 50 mg of the active ingredient. It is important to remember that the drug should never be taken on its own. Before being appointed, you must submitblood test for hormones. In addition, tablets are taken under ultrasound guidance.
You can often find negative feedback from women about "Klostilbegit" - in all cases, the patients self-medicated. This not only did not lead to pregnancy, but also caused serious side effects. It is important to remember that this medicine actively affects the hormonal background, and if it is used without indications, it will cause malfunctions in the endocrine glands. In addition, there are contraindications to the appointment of this medication.
Indications and contraindications for the use of the drug
The drug is effective only in anovulatory form of endocrine infertility. If problems with conception are caused by other reasons, then this remedy will not help. Before prescribing a medication, a comprehensive examination of the body for hormone levels is carried out. The drug is used in the following diseases, accompanied by the absence of ovulation:
- Total absence of periods for a long period of time (amenorrhea).
- Infrequent periods with an increase in the cycle of more than 45 - 60 days (oligomenorrhea).
- Polycystic ovaries (Stein-Leventhal syndrome).
- Too long maturation of the dominant follicle and delayed ovulation.
- Chiari-Frommel syndrome - a disease accompanied by the cessation of menstruation, atrophy of the reproductive organs and the release of milk from the mammary glands outside of feeding.
However, there are conditions and diseases in which thisthe drug is contraindicated. These include:
- pregnancy;
- ovarian cysts (except polycystic);
- diseases of the thyroid and adrenal glands;
- tumors dependent on hormone production;
- visual impairment;
- lack of hypothalamic function;
- malignant neoplasms;
- endometrial proliferation;
- Uterine bleeding of unknown origin.
How the drug is taken
The drug is started on the 5th day of the menstrual cycle. If a woman suffers from amenorrhea, then the medication can be started any day. In this case, the following algorithm must be observed:
- In the first month, take 50 mg (1 tablet) of the drug from the 5th to the 10th day of the menstrual cycle. At the same time, with the help of ultrasound, the growth of follicles in the ovaries is observed. If ovulation occurs between the 11th and 15th day, then this indicates a positive result of the treatment.
- If the therapy was ineffective, then the next month the dosage is doubled. Assign 100 mg (2 tablets) on the same days of the cycle.
- If there is still no result, then the treatment at a dosage of 100 mg is repeated again in the next cycle.
If there is no result within 3 months, take a break for 90 days. Then the treatment is repeated again according to the above scheme.
Reviews of "Klostilbegit" and the results of therapy indicate that many women became pregnant after the first month of treatment. In some patients, ovulation was observed during a three-month course of therapy after discontinuationdrug.
Unwanted effects
During treatment, it is very important to monitor the condition of the ovaries. Reception "Klostilbegit" contributes to their increase. There may be hyperstimulation of the ovaries, which leads to their rupture. Therefore, during the treatment period, ultrasound should be done regularly.
In reviews of "Klostilbegit" other undesirable phenomena are also reported:
- appearance of spots before the eyes;
- dyspeptic symptoms (nausea, diarrhea);
- reaction slowdown;
- headache;
- dizzy;
- sleep disorders;
- intermenstrual bleeding;
- dryness of the vaginal mucosa.
These manifestations are transient and disappear when the drug is discontinued.
It is important to remember that this remedy promotes the growth of fibroids and ovarian tumors, therefore, in the presence of neoplasms of the reproductive organs, the drug is strictly contraindicated.
What to do if the result is unsuccessful
There are cases when, even after long-term treatment with the drug, a woman still does not ovulate. Reviews of "Klostilbegit" indicate that this is often noted. However, it is impossible to use the drug for too long, as this increases the risk of tumor formation. What if the result of the treatment was unsuccessful?
If the therapy was ineffective, the doctor uses additional methods to stimulate ovulation, but before that, you need to establish the exact causeinfertility.
Sometimes egg production disorders are associated with a deficiency of the hormone progesterone. In this case, the treatment with "Klostilbegit" is supplemented by taking the drug "Dufaston", which is used from the 5th to the 25th day of the cycle.
It is very important to remember that prolonged attempts to stimulate ovulation deplete the ovarian reserve, which leads to an early onset of menopause, so Clostilbegit can be used for no more than 6-7 cycles in life.
If a woman has initial signs of depletion of ovarian function, then "Klostilbegit" is supplemented with other drugs. In this case, the following treatment scheme is used:
- Reception of "Klostilbegit" starts from the 3-5th day of the cycle, while constantly doing ultrasound to control the growth of the follicle.
- When the dominant follicle reaches a sufficient size, an injection of a preparation containing human chorionic gonadotropin is given. Ovulation occurs a few days after the injection.
- Additionally, from the 5th to the 21st day of the cycle, the patient takes Proginova. It contains estrogens and prevents premature depletion of the ovarian reserve.
Multiple pregnancy
Reviews of "Klostilbegit" suggest that some patients, after stimulating ovulation, began multiple pregnancy. However, this result is rarely seen. According to medical statistics, after treatment with this drug, twins or tripletswas born only in 10-12% of women. It can be concluded that this medicine cannot be used for the special planning of multiple pregnancies.
Reviews of doctors
Experts leave positive feedback on the stimulation of ovulation "Klostilbegit". According to doctors, a positive result after the first attempt was noted in about 50% of cases. The success of stimulation largely depends on the degree of hormonal disturbance and the age of the patient. After the fifth stimulation attempt, pregnancy occurred in 70-75% of women.
Patient testimonials
Patients leave a lot of positive feedback about the stimulation of "Klostilbegit". This medicine is especially effective in helping with polycystic ovary syndrome. Many women with PCOS have managed to conceive after years of infertility. However, it must be remembered that the result does not always come on the first try. In many cases, pregnancy occurred in the second or third month of therapy, but even in the first days of treatment with ultrasound examination, the response of the ovaries to stimulation was clearly visible.
However, there are times when the drug did not help and the long-awaited pregnancy did not occur. In the absence of a result, additional examinations should be performed. It is possible that infertility is not associated with anovulation, but with other causes. In such cases, the doctor may recommend other treatments. In the absence of the effect of drug therapy, patients are shownIVF procedure.
