Ibuklin Junior drug with ibuprofen is produced by the Indian pharmaceutical company Dr. Reddy's Laboratories and is an antipyretic and analgesic drug with an anti-inflammatory effect. The cost of this medicine in Russian pharmacies is about 100 rubles per pack.
Composition and release form
What is the release form of Ibuclin Junior with ibuprofen? These are dispersible tablets: flat, round, pink in color with bright patches, have a fruity-mint smell, at risk and bevel on one side. Packed tablets of 10 pieces in blisters. The carton box contains 20, 2 or 1 blister.
One tablet contains active substances: ibuprofen - 100 mg, paracetamol - 125 mg. The following substances are used as auxiliary components in the production of tablets: corn starch, sodium carboxymethyl starch (type A), microcrystalline cellulose, aspartame, colloidal silicon dioxide, lactose, talc, flavors, glycerol, mint leaf oilpepper, magnesium stearate, color.
Pharmacological action
"Ibuklin Junior" with ibuprofen is a combined drug, the pharmacological properties of which are due to the action of its constituent elements. Paracetamol, as one of them, has analgesic and antipyretic effects, indiscriminately blocks cyclooxygenase (COX). Another element - ibuprofen - belongs to the category of non-steroidal anti-inflammatory drugs (NSAIDs), and also has antipyretic and analgesic properties. Its therapeutic effect is due to the suppression of COX-1 and COX-2 and a change in the metabolic processes of arachidonic acid, due to which the concentration of prostaglandins in the blood (mediators of inflammation, pain and hyperthermic reaction) decreases. In addition, this substance has a suppressive effect on the proliferative and exudative phases of inflammation.
The combination of these active elements is the most effective in comparison with monotherapy with one of them. This confirms the instructions for use for Ibuklin Junior with ibuprofen.
Pharmacokinetic characteristics
Paracetamol is characterized by high absorption. It binds to plasma proteins by more than 10%. The highest concentration of the substance in the blood is 5-20 mcg / ml, and this level is reached in about 30-120 minutes. Paracetamol is able to pass through the blood-brain barrier. Less than 1% of the accepted dosage is found in women's milk. 90-95% of the metabolic changes in paracetamol occur inliver. The half-life is 2-3 hours. This component is excreted mainly by the kidneys, with urine.
Ibuprofen tablets "Junior Ibuklin" when taken orally, is almost completely absorbed from the digestive tract. The maximum level of the substance is reached in approximately 60-120 minutes. The half-life is about 2 hours. Communication with plasma proteins - more than 90%. Ibuprofen gradually penetrates into the joint cavity, concentrates in the synovial fluid, where its level is higher than in plasma. This substance is excreted mainly by the kidneys, some of it - with bile.
Consider Ibuklin Junior with ibuprofen indications for use.
Indications for prescription
According to the instructions, the medication is indicated in children from 3 to 12 years of age in the event of such pathological conditions:
- fever syndrome;
- pain of various origins (sprains, toothache, dislocations, fractures);
- as an adjunct in the treatment of tonsillitis and other acute inflammatory diseases of the upper respiratory organs with infectious lesions (tracheitis, pharyngitis, laryngitis).
Are there any contraindications for the drug?
List of contraindications
Absolute contraindications to the use of the drug "Ibuklin Junior" are:
- pathology of the optic nerve;
- ulcerative lesion of the stomach or duodenum at the stage of exacerbation;
- aspirin asthma;
- impaired kidney or liver function;
- hemorrhagic diathesis, bleeding disorder (hypocoagulation, hemophilia);
- bleeding of any origin;
- lack of glucose-6-phosphate dehydrogenase;
- children under 3 years of age;
- high sensitivity to the constituent elements of the drug, other NSAIDs, or to acetylsalicylic acid.
As relative contraindications, it should be noted:
- arterial hypertension;
- chronic heart failure;
- liver or kidney failure;
- hyperbilirubinemia;
- nephrotic syndrome;
- a history of peptic ulcer of the digestive departments;
- gastritis;
- colitis;
- bronchial asthma;
- leukopenia and anemia of unknown origin.
Instructions for use
The medical preparation "Ibuklin Junior" should be taken orally by dissolving the tablet in 5 ml of water. The break between taking the medicine should be at least 4 hours, and in case of functional disorders of the kidneys or liver - 8 hours.
Daily dosage is recommended to be divided into 2-3 doses. The recommended dosage of the drug per day for children is: 3–6 years old with a body weight of 13–20 kg: 3 tablets; with a body weight of 20-40 kg (6-12 years) - up to 6 tablets.
Duration of the course of use of the drug without medical supervision as a means to reduce the temperature should not be more than 3 days, and in the form of an anesthetic - 5 days.
Side effect
Medication "Ibuklin Junior" with ibuprofen can provoke the following adverse reactions:
- Digestive system: dyspepsia, long-term use of high doses - hepatotoxic effect;
- Hematopoiesis: agranulocytosis, thrombocytopenia, pancytopenia, neutropenia;
- Allergic phenomena: skin itching, urticaria, rash.
- Respiratory system: bronchospasm, shortness of breath.
- Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome, edema, cystitis, polyuria.
- CNS: symptoms of cephalalgia, dizziness, anxiety, insomnia, irritability, drowsiness, agitation, depression, hallucinations, confusion, in rare cases, aseptic meningitis (more often in patients suffering from autoimmune diseases).
- Sense organs: tinnitus, hearing loss, visual impairment, optic nerve toxicity, double vision or blurred vision, amblyopia, scotoma.
- Other: excessive sweating.
When the above pathological reactions appear, it is recommended to stop taking the drug and seek medical help. The dosage recommended in the instructions for Ibuklin Junior with ibuprofen must be strictly observed.
Overdose symptoms
Drug in overdose can provoke the development of abdominal pain, nausea, vomiting, diarrhea, anorexia, pain inepigastric region, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, acute renal failure, coma, low blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
The following therapeutic measures are recommended: gastric lavage (in the first hour after ingestion), alkaline drinking, sorbents, forced diuresis, symptomatic treatment aimed at correcting blood pressure indicators and the general condition of the patient. Other methods of therapy are determined individually and depend on the concentration of the drug in the patient's body.
Special Recommendations
The decision to take the drug "Ibuklin Junior" with ibuprofen and paracetamol as an antipyretic drug is taken individually, depending on the tolerance and severity of the febrile syndrome. Care must also be taken when prescribing the drug to patients with infectious diseases, due to the high likelihood of masking symptoms and difficulty in making a diagnosis. In order to reduce the risk of undesirable effects on the part of digestion, it is recommended to use this drug in the minimum effective doses, the minimum course. When using "Ibuklin Junior" with ibuprofen for more than 5 days in a row, monitoring of peripheral blood parameters and the state of the liver is required. In order to prevent distortion of test results (quantitative determination of uric acid, serum glucose, 17-ketosteroids), it is recommended to cancel the drug 48 hours before theirholding.
For the duration of taking this medication, it is advisable to refrain from driving vehicles and other complex mechanisms, as this requires the speed of psychomotor reactions.
Ibuklin Junior with ibuprofen can adults?
Despite the fact that the pharmacological agent is intended for children, adults can also use it for all the pathological symptoms indicated in the list of indications for use. However, in this case, it is necessary to correctly adjust the dosage of the medicine.
Use during lactation and pregnancy
During pregnancy, it is possible to use the medication only for a minimal course, and also in the case when the benefit to the mother is higher than the risk to the fetus. Experimental studies have not revealed the embryotoxic, teratogenic and mutagenic properties of this drug. In case of need for a short intake during lactation, cessation of feeding is usually not required.
Interaction with other medicines
The combined use of Ibuklina Junior with ibuprofen for fever is contraindicated for children with other NSAIDs. Features of combination with other drugs:
- Paracetamol: increased risk of nephrotoxic effects.
- Anticoagulants, thrombolytic agents (anistreplase, alteplase, urokinase, streptokinase), colchicine, antiplatelet agents: increased risk of hemorrhagic complications.
- Glucocorticosteroids, corticotropin, ethanol: increasingrisk of erosive and ulcerative lesions of the digestive organs.
- Indirect anticoagulants: blood clotting control needed.
- Hypoglycemic oral drugs, insulin: hypoglycemic effect is enhanced.
- Diuretics, antihypertensives: their effect is reduced.
- Digoxin, lithium preparations, methotrexate: increased blood levels.
- Caffeine: there is an increase in the analgesic effect of Ibuklin Junior with ibuprofen.
- Gold preparations, cyclosporine: increased nephrotoxicity.
- Cefoperazone, cefamandol, cefotetan, plicamycin, valproic acid: increased incidence of hypoprothrombinemia.
- Colestyramine, antacids: reduced drug absorption.
- Myelotoxic agents: contribute to hematotoxicity.
Analogues
The following drugs are analogues of the drug "Ibuklin Junior" with ibuprofen:
- Brufika Plus;
- "Brustan";
- "Next";
- Khairumat;
- Nurofen.
Only a doctor should select a replacement.
The most popular substitute is the drug "Nurofen". True, it does not contain paracetamol, so it is not so strong. Available in tablets, suspensions, rectal suppositories.
"Nurofen" for children, depending on the dosage form, is used to treat patients of different age groups: suppositories are prescribed for children from 3 months to 2 years, suspension - for children from 3 months to 12 years, tablets - for childrenfrom 6 years of age and adult patients.
All forms of release of the drug are used as an analgesic for the relief of headache, ear, tooth, muscle, joint, menstrual, rheumatic pain, back pain, sore throat, neuralgia, migraines and other pathological conditions.
Reviews
About the drug "Ibuklin Junior" with ibuprofen reviews are mostly positive. Parents who gave this medicine to their children note that it is effective when other drugs do not help reduce the temperature. In addition, it is noted that if the rules described in the instructions are followed, the results from Ibuklin Junior come much faster than from other means.
Side effects include loose stools and abdominal discomfort. As for the use of this medication by adult patients, such cases are also indicated in the reviews. Patients say that the medicine helped them very quickly, eliminated the fever, muscle pain, and reduced the symptoms of intoxication with colds. In the case of the use of the drug by adult patients, the dosage can be doubled, compared with children. However, body weight should be taken into account, and a maximum pediatric dose may be appropriate for a low-weight adult.
Doctors in the reviews note that "Ibuklin Junior" with ibuprofen for children is one of the most modern and effective means. However, they warn that it is necessary init is imperative to observe the intervals between taking this medication, since when ingesting large doses, there is a high likelihood of signs of an overdose.
Regarding the analogues of this drug on medical sites, there are also some reviews. The drug "Nurofen" is in the widest demand, which is available in a variety of dosage forms intended for different age categories of patients. This remedy also relieves fever and muscle pain well, but does not contain paracetamol in its composition. The medicine "Next" is also mentioned, which has a composition identical to "Ibuklin Junior". This drug is also widely popular and in high demand in the pharmacy chain.
Despite its high efficiency, the drug also has some negative reviews, which contain information that the drug caused a lot of side effects. This, according to experts, is extremely rare, mainly in people suffering from allergic reactions and weak immunity. They experienced severe dizziness, severe dyspeptic disorders, headache, visual disturbances. In elderly people, the drug provoked an increase in blood pressure, an increase in heart rate, the occurrence of failures in the rhythm of heart contractions, etc. In these cases, the medication had to be canceled.
