"Vesikar" is a medicine that helps to reduce the tone of the smooth muscles of the urinary tract. The drug belongs to the group of antispasmodics. Used for the treatment of urological diseases.
"Vesikar" is produced in tablet form, in dosages of 5 and 10 milligrams. The main component is solifenacin succinate.
Additional substances are:
- lactose monohydrate;
- cornstarch;
- hypromellose;
- magnesium stearate;
- macrogoal;
- hypromellose;
- talc;
- titanium dioxide;
- dyes.
What analogues of the drug "Vesikar" exist?
Pharmacological action
The active substance has an intense antispasmodic effect. A component of a specific competitive inhibitor of muscarinic cholinergic receptors.
Pharmacological effect of the drugnoted already in the first week of therapy, normalizes in the next twelve weeks of using Vezikar. The maximum therapeutic effect is achieved on average after 4 weeks of treatment. The effectiveness of therapy lasts up to a year.
Maximum blood levels of solifenacin are reached 3-8 hours after taking the tablets. At the same time, the indicator of the maximum content increases in proportion to the increase in dosage from 5 to 40 milligrams. The absolute bioavailability of solifenacin is ninety percent.
Indications
Vesicar is used in the symptomatic treatment of people with overactive bladder syndrome, which is accompanied by:
- Imperative urinary incontinence.
- The imperative urge to urinate.
- Increased urination.
Restrictions
Prohibitions for the use of medicines are:
- Retention of urination.
- Severe kidney disease.
- Angle-closure glaucoma (a pathological process that leads to injury to the optic nerve).
- Severe diseases of the digestive system.
- Myasthenia gravis (an autoimmune neuromuscular disease characterized by abnormal fatigue of the striated muscles).
- Severe liver disease.
- Performing hemodialysis.
- Hereditary galactose intolerancelack of enzymes that convert galactose to glucose).
- Lactase deficiency (impaired digestion of lactose due to deficiency of the enzyme lactase of the mucous membrane of the small intestine, accompanied by clinical symptoms).
- Glucose-galactose malabsorption (a rare metabolic disease in which the cells lining the intestines are unable to absorb two specific sugars, such as glucose and galactose).
- Individual intolerance.
- Children's age.
How to take medication
According to the instructions for use for "Vesikar", the recommended concentration of the drug for adults (from 18 years old) and elderly patients is 5 milligrams per day. If necessary, the concentration of the active substance is increased to 10 mg per day. Tablets are taken orally, whole, daily, regardless of food intake. Washed down with water.
Adverse reactions
When using "Vesicar" in rare situations, negative effects may occur:
- Mild headache.
- Moderate dizziness.
- Moderate dry mouth.
- Drowsy.
- Delirium (a mental disorder with painful reasoning, ideas, and conclusions inherent in this state that do not correspond to reality).
- Confusion.
- Hallucinations (an image that appears in the mind without an external stimulus).
- Violation of accommodation (the problem of adapting an organ or organism as a whole to changes in external conditions).
- Dryness of the mucous membrane of the eyes.
- Glaucoma (a large group of eye diseases characterized by a constant or intermittent increase in intraocular pressure (IOP) followed by the development of typical visual field defects, decreased vision and optic nerve atrophy).
- Nausea.
- Heartburn.
- Flatulence (a pathological condition of the body resulting from excessive gas formation and accumulation of gases in the gastrointestinal tract).
- Pain in the abdomen.
- Constipation.
- Gastroesophageal reflux disease (a chronic relapsing disease caused by spontaneous, regularly repeated reflux of gastric and/or duodenal contents into the esophagus, leading to damage to the lower esophagus).
- Intestinal obstruction.
- Coprostasis (fecal stasis that causes blockage of the lumen of the large intestine).
- Loss of appetite.
- Gagging.
- Liver dysfunction.
- Change in laboratory parameters of liver tests.
- Difficulty urinating.
- Infectious inflammation of the urinary tract.
- Cystitis (inflammation of the bladder, a common urological disease of the urinary system).
- Acute urinary retention.
- Kidney failure.
- Dryness of the nasal mucosa.
- Swelling of the legs.
- Fatigue.
- Dry skin.
- Itching and rash.
- Urticaria (skin disease, dermatitis predominantlyallergic origin, characterized by the rapid appearance of intensely itchy blisters).
- Erythema multiforme (an acute immune-mediated inflammatory reaction of the skin and, in some cases, mucous membranes to various stimuli, characterized by target-like lesions with peripheral localization, prone to recurrence and self-resolution).
- Exfoliative dermatitis (a whole group of diseases manifested by extensive lesions of the skin in the form of redness, thickening, thickening and strengthening of their pattern).
- Tachycardia (a sharp increase in heart rate, a sign of serious disorders).
- Mydriasis (the condition of the pupil in which this element increases in diameter and stops responding to light).
- Acute urinary retention.
Recommendations for use
From the instructions for use for "Vesikar" it is known that with extreme caution the drug is prescribed to patients with certain concomitant diseases, including:
- Obstruction of the bladder outlet (a pathological condition in which there is a violation of the outflow of urine).
- Obstructive diseases of the digestive tract (including stagnation of food in the stomach).
- Delayed motility of the digestive tract.
- Hiatal hernia.
- Gastroesophageal reflux (reflux of gastric (gastrointestinal) contents into the lumen of the esophagus).
- Autonomic neuropathy (disorders of the nervous system associated with damage to small blood vessels in diabetes).
- Hypokalemia (a human condition characterized by low levels of potassium in the blood).
During therapy with Vezikar, you need to pay attention to the following nuances:
- Before treatment, you need to make sure that there are no other reasons that provoke involuntary urination.
- If infectious processes of the urinary tract are detected, antibiotic therapy is required.
- No need for dosage adjustments for elderly patients.
- Under 18 years of age, the drug is contraindicated.
- After therapy with Vezikar, it is necessary to take a week break before using drugs of the M-anticholinergic group.
- The drug can provoke a violation of the visual ability to clearly distinguish objects, fatigue, so care must be taken during therapy for people whose activities require increased attention.
Drug Interactions
When combined with M-cholinomimetics, the pharmacological effect of solifenacin decreases.
With the simultaneous use of Vezikar with M-anticholinergics, the therapeutic effect and side reactions of solifenacin increase.
When interacting with solifenacin, Vesicar reduces the pharmacological effects of drugs that activate the motility of the digestive organs.
"Ketoconazole", "Itraconazole", "Ritonavir" enhance the bioavailability of solifenacin, therefore, when combined with these medicines, the maximum dosage of "Vesikar" does notmust exceed 5 mg. And people with kidney and liver diseases are not recommended to use these drugs.
You can not combine Vesicar with Verapamil, Diltiazem, Rifampicin, Carbamazepine, Phenytoin.
Pregnancy and breastfeeding
Clinical data on the safety and effectiveness of the use of "Vesikar" in women in the position are not available, so it is necessary to use the drug with extreme caution during the "interesting position.
No information on solifenacin passing into breast milk. The medication should not be used during lactation. What analogues and cost does "Vesikar" have?
Substitutes
Generics, the structure of which includes solifenacin, is the drug "Zevesin".
Cheap analogues of Vezikar include:
- "Novitropan".
- "Driptan".
- "Detrusitol".
- "Urotol".
Before replacing the drug, you should consult with a specialist. The cost of the study drug varies from 800 to 1300 rubles.
Urotol or Vesicar, which is better
Medication with antidysuric and m-anticholinergic action. According to the annotation, "Urotol" is recommended to eliminate bladder hyperreflexia, which manifests itself in the form of frequenturge to urinate, urinary incontinence.
Pills are taken orally, regardless of food. Recommended concentration of the drug: twice a day, 2 mg.
"Urotol" is considered a cheap analogue of "Vezikar". This is the advantage of the drug, its cost. The effectiveness of Urotol is no worse than that of Vezikar.
With individual tolerance, a single dosage can be reduced to 1 mg. In the same dose, the drug is prescribed for diseases of the liver and kidneys. The cost of the medication varies from 500 to 700 rubles.
Detrusitol
Blocker of m-cholinergic receptors, lowering the tone of the smooth muscles of the urinary tract. The drug is suitable for the treatment of overactive bladder, which are characterized by increased urination.
"Detrusitol" is a cheap analogue of "Vezikar". Before therapy with Detruzitol, it is necessary to conduct an examination of the patient in order to exclude organic causes of frequent urge to urinate. The daily concentration of the drug should be reduced to 2 mg if necessary, the simultaneous use of antibiotics of the macrolide group, as well as antifungal agents.
The drug should not be prescribed to children, as the safety of its use in this age group of people has not been fully studied. Women of childbearing age should use contraception during therapy.
Feedback about "Detruzitol" are few. Many of them tell about the increased effectiveness of the drug. It is noted that when using long-acting capsules in comparison with treatment with tablets, the pharmacological effect is more pronounced.
Adverse reactions are rarely reported. Dryness in the oral region, as a rule, is unexpressed. The cost is from 500 to 700 rubles.
Driptan or Vesicar, which is better?
The drug is a drug whose pharmacological effect is aimed at lowering the tone of the smooth muscles of the urinary tract. The drug is available in tablets.
"Driptan" is recommended with extreme caution for people with kidney or liver disease. As well as people who suffer from cardiac ischemia, hyperthyroidism, arterial hypertension, benign prostatic hyperplasia.
In the first three months of pregnancy, "Driptan" is not recommended for women, since there is no reliable information regarding the safety of the drug components on the fetus, in addition, all important organs and systems of the unborn baby are laid in the first twelve weeks, and the use of any medication can be detrimental affects this process. The price of the medicine ranges from 600 to 900 rubles.
Novitropan
An antispasmodic that affects the frequency of urination and is effective in urinary incontinence. Available in tablet form.
The drug hasantispasmodic efficacy, with the help of which it helps to eliminate stenosis and lowers the tone of smooth muscles of the biliary tract, gastrointestinal tract, uterus, exerting a myotropic and m-anticholinergic effect. The drug increases the capacity of the bladder, reduces the frequency of involuntary contractions and restrains the urge to urinate.
Children and the elderly are recommended to use Novitropan with special care. In addition, precautions must be observed in case of autonomic neuropathy, severe gastric motility disorders, and liver diseases.
When the gastrointestinal tract is affected, the use of anticholinergic drugs can weaken the motility of the digestive organs, which should be taken into account in the treatment of patients with intestinal atony, ulcerative colitis. The cost of Novitropan is 600 rubles.
Spasmex
The drug has an antispasmodic effect, which helps to reduce the tone of the smooth muscles of the bladder. What is more effective - "Spazmeks" or "Vesikar"? Both drugs work in the same direction. That one, that the second drug has the same pharmacological activity. The cost of "Spasmex" is much cheaper than that of "Vezikar" - it starts from 300 and ends with 900 rubles.
Zevesin
The drug belongs to cholinergic receptor antagonists. As a rule, Zevesin is prescribed to patients who suffer from overactive bladder.
Average costthe drug is 3800 rubles. "Zevesin" is necessary for the treatment of frequent urination, urinary incontinence, which are recorded in people with increased organ activity syndrome. The drug is taken as a whole, washed down with water. Zevesin is taken regardless of food.
Storage conditions
"Vesikar" should be stored away from moisture and the sun, away from children, at a temperature not exceeding 25 degrees. The shelf life is three years. It is not recommended to use the drug after the expiration date. "Vesikar" has no Russian analogues.
Opinions
Reviews about "Vesikar" on medical Internet resources tell that the drug could not establish itself as the most effective remedy for urinary incontinence. Most patient reviews do not report relief after taking the drug. In addition, most people report frequent side effects. From the reviews it is known that there are no cheap analogues of Vezikar without side effects.
But there is evidence of a situation where the best result was noted precisely after the use of the studied medication.
It must be remembered that the treatment of overactive bladder syndrome is considered complex, and largely depends on the individuality of each organism.
